TDR Targets

Basic information

Technical information

TDR Targets ID: 210601
Name: 3-[2-[1-(2,3-dihydro-1,4-benzodioxin-2-ylmeth yl)piperidin-4-yl]ethyl]-4,5-dihydro-1H-1,3-b enzodiazepin-2-one
MW: 421.532 | Formula: C25H31N3O3
H donors: 1 H acceptors: 1 LogP: 3.76 Rotable bonds: 5
Rule of 5 violations (Lipinski): 1
SMILES: O=C1Nc2ccccc2CCN1CCC1CCN(CC1)CC1COc2c(O1)cccc2
InChi: 1S/C25H31N3O3/c29-25-26-22-6-2-1-5-20(22)12-16-28(25)15-11-19-9-13-27(14-10-19)17-21-18-30-23-7-3-4-8-24(23)31-21/h1-8,19,21H,9-18H2,(H,26,29)
InChiKey: AVPPBLUOVDZTAO-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

3-[2-[1-(2,3-dihydro-1,4-benzodioxin-2-ylmethyl)-4-piperidyl]ethyl]-4,5-dihydro-1H-1,3-benzodiazepin-2-one
3-[2-[1-(2,3-dihydro-1,4-benzodioxin-2-ylmethyl)-4-piperidinyl]ethyl]-4,5-dihydro-1H-1,3-benzodiazepin-2-one

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Rattus norvegicus	Adrenergic receptor alpha-2	Starlite/ChEMBL	References
Rattus norvegicus	Dopamine D2 receptor	Starlite/ChEMBL	References
Rattus norvegicus	Adrenergic receptor alpha-1	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Schistosoma japonicum	ko:K04207 neuropeptide Y receptor Y5, putative	Dopamine D2 receptor	444 aa	386 aa	19.7 %
Echinococcus granulosus	biogenic amine 5HT receptor	Dopamine D2 receptor	444 aa	429 aa	31.7 %
Schistosoma japonicum	ko:K04145 dopamine receptor D2, putative	Dopamine D2 receptor	444 aa	432 aa	30.8 %
Echinococcus granulosus	g protein coupled receptor	Dopamine D2 receptor	444 aa	457 aa	21.0 %
Schistosoma japonicum	ko:K04145 dopamine receptor D2, putative	Adrenergic receptor alpha-2	450 aa	473 aa	24.1 %
Loa Loa (eye worm)	hypothetical protein	Dopamine D2 receptor	444 aa	433 aa	21.2 %
Schistosoma mansoni	biogenic amine receptor	Dopamine D2 receptor	444 aa	452 aa	30.1 %
Onchocerca volvulus	RB1-inducible coiled-coil protein 1 homolog	Dopamine D2 receptor	444 aa	474 aa	23.4 %
Schistosoma mansoni	biogenic amine (5HT) receptor	Adrenergic receptor alpha-2	450 aa	433 aa	27.9 %
Echinococcus multilocularis	serotonin receptor	Dopamine D2 receptor	444 aa	428 aa	31.3 %
Echinococcus granulosus	alpha 1A adrenergic receptor	Adrenergic receptor alpha-2	450 aa	476 aa	21.0 %
Schistosoma mansoni	biogenic amine (dopamine) receptor	Dopamine D2 receptor	444 aa	494 aa	26.3 %
Onchocerca volvulus		Dopamine D2 receptor	444 aa	418 aa	23.0 %
Onchocerca volvulus		Adrenergic receptor alpha-2	450 aa	467 aa	25.1 %
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	Dopamine D2 receptor	444 aa	487 aa	23.8 %
Echinococcus multilocularis	neuropeptides capa receptor	Adrenergic receptor alpha-2	450 aa	486 aa	20.6 %
Loa Loa (eye worm)	TYRA-2 protein	Adrenergic receptor alpha-2	450 aa	488 aa	23.8 %
Onchocerca volvulus	Glycoprotein hormone beta 5 homolog	Dopamine D2 receptor	444 aa	476 aa	24.2 %
Echinococcus multilocularis	alpha 1A adrenergic receptor	Adrenergic receptor alpha-2	450 aa	478 aa	20.7 %
Schistosoma mansoni	amine GPCR	Dopamine D2 receptor	444 aa	424 aa	32.1 %
Echinococcus multilocularis	g protein coupled receptor	Dopamine D2 receptor	444 aa	465 aa	21.5 %
Schistosoma japonicum	ko:K04136 adrenergic receptor, alpha 1b, putative	Dopamine D2 receptor	444 aa	440 aa	30.0 %
Echinococcus multilocularis	fmrfamide receptor	Adrenergic receptor alpha-2	450 aa	366 aa	19.9 %
Schistosoma japonicum	Octopamine receptor, putative	Dopamine D2 receptor	444 aa	456 aa	29.4 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0014	0.0099	0.0161
Toxoplasma gondii	SWI2/SNF2 Brahma-like putative	0.0013	0.0078	0.2425
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0099	0.0099
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0099	0.0099
Echinococcus multilocularis	Chromo domain	0.0013	0.0067	0.0109
Schistosoma mansoni	growth hormone secretagogue receptor	0.0014	0.0099	0.0382
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0014	0.0099	0.0161
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0014	0.0099	0.0099
Brugia malayi	AKH receptor	0.0014	0.0099	0.0099
Echinococcus multilocularis	calpain	0.0019	0.0176	0.0286
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0014	0.0099	0.0382
Schistosoma mansoni	hypothetical protein	0.0014	0.0099	0.0382
Echinococcus granulosus	calpain A	0.0019	0.0176	0.0286
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.0014	0.0099	0.0382
Loa Loa (eye worm)	hypothetical protein	0.0177	0.2935	0.2935
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0099	0.0099
Echinococcus granulosus	hypothetical protein	0.0014	0.0099	0.0161
Echinococcus multilocularis	calpain A	0.0066	0.1006	0.1638
