Detailed information for compound 2073974

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 522.591 | Formula: C25H38N4O8
  • H donors: 6 H acceptors: 8 LogP: -4.28 Rotable bonds: 10
    Rule of 5 violations (Lipinski): 3
  • SMILES: OC(=O)C(CC(=O)O)(CC(=O)O)O.Cc1ccc(o1)CN(C1CC(C)(C)NC(C1)(C)C)Cc1c[nH]cn1
  • InChi: 1S/C19H30N4O.C6H8O7/c1-14-6-7-17(24-14)12-23(11-15-10-20-13-21-15)16-8-18(2,3)22-19(4,5)9-16;7-3(8)1-6(13,5(11)12)2-4(9)10/h6-7,10,13,16,22H,8-9,11-12H2,1-5H3,(H,20,21);13H,1-2H2,(H,7,8)(H,9,10)(H,11,12)
  • InChiKey: WQRQLGYQJFYQIK-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0017 0.0051 0.0051
Trypanosoma brucei hypothetical protein, conserved 0.0246 0.1373 0.3829
Giardia lamblia Hypothetical protein 0.0246 0.1373 0.1334
Giardia lamblia Histone acetyltransferase GCN5 0.0035 0.0153 0.0108
Echinococcus granulosus high affinity cAMP specific 3'5' cyclic 0.0246 0.1373 0.1373
Trypanosoma brucei Mitochondrial SSU ribosomal protein, putative 0.0029 0.0119 0.0214
Trypanosoma brucei 3', 5'-cyclic nucleotide phosphodiesterase, putative 0.0246 0.1373 0.3829
Echinococcus multilocularis geminin 0.0138 0.0748 0.0748
Trypanosoma cruzi iron superoxide dismutase, putative 0.0115 0.0617 0.165
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0037 0.0168 0.0168
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0246 0.1373 0.1334
Brugia malayi Regulator of G protein signaling domain containing protein 0.0017 0.0051 0.006
Trichomonas vaginalis cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative 0.0246 0.1373 1
Plasmodium falciparum cGMP-specific phosphodiesterase 0.0246 0.1373 1
Schistosoma mansoni regulator of G protein signaling 0.0017 0.0051 0.0051
Trypanosoma cruzi iron superoxide dismutase A, mitochondrial 0.0115 0.0617 0.165
Trypanosoma brucei cAMP-specific phosphodiesterase 0.0246 0.1373 0.3829
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0037 0.0168 0.0168
Plasmodium falciparum cGMP-specific phosphodiesterase 0.0246 0.1373 1
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0246 0.1373 1
Echinococcus multilocularis axis inhibition protein axin 0.0017 0.0051 0.0051
Echinococcus granulosus geminin 0.0138 0.0748 0.0748
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.1741 1 1
Trichomonas vaginalis bromodomain-containing protein, putative 0.0038 0.0171 0.0946
Schistosoma mansoni regulator of G protein signaling 0.0017 0.0051 0.0051
Loa Loa (eye worm) PDE1B protein 0.0395 0.2233 0.2233
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0037 0.0168 0.0168
Echinococcus granulosus regulator of G protein signaling 7 0.0017 0.0051 0.0051
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0246 0.1373 1
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0395 0.2233 0.2197
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0246 0.1373 0.1373
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0016 0.0045 0.0045
Echinococcus granulosus dual 3'5' cyclic AMP and GMP phosphodiesterase 0.0246 0.1373 0.1373
Trypanosoma brucei superoxide dismutase, putative 0.0065 0.033 0.0821
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0246 0.1373 1
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0246 0.1373 1
Echinococcus multilocularis survival motor neuron protein 1 0.0209 0.1158 0.1158
Schistosoma mansoni serine/threonine protein kinase 0.0017 0.0051 0.0051
Brugia malayi PXA domain containing protein 0.0017 0.0051 0.006
Loa Loa (eye worm) hypothetical protein 0.0115 0.0617 0.0617
Schistosoma mansoni hypothetical protein 0.0046 0.0217 0.0217
Trypanosoma brucei iron superoxide dismutase A, mitochondrial 0.0115 0.0617 0.165
Echinococcus granulosus manganese superoxide dismutase 0.0115 0.0617 0.0617
Schistosoma mansoni hypothetical protein 0.0043 0.0199 0.0199
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0246 0.1373 0.1334
Loa Loa (eye worm) acetyltransferase 0.0128 0.0692 0.0692
