Detailed information for compound 215444

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 339.385 | Formula: C20H21NO4
  • H donors: 3 H acceptors: 4 LogP: 0.32 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: OC(=O)[C@H]1CC1[C@@](C(=O)O)(CCc1cccc(c1)c1ccccc1)N
  • InChi: 1S/C20H21NO4/c21-20(19(24)25,17-12-16(17)18(22)23)10-9-13-5-4-8-15(11-13)14-6-2-1-3-7-14/h1-8,11,16-17H,9-10,12,21H2,(H,22,23)(H,24,25)/t16-,17?,20+/m0/s1
  • InChiKey: SMQMSJRCILTZPI-YKBQRGLWSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni loxhd1 0.012 0.0835 0.1071
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0069 0.024 0.5
Echinococcus granulosus lipoxygenase domain containing protein 0.012 0.0835 0.1071
Brugia malayi hypothetical protein 0.0256 0.2412 0.3478
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.007 0.0252 0.0323
Loa Loa (eye worm) hypothetical protein 0.0256 0.2412 0.349
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.005 0.0013 0.0017
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0149 0.1165 0.1493
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0149 0.1165 0.167
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0069 0.024 0.5
Brugia malayi Hypothetical tyrosinase-like protein F21C3.2 in chromosome I 0.0089 0.0469 0.0662
Plasmodium falciparum LCCL domain-containing protein 0.012 0.0835 0.5
Schistosoma mansoni retinoic acid receptor RXR 0.0256 0.2405 0.3084
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0149 0.1165 0.1493
Schistosoma mansoni RAR-like nuclear receptor 0.0149 0.1165 0.1493
Onchocerca volvulus Protein ultraspiracle homolog 0.0149 0.1165 0.5741
Schistosoma mansoni tar DNA-binding protein 0.0066 0.0208 0.0267
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0149 0.1165 0.167
Brugia malayi nuclear receptor RXR 0.007 0.0252 0.0347
Leishmania major cathepsin L-like protease 0.0069 0.024 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0149 0.1165 0.1685
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0105 0.0656 0.0932
Echinococcus granulosus FTZ F1 alpha 0.0149 0.1165 0.1493
Brugia malayi RNA recognition motif domain containing protein 0.0066 0.0208 0.0283
Schistosoma mansoni polycystin 1-related 0.012 0.0835 0.1071
Brugia malayi Steroid receptor seven-up type 2 0.0149 0.1165 0.167
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0149 0.1165 0.1493
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0149 0.1165 0.1493
Schistosoma mansoni single-minded 0.0103 0.0636 0.0816
Brugia malayi hypothetical protein 0.007 0.0252 0.0347
Schistosoma mansoni hypothetical protein 0.0228 0.2085 0.2674
Echinococcus multilocularis RUN 0.012 0.0835 0.1071
Brugia malayi nuclear receptor NHR-88 0.0149 0.1165 0.167
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.005 0.0013 0.0019
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0149 0.1165 0.167
Echinococcus multilocularis thyroid hormone receptor alpha 0.0149 0.1165 0.1493
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.006 0.0129 0.0166
Loa Loa (eye worm) hypothetical protein 0.0149 0.1165 0.1685
Loa Loa (eye worm) hypothetical protein 0.007 0.0252 0.0365
Onchocerca volvulus Bile acid receptor homolog 0.0149 0.1165 0.5741
Schistosoma mansoni rab6-interacting 0.012 0.0835 0.1071
Echinococcus granulosus nuclear receptor nhr 48 0.007 0.0252 0.0323
Echinococcus multilocularis FTZ F1 alpha 0.0149 0.1165 0.1493
Loa Loa (eye worm) hypothetical protein 0.012 0.0835 0.1209
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0149 0.1165 0.1493
Loa Loa (eye worm) steroid hormone receptor 0.0149 0.1165 0.1685
Loa Loa (eye worm) hypothetical protein 0.007 0.0252 0.0365
Schistosoma mansoni aryl hydrocarbon receptor 0.0103 0.0636 0.0816