Brugia malayi	nuclear hormone receptor	0.001	0.0021	0.0021
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0099	0.0099
Toxoplasma gondii	SWI2/SNF2 Brahma-like putative	0.0011	0.0045	0.1388
Schistosoma mansoni	family C2 unassigned peptidase (C02 family)	0.0066	0.1006	0.3878
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0014	0.0099	0.0161
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0099	0.0099
Onchocerca volvulus		0.0581	1	1
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0032	0.0414	0.0674
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0099	0.0099
Onchocerca volvulus		0.0014	0.0099	0.0099
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.001	0.0021	0.0034
Echinococcus multilocularis	neuropeptide receptor	0.0014	0.0099	0.0161
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.001	0.0021	0.0021
Loa Loa (eye worm)	neuropeptide F receptor	0.0014	0.0099	0.0099
Schistosoma mansoni	dihydropyridine-sensitive l-type calcium channel	0.0157	0.2593	1
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.0014	0.0099	0.0099
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0099	0.0099
Brugia malayi	neuropeptide F receptor	0.0014	0.0099	0.0099
Brugia malayi	Cache domain containing protein	0.0072	0.1115	0.1115
Entamoeba histolytica	protein tyrosine phosphatase, putative	0.0581	1	1
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.0014	0.0099	0.0161
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0099	0.0099
Schistosoma mansoni	hypothetical protein	0.0032	0.0414	0.1597
Schistosoma mansoni	neuropeptide receptor	0.0014	0.0099	0.0382
Echinococcus granulosus	FTZ F1 alpha	0.001	0.0021	0.0034
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0014	0.0099	0.0382
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.0014	0.0099	0.0382
Echinococcus multilocularis	fmrfamide receptor	0.0014	0.0099	0.0161
Onchocerca volvulus		0.0014	0.0099	0.0099
Brugia malayi	Tachykinin-like peptides receptor 99D	0.0014	0.0099	0.0099
Onchocerca volvulus		0.0014	0.0099	0.0099
Brugia malayi	putative neuropeptide receptor	0.0014	0.0099	0.0099
Echinococcus granulosus	calpain 5	0.0019	0.0176	0.0286
Brugia malayi	Nuclear hormone receptor-like 1	0.001	0.0021	0.0021
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0099	0.0099
Loa Loa (eye worm)	TYRA-2 protein	0.0014	0.0099	0.0099
Echinococcus granulosus	biogenic amine 5HT receptor	0.0014	0.0099	0.0161
Echinococcus multilocularis	serotonin receptor	0.0014	0.0099	0.0161
Echinococcus multilocularis	g protein coupled receptor	0.0014	0.0099	0.0161
Schistosoma mansoni	myosin xvIII	0.0014	0.0099	0.0382
Echinococcus granulosus	neuropeptide s receptor	0.0014	0.0099	0.0161
Trypanosoma cruzi	PAB1-binding protein , putative	0.0027	0.0322	0.052
Brugia malayi	putative neuropeptide receptor NPR1	0.0014	0.0099	0.0099
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0099	0.0099
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0045	0.063	0.1026
Trichomonas vaginalis	low molecular weight protein tyrosine phosphatase, putative	0.0179	0.2978	0.2922
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.0014	0.0099	0.0161
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.0014	0.0099	0.0161
Onchocerca volvulus		0.0014	0.0099	0.0099
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0014	0.0099	0.0382
Schistosoma mansoni	thyroid hormone receptor	0.001	0.0021	0.0081
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0099	0.0099
Schistosoma mansoni	helicase	0.0072	0.111	0.428
Echinococcus multilocularis	calpain family protein 1, d	0.0044	0.0622	0.1012
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0099	0.0099
Schistosoma mansoni	alpha-1 adrenergic receptor	0.0014	0.0099	0.0382
Loa Loa (eye worm)	hypothetical protein	0.0044	0.0622	0.0622
Brugia malayi	calpain 5	0.0019	0.0176	0.0176
Echinococcus multilocularis	neuropeptide FF receptor 2	0.0014	0.0099	0.0161
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.001	0.0021	0.0021
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0014	0.0099	0.0161
Echinococcus multilocularis	neuropeptide Y receptor	0.0014	0.0099	0.0161
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0014	0.0099	0.0161
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0099	0.0099
Loa Loa (eye worm)	hypothetical protein	0.001	0.0021	0.0021
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0014	0.0099	0.0161
Trichomonas vaginalis	low molecular weight protein tyrosine phosphatase, putative	0.0179	0.2978	0.2922
Schistosoma mansoni	calpain C (C02 family)	0.0019	0.0176	0.0678
Brugia malayi	BRM protein	0.0072	0.111	0.111