Brugia malayi acetyltransferase, GNAT family protein 0.0128 0.0692 0.0807
Trypanosoma cruzi cAMP phosphodiesterase A, putative 0.0395 0.2233 0.6307
Toxoplasma gondii superoxide dismutase 0.0115 0.0617 0.0575
Echinococcus granulosus regulator of G protein signaling 3 0.0017 0.0051 0.0051
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0246 0.1373 1
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0246 0.1373 0.1334
Onchocerca volvulus Superoxide dismutase [Mn], mitochondrial homolog 0.0079 0.0407 0.6586
Loa Loa (eye worm) cyclic AMP specific phosphodiesterase PDE4D5A 0.1495 0.858 0.858
Entamoeba histolytica acetyltransferase, GNAT family 0.0035 0.0153 0.1879
Schistosoma mansoni calcium/calmodulin-dependent 35-cyclic nucleotide phosphodiesterase 0.0395 0.2233 0.2233
Entamoeba histolytica hypothetical protein 0.0017 0.0051 0.0107
Plasmodium vivax 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0395 0.2233 1
Plasmodium vivax phosphodiesterase gamma, putative 0.0246 0.1373 0.6072
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0246 0.1373 0.1334
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0246 0.1373 1
Trichomonas vaginalis superoxide dismutase, putative 0.0115 0.0617 0.4308
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0246 0.1373 1
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0246 0.1373 1
Echinococcus multilocularis regulator of G protein signaling 3 0.0017 0.0051 0.0051
Leishmania major iron superoxide dismutase, putative 0.0115 0.0617 0.165
Echinococcus multilocularis dual 3',5' cyclic AMP and GMP phosphodiesterase 0.0246 0.1373 0.1373
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0246 0.1373 0.1373
Echinococcus multilocularis cAMP and cAMP inhibited cGMP 3',5' cyclic 0.0246 0.1373 0.1373
Echinococcus granulosus histone acetyltransferase KAT2B 0.0038 0.0171 0.0171
Echinococcus granulosus beta-adrenergic receptor kinase 0.0017 0.0051 0.0051
Echinococcus granulosus regulator of G protein signaling 7 0.0017 0.0051 0.0051
Brugia malayi PXA domain containing protein 0.0017 0.0051 0.006
Loa Loa (eye worm) hypothetical protein 0.0017 0.0051 0.0051
Plasmodium falciparum superoxide dismutase [Fe] 0.0065 0.033 0.2145
Brugia malayi exodeoxyribonuclease III family protein 0.0016 0.0045 0.0053
Onchocerca volvulus Superoxide dismutase [Mn], mitochondrial homolog 0.0115 0.0617 1
Echinococcus granulosus survival motor neuron protein 1 0.0209 0.1158 0.1158
Echinococcus multilocularis high affinity cAMP specific 3',5' cyclic 0.0246 0.1373 0.1373
Chlamydia trachomatis superoxide dismutase 0.0115 0.0617 0.5
Mycobacterium leprae Probable superoxide dismutase SodA 0.0115 0.0617 0.5
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0684 0.39 0.39
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0246 0.1373 0.1334
Entamoeba histolytica hypothetical protein 0.0017 0.0051 0.0107
Echinococcus granulosus neuropeptide s receptor 0.0393 0.2224 0.2224
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0246 0.1373 0.3829
Plasmodium falciparum 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0246 0.1373 1
Schistosoma mansoni regulator of G protein signaling 0.0017 0.0051 0.0051
Trypanosoma brucei cAMP-specific phosphodiesterase, putative 0.0617 0.3513 1
Trypanosoma cruzi cAMP phosphodiesterase A, putative 0.0395 0.2233 0.6307
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0246 0.1373 0.3829
Schistosoma mansoni ap endonuclease 0.0016 0.0045 0.0045
Loa Loa (eye worm) hypothetical protein 0.0017 0.0051 0.0051
Trichomonas vaginalis superoxide dismutase [fe], putative 0.0115 0.0617 0.4308
Trypanosoma cruzi superoxide dismutase, putative 0.0065 0.033 0.0821
Trypanosoma cruzi iron superoxide dismutase A, mitochondrial 0.0115 0.0617 0.165
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0246 0.1373 1
Brugia malayi hypothetical protein 0.0017 0.0051 0.006
Schistosoma mansoni axis inhibition protein axin 0.0017 0.0051 0.0051