Loa Loa (eye worm) hypothetical protein 0.007 0.0252 0.0365
Schistosoma mansoni hypothetical protein 0.0052 0.0044 0.0057
Brugia malayi follicle stimulating hormone receptor 0.0229 0.2094 0.3016
Echinococcus granulosus Polycystic kidney disease protein 0.012 0.0835 0.1071
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.005 0.0013 0.0017
Loa Loa (eye worm) hypothetical protein 0.007 0.0252 0.0365
Loa Loa (eye worm) hypothetical protein 0.0105 0.0656 0.0949
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.005 0.0013 0.0017
Onchocerca volvulus 0.0089 0.0469 0.2178
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0069 0.024 0.5
Leishmania major cathepsin L-like protease 0.0069 0.024 1
Schistosoma mansoni tyrosinase precursor 0.0089 0.0469 0.0602
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0069 0.024 0.5
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.005 0.0013 0.0017
Trypanosoma cruzi cysteine peptidase, putative 0.0069 0.024 1
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0149 0.1165 0.1493
Loa Loa (eye worm) hypothetical protein 0.0346 0.3459 0.5005
Onchocerca volvulus 0.0089 0.0469 0.2178
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0149 0.1165 0.1493
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0066 0.0208 0.0301
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0149 0.1165 0.1493
Brugia malayi PAS domain containing protein 0.0103 0.0636 0.0904
Brugia malayi Calcitonin receptor-like protein seb-1 0.0105 0.0656 0.0932
Loa Loa (eye worm) hypothetical protein 0.0644 0.6912 1
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0149 0.1165 0.1493
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0149 0.1165 0.5741
Loa Loa (eye worm) hypothetical protein 0.0273 0.2606 0.3771
Plasmodium vivax multidomain scavenger receptor, putative 0.012 0.0835 0.5
Loa Loa (eye worm) tyrosinase 1 0.0089 0.0469 0.0679
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0052 0.0044 0.0045
Loa Loa (eye worm) hypothetical protein 0.007 0.0252 0.0365
Echinococcus multilocularis nuclear receptor nhr 48 0.007 0.0252 0.0323
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0063 0.017 0.5946
Onchocerca volvulus 0.022 0.1996 1
Brugia malayi ShTK domain containing protein 0.0089 0.0469 0.0662
Loa Loa (eye worm) doublecortin family protein 0.012 0.0835 0.1209
Loa Loa (eye worm) hypothetical protein 0.007 0.0252 0.0365
Schistosoma mansoni survival motor neuron protein 0.0052 0.0044 0.0057
Schistosoma mansoni tar DNA-binding protein 0.0066 0.0208 0.0267
Echinococcus granulosus arachidonate 5 lipoxygenase 0.072 0.7799 1
Brugia malayi tailless protein 0.007 0.0252 0.0347
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.007 0.0252 0.1066
Trypanosoma cruzi cysteine peptidase, putative 0.0069 0.024 1
Loa Loa (eye worm) hypothetical protein 0.0072 0.027 0.0391
Loa Loa (eye worm) hypothetical protein 0.0149 0.1165 0.1685
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0149 0.1165 0.1493
Loa Loa (eye worm) hypothetical protein 0.007 0.0252 0.0365
Schistosoma mansoni hypothetical protein 0.0173 0.1447 0.1856
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0149 0.1165 0.1685
Loa Loa (eye worm) hypothetical protein 0.007 0.0252 0.0365
Echinococcus multilocularis nuclear factor of activated T cells 5 0.0246 0.2295 0.2942
Schistosoma mansoni nuclear receptor 0.007 0.0252 0.0323
Brugia malayi nuclear hormone receptor 0.0149 0.1165 0.167
Onchocerca volvulus 0.0089 0.0469 0.2178
Brugia malayi Doublecortin family protein 0.012 0.0835 0.1192
Loa Loa (eye worm) ShTK domain-containing protein 0.0089 0.0469 0.0679
Loa Loa (eye worm) hypothetical protein 0.0079 0.035 0.0506
Loa Loa (eye worm) nuclear hormone receptor 0.007 0.0252 0.0365
