Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Equus caballus | Cholinesterase | References | |
Electrophorus electricus | Acetylcholinesterase | References | |
Homo sapiens | acetylcholinesterase (Yt blood group) | References | |
Homo sapiens | butyrylcholinesterase | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Echinococcus granulosus | BC026374 protein S09 family | Acetylcholinesterase | 633 aa | 690 aa | 31.7 % |
Onchocerca volvulus | Cholinesterase | 574 aa | 578 aa | 25.3 % | |
Onchocerca volvulus | Galectin homolog | Cholinesterase | 574 aa | 531 aa | 39.7 % |
Echinococcus granulosus | neuroligin | Cholinesterase | 574 aa | 492 aa | 24.4 % |
Loa Loa (eye worm) | hypothetical protein | Acetylcholinesterase | 633 aa | 597 aa | 25.1 % |
Drosophila melanogaster | CG10175 gene product from transcript CG10175-RE | Acetylcholinesterase | 633 aa | 549 aa | 30.4 % |
Echinococcus multilocularis | BC026374 protein (S09 family) | Acetylcholinesterase | 633 aa | 690 aa | 32.3 % |
Loa Loa (eye worm) | hypothetical protein | Acetylcholinesterase | 633 aa | 576 aa | 23.4 % |
Onchocerca volvulus | Cholinesterase | 574 aa | 551 aa | 29.9 % | |
Schistosoma mansoni | gliotactin | Cholinesterase | 574 aa | 587 aa | 27.9 % |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | Acetylcholinesterase | 633 aa | 622 aa | 24.9 % |
Onchocerca volvulus | Acetylcholinesterase | 633 aa | 648 aa | 25.3 % | |
Brugia malayi | Carboxylesterase family protein | Cholinesterase | 574 aa | 538 aa | 31.4 % |
Brugia malayi | Carboxylesterase family protein | Acetylcholinesterase | 633 aa | 517 aa | 25.1 % |
Onchocerca volvulus | Molybdopterin synthase catalytic subunit homolog | Acetylcholinesterase | 633 aa | 576 aa | 28.8 % |
Brugia malayi | Carboxylesterase family protein | acetylcholinesterase (Yt blood group) | 614 aa | 510 aa | 26.5 % |
Brugia malayi | Carboxylesterase family protein | Acetylcholinesterase | 633 aa | 620 aa | 28.4 % |
Schistosoma japonicum | ko:K01050 cholinesterase [EC3.1.1.8], putative | Cholinesterase | 574 aa | 577 aa | 36.9 % |
Onchocerca volvulus | Putative nuclear protein | Cholinesterase | 574 aa | 572 aa | 40.9 % |
Brugia malayi | Carboxylesterase family protein | butyrylcholinesterase | 602 aa | 546 aa | 30.2 % |
Echinococcus multilocularis | neuroligin | Acetylcholinesterase | 633 aa | 507 aa | 23.9 % |
Onchocerca volvulus | Carnitine O-palmitoyltransferase 2, mitochondrial homolog | Cholinesterase | 574 aa | 554 aa | 36.1 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | acetylcholinesterase | 0.0327 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0327 | 0.5 | 0.5 |
Echinococcus granulosus | carboxylesterase 5A | 0.0327 | 0.5 | 0.5 |
Echinococcus granulosus | acetylcholinesterase | 0.0327 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0327 | 0.5 | 0.5 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0327 | 0.5 | 0.5 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0327 | 0.5 | 0.5 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0327 | 0.5 | 0.5 |
Loa Loa (eye worm) | carboxylesterase | 0.0327 | 0.5 | 0.5 |
Echinococcus multilocularis | acetylcholinesterase | 0.0327 | 0.5 | 0.5 |
Echinococcus multilocularis | acetylcholinesterase | 0.0327 | 0.5 | 0.5 |
Brugia malayi | Carboxylesterase family protein | 0.0327 | 0.5 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity | Hepatotoxicity in scopolamine-induced memory deficit Kunming mouse model assessed as area of necrosis in hepatocytes at 10 mg/Kg, po for 6 days by hematoxylin and eosin-staining based microscopic analysis | LITERATURE. | 27484514 | |
Activity | Toxicity in scopolamine-induced memory deficit Kunming mouse model assessed as effect on survival at 2 | LITERATURE. | 27484514 | |
Activity | Toxicity in scopolamine-induced memory deficit Kunming mouse model assessed as change in body weight at 2 | LITERATURE. | 27484514 | |
Activity | Hepatotoxicity in scopolamine-induced memory deficit Kunming mouse model assessed as increase in alanine aminotransferase levels at 10 mg/kg, po for 6 days | LITERATURE. | 27484514 | |
Activity | Hepatotoxicity in scopolamine-induced memory deficit Kunming mouse model assessed as distinct fatty degeneration in hepatocytes at 10 mg/Kg, po for 6 days by hematoxylin and eosin-staining based microscopic analysis | LITERATURE. | 27484514 | |
Activity | Hepatotoxicity in scopolamine-induced memory deficit Kunming mouse model assessed as increase in number of inflammatory cells in portal fields of liver at 10 mg/Kg, po for 6 days by hematoxylin and eosin-staining based microscopic analysis | LITERATURE. | 27484514 | |
Activity | Hepatotoxicity in scopolamine-induced memory deficit Kunming mouse model assessed as increased aspartate aminotransferase at 10 mg/Kg, po for 6 days | LITERATURE. | 27484514 | |
IC50 (binding) | = 0.032 uM | Inhibition of human erythrocytes AChE using acetylthiocholine iodide as substrate preincubated for 5 mins followed by substrate addition measured up to 3 mins by Ellman's method | LITERATURE. | 27484514 |
IC50 (binding) | = 0.043 uM | Inhibition of electric eel AChE using acetylthiocholine iodide as substrate preincubated for 5 mins followed by substrate addition measured up to 3 mins by Ellman's method | LITERATURE. | 27484514 |
IC50 (binding) | = 3.71 uM | Inhibition of equine serum BuChE using s-butyrylthiocholine iodide as substrate preincubated for 5 mins followed by substrate addition measured up to 3 mins by Ellman's method | LITERATURE. | 27484514 |
IC50 (binding) | = 12.8 uM | Inhibition of human serum BuChE using s-butyrylthiocholine iodide as substrate preincubated for 5 mins followed by substrate addition measured up to 3 mins by Ellman's method | LITERATURE. | 27484514 |
Inhibition (binding) | Mixed-type inhibition of human erythrocyte AChE preincubated for 15 mins followed by addition of acetylthiocholine iodide as substrate in varying concentrations by Lineweaver-Burk reciprocal plot analysis | LITERATURE. | 27484514 | |
Inhibition (binding) | = 47.9 % | Inhibition of human AChE mediated aggregation of amyloid beta (1 to 40 residues) at 100 uM incubated for 46-48 hrs by thioflavin-T binding assay relative to control | LITERATURE. | 27484514 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.