Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Human immunodeficiency virus 1 | Human immunodeficiency virus type 1 protease | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Schistosoma mansoni | intracisternal A-particle retropepsin (A02 family) | Get druggable targets OG5_131408 | All targets in OG5_131408 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | purine nucleoside phosphorylase | 0.0968 | 0.5524 | 1 |
Echinococcus multilocularis | purine nucleoside phosphorylase | 0.0968 | 0.5524 | 1 |
Brugia malayi | purine nucleoside phosphorylase I, inosine and guanosine-specific family protein | 0.0968 | 0.5524 | 0.5 |
Echinococcus granulosus | purine nucleoside phosphorylase | 0.0968 | 0.5524 | 1 |
Echinococcus granulosus | purine nucleoside phosphorylase | 0.0968 | 0.5524 | 1 |
Echinococcus granulosus | purine nucleoside phosphorylase | 0.0968 | 0.5524 | 1 |
Schistosoma mansoni | purine nucleoside phosphorylase | 0.0968 | 0.5524 | 0.5524 |
Loa Loa (eye worm) | hypothetical protein | 0.0695 | 0.3337 | 0.5 |
Treponema pallidum | purine nucleoside phosphorylase (deoD) | 0.07 | 0.3377 | 0.5 |
Plasmodium vivax | purine nucleoside phosphorylase, putative | 0.07 | 0.3377 | 0.5 |
Treponema pallidum | uridine phosphorylase (udp) | 0.07 | 0.3377 | 0.5 |
Trichomonas vaginalis | purine nucleoside phosphorylase I, putative | 0.0968 | 0.5524 | 1 |
Toxoplasma gondii | Purine nucleoside phosphorylase | 0.07 | 0.3377 | 0.5 |
Mycobacterium tuberculosis | Probable purine nucleoside phosphorylase DeoD (inosine phosphorylase) (PNP) | 0.0968 | 0.5524 | 0.5 |
Echinococcus granulosus | purine nucleoside phosphorylase | 0.0968 | 0.5524 | 1 |
Echinococcus granulosus | purine nucleoside phosphorylase | 0.0968 | 0.5524 | 1 |
Echinococcus multilocularis | purine nucleoside phosphorylase | 0.0968 | 0.5524 | 1 |
Echinococcus multilocularis | purine nucleoside phosphorylase | 0.0968 | 0.5524 | 1 |
Echinococcus granulosus | purine nucleoside phosphorylase | 0.0968 | 0.5524 | 1 |
Plasmodium falciparum | purine nucleoside phosphorylase | 0.07 | 0.3377 | 0.5 |
Echinococcus granulosus | purine nucleoside phosphorylase | 0.0968 | 0.5524 | 1 |
Echinococcus multilocularis | purine nucleoside phosphorylase | 0.0968 | 0.5524 | 1 |
Schistosoma mansoni | purine nucleoside phosphorylase | 0.0968 | 0.5524 | 0.5524 |
Entamoeba histolytica | purine nucleoside phosphorylase, putative | 0.07 | 0.3377 | 0.5 |
Onchocerca volvulus | Purine nucleoside phosphorylase homolog | 0.0968 | 0.5524 | 0.5 |
Echinococcus multilocularis | purine nucleoside phosphorylase | 0.0968 | 0.5524 | 1 |
Giardia lamblia | Purine nucleoside phosphorylase lateral transfer candidate | 0.0968 | 0.5524 | 0.5 |
Entamoeba histolytica | purine nucleoside phosphorylase, putative | 0.07 | 0.3377 | 0.5 |
Mycobacterium ulcerans | purine nucleoside phosphorylase | 0.0968 | 0.5524 | 0.5 |
Echinococcus multilocularis | purine nucleoside phosphorylase | 0.0968 | 0.5524 | 1 |
Mycobacterium leprae | Probable purine nucleoside phosphorylase DeoD (INOSINE PHOSPHORYLASE) (PNP) | 0.0968 | 0.5524 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (functional) | > 21 uM | Antiviral activity in HIV infected CEM cells. | ChEMBL. | 9371233 |
EC50 (functional) | > 21 uM | Antiviral activity in HIV infected CEM cells. | ChEMBL. | 9371233 |
IC50 (binding) | = 120 nM | In vitro inhibition activity against HIV-1 protease . | ChEMBL. | 9371233 |
IC50 (binding) | = 120 nM | In vitro inhibition activity against HIV-1 protease . | ChEMBL. | 9371233 |
TC50 (ADMET) | = 21 uM | Cytotoxicity in CEM cells in the absence of virus | ChEMBL. | 9371233 |
TC50 (ADMET) | = 21 uM | Cytotoxicity in CEM cells in the absence of virus | ChEMBL. | 9371233 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.