Brugia malayi hypothetical protein 0.007 0.0252 0.0347
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0149 0.1165 0.1685
Schistosoma mansoni steroid hormone receptor ad4bp 0.0149 0.1165 0.1493
Brugia malayi conserved hypotetical protein 0.007 0.0252 0.0347
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0069 0.024 0.5
Brugia malayi small heat shock protein 0.0644 0.6912 1
Brugia malayi bZIP transcription factor family protein 0.0281 0.2696 0.3889
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0056 0.0083 0.012
Loa Loa (eye worm) hypothetical protein 0.007 0.0252 0.0365
Schistosoma mansoni thyroid hormone receptor 0.0149 0.1165 0.1493
Schistosoma mansoni nuclear receptor nhr-48 0.007 0.0252 0.0323
Loa Loa (eye worm) hypothetical protein 0.0149 0.1165 0.1685
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0069 0.024 0.5
Brugia malayi bHLH-PAS transcription factor 0.0076 0.0325 0.0452
Loa Loa (eye worm) hypothetical protein 0.007 0.0252 0.0365
Echinococcus granulosus survival motor neuron protein 1 0.0256 0.2412 0.3093
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0149 0.1165 0.1493
Brugia malayi photoreceptor-specific nuclear receptor 0.0149 0.1165 0.167
Brugia malayi Hypothetical tyrosinase-like protein C02C2.1 in chromosome III 0.0089 0.0469 0.0662
Leishmania major cathepsin L-like protease 0.0069 0.024 1
Echinococcus granulosus Nuclear hormone receptor HR96 0.007 0.0252 0.0323
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0149 0.1165 0.1493
Trypanosoma cruzi cruzipain precursor, putative 0.0069 0.024 1
Loa Loa (eye worm) hypothetical protein 0.007 0.0252 0.0365
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0149 0.1165 0.167
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0149 0.1165 0.1493
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0149 0.1165 0.1493
Echinococcus granulosus Basic leucine zipper bZIP transcription factor 0.0281 0.2696 0.3457
Schistosoma mansoni lipoxygenase 0.072 0.7799 1
Brugia malayi nuclear hormone receptor 0.007 0.0252 0.0347
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.007 0.0252 0.1066
Schistosoma mansoni nuclear hormone receptor 0.0149 0.1165 0.1493
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0149 0.1165 0.167
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0229 0.2094 0.303
Brugia malayi TAR-binding protein 0.0066 0.0208 0.0283
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0069 0.024 0.5
Schistosoma mansoni tar DNA-binding protein 0.0066 0.0208 0.0267
Echinococcus granulosus RUN 0.012 0.0835 0.1071
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.007 0.0252 0.0323
Echinococcus granulosus tar DNA binding protein 0.0066 0.0208 0.0267
Echinococcus multilocularis lipoxygenase domain containing protein 0.012 0.0835 0.1071
Loa Loa (eye worm) hypothetical protein 0.0149 0.1165 0.1685
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0149 0.1165 0.1493
Loa Loa (eye worm) hypothetical protein 0.0149 0.1165 0.1685
Echinococcus granulosus geminin 0.0173 0.1447 0.1856
Loa Loa (eye worm) hypothetical protein 0.0079 0.035 0.0506
Brugia malayi RNA binding protein 0.0066 0.0208 0.0283
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0069 0.024 0.5
Brugia malayi Common central domain of tyrosinase family protein 0.0089 0.0469 0.0662
Echinococcus granulosus jun protein 0.0281 0.2696 0.3457
Brugia malayi Nuclear hormone receptor-like 1 0.0079 0.035 0.0489
Brugia malayi Cytochrome P450 family protein 0.0151 0.1195 0.1713
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0079 0.035 0.0506
Schistosoma mansoni coup transcription factor 0.0149 0.1165 0.1493
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0079 0.035 0.0449