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.001	0.0021	0.0034
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0099	0.0099
Schistosoma mansoni	opsin-like receptor	0.0014	0.0099	0.0382
Echinococcus granulosus	rhodopsin orphan GPCR	0.0014	0.0099	0.0161
Echinococcus multilocularis	BRK domain containing protein	0.0012	0.0066	0.0108
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.001	0.0021	0.0021
Echinococcus granulosus	7TM GPCR rhodopsin	0.0014	0.0099	0.0161
Onchocerca volvulus		0.0014	0.0099	0.0099
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0099	0.0099
Onchocerca volvulus		0.0014	0.0099	0.0099
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.0014	0.0099	0.0161
Echinococcus multilocularis	global transcription activator snf2l2	0.0072	0.111	0.1807
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0099	0.0099
Brugia malayi	hypothetical protein	0.0014	0.0099	0.0099
Onchocerca volvulus		0.0014	0.0099	0.0099
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.0014	0.0099	0.0099
Echinococcus granulosus	fmrfamide receptor	0.0014	0.0099	0.0161
Echinococcus granulosus	BRK domain containing protein	0.0012	0.0066	0.0108
Echinococcus granulosus	GPCR family 2	0.0032	0.0414	0.0674
Echinococcus multilocularis	BRK domain containing protein	0.0012	0.0066	0.0108
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0014	0.0099	0.0161
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.001	0.0021	0.0021
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0099	0.0099
Echinococcus multilocularis	serotonin receptor	0.0014	0.0099	0.0161
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.001	0.0021	0.0021
Plasmodium falciparum	ataxin-2 like protein, putative	0.0027	0.0322	1
Plasmodium falciparum	ataxin-2 like protein, putative	0.0027	0.0322	1
Entamoeba histolytica	protein tyrosine phosphatase, putative	0.0581	1	1
Trypanosoma brucei	low molecular weight protein tyrosine phosphatase, putative	0.0179	0.2978	1
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0032	0.0414	0.0414
Echinococcus multilocularis	G-protein coupled receptor, putative	0.0014	0.0099	0.0161
Brugia malayi	G protein-coupled receptor F59B2.13	0.0014	0.0099	0.0099
Echinococcus granulosus	orexin receptor type 2	0.0014	0.0099	0.0161
Onchocerca volvulus		0.0014	0.0099	0.0099
Echinococcus multilocularis	fmrfamide receptor	0.0014	0.0099	0.0161
Entamoeba histolytica	DNA repair and recombination protein RAD52, putative	0.0374	0.6379	0.6314
Echinococcus multilocularis	somatostatin receptor	0.0014	0.0099	0.0161
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.001	0.0021	0.0021
Brugia malayi	ORL1-like opioid receptor	0.0014	0.0099	0.0099
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.001	0.0021	0.0021
Echinococcus multilocularis	g protein coupled receptor	0.0014	0.0099	0.0161
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0322	0.0322
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.001	0.0021	0.0034
Trichomonas vaginalis	low molecular weight protein tyrosine phosphatase, putative	0.0581	1	1
Echinococcus granulosus	rhodopsin orphan GPCR	0.0014	0.0099	0.0161
Echinococcus granulosus	tm gpcr rhodopsin	0.0014	0.0099	0.0161
Schistosoma mansoni	amine GPCR	0.0014	0.0099	0.0382
Schistosoma mansoni	family C2 unassigned peptidase (C02 family)	0.0066	0.1006	0.3878
Trichomonas vaginalis	low molecular weight protein-tyrosine-phosphatase, putative	0.0581	1	1
Loa Loa (eye worm)	hypothetical protein	0.0044	0.0622	0.0622
Brugia malayi	steroid hormone receptor	0.001	0.0021	0.0021
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0099	0.0099
Onchocerca volvulus		0.0014	0.0099	0.0099
Onchocerca volvulus		0.0044	0.0622	0.0622
Schistosoma mansoni	neuropeptide receptor	0.0014	0.0099	0.0382
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0014	0.0099	0.0382
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.0014	0.0099	0.0099
Echinococcus granulosus	peptide allatostatin:somatostatin	0.0014	0.0099	0.0161
Echinococcus granulosus	neuropeptide Y receptor	0.0014	0.0099	0.0161
Brugia malayi	hypothetical protein	0.0014	0.0099	0.0099
Echinococcus multilocularis	orexin receptor type 2	0.0014	0.0099	0.0161
Brugia malayi	hypothetical protein	0.0014	0.0099	0.0099
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0045	0.063	0.243
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.001	0.0021	0.0034
Schistosoma mansoni	calpain (C02 family)	0.0019	0.0176	0.0678
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0099	0.0099
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0099	0.0099