Trypanosoma cruzi hypothetical protein, conserved 0.0246 0.1373 0.3829
Plasmodium vivax superoxide dismutase [Fe], putative 0.0115 0.0617 0.2616
Loa Loa (eye worm) hypothetical protein 0.0017 0.0051 0.0051
Leishmania major hypothetical protein, conserved 0.0246 0.1373 0.3829
Loa Loa (eye worm) hypothetical protein 0.0246 0.1373 0.1373
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0246 0.1373 1
Brugia malayi regulator of G-protein signaling egl-10 0.0017 0.0051 0.006
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0246 0.1373 0.1601
Echinococcus granulosus histone acetyltransferase KAT2B 0.0124 0.0671 0.0671
Plasmodium falciparum phosphodiesterase delta, putative 0.0246 0.1373 1
Trypanosoma brucei iron superoxide dismutase 0.0115 0.0617 0.165
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0246 0.1373 1
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.1495 0.858 0.858
Schistosoma mansoni z-protein (S1r protein) 0.0017 0.0051 0.0051
Loa Loa (eye worm) RGS-3 protein 0.0017 0.0051 0.0051
Loa Loa (eye worm) hypothetical protein 0.0209 0.1158 0.1158
Leishmania major iron superoxide dismutase 0.0115 0.0617 0.165
Trypanosoma cruzi cAMP-specific phosphodiesterase, putative 0.0617 0.3513 1
Brugia malayi Probable 3',5'-cyclic phosphodiesterase C32E12.2, putative 0.0246 0.1373 0.1601
Trichomonas vaginalis superoxide dismutase [fe], putative 0.0115 0.0617 0.4308
Brugia malayi regulator of G-protein signaling rgs-7 0.0017 0.0051 0.006
Mycobacterium tuberculosis Superoxide dismutase [FE] SodA 0.0115 0.0617 1
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0246 0.1373 1
Trypanosoma cruzi hypothetical protein, conserved 0.0246 0.1373 0.3829
Echinococcus granulosus A kinase anchor protein 10 mitochondrial 0.0017 0.0051 0.0051
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0246 0.1373 1
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0246 0.1373 1
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0038 0.0171 0.0126
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0043 0.0199 0.0232
Plasmodium vivax 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0246 0.1373 0.6072
Toxoplasma gondii superoxide dismutase SOD2 0.0115 0.0617 0.0575
Trypanosoma cruzi superoxide dismutase, putative 0.0065 0.033 0.0821
Echinococcus multilocularis high affinity cgmp specific 3' 5' cyclic 0.0246 0.1373 0.1373
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0037 0.0168 0.0168
Trypanosoma cruzi hypothetical protein, conserved 0.0246 0.1373 0.3829
Echinococcus granulosus Regulator of G protein signaling 20 0.0017 0.0051 0.0051
Trichomonas vaginalis cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative 0.0246 0.1373 1
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0128 0.0692 0.0692
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0246 0.1373 1
Leishmania major iron superoxide dismutase, putative 0.0115 0.0617 0.165
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0246 0.1373 1
Brugia malayi Probable 3',5'-cyclic phosphodiesterase R153.1, putative 0.0246 0.1373 0.1601
Schistosoma mansoni survival motor neuron protein 0.0043 0.0199 0.0199
Echinococcus multilocularis regulator of G protein signaling 0.0017 0.0051 0.0051
Echinococcus granulosus high affinity cgmp specific 3' 5' cyclic 0.0246 0.1373 0.1373
Loa Loa (eye worm) hypothetical protein 0.0246 0.1373 0.1373
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0017 0.0051 0.0051
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0128 0.0692 0.0692
Mycobacterium ulcerans superoxide dismutase [Fe] SodA 0.0115 0.0617 1
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0246 0.1373 1
Plasmodium falciparum phosphodiesterase gamma, putative 0.0246 0.1373 1
Loa Loa (eye worm) hypothetical protein 0.0246 0.1373 0.1373
Trypanosoma cruzi superoxide dismutase, putative 0.0065 0.033 0.0821
Schistosoma mansoni ap endonuclease 0.0016 0.0045 0.0045