Brugia malayi hypothetical protein 0.012 0.0835 0.1192
Schistosoma mansoni jun-related protein 0.0228 0.2085 0.2674
Brugia malayi nuclear receptor RXR 0.0079 0.035 0.0489
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0177 0.1492 0.1914
Brugia malayi nuclear receptor NHR-67 0.007 0.0252 0.0347
Echinococcus granulosus nuclear receptor 2DBD gamma 0.007 0.0252 0.0323
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.007 0.0252 0.0323
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0149 0.1165 0.167
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0149 0.1165 0.167
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0069 0.024 0.5
Schistosoma mansoni zinc finger protein 0.007 0.0252 0.0323
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0149 0.1165 0.167
Schistosoma mansoni nuclear receptor 0.007 0.0252 0.0323
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.005 0.0013 0.0017
Schistosoma mansoni tyrosinase precursor 0.0089 0.0469 0.0602
Brugia malayi ecdysone receptor 0.007 0.0252 0.0347
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0069 0.024 0.5
Loa Loa (eye worm) hypothetical protein 0.0079 0.035 0.0506
Brugia malayi latrophilin 2 splice variant baaae 0.0072 0.027 0.0373
Echinococcus multilocularis survival motor neuron protein 1 0.0256 0.2412 0.3093
Echinococcus multilocularis jun protein 0.0281 0.2696 0.3457
Brugia malayi nuclear receptor NHR-88 0.007 0.0252 0.0347
Echinococcus granulosus Nuclear hormone receptor HR96 0.007 0.0252 0.0323
Loa Loa (eye worm) hypothetical protein 0.0079 0.035 0.0506
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0149 0.1165 0.167
Echinococcus multilocularis Nuclear hormone receptor HR96 0.007 0.0252 0.0323
Schistosoma mansoni thyroid hormone receptor 0.0149 0.1165 0.1493
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.072 0.7799 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.005 0.0013 0.0017
Loa Loa (eye worm) DR-78 0.007 0.0252 0.0365
Echinococcus multilocularis Nuclear hormone receptor HR96 0.007 0.0252 0.0323
Echinococcus multilocularis transfer RNA-Lys 0.0076 0.0325 0.0416
Onchocerca volvulus 0.0149 0.1165 0.5741
Loa Loa (eye worm) hypoxia-induced factor 1 0.032 0.3148 0.4554
Schistosoma mansoni lipoxygenase 0.0504 0.5283 0.6774
Brugia malayi Hypothetical tyrosinase-like protein C02C2.1 in chromosome III 0.0089 0.0469 0.0662
Onchocerca volvulus 0.0076 0.0325 0.1437
Loa Loa (eye worm) hypothetical protein 0.0149 0.1165 0.1685
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0079 0.035 0.0449
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.007 0.0252 0.0323
Brugia malayi orphan nuclear receptor NR2E1 0.007 0.0252 0.0347
Brugia malayi nuclear hormone receptor family member odr-7 0.007 0.0252 0.0347
Brugia malayi hypoxia-induced factor 1 0.032 0.3148 0.4544
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0256 0.2405 0.3084
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0149 0.1165 0.167
Brugia malayi Nuclear hormone receptor-like 1 0.0149 0.1165 0.167
Onchocerca volvulus 0.0089 0.0469 0.2178
Onchocerca volvulus 0.012 0.0835 0.4053
Brugia malayi Nuclear hormone receptor-like 1 0.0079 0.035 0.0489
Loa Loa (eye worm) ShTK domain-containing protein 0.0089 0.0469 0.0679
Schistosoma mansoni tar DNA-binding protein 0.0066 0.0208 0.0267
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0105 0.0656 0.0949
Onchocerca volvulus 0.007 0.0252 0.1066
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0149 0.1165 0.1493
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0149 0.1165 0.167
Mycobacterium tuberculosis Proteasome alpha subunit PrcA; assembles with beta subunit PrcB. 0.091 1 1
Onchocerca volvulus 0.012 0.0835 0.4053