Schistosoma mansoni	Mername-AA248 (C02 family)	0.0019	0.0176	0.0678
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0014	0.0099	0.0382
Schistosoma mansoni	hypothetical protein	0.007	0.1071	0.4129
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.001	0.0021	0.0034
Echinococcus multilocularis	voltage dependent calcium channel subunit	0.036	0.6141	1
Schistosoma mansoni	amine GPCR	0.0014	0.0099	0.0382
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0099	0.0099
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0014	0.0099	0.0382
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0014	0.0099	0.0382
Echinococcus multilocularis	neuropeptide receptor A26	0.0014	0.0099	0.0161
Loa Loa (eye worm)	calpain family protein 1	0.0063	0.0949	0.0949
Loa Loa (eye worm)	hypothetical protein	0.0063	0.0949	0.0949
Echinococcus multilocularis	calpain 5	0.0019	0.0176	0.0286
Echinococcus multilocularis	calpain 7 (C02 family)	0.0019	0.0176	0.0286
Leishmania major	hypothetical protein, conserved	0.0179	0.2978	1
Schistosoma mansoni	neuropeptide receptor	0.0014	0.0099	0.0382
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0014	0.0099	0.0382
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0045	0.063	0.1026
Echinococcus multilocularis	Ataxin 2, N terminal,domain containing protein	0.0012	0.006	0.0098
Schistosoma mansoni	biogenic amine receptor	0.0014	0.0099	0.0382
Echinococcus granulosus	somatostatin receptor	0.0014	0.0099	0.0161
Echinococcus granulosus	tachykinin peptides receptor 99D	0.0014	0.0099	0.0161
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0102	0.1637	0.1637
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0099	0.0099
Mycobacterium ulcerans	phosphotyrosine protein phosphatase PtpA	0.0581	1	0.5
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.0014	0.0099	0.0161
Schistosoma mansoni	hypothetical protein	0.0012	0.006	0.0233
Brugia malayi	Melatonin receptor type 1A	0.0014	0.0099	0.0099
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0014	0.0099	0.0382
Echinococcus granulosus	calpain A	0.0066	0.1006	0.1638
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.0014	0.0099	0.0382
Echinococcus granulosus	Chromo domain	0.0013	0.0067	0.0109
Schistosoma mansoni	hypothetical protein	0.0085	0.1326	0.5114
Onchocerca volvulus	Steroid hormone receptor family member cnr14 homolog	0.001	0.0021	0.0021
Echinococcus multilocularis	neuropeptide Y receptor	0.0014	0.0099	0.0161
Brugia malayi	follicle stimulating hormone receptor	0.0014	0.0099	0.0099
Leishmania major	hypothetical protein, conserved	0.0027	0.0322	0.052
Echinococcus granulosus	rhodopsin orphan GPCR	0.0014	0.0099	0.0161
Onchocerca volvulus		0.0014	0.0099	0.0099
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0099	0.0099
Brugia malayi	Dopamine receptor	0.0014	0.0099	0.0099
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.001	0.0021	0.0034
Brugia malayi	hypothetical protein	0.0027	0.0322	0.0322
Loa Loa (eye worm)	hypothetical protein	0.001	0.0021	0.0021
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0045	0.063	0.1026
Loa Loa (eye worm)	hypothetical protein	0.001	0.0021	0.0021
Loa Loa (eye worm)	helicase DNA-binding protein	0.0012	0.0066	0.0066
Echinococcus granulosus	neuropeptide receptor	0.0014	0.0099	0.0161
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.001	0.0021	0.0021
Echinococcus multilocularis	ecdysone induced protein 78C	0.001	0.0021	0.0034
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.001	0.0021	0.0034
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0099	0.0099
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0014	0.0099	0.0161
Toxoplasma gondii	LsmAD domain-containing protein	0.0027	0.0322	1
Echinococcus multilocularis	thyroid hormone receptor alpha	0.001	0.0021	0.0034
Schistosoma mansoni	hypothetical protein	0.0012	0.0066	0.0256
Echinococcus multilocularis	BRK domain	0.0012	0.0066	0.0108
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0102	0.1637	0.1637
Trichomonas vaginalis	low molecular weight protein tyrosine phosphatase, putative	0.0581	1	1
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.001	0.0021	0.0021
Echinococcus granulosus	neuropeptide receptor	0.0014	0.0099	0.0161
Brugia malayi	latrophilin 2 splice variant baaae	0.007	0.1071	0.1071
Echinococcus granulosus	rhodopsin orphan GPCR	0.0014	0.0099	0.0161
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.001	0.0021	0.0021
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0099	0.0099
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0045	0.063	0.1026