Trichomonas vaginalis superoxide dismutase, putative 0.0115 0.0617 0.4308
Trypanosoma brucei cAMP phosphodiesterase A, putative 0.0395 0.2233 0.6307
Plasmodium vivax cyclic nucleotide phosphodiesterase, putative 0.0246 0.1373 0.6072
Echinococcus multilocularis regulator of G protein signaling 7 0.0017 0.0051 0.0051
Trichomonas vaginalis superoxide dismutase [mn], putative 0.0115 0.0617 0.4308
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0246 0.1373 1
Trypanosoma cruzi hypothetical protein, conserved 0.0246 0.1373 0.3829
Trichomonas vaginalis conserved hypothetical protein 0.0017 0.0051 0.0046
Echinococcus granulosus expressed protein 0.033 0.1855 0.1855
Echinococcus granulosus axis inhibition protein axin 0.0017 0.0051 0.0051
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0037 0.0168 0.0168
Echinococcus multilocularis A kinase anchor protein 10, mitochondrial 0.0017 0.0051 0.0051
Trypanosoma cruzi hypothetical protein, conserved 0.0246 0.1373 0.3829
Trypanosoma cruzi iron superoxide dismutase, putative 0.0115 0.0617 0.165
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0037 0.0168 0.0168
Echinococcus multilocularis neuropeptide receptor A26 0.0393 0.2224 0.2224
Trichomonas vaginalis iron superoxide dismutase A, putative 0.0115 0.0617 0.4308
Echinococcus granulosus regulator of G protein signaling 3 0.0017 0.0051 0.0051
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0246 0.1373 0.1373
Schistosoma mansoni cgmp-dependent 35-cyclic phosphodiesterase 0.0246 0.1373 0.1373
Trichomonas vaginalis conserved hypothetical protein 0.0017 0.0051 0.0046
Trichomonas vaginalis conserved hypothetical protein 0.0246 0.1373 1
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0246 0.1373 1
Echinococcus multilocularis calcium:calmodulin dependent 3',5' cyclic 0.0395 0.2233 0.2233
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0246 0.1373 0.1334
Onchocerca volvulus 0.0043 0.0199 0.3229
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0246 0.1373 1
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0246 0.1373 1
Trichomonas vaginalis conserved hypothetical protein 0.0017 0.0051 0.0046
Echinococcus multilocularis manganese superoxide dismutase 0.0115 0.0617 0.0617
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0038 0.0171 0.0574
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0395 0.2233 0.2197
Brugia malayi hypothetical protein 0.0209 0.1158 0.135
Leishmania major hypothetical protein, conserved 0.0246 0.1373 0.3829
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0246 0.1373 0.1373
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0246 0.1373 1
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.0246 0.1373 1
Brugia malayi hypothetical protein 0.0017 0.0051 0.006
Trypanosoma cruzi Iron/manganese superoxide dismutases, C-terminal domain containing protein, putative 0.0029 0.0119 0.0214
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.1741 1 1
Trichomonas vaginalis regulator of G protein signaling 5, rgs5, putative 0.0017 0.0051 0.0046
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0246 0.1373 1
Schistosoma mansoni serine/threonine protein kinase 0.0017 0.0051 0.0051
Brugia malayi Regulator of G protein signaling domain containing protein 0.0017 0.0051 0.006
Entamoeba histolytica hypothetical protein 0.0017 0.0051 0.0107
Trypanosoma brucei cAMP-specific phosphodiesterase 0.0246 0.1373 0.3829
Trichomonas vaginalis superoxide dismutase [fe], putative 0.0115 0.0617 0.4308
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0246 0.1373 0.3829
Loa Loa (eye worm) hypothetical protein 0.0017 0.0051 0.0051
Trichomonas vaginalis conserved hypothetical protein 0.0017 0.0051 0.0046
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0038 0.0171 0.0946
Loa Loa (eye worm) hypothetical protein 0.0017 0.0051 0.0051
Trypanosoma cruzi iron superoxide dismutase, putative 0.0115 0.0617 0.165
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0017 0.0051 0.0051
