Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | ATP dependent Clp protease proteolytic subunit | 0.0077 | 0.0559 | 0.0367 |
Schistosoma mansoni | Lamin B receptor (ERG24) | 0.005 | 0.0203 | 0.0203 |
Onchocerca volvulus | 0.0147 | 0.1514 | 0.319 | |
Brugia malayi | Probable ClpP-like protease | 0.0077 | 0.0559 | 0.2274 |
Echinococcus multilocularis | tumor protein p63 | 0.0684 | 0.8842 | 0.8819 |
Plasmodium vivax | ATP-dependent Clp protease proteolytic subunit, putative | 0.0077 | 0.0559 | 0.5 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0152 | 0.1591 | 0.1591 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0152 | 0.1591 | 0.142 |
Treponema pallidum | ATP-dependent Clp protease proteolytic subunit | 0.0077 | 0.0559 | 0.5 |
Leishmania major | 3-Beta-hydroxysteroid-delta(8), delta(7)-isomerase, putative | 0.0147 | 0.1514 | 0.69 |
Schistosoma mansoni | microtubule-associated protein tau | 0.0769 | 1 | 1 |
Wolbachia endosymbiont of Brugia malayi | ATP-dependent Clp protease proteolytic subunit | 0.0077 | 0.0559 | 0.5 |
Trypanosoma cruzi | Emopamil binding protein, putative | 0.0147 | 0.1514 | 0.69 |
Schistosoma mansoni | hypothetical protein | 0.0152 | 0.1591 | 0.1591 |
Loa Loa (eye worm) | hypothetical protein | 0.019 | 0.2103 | 0.3387 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0052 | 0.0225 | 0.0913 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0152 | 0.1591 | 0.142 |
Chlamydia trachomatis | ATP-dependent Clp protease proteolytic subunit | 0.0077 | 0.0559 | 0.5 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0052 | 0.0225 | 0.0362 |
Chlamydia trachomatis | ATP-dependent Clp protease proteolytic subunit | 0.0077 | 0.0559 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0077 | 0.0559 | 0.0901 |
Loa Loa (eye worm) | hypothetical protein | 0.0491 | 0.621 | 1 |
Trypanosoma cruzi | 3-oxo-5-alpha-steroid 4-dehydrogenase, putative | 0.019 | 0.2103 | 1 |
Trypanosoma cruzi | Emopamil binding protein, putative | 0.0147 | 0.1514 | 0.69 |
Schistosoma mansoni | peptidase Clp (S14 family) | 0.0077 | 0.0559 | 0.0559 |
Brugia malayi | Pre-SET motif family protein | 0.0216 | 0.246 | 1 |
Mycobacterium ulcerans | hypothetical protein | 0.019 | 0.2103 | 1 |
Trypanosoma brucei | 3-oxo-5-alpha-steroid 4-dehydrogenase-like, putative | 0.019 | 0.2103 | 1 |
Echinococcus multilocularis | lamin b receptor | 0.005 | 0.0203 | 0.0003 |
Echinococcus multilocularis | microtubule associated protein 2 | 0.0769 | 1 | 1 |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | 0.0216 | 0.246 | 0.3962 |
Trichomonas vaginalis | set domain proteins, putative | 0.0246 | 0.2867 | 1 |
Echinococcus granulosus | tumor protein p63 | 0.0684 | 0.8842 | 0.8819 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0052 | 0.0225 | 0.0913 |
Plasmodium falciparum | ATP-dependent Clp protease proteolytic subunit | 0.0077 | 0.0559 | 0.5 |
Echinococcus granulosus | lamin b receptor | 0.005 | 0.0203 | 0.0003 |
Loa Loa (eye worm) | hypothetical protein | 0.01 | 0.088 | 0.1417 |
Toxoplasma gondii | 3-oxo-5-alpha-steroid 4-dehydrogenase | 0.019 | 0.2103 | 1 |
Leishmania major | hypothetical protein, conserved | 0.0147 | 0.1514 | 0.69 |
Trypanosoma cruzi | 3-oxo-5-alpha-steroid 4-dehydrogenase, putative | 0.019 | 0.2103 | 1 |
Mycobacterium tuberculosis | Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) | 0.005 | 0.0199 | 0.5 |
Schistosoma mansoni | cellular tumor antigen P53 | 0.01 | 0.088 | 0.088 |
Mycobacterium tuberculosis | Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) | 0.005 | 0.0199 | 0.5 |
Entamoeba histolytica | steroid 5-alpha reductase, putative | 0.019 | 0.2103 | 1 |
Onchocerca volvulus | 0.0246 | 0.2867 | 1 | |
Trypanosoma brucei | Emopamil binding protein, putative | 0.0147 | 0.1514 | 0.69 |
Leishmania major | 3-oxo-5-alpha-steroid 4-dehydrogenase-like protein | 0.019 | 0.2103 | 1 |
Echinococcus granulosus | ATP dependent Clp protease proteolytic subunit | 0.0077 | 0.0559 | 0.0367 |
Brugia malayi | 3-oxo-5-alpha-steroid 4-dehydrogenase 1 | 0.019 | 0.2103 | 0.8548 |
Trypanosoma cruzi | 3-Beta-hydroxysteroid-delta(8), delta(7)-isomerase, putative | 0.0147 | 0.1514 | 0.69 |
Trypanosoma cruzi | 3-Beta-hydroxysteroid-delta(8), delta(7)-isomerase, putative | 0.0147 | 0.1514 | 0.69 |
Loa Loa (eye worm) | hypothetical protein | 0.0052 | 0.0225 | 0.0362 |
Brugia malayi | hypothetical protein | 0.0152 | 0.1591 | 0.6467 |
Mycobacterium leprae | PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) | 0.0077 | 0.0559 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.