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.0014	0.0099	0.0099
Trypanosoma cruzi	PAB1-binding protein , putative	0.0027	0.0322	0.052
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0099	0.0099
Echinococcus granulosus	calpain	0.0019	0.0176	0.0286
Trypanosoma brucei	PAB1-binding protein , putative	0.0027	0.0322	0.052
Schistosoma mansoni	family C2 unassigned peptidase (C02 family)	0.0063	0.0949	0.3661
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.001	0.0021	0.0034
Loa Loa (eye worm)	calpain	0.0019	0.0176	0.0176
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0014	0.0099	0.0161
Schistosoma mansoni	hypothetical protein	0.0014	0.0099	0.0382
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.0014	0.0099	0.0382
Echinococcus granulosus	G protein coupled receptor 139	0.0014	0.0099	0.0161
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.001	0.0021	0.0021
Loa Loa (eye worm)	hypothetical protein	0.0102	0.1637	0.1637
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.001	0.0021	0.0034
Brugia malayi	nuclear receptor NHR-88	0.001	0.0021	0.0021
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.0014	0.0099	0.0099
Echinococcus granulosus	allatostatin A receptor	0.0014	0.0099	0.0161
Schistosoma mansoni	hypothetical protein	0.0013	0.0067	0.0257
Echinococcus multilocularis	neuropeptide receptor	0.0014	0.0099	0.0161
Loa Loa (eye worm)	phosphotyrosine protein phosphatase	0.0581	1	1
Trichomonas vaginalis	low molecular weight protein-tyrosine-phosphatase, putative	0.0581	1	1
Echinococcus multilocularis	dro:myosuppressin receptor	0.0014	0.0099	0.0161
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.001	0.0021	0.0021
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.001	0.0021	0.0034
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.001	0.0021	0.0034
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.001	0.0021	0.0081
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.0014	0.0099	0.0099
Trichomonas vaginalis	low molecular weight protein-tyrosine-phosphatase, putative	0.0581	1	1
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0099	0.0099
Echinococcus granulosus	neuropeptide FF receptor 2	0.0014	0.0099	0.0161
Echinococcus granulosus	serotonin receptor	0.0014	0.0099	0.0161
Brugia malayi	hypothetical protein	0.0014	0.0099	0.0099
Echinococcus granulosus	global transcription activator snf2l2	0.0072	0.111	0.1807
Loa Loa (eye worm)	hypothetical protein	0.001	0.0021	0.0021
Brugia malayi	Serotonin receptor	0.0014	0.0099	0.0099
Brugia malayi	Serotonin receptor	0.0014	0.0099	0.0099
Echinococcus granulosus	rhodopsin orphan GPCR	0.0014	0.0099	0.0161
Onchocerca volvulus		0.0014	0.0099	0.0099
Echinococcus granulosus	g protein coupled receptor	0.0014	0.0099	0.0161
Schistosoma mansoni	neuropeptide receptor	0.0014	0.0099	0.0382
Echinococcus granulosus	dro:myosuppressin receptor	0.0014	0.0099	0.0161
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.0014	0.0099	0.0161
Echinococcus multilocularis	BRK domain containing protein	0.0012	0.0066	0.0108
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0014	0.0099	0.0382
Loa Loa (eye worm)	hypothetical protein	0.001	0.0021	0.0021
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0045	0.063	0.243
Trypanosoma cruzi	hypothetical protein, conserved	0.0179	0.2978	1
Schistosoma mansoni	opsin-like receptor	0.0014	0.0099	0.0382
Loa Loa (eye worm)	calpain 5	0.0019	0.0176	0.0176
Brugia malayi	calpain 7	0.0019	0.0176	0.0176
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.0014	0.0099	0.0099
Loa Loa (eye worm)	hypothetical protein	0.001	0.0021	0.0021
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0099	0.0099
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0099	0.0099
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.0014	0.0099	0.0161
Brugia malayi	N-terminal motif family protein	0.0177	0.2935	0.2935
Brugia malayi	Associated with TFs and helicases family protein	0.0013	0.0067	0.0067
Schistosoma mansoni	neuropeptide F-like receptor	0.0014	0.0099	0.0382
Echinococcus granulosus	neuropeptides capa receptor	0.0014	0.0099	0.0161
Loa Loa (eye worm)	BRM protein	0.0046	0.0654	0.0654
Trypanosoma cruzi	hypothetical protein, conserved	0.0179	0.2978	1
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.0014	0.0099	0.0099
Plasmodium vivax	calpain, putative	0.0019	0.0176	0.4737
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.001	0.0021	0.0021
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0045	0.063	0.243
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0099	0.0099
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0099	0.0099
