Detailed information for compound 207213

Basic information

Technical information
  • TDR Targets ID: 207213
  • Name: benzyl N-[(2S)-1-[(3R,4R)-3-hydroxy-4-[[(2S)- 4-methyl-2-(phenylmethoxycarbonylamino)pentan oyl]amino]piperidin-1-yl]-4-methyl-1-oxopenta n-2-yl]carbamate
  • MW: 610.741 | Formula: C33H46N4O7
  • H donors: 4 H acceptors: 5 LogP: 4.55 Rotable bonds: 19
    Rule of 5 violations (Lipinski): 2
  • SMILES: CC(C[C@@H](C(=O)N[C@@H]1CCN(C[C@H]1O)C(=O)[C@@H](NC(=O)OCc1ccccc1)CC(C)C)NC(=O)OCc1ccccc1)C
  • InChi: 1S/C33H46N4O7/c1-22(2)17-27(35-32(41)43-20-24-11-7-5-8-12-24)30(39)34-26-15-16-37(19-29(26)38)31(40)28(18-23(3)4)36-33(42)44-21-25-13-9-6-10-14-25/h5-14,22-23,26-29,38H,15-21H2,1-4H3,(H,34,39)(H,35,41)(H,36,42)/t26-,27+,28+,29-/m1/s1
  • InChiKey: OOIGXWNGPHUGLB-GIFPIDKJSA-N  


Substructure search Similarity search

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Synonyms

  • benzyl N-[(1S)-1-[(3R,4R)-4-[[(2S)-2-(benzyloxycarbonylamino)-4-methyl-pentanoyl]amino]-3-hydroxy-piperidine-1-carbonyl]-3-methyl-butyl]carbamate
  • N-[(1S)-1-[[(3R,4R)-4-[[(2S)-2-(benzyloxycarbonylamino)-4-methyl-1-oxopentyl]amino]-3-hydroxy-1-piperidinyl]-oxomethyl]-3-methylbutyl]carbamic acid benzyl ester
  • phenylmethyl N-[(2S)-1-[(3R,4R)-3-hydroxy-4-[[(2S)-4-methyl-2-(phenylmethoxycarbonylamino)pentanoyl]amino]piperidin-1-yl]-4-methyl-1-oxo-pentan-2-yl]carbamate
  • N-[(1S)-1-[(3R,4R)-4-[[(2S)-2-(benzyloxycarbonylamino)-4-methyl-pentanoyl]amino]-3-hydroxy-piperidine-1-carbonyl]-3-methyl-butyl]carbamic acid benzyl ester
  • phenylmethyl N-[(2S)-1-[(3R,4R)-3-hydroxy-4-[[(2S)-4-methyl-2-(phenylmethoxycarbonylamino)pentanoyl]amino]piperidin-1-yl]-4-methyl-1-oxopentan-2-yl]carbamate
  • phenylmethyl N-[(1S)-1-[(3R,4R)-3-hydroxy-4-[[(2S)-4-methyl-2-(phenylmethoxycarbonylamino)pentanoyl]amino]piperidine-1-carbonyl]-3-methyl-butyl]carbamate
  • N-[(1S)-1-[[(3R,4R)-3-hydroxy-4-[[(2S)-4-methyl-1-oxo-2-[[oxo-(phenylmethoxy)methyl]amino]pentyl]amino]-1-piperidinyl]-oxomethyl]-3-methylbutyl]carbamic acid phenylmethyl ester

