Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | uncharacterized sodium dependent transporter | 0.0194 | 0.0501 | 0.1282 |
Echinococcus multilocularis | sodium and chloride dependent glycine | 0.0194 | 0.0501 | 0.1282 |
Echinococcus multilocularis | sodium and chloride dependent glycine | 0.0194 | 0.0501 | 0.1282 |
Echinococcus multilocularis | uncharacterized sodium dependent transporter | 0.0194 | 0.0501 | 0.1282 |
Schistosoma mansoni | sodium/chloride dependent transporter | 0.1142 | 0.3905 | 1 |
Loa Loa (eye worm) | NNMT/PNMT/TEMT family protein | 0.2841 | 1 | 1 |
Echinococcus multilocularis | sodium dependent neurotransmitter transporter | 0.0194 | 0.0501 | 0.1282 |
Mycobacterium tuberculosis | Probable flavin-containing monoamine oxidase AofH (amine oxidase) (MAO) | 0.0575 | 0.187 | 0.5 |
Schistosoma mansoni | sodium/chloride dependent transporter | 0.0194 | 0.0501 | 0.1282 |
Loa Loa (eye worm) | hypothetical protein | 0.0194 | 0.0501 | 0.0501 |
Brugia malayi | Sodium:neurotransmitter symporter family protein 1, putative | 0.0194 | 0.0501 | 0.0501 |
Schistosoma mansoni | sodium/chloride dependent transporter | 0.0194 | 0.0501 | 0.1282 |
Onchocerca volvulus | 0.0194 | 0.0501 | 0.1282 | |
Schistosoma mansoni | sodium-dependent neurotransmitter transporter | 0.0194 | 0.0501 | 0.1282 |
Brugia malayi | Sodium:neurotransmitter symporter family protein | 0.0194 | 0.0501 | 0.0501 |
Schistosoma mansoni | norepinephrine/norepinephrine transporter | 0.1142 | 0.3905 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.2841 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.1142 | 0.3905 | 0.3905 |
Schistosoma mansoni | sodium/chloride dependent neurotransmitter transporter | 0.0194 | 0.0501 | 0.1282 |
Brugia malayi | Sodium:neurotransmitter symporter family protein | 0.1142 | 0.3905 | 0.3905 |
Loa Loa (eye worm) | hypothetical protein | 0.0194 | 0.0501 | 0.0501 |
Toxoplasma gondii | Sodium:neurotransmitter symporter family protein | 0.0194 | 0.0501 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.1142 | 0.3905 | 0.3905 |
Loa Loa (eye worm) | norepinephrine transporter | 0.1142 | 0.3905 | 0.3905 |
Toxoplasma gondii | hypothetical protein | 0.0194 | 0.0501 | 0.5 |
Toxoplasma gondii | Sodium:neurotransmitter symporter family protein | 0.0194 | 0.0501 | 0.5 |
Leishmania major | C-8 sterol isomerase-like protein | 0.1113 | 0.38 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0569 | 0.1847 | 0.1847 |
Loa Loa (eye worm) | serotonin transporter b | 0.1142 | 0.3905 | 0.3905 |
Toxoplasma gondii | Sodium:neurotransmitter symporter family protein | 0.0194 | 0.0501 | 0.5 |
Schistosoma mansoni | sodium/chloride dependent neurotransmitter transporter | 0.0194 | 0.0501 | 0.1282 |
Plasmodium vivax | amine transporter, putative | 0.0194 | 0.0501 | 0.5 |
Onchocerca volvulus | 0.0194 | 0.0501 | 0.1282 | |
Plasmodium vivax | hypothetical protein, conserved | 0.0194 | 0.0501 | 0.5 |
Schistosoma mansoni | sodium-dependent neurotransmitter transporter | 0.0194 | 0.0501 | 0.1282 |
Trypanosoma brucei | C-8 sterol isomerase, putative | 0.1113 | 0.38 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0194 | 0.0501 | 0.0501 |
Loa Loa (eye worm) | hypothetical protein | 0.1113 | 0.38 | 0.38 |
Schistosoma mansoni | hypothetical protein | 0.0349 | 0.1055 | 0.2703 |
Echinococcus granulosus | serotonin transporter | 0.1142 | 0.3905 | 1 |