Schistosoma mansoni	steroid hormone receptor ad4bp	0.001	0.0021	0.0081
Echinococcus multilocularis	FTZ F1 alpha	0.001	0.0021	0.0034
Loa Loa (eye worm)	calpain family protein 1	0.0044	0.0622	0.0622
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0014	0.0099	0.0382
Schistosoma mansoni	neuropeptide f receptor 76f	0.0014	0.0099	0.0382
Echinococcus multilocularis	voltage dependent calcium channel subunit	0.0164	0.271	0.4413
Echinococcus granulosus	voltage dependent calcium channel subunit	0.0164	0.271	0.4413
Brugia malayi	RE15519p	0.0014	0.0099	0.0099
Schistosoma mansoni	neuropeptide F-like receptor	0.0014	0.0099	0.0382
Schistosoma mansoni	biogenic amine receptor	0.0014	0.0099	0.0382
Loa Loa (eye worm)	G-protein coupled receptor	0.0014	0.0099	0.0099
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0099	0.0099
Echinococcus granulosus	voltage dependent calcium channel subunit	0.036	0.6141	1
Schistosoma mansoni	hypothetical protein	0.0032	0.0414	0.1597
Loa Loa (eye worm)	G-protein coupled receptor	0.0014	0.0099	0.0099
Onchocerca volvulus	Bile acid receptor homolog	0.001	0.0021	0.0021
Schistosoma mansoni	nuclear hormone receptor	0.001	0.0021	0.0081
Brugia malayi	Latrophilin receptor protein 2	0.0032	0.0414	0.0414
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0099	0.0099
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0014	0.0099	0.0161
Echinococcus granulosus	7tm_1 domain containing protein	0.0014	0.0099	0.0161
Schistosoma mansoni	thyroid hormone receptor	0.001	0.0021	0.0081
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0099	0.0099
Onchocerca volvulus		0.0014	0.0099	0.0099
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0045	0.063	0.063
Echinococcus granulosus	neuropeptides capa receptor	0.0014	0.0099	0.0161
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0014	0.0099	0.0382
Schistosoma mansoni	amine GPCR	0.0014	0.0099	0.0382
Schistosoma mansoni	hypothetical protein	0.0014	0.0099	0.0382
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0099	0.0099
Echinococcus multilocularis	neuropeptides capa receptor	0.0014	0.0099	0.0161
Brugia malayi	Steroid receptor seven-up type 2	0.001	0.0021	0.0021
Brugia malayi	ecdysteroid receptor	0.001	0.0021	0.0021
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.001	0.0021	0.0081
Brugia malayi	hypothetical protein	0.0014	0.0099	0.0099
Loa Loa (eye worm)	hypothetical protein	0.007	0.1071	0.1071
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.0014	0.0099	0.0382
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.001	0.0021	0.0021
Entamoeba histolytica	hypothetical protein	0.0106	0.1706	0.1558
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0099	0.0099
Schistosoma mansoni	opsin-like receptor	0.0014	0.0099	0.0382
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0099	0.0099
Echinococcus granulosus	family C2 unassigned peptidase C02 family	0.0066	0.1006	0.1638
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.0014	0.0099	0.0382
Brugia malayi	calpain family protein 1	0.0063	0.0949	0.0949
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0014	0.0099	0.0382
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.0014	0.0099	0.0099
Schistosoma mansoni	hypothetical protein	0.0032	0.0414	0.1597
Loa Loa (eye worm)	hypothetical protein	0.001	0.0021	0.0021
Echinococcus multilocularis	g protein coupled receptor	0.0014	0.0099	0.0161
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.001	0.0021	0.0034
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0099	0.0099
Schistosoma mansoni	amine GPCR	0.0014	0.0099	0.0382
Brugia malayi	G protein-coupled receptor	0.0014	0.0099	0.0099
Brugia malayi	hypothetical protein	0.0014	0.0099	0.0099
Echinococcus multilocularis	family C2 unassigned peptidase (C02 family)	0.0066	0.1006	0.1638
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0099	0.0099
Schistosoma mansoni	histamine h1 receptor	0.0014	0.0099	0.0382
Onchocerca volvulus		0.0014	0.0099	0.0099
Echinococcus granulosus	Ataxin 2 N terminaldomain containing protein	0.0012	0.006	0.0098
Brugia malayi	Dopamine receptor protein 1	0.0014	0.0099	0.0099
Onchocerca volvulus		0.001	0.0021	0.0021
Brugia malayi	hypothetical protein	0.0014	0.0099	0.0099
Echinococcus multilocularis	GPCR, family 2	0.0032	0.0414	0.0674
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0032	0.0414	0.0414
Loa Loa (eye worm)	hypothetical protein	0.0072	0.1115	0.1115
Brugia malayi	G-protein coupled receptor	0.0014	0.0099	0.0099
Echinococcus multilocularis	allatostatin A receptor	0.0014	0.0099	0.0161
Brugia malayi	neuropeptide F receptor	0.0014	0.0099	0.0099