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens cathepsin L Starlite/ChEMBL References
Homo sapiens cathepsin K Starlite/ChEMBL References
Homo sapiens cathepsin B Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Loa Loa (eye worm) cathepsin B Get druggable targets OG5_127800 All targets in OG5_127800
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like Get druggable targets OG5_127800 All targets in OG5_127800
Giardia lamblia Cathepsin B precursor Get druggable targets OG5_127800 All targets in OG5_127800
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Cryptosporidium parvum cryptopain - cysteine proteinase secreted, possible transmembrane domain near N-terminus Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania donovani cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Schistosoma mansoni SmCB2 peptidase (C01 family) Get druggable targets OG5_127800 All targets in OG5_127800
Schistosoma mansoni cathepsin B-like peptidase (C01 family) Get druggable targets OG5_127800 All targets in OG5_127800
Leishmania major cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Echinococcus granulosus cathepsin l1 Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium falciparum cysteine proteinase falcipain 2b Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium vivax vivapain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium vivax vivapain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Toxoplasma gondii cathepsin B Get druggable targets OG5_127800 All targets in OG5_127800
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin L-like proteinase precursor, putative Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium falciparum cysteine proteinase falcipain 3 Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) ctsf protein Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin L cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Neospora caninum Cathepsin B-like protease (Precursor), related Get druggable targets OG5_127800 All targets in OG5_127800
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase C (CPC), putative Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma brucei cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin b Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium falciparum cysteine proteinase falcipain 2a Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like Get druggable targets OG5_127800 All targets in OG5_127800
Echinococcus granulosus cathepsin b Get druggable targets OG5_127800 All targets in OG5_127800
Theileria parva cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin l1 Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium knowlesi knowpain-3 Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Schistosoma mansoni cathepsin B-like peptidase (C01 family) Get druggable targets OG5_127800 All targets in OG5_127800
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense cysteine peptidase C (CPC), putative,CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like, putative Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Echinococcus granulosus cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin L cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Cathepsin L homolog Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi cathepsin B-like cysteine proteinase Get druggable targets OG5_127800 All targets in OG5_127800
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Giardia lamblia Cathepsin B precursor Get druggable targets OG5_127800 All targets in OG5_127800
Leishmania braziliensis cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) fibroinase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cruzipain precursor, putative Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana cysteine peptidase A (CBA) Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium knowlesi knowpain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania donovani cysteine peptidase A (CBA) Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Onchocerca volvulus Cathepsin F homolog Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin B-like peptidase (C01 family) Get druggable targets OG5_127800 All targets in OG5_127800
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin b Get druggable targets OG5_127800 All targets in OG5_127800
Echinococcus granulosus cathepsin b Get druggable targets OG5_127800 All targets in OG5_127800
Toxoplasma gondii cathepsin CPL Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana cathepsin L-like protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Cathepsin L homolog Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase Get druggable targets OG5_127800 All targets in OG5_127800
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127800 All targets in OG5_127800
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Cryptosporidium hominis cryptopain precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium berghei berghepain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium knowlesi knowpain-4 Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Neospora caninum Cathepsin L, related Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase C (CPC), putative Get druggable targets OG5_127800 All targets in OG5_127800
Echinococcus granulosus cathepsin L cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum ko:K01373 cathepsin F [EC3.4.22.41], putative Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum expressed protein Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana cathepsin L-like protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) papain family cysteine protease containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Papain family cysteine protease containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium yoelii berghepain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum ko:K01363 cathepsin B [EC3.4.22.1], putative Get druggable targets OG5_127800 All targets in OG5_127800
