Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium tuberculosis | Probable short-chain type dehydrogenase/reductase | 0.0042 | 0.0216 | 0.0216 |
Trypanosoma cruzi | proteasome subunit beta type-5, putative | 0.0368 | 1 | 1 |
Plasmodium vivax | proteasome subunit beta type-2, putative | 0.0051 | 0.05 | 0.05 |
Trypanosoma cruzi | proteasome beta 6 subunit, putative | 0.0069 | 0.1019 | 0.1019 |
Echinococcus multilocularis | 3 hydroxyacyl coenzyme A dehydrogenase type 2 | 0.0042 | 0.0216 | 0.0216 |
Trichomonas vaginalis | Family T1, proteasome beta subunit, threonine peptidase | 0.0051 | 0.05 | 0.05 |
Entamoeba histolytica | proteasome subunit beta type 5 precursor, putative | 0.0368 | 1 | 1 |
Brugia malayi | proteasome subunit beta type 1 | 0.0069 | 0.1019 | 0.1019 |
Mycobacterium tuberculosis | Proteasome beta subunit PrcB; assembles with alpha subunit PrcA. | 0.0368 | 1 | 1 |
Leishmania major | proteasome beta 2 subunit, putative | 0.0051 | 0.05 | 0.05 |
Echinococcus multilocularis | sn1 specific diacylglycerol lipase beta | 0.0069 | 0.1017 | 0.1017 |
Plasmodium vivax | proteasome subunit beta type-1, putative | 0.0069 | 0.1019 | 0.1019 |
Echinococcus granulosus | sn1 specific diacylglycerol lipase beta | 0.0069 | 0.1017 | 0.1017 |
Entamoeba histolytica | proteasome subunit beta type 1, putative | 0.0069 | 0.1019 | 0.1019 |
Leishmania major | proteasome beta 6 subunit, putative,20S proteasome beta 6 subunit, putative | 0.0069 | 0.1019 | 0.1019 |
Mycobacterium ulcerans | short-chain type dehydrogenase/reductase | 0.0042 | 0.0216 | 0.0216 |
Brugia malayi | proteasome subunit beta type 2 | 0.0051 | 0.05 | 0.05 |
Leishmania major | 3-oxoacyl-(acyl-carrier protein) reductase, putative | 0.0042 | 0.0216 | 0.0216 |
Loa Loa (eye worm) | proteasome subunit beta type 2 | 0.0051 | 0.05 | 0.05 |
Echinococcus granulosus | proteasome prosome macropain subunit beta | 0.0069 | 0.1019 | 0.1019 |
Brugia malayi | 3-hydroxyacyl-CoA dehydrogenase type II | 0.0042 | 0.0216 | 0.0216 |
Echinococcus multilocularis | proteasome (prosome, macropain) | 0.0368 | 1 | 1 |
Trypanosoma brucei | lipase domain protein, putative | 0.0069 | 0.1017 | 0.1017 |
Trypanosoma cruzi | 20S proteasome subunit | 0.0051 | 0.05 | 0.05 |
Schistosoma mansoni | proteasome subunit beta 1 (T01 family) | 0.0069 | 0.1019 | 0.1019 |
Entamoeba histolytica | probable proteasome subunit beta type 2, putative | 0.0051 | 0.05 | 0.05 |
Loa Loa (eye worm) | proteasome subunit beta type 1 | 0.0069 | 0.1019 | 0.1019 |
Mycobacterium leprae | proteasome (beta subunit) PrcB | 0.0368 | 1 | 1 |
Brugia malayi | Lipase family protein | 0.0069 | 0.1017 | 0.1017 |
Schistosoma mansoni | proteasome subunit beta 2 (T01 family) | 0.0051 | 0.05 | 0.05 |
Mycobacterium ulcerans | short-chain type dehydrogenase/reductase | 0.0042 | 0.0216 | 0.0216 |
Trypanosoma brucei | proteasome beta 6 subunit | 0.0069 | 0.1019 | 0.1019 |
Plasmodium falciparum | proteasome subunit beta type-5 | 0.0368 | 1 | 1 |
Trichomonas vaginalis | Family T1, proteasome beta subunit, threonine peptidase | 0.0069 | 0.1019 | 0.1019 |