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0032	0.0414	0.0674
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0099	0.0099
Onchocerca volvulus	Rap guanine nucleotide exchange factor 1 homolog	0.0177	0.2935	0.2935
Schistosoma mansoni	dihydropyridine-sensitive l-type calcium channel	0.0079	0.1232	0.4751
Loa Loa (eye worm)	BRM protein	0.0037	0.0501	0.0501
Schistosoma mansoni	calpain-7 (C02 family)	0.0019	0.0176	0.0678
Brugia malayi	larval opioid receptor	0.0014	0.0099	0.0099
Brugia malayi	hypothetical protein	0.0017	0.0154	0.0154
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.0014	0.0099	0.0161
Echinococcus granulosus	tm gpcr rhodopsin	0.0014	0.0099	0.0161
Schistosoma mansoni	hypothetical protein	0.0032	0.0414	0.1597
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0032	0.0414	0.0674
Schistosoma mansoni	amine GPCR	0.0014	0.0099	0.0382
Schistosoma mansoni	serine-rich repeat protein	0.0085	0.1326	0.5114
Trichomonas vaginalis	low molecular weight protein tyrosine phosphatase, putative	0.0581	1	1
Loa Loa (eye worm)	hypothetical protein	0.0063	0.0949	0.0949
Echinococcus granulosus	biogenic amine 5HT receptor	0.0014	0.0099	0.0161
Echinococcus granulosus	alpha 1A adrenergic receptor	0.0014	0.0099	0.0161
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.001	0.0021	0.0021
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0014	0.0099	0.0382
Schistosoma mansoni	calpain-7 (C02 family)	0.0019	0.0176	0.0678
Schistosoma mansoni	adenoreceptor	0.0014	0.0099	0.0382
Echinococcus granulosus	g protein coupled receptor	0.0014	0.0099	0.0161
Onchocerca volvulus	Neuropeptide F receptor homolog	0.0014	0.0099	0.0099
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.0014	0.0099	0.0382
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.001	0.0021	0.0081
Echinococcus multilocularis	sex peptide receptor	0.0014	0.0099	0.0161
Onchocerca volvulus	Dopamine\/Ecdysteroid receptor homolog	0.0014	0.0099	0.0099
Loa Loa (eye worm)	steroid hormone receptor	0.001	0.0021	0.0021
Schistosoma mansoni	biogenic amine receptor	0.0014	0.0099	0.0382
Echinococcus granulosus	neuropeptide Y receptor	0.0014	0.0099	0.0161
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.001	0.0021	0.0021
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0414	0.0414
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.001	0.0021	0.0081
Echinococcus multilocularis	neuropeptide s receptor	0.0014	0.0099	0.0161
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.001	0.0021	0.0021
Brugia malayi	GnHR receptor homolog	0.0014	0.0099	0.0099
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.0014	0.0099	0.0382
Echinococcus multilocularis	hypothetical protein	0.0019	0.0176	0.0286
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0099	0.0099
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.001	0.0021	0.0034
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0014	0.0099	0.0382
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0014	0.0099	0.0161
Echinococcus granulosus	rhodopsin orphan GPCR	0.0014	0.0099	0.0161
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0014	0.0099	0.0161
Brugia malayi	G-protein coupled receptor	0.0014	0.0099	0.0099
Onchocerca volvulus		0.0014	0.0099	0.0099
Echinococcus multilocularis	g-protein coupled receptor	0.0014	0.0099	0.0161
Brugia malayi	hypothetical protein	0.0014	0.0099	0.0099
Onchocerca volvulus		0.0014	0.0099	0.0099
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0099	0.0099
Brugia malayi	hypothetical protein	0.0014	0.0099	0.0099
Mycobacterium tuberculosis	Phosphotyrosine protein phosphatase PtpA (protein-tyrosine-phosphatase) (PTPase) (LMW phosphatase)	0.0402	0.6871	0.5
Echinococcus granulosus	rhodopsin orphan GPCR	0.0014	0.0099	0.0161
Loa Loa (eye worm)	neuropeptide F receptor	0.0014	0.0099	0.0099
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.001	0.0021	0.0021
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0014	0.0099	0.0161
Onchocerca volvulus		0.0014	0.0099	0.0099
Echinococcus granulosus	tm gpcr rhodopsin	0.0014	0.0099	0.0161
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0032	0.0414	0.0674
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.001	0.0021	0.0081
Giardia lamblia	Low molecular weight protein-tyrosine-phosphatase	0.0581	1	1
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0099	0.0099
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.001	0.0021	0.0021
Schistosoma mansoni	hypothetical protein	0.0014	0.0099	0.0382
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0014	0.0099	0.0382