Schistosoma mansoni | sodium/chloride dependent neurotransmitter transporter | 0.0194 | 0.0501 | 0.1282 |
Treponema pallidum | sodium- and chloride- dependent transporter | 0.1142 | 0.3905 | 0.5 |
Mycobacterium ulcerans | flavin-containing monoamine oxidase AofH | 0.0619 | 0.2026 | 0.5 |
Echinococcus granulosus | uncharacterized sodium dependent transporter | 0.0194 | 0.0501 | 0.1282 |
Chlamydia trachomatis | Ssodium-dependent amino acid transporter | 0.0194 | 0.0501 | 0.5 |
Brugia malayi | ERG2 and Sigma1 receptor like protein | 0.1113 | 0.38 | 0.38 |
Echinococcus granulosus | sodium and chloride dependent glycine | 0.0194 | 0.0501 | 0.1282 |
Echinococcus multilocularis | sodium:chloride dependent neurotransmitter | 0.0194 | 0.0501 | 0.1282 |
Echinococcus granulosus | sodium dependent neurotransmitter transporter | 0.0194 | 0.0501 | 0.1282 |
Toxoplasma gondii | hypothetical protein | 0.0194 | 0.0501 | 0.5 |
Loa Loa (eye worm) | Sodium:neurotransmitter symporter family protein | 0.0194 | 0.0501 | 0.0501 |
Trypanosoma cruzi | C-8 sterol isomerase, putative | 0.1113 | 0.38 | 0.5 |
Mycobacterium ulcerans | flavin-containing monoamine oxidase AofH | 0.0619 | 0.2026 | 0.5 |
Echinococcus granulosus | kinesin family 1 | 0.0401 | 0.1242 | 0.3181 |
Brugia malayi | Sodium:neurotransmitter symporter family protein | 0.0194 | 0.0501 | 0.0501 |
Onchocerca volvulus | 0.0194 | 0.0501 | 0.1282 | |
Loa Loa (eye worm) | hypothetical protein | 0.2841 | 1 | 1 |
Loa Loa (eye worm) | solute carrier family 6 member 4 | 0.1142 | 0.3905 | 0.3905 |
Echinococcus granulosus | sodium:chloride dependent neurotransmitter | 0.0194 | 0.0501 | 0.1282 |
Schistosoma mansoni | norepinephrine/norepinephrine transporter | 0.0194 | 0.0501 | 0.1282 |
Brugia malayi | hypothetical protein | 0.0194 | 0.0501 | 0.0501 |
Loa Loa (eye worm) | hypothetical protein | 0.0194 | 0.0501 | 0.0501 |
Echinococcus multilocularis | serotonin transporter | 0.1142 | 0.3905 | 1 |
Echinococcus granulosus | sodium and chloride dependent glycine | 0.0194 | 0.0501 | 0.1282 |
Onchocerca volvulus | 0.1142 | 0.3905 | 1 | |
Echinococcus multilocularis | kinesin family 1 | 0.0401 | 0.1242 | 0.3181 |
Schistosoma mansoni | sodium-dependent neurotransmitter transporter | 0.0194 | 0.0501 | 0.1282 |
Loa Loa (eye worm) | hypothetical protein | 0.0194 | 0.0501 | 0.0501 |
Plasmodium falciparum | amino acid transporter, putative | 0.0194 | 0.0501 | 0.5 |
Plasmodium falciparum | transporter, putative | 0.0194 | 0.0501 | 0.5 |
Loa Loa (eye worm) | Sodium:neurotransmitter symporter family protein | 0.0194 | 0.0501 | 0.0501 |
Loa Loa (eye worm) | hypothetical protein | 0.1142 | 0.3905 | 0.3905 |
Loa Loa (eye worm) | hypothetical protein | 0.0194 | 0.0501 | 0.0501 |
Brugia malayi | Sodium:neurotransmitter symporter family protein | 0.0194 | 0.0501 | 0.0501 |
Schistosoma mansoni | sodium-dependent amino acid transporter | 0.0194 | 0.0501 | 0.1282 |
Loa Loa (eye worm) | hypothetical protein | 0.0194 | 0.0501 | 0.0501 |
Schistosoma mansoni | norepinephrine/norepinephrine transporter | 0.0194 | 0.0501 | 0.1282 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Log 1/IC50 (functional) | = 1.19 | Compound was tested against gram-negative Caulobacter crescentus, strain NA 1000 bacteria | ChEMBL. | 11606132 |
Log 1/IC50 (functional) | = 2.14 | Activity against gram-positive Staphylococcus aureus strain ATCC 25923 bacteria | ChEMBL. | 11606132 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.