Toxoplasma gondii superoxide dismutase SOD3 0.0115 0.0617 0.0575
Plasmodium falciparum histone acetyltransferase GCN5 0.0035 0.0153 0.081
Schistosoma mansoni regulator of G protein signaling 0.0017 0.0051 0.0051
Echinococcus granulosus calcium:calmodulin dependent 3'5' cyclic 0.0395 0.2233 0.2233
Entamoeba histolytica iron-containing superoxide dismutase 0.0115 0.0617 1
Echinococcus multilocularis regulator of G protein signaling 7 0.0017 0.0051 0.0051
Echinococcus granulosus cAMP and cAMP inhibited cGMP 3'5' cyclic 0.0246 0.1373 0.1373
Schistosoma mansoni hypothetical protein 0.0138 0.0748 0.0748
Loa Loa (eye worm) hypothetical protein 0.0017 0.0051 0.0051
Trichomonas vaginalis conserved hypothetical protein 0.0246 0.1373 1
Schistosoma mansoni hypothetical protein 0.0138 0.0748 0.0748
Echinococcus granulosus neuropeptide receptor A26 0.0393 0.2224 0.2224
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.1741 1 1
Echinococcus multilocularis calcium:calmodulin dependent 3',5' cyclic 0.0395 0.2233 0.2233
Echinococcus multilocularis expressed protein 0.033 0.1855 0.1855
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0246 0.1373 1
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0246 0.1373 1
Giardia lamblia CAMP-specific 3,5-cyclic phosphodiesterase 4B 0.1741 1 1
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0246 0.1373 0.1334
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0246 0.1373 1
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0037 0.0168 0.0168
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.0017 0.0051 0.0051
Brugia malayi A-kinase anchor protein 10, precursor 0.0017 0.0051 0.006
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0246 0.1373 0.1334
Loa Loa (eye worm) PXA domain-containing protein 0.0017 0.0051 0.0051
Echinococcus multilocularis beta adrenergic receptor kinase 0.0017 0.0051 0.0051
Loa Loa (eye worm) calcium/calmodulin-stimulated cyclic nucleotide phosphodiesterase 0.0246 0.1373 0.1373
Brugia malayi Probable 3',5'-cyclic phosphodiesterase R153.1, putative 0.1495 0.858 1
Leishmania major cAMP phosphodiesterase A, putative;with=GeneDB:LinJ18_V3.1100 0.0395 0.2233 0.6307
Onchocerca volvulus Superoxide dismutase [Mn], mitochondrial homolog 0.0115 0.0617 1
Echinococcus multilocularis axis inhibition protein axin 0.0017 0.0051 0.0051
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.1495 0.858 0.858
Loa Loa (eye worm) hypothetical protein 0.1741 1 1
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.1741 1 1
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0246 0.1373 1
Schistosoma mansoni axis inhibition protein axin 0.0017 0.0051 0.0051
Plasmodium vivax superoxide dismutase [Fe], putative 0.0065 0.033 0.1302
Echinococcus granulosus axis inhibition protein axin 0.0017 0.0051 0.0051
Treponema pallidum exodeoxyribonuclease (exoA) 0.0016 0.0045 0.5
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0246 0.1373 0.1373
Echinococcus multilocularis Regulator of G protein signaling 20 0.0017 0.0051 0.0051
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0246 0.1373 1
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0246 0.1373 0.1373
Leishmania major superoxide dismutase, putative 0.0065 0.033 0.0821
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0246 0.1373 0.1601
Plasmodium falciparum 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0246 0.1373 1
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0016 0.0045 0.0045
Trichomonas vaginalis cAMP/cGMP cyclic nucleotide phosphodiesterase, putative 0.0246 0.1373 1
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0246 0.1373 0.1601
Trypanosoma cruzi superoxide dismutase, putative 0.0065 0.033 0.0821
Trypanosoma cruzi Iron/manganese superoxide dismutases, C-terminal domain containing protein, putative 0.0029 0.0119 0.0214
Schistosoma mansoni regulator of G protein signaling 0.0017 0.0051 0.0051