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Giardia lamblia Cathepsin B precursor Get druggable targets OG5_127800 All targets in OG5_127800
Schistosoma mansoni cathepsin B-like peptidase (C01 family) Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like Get druggable targets OG5_127800 All targets in OG5_127800
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Plasmodium falciparum cysteine proteinase falcipain 1 cathepsin L 333 aa 359 aa 30.1 %
Plasmodium falciparum dipeptidyl aminopeptidase 1 cathepsin B 339 aa 368 aa 26.9 %
Plasmodium falciparum cysteine proteinase falcipain 1 cathepsin K 329 aa 349 aa 33.2 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0059 0.1078 0.0943
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0059 0.1078 0.0943
Loa Loa (eye worm) ctsf protein 0.0059 0.1078 0.1323
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0065 0.1283 0.1152
Echinococcus granulosus cathepsin b 0.0176 0.5233 1
Plasmodium vivax vivapain-2 0.0059 0.1078 0.558
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0041 0.0444 0.03
Onchocerca volvulus 0.0059 0.1078 1
Schistosoma mansoni cathepsin F (C01 family) 0.0041 0.0444 0.0582
Plasmodium vivax vivapain-3 0.0033 0.0149 0.077
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0059 0.1078 0.0943
Echinococcus multilocularis cysteine protease 0.0059 0.1078 0.1828
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0059 0.1078 0.0943
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0059 0.1078 0.8189
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0083 0.1932 0.3507
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0083 0.1932 0.5
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0059 0.1078 0.0943
Echinococcus multilocularis cathepsin b 0.0176 0.5233 1
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0151 0.4366 1
Treponema pallidum fructose-bisphosphate aldolase 0.031 1 1
Entamoeba histolytica cysteine proteinase, putative 0.0041 0.0444 0.03
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.031 1 1
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0059 0.1078 0.1323
Onchocerca volvulus Cathepsin L homolog 0.0059 0.1078 1
Schistosoma mansoni cathepsin F (C01 family) 0.0059 0.1078 0.1828
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.031 1 1
Plasmodium vivax vivapain-2 0.0059 0.1078 0.558
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.031 1 1
Brugia malayi Papain family cysteine protease containing protein 0.0059 0.1078 0.1828
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.0176 0.5233 1
Brugia malayi Cathepsin L-like cysteine proteinase 0.0041 0.0444 0.0582
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0059 0.1078 0.0943
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0083 0.1932 0.5
Echinococcus granulosus cathepsin l1 0.0041 0.0444 0.0582
Loa Loa (eye worm) hypothetical protein 0.0083 0.1932 0.3106
Plasmodium falciparum cysteine proteinase falcipain 3 0.0059 0.1078 0.558
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0065 0.1283 0.2232
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0059 0.1078 0.8189
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0059 0.1078 0.8189
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0176 0.5233 1
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0064 0.1273 0.9492
Echinococcus multilocularis cathepsin L cysteine protease 0.0059 0.1078 0.1828
Brugia malayi Cathepsin L-like precursor 0.0059 0.1078 0.1828
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0083 0.1932 0.5
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0059 0.1078 0.0943
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0059 0.1078 0.0943
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0064 0.1273 0.2211
Loa Loa (eye worm) cysteine protease 0.0059 0.1078 0.1323
Loa Loa (eye worm) hypothetical protein 0.0176 0.5233 1
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0083 0.1932 1
Entamoeba histolytica cysteine protease, putative 0.0059 0.1078 0.0943
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0059 0.1078 0.0943
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0059 0.1078 0.8189
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0083 0.1932 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0059 0.1078 0.0943
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0083 0.1932 0.4425
Entamoeba histolytica cysteine proteinase, putative 0.0059 0.1078 0.0943
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0059 0.1078 0.0943
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0083 0.1932 0.3507
Echinococcus granulosus cathepsin L cysteine proteinase 0.0059 0.1078 0.1828
Toxoplasma gondii cathepsin CPL 0.0059 0.1078 0.558
Brugia malayi Cathepsin L-like precursor 0.0059 0.1078 0.1828
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0083 0.1932 1
Onchocerca volvulus Cathepsin L homolog 0.0059 0.1078 1
Trypanosoma cruzi cruzipain precursor, putative 0.0059 0.1078 0.1828
Loa Loa (eye worm) cathepsin B 0.0065 0.1283 0.1752
Echinococcus multilocularis cathepsin L cysteine protease 0.0059 0.1078 0.1828
Trypanosoma cruzi cysteine peptidase, putative 0.0059 0.1078 0.1828
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0059 0.1078 0.0943
Onchocerca volvulus 0.0059 0.1078 1
Brugia malayi Cathepsin L-like precursor 0.0059 0.1078 0.1828
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0059 0.1078 0.0943
Loa Loa (eye worm) fibroinase 0.0059 0.1078 0.1323
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0083 0.1932 0.213
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0083 0.1932 0.213
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0064 0.1273 0.2211