Plasmodium falciparum | proteasome subunit beta type-2, putative | 0.0051 | 0.05 | 0.05 |
Trypanosoma cruzi | proteasome subunit beta type-5, putative | 0.0368 | 1 | 1 |
Loa Loa (eye worm) | proteasome A-type and B-type family protein | 0.0368 | 1 | 1 |
Trypanosoma brucei | lipase domain protein, putative | 0.0069 | 0.1017 | 0.1017 |
Trypanosoma brucei | proteasome subunit beta type-5, putative | 0.0368 | 1 | 1 |
Schistosoma mansoni | proteasome catalytic subunit 3 (T01 family) | 0.0368 | 1 | 1 |
Echinococcus granulosus | 3 hydroxyacyl coenzyme A dehydrogenase type 2 | 0.0042 | 0.0216 | 0.0216 |
Echinococcus granulosus | proteasome prosome macropain subunit beta | 0.0051 | 0.05 | 0.05 |
Trichomonas vaginalis | Family T1, proteasome beta subunit, threonine peptidase | 0.0368 | 1 | 1 |
Toxoplasma gondii | proteasome subunit beta type, putative | 0.0368 | 1 | 1 |
Loa Loa (eye worm) | lipase | 0.0069 | 0.1017 | 0.1017 |
Giardia lamblia | Proteasome subunit beta type 2 | 0.0051 | 0.05 | 0.05 |
Loa Loa (eye worm) | 3-hydroxyacyl-CoA dehydrogenase type II | 0.0039 | 0.0131 | 0.0131 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0069 | 0.1017 | 0.1017 |
Plasmodium vivax | proteasome subunit beta type-5, putative | 0.0368 | 1 | 1 |
Giardia lamblia | Proteasome subunit beta type 1 | 0.0069 | 0.1019 | 0.1019 |
Trypanosoma cruzi | proteasome beta 6 subunit, putative | 0.0069 | 0.1019 | 0.1019 |
Trichomonas vaginalis | Family T1, proteasome beta subunit, threonine peptidase | 0.0051 | 0.05 | 0.05 |
Leishmania major | hypothetical protein, conserved | 0.0069 | 0.1017 | 0.1017 |
Echinococcus granulosus | proteasome prosome macropain | 0.0368 | 1 | 1 |
Schistosoma mansoni | 3-hydroxyacyl-CoA dehydrogenase | 0.0042 | 0.0216 | 0.0216 |
Toxoplasma gondii | proteasome subunit beta type 1, putative | 0.0069 | 0.1019 | 0.1019 |
Mycobacterium ulcerans | proteasome PrcB | 0.0368 | 1 | 1 |
Trichomonas vaginalis | lipase containing protein, putative | 0.0069 | 0.1017 | 0.1017 |
Onchocerca volvulus | 0.0069 | 0.1017 | 1 | |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0069 | 0.1017 | 0.1017 |
Echinococcus multilocularis | proteasome (prosome, macropain) subunit, beta | 0.0069 | 0.1019 | 0.1019 |
Trypanosoma cruzi | proteasome subunit beta type-2, putative | 0.0051 | 0.05 | 0.05 |
Trichomonas vaginalis | lipase containing protein, putative | 0.0069 | 0.1017 | 0.1017 |
Wolbachia endosymbiont of Brugia malayi | ATP-dependent protease peptidase subunit | 0.0035 | 0 | 0.5 |
Toxoplasma gondii | proteasome subunit beta type 2, putative | 0.0051 | 0.05 | 0.05 |
Echinococcus multilocularis | proteasome (prosome, macropain) subunit, beta | 0.0051 | 0.05 | 0.05 |
Plasmodium falciparum | proteasome subunit beta type-1, putative | 0.0069 | 0.1019 | 0.1019 |
Giardia lamblia | Proteasome subunit beta type 5 precursor | 0.0368 | 1 | 1 |
Leishmania major | proteasome beta 5 subunit, putative | 0.0368 | 1 | 1 |
Schistosoma mansoni | proteasome subunit beta 2 (T01 family) | 0.0051 | 0.05 | 0.05 |
Trypanosoma brucei | proteasome subunit beta type-2, putative | 0.0051 | 0.05 | 0.05 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.