Trypanosoma brucei iron superoxide dismutase 0.0115 0.0617 0.165
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0246 0.1373 0.1334
Trichomonas vaginalis cGMP-inhibited 3,5-cyclic phosphodiesterase, putative 0.0246 0.1373 1
Trypanosoma brucei iron superoxide dismutase C, mitochondrial 0.0065 0.033 0.0821
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0246 0.1373 1
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0246 0.1373 0.1334
Echinococcus granulosus calcium:calmodulin dependent 3'5' cyclic 0.0395 0.2233 0.2233
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0246 0.1373 1
Plasmodium falciparum superoxide dismutase [Fe] 0.0115 0.0617 0.4308
Trichomonas vaginalis conserved hypothetical protein 0.0017 0.0051 0.0046
Trypanosoma cruzi cyclic nucleotide phosphodiesterase 0.0246 0.1373 0.3829
Trypanosoma brucei 3', 5'-cyclic nucleotide phosphodiesterase, putative 0.0246 0.1373 0.3829
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0037 0.0168 0.0196
Giardia lamblia hypothetical protein 0.0246 0.1373 0.1334
Trichomonas vaginalis cGMP-inhibited 3,5-cyclic phosphodiesterase, putative 0.0246 0.1373 1
Echinococcus multilocularis neuropeptide s receptor 0.0393 0.2224 0.2224
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.0017 0.0051 0.0051
Schistosoma mansoni regulator of G protein signaling 3 rgs3 0.0017 0.0051 0.0051
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0246 0.1373 0.1334
Trypanosoma cruzi hypothetical protein, conserved 0.0246 0.1373 0.3829
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0246 0.1373 1
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0246 0.1373 1
Trypanosoma cruzi superoxide dismutase, putative 0.0029 0.0119 0.0214
Brugia malayi Probable 3',5'-cyclic phosphodiesterase T04D3.3, putative 0.0395 0.2233 0.2602
Trypanosoma cruzi iron superoxide dismutase, putative 0.0079 0.0407 0.1042
Leishmania major superoxide dismutase, putative 0.0065 0.033 0.0821
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.1741 1 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0037 0.0168 0.0168
Trichomonas vaginalis conserved hypothetical protein 0.0246 0.1373 1
Brugia malayi Superoxide dismutase, mitochondrial precursor, putative 0.0115 0.0617 0.0719
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0038 0.0171 0.0126
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0246 0.1373 0.3829
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0246 0.1373 1
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0016 0.0045 0.0045
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0246 0.1373 1
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0246 0.1373 0.1334
Schistosoma mansoni serine/threonine protein kinase 0.0017 0.0051 0.0051
Schistosoma mansoni camp/cgmp cyclic nucleotide phosphodiesterase 0.0246 0.1373 0.1373
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.0017 0.0051 0.006
Trichomonas vaginalis calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0246 0.1373 1
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.0246 0.1373 1
Echinococcus multilocularis regulator of G protein signaling 3 0.0017 0.0051 0.0051
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0246 0.1373 1
Schistosoma mansoni superoxide dismutase [mn] 0.0115 0.0617 0.0617
Schistosoma mansoni camp-specific cyclic nucleotide phosphodiesterase 0.0246 0.1373 0.1373
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0246 0.1373 0.1334
Trichomonas vaginalis conserved hypothetical protein 0.0017 0.0051 0.0046
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0246 0.1373 0.1334
Leishmania major cAMP-specific phosphodiesterase, putative 0.0617 0.3513 1
Wolbachia endosymbiont of Brugia malayi superoxide dismutase, SodA 0.0115 0.0617 1
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0246 0.1373 0.1334

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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