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0176 0.5233 1
Trypanosoma brucei cysteine peptidase C (CPC) 0.0065 0.1283 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0059 0.1078 0.0943
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0059 0.1078 0.1828
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0059 0.1078 0.8189
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.0054 0.0916 0.2099
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0059 0.1078 0.0943
Trypanosoma cruzi cysteine peptidase, putative 0.0059 0.1078 0.1828
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0064 0.1273 0.1034
Onchocerca volvulus Cathepsin F homolog 0.0059 0.1078 1
Toxoplasma gondii cathepsin B 0.0065 0.1283 0.6644
Onchocerca volvulus 0.0059 0.1078 1
Trypanosoma cruzi cysteine peptidase, putative 0.0059 0.1078 0.1828
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0041 0.0444 0.03
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0083 0.1932 1
Giardia lamblia Fructose-bisphosphate aldolase 0.031 1 1
Onchocerca volvulus 0.0059 0.1078 1
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0059 0.1078 0.558
Toxoplasma gondii aldehyde dehydrogenase 0.0064 0.1273 0.659
Echinococcus multilocularis peptidase Clp (S14 family) 0.0054 0.0916 0.151
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0059 0.1078 0.0943
Schistosoma mansoni peptidase Clp (S14 family) 0.0083 0.1932 0.3507
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0176 0.5233 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0059 0.1078 0.8189
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.031 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0059 0.1078 0.0943
Echinococcus granulosus cathepsin l cysteine peptidase 0.0059 0.1078 0.1828
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0041 0.0444 0.0582
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.031 1 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.031 1 1
Brugia malayi Cathepsin L-like precursor 0.0059 0.1078 0.1828
Trypanosoma cruzi cysteine peptidase, putative 0.0059 0.1078 0.1828
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.031 1 1
Brugia malayi Cathepsin L-like precursor 0.0059 0.1078 0.1828
Plasmodium vivax unspecified product 0.0033 0.0149 0.077
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0059 0.1078 0.0943
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.0065 0.1283 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0059 0.1078 0.8189
Schistosoma mansoni aldehyde dehydrogenase 0.0064 0.1273 0.2211
Plasmodium vivax vivapain-1 0.0033 0.0149 0.077
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.031 1 1
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0059 0.1078 0.1323
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0151 0.4366 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0059 0.1078 0.8189
Entamoeba histolytica cysteine proteinase, putative 0.0059 0.1078 0.0943
Brugia malayi cathepsin L-like precursor 0.0041 0.0444 0.0582
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0176 0.5233 1
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0151 0.4366 1
Plasmodium falciparum cysteine proteinase falcipain 1 0.0033 0.0149 0.077
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0059 0.1078 0.0943
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0059 0.1078 0.0943
Echinococcus granulosus peptidase Clp S14 family 0.0054 0.0916 0.151
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.031 1 1
Brugia malayi Cathepsin L-like precursor 0.0041 0.0444 0.0582
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0083 0.1932 0.1932
Brugia malayi Probable ClpP-like protease 0.0083 0.1932 0.3507
Brugia malayi Cathepsin L-like precursor 0.0059 0.1078 0.1828
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0059 0.1078 0.0943
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0059 0.1078 0.1828
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0059 0.1078 0.0943
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0059 0.1078 0.0943
Onchocerca volvulus 0.0059 0.1078 1
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0065 0.1283 0.2232
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0059 0.1078 0.8189
Brugia malayi Cathepsin L-like precursor 0.0041 0.0444 0.0582
Schistosoma mansoni aldehyde dehydrogenase 0.0064 0.1273 0.2211
Echinococcus multilocularis cathepsin b 0.0176 0.5233 1
Echinococcus multilocularis cysteine protease 0.0059 0.1078 0.1828
Echinococcus granulosus cathepsin b 0.0176 0.5233 1
Loa Loa (eye worm) hypothetical protein 0.0059 0.1078 0.1323
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0059 0.1078 0.0943
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0059 0.1078 0.558
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0059 0.1078 0.8189
Onchocerca volvulus 0.0059 0.1078 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0059 0.1078 0.0943
Onchocerca volvulus 0.0059 0.1078 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0059 0.1078 0.8189
Schistosoma mansoni cathepsin F (C01 family) 0.0059 0.1078 0.1828
Echinococcus granulosus cathepsin l1 0.0059 0.1078 0.1828
Brugia malayi cathepsin B-like cysteine proteinase 0.0176 0.5233 1

Activities

Activity type Activity value Assay description Source Reference
Ki (binding) > 1000 nM Inhibition of cathepsin B ChEMBL. 9733481
Ki (binding) > 1000 nM Inhibition of cathepsin L ChEMBL. 9733481
Ki (binding) > 1000 nM Inhibition of cathepsin B ChEMBL. 9733481
Ki (binding) > 1000 nM Inhibition of cathepsin L ChEMBL. 9733481
Ki (binding) = 8200 nM Inhibition of cathepsin K ChEMBL. 9733481
Ki (binding) = 8200 nM Inhibition of cathepsin K ChEMBL. 9733481

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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