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.0014	0.0099	0.0161
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0014	0.0099	0.0161
Echinococcus granulosus	sex peptide receptor	0.0014	0.0099	0.0161
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0102	0.1637	0.1637
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.001	0.0021	0.0021
Schistosoma mansoni	retinoic acid receptor RXR	0.001	0.0021	0.0081
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.0014	0.0099	0.0161
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.001	0.0021	0.0081
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.0014	0.0099	0.0161
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.0014	0.0099	0.0161
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0099	0.0099
Schistosoma mansoni	coup transcription factor	0.001	0.0021	0.0081
Echinococcus multilocularis	chromodomain helicase DNA binding protein 7	0.0012	0.0066	0.0108
Brugia malayi	sulfakinin receptor protein	0.0014	0.0099	0.0099
Echinococcus multilocularis	neuropeptides capa receptor	0.0014	0.0099	0.0161
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0014	0.0099	0.0161
Echinococcus granulosus	neuropeptide receptor A26	0.0014	0.0099	0.0161
Onchocerca volvulus	Protein ultraspiracle homolog	0.001	0.0021	0.0021
Entamoeba histolytica	Rad52/22 family double-strand break repair protein, putative	0.0106	0.1706	0.1558
Brugia malayi	Dopamine receptor protein 2	0.0014	0.0099	0.0099
Plasmodium vivax	ataxin-2 like protein, putative	0.0027	0.0322	1
Onchocerca volvulus		0.0014	0.0099	0.0099
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0099	0.0099
Brugia malayi	photoreceptor-specific nuclear receptor	0.001	0.0021	0.0021
Echinococcus granulosus	g protein coupled receptor	0.0014	0.0099	0.0161
Loa Loa (eye worm)	hypothetical protein	0.001	0.0021	0.0021
Echinococcus multilocularis	G protein coupled receptor 139	0.0014	0.0099	0.0161
Loa Loa (eye worm)	melatonin receptor type 1A	0.0014	0.0099	0.0099
Schistosoma mansoni	RAR-like nuclear receptor	0.001	0.0021	0.0081
Brugia malayi	calpain family protein 1	0.0063	0.0949	0.0949
Echinococcus granulosus	calpain 7 C02 family	0.0019	0.0176	0.0286
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0045	0.063	0.063
Echinococcus granulosus	ecdysone induced protein 78C	0.001	0.0021	0.0034
Echinococcus multilocularis	BRK domain containing protein	0.0012	0.0066	0.0108
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.0014	0.0099	0.0161
Echinococcus multilocularis	BRK domain containing protein	0.0012	0.0066	0.0108
Echinococcus multilocularis	BRK domain containing protein	0.0012	0.0066	0.0108
Brugia malayi	hypothetical protein	0.0014	0.0099	0.0099
Echinococcus granulosus	g-protein coupled receptor	0.0014	0.0099	0.0161

Activities

Activity type	Activity value	Assay description	Source	Reference
ED50 (functional)	= 0.23 mg kg-1	IIn vivo antagonism of guanabenz-induced hypothermia in mice after intraperitoneal administration at a dose of 0.63-2.5 mg/kg	ChEMBL.	11020279
ED50 (functional)	= 0.23 mg kg-1	IIn vivo antagonism of guanabenz-induced hypothermia in mice after intraperitoneal administration at a dose of 0.63-2.5 mg/kg	ChEMBL.	11020279
ED50 (functional)	= 5.09 mg kg-1	In vivo antagonism of guanabenz-induced hypothermia in mice after peroral administration at a dose of 10 mg/kg	ChEMBL.	11020279
ED50 (functional)	= 5.09 mg kg-1	In vivo antagonism of guanabenz-induced hypothermia in mice after peroral administration at a dose of 10 mg/kg	ChEMBL.	11020279
IC50 (binding)	= 4.4 nM	In vitro inhibition of binding of [3H]-RX-821002 to alpha-2 adrenergic receptor site in rat brain membranes.	ChEMBL.	11020279
IC50 (binding)	= 4.4 nM	In vitro inhibition of binding of [3H]-RX-821002 to alpha-2 adrenergic receptor site in rat brain membranes.	ChEMBL.	11020279
IC50 (binding)	= 28 nM	In vitro inhibition of specific binding of [3H]-YM 09151-2 to Dopamine receptor D2 site in rat striatal tissue.	ChEMBL.	11020279
IC50 (binding)	= 28 nM	In vitro inhibition of specific binding of [3H]-YM 09151-2 to Dopamine receptor D2 site in rat striatal tissue.	ChEMBL.	11020279
IC50 (binding)	= 50 nM	In vitro inhibition of specific binding of [3H]- prazosin to alpha-1 adrenergic receptor site in rat brain membranes.	ChEMBL.	11020279
IC50 (binding)	= 50 nM	In vitro inhibition of specific binding of [3H]- prazosin to alpha-1 adrenergic receptor site in rat brain membranes.	ChEMBL.	11020279

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL120836
PubChem: 10622094

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 210601