Loa Loa (eye worm) nuclear receptor nhr-7B 0.007 0.0252 0.0365
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0069 0.024 0.5
Echinococcus multilocularis lipoxygenase domain containing protein 0.012 0.0835 0.1071
Loa Loa (eye worm) hypothetical protein 0.007 0.0252 0.0365
Loa Loa (eye worm) hypothetical protein 0.012 0.0835 0.1209
Brugia malayi Hypothetical tyrosinase-like protein C02C2.1 in chromosome III 0.0089 0.0469 0.0662
Loa Loa (eye worm) hypothetical protein 0.0089 0.0469 0.0679
Echinococcus granulosus lipoxygenase domain containing protein 0.012 0.0835 0.1071
Loa Loa (eye worm) hypothetical protein 0.007 0.0252 0.0365
Loa Loa (eye worm) hypothetical protein 0.0149 0.1165 0.1685
Loa Loa (eye worm) RNA binding protein 0.0066 0.0208 0.0301
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0149 0.1165 0.1685
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0149 0.1165 0.1685
Mycobacterium ulcerans putative regulatory protein 0.0076 0.0325 0.0198
Schistosoma mansoni rab6-interacting 0.012 0.0835 0.1071
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0264 0.2499 0.2401
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.006 0.0129 0.0166
Brugia malayi hypothetical protein 0.022 0.1996 0.2875
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0149 0.1165 0.167
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0079 0.035 0.0449
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0149 0.1165 0.1493
Schistosoma mansoni nuclear hormone receptor 0.007 0.0252 0.0323
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription factor 0.0281 0.2696 0.3457
Loa Loa (eye worm) nuclear receptor NHR-67 0.007 0.0252 0.0365
Brugia malayi steroid hormone receptor 0.0149 0.1165 0.167
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.007 0.0252 0.0347
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0079 0.035 0.0449
Echinococcus multilocularis tar DNA binding protein 0.0066 0.0208 0.0267
Echinococcus multilocularis geminin 0.0173 0.1447 0.1856
Loa Loa (eye worm) hypothetical protein 0.0089 0.0469 0.0679
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0149 0.1165 0.167
Echinococcus granulosus ecdysone induced protein 78C 0.0149 0.1165 0.1493
Trypanosoma cruzi cysteine peptidase, putative 0.0069 0.024 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0149 0.1165 0.1685
Mycobacterium ulcerans proteasome PrcA 0.091 1 1
Onchocerca volvulus 0.007 0.0252 0.1066
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0444 0.4593 0.5889
Echinococcus multilocularis Polycystic kidney disease protein 0.012 0.0835 0.1071
Brugia malayi hypothetical protein 0.012 0.0835 0.1192
Schistosoma mansoni hypothetical protein 0.0072 0.027 0.0347
Brugia malayi hypothetical protein 0.0346 0.3459 0.4996
Schistosoma mansoni tar DNA-binding protein 0.0066 0.0208 0.0267
Brugia malayi Nuclear hormone receptor E75 0.007 0.0252 0.0347
Loa Loa (eye worm) cytochrome P450 family protein 0.0151 0.1195 0.1729
Brugia malayi hypothetical protein 0.0079 0.035 0.0489
Brugia malayi hypothetical protein 0.0079 0.035 0.0489
Brugia malayi ecdysteroid receptor 0.0149 0.1165 0.167
Schistosoma mansoni hypothetical protein 0.0173 0.1447 0.1856
Schistosoma mansoni nuclear hormone receptor 0.007 0.0252 0.0323
Echinococcus granulosus single minded 2 0.0076 0.0325 0.0416
Brugia malayi nuclear hormone receptor family member nhr-6 0.007 0.0252 0.0347
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0149 0.1165 0.1493
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.006 0.0129 0.0166
Loa Loa (eye worm) hypothetical protein 0.0079 0.035 0.0506
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0149 0.1165 0.1685
Echinococcus multilocularis ecdysone induced protein 78C 0.0149 0.1165 0.1493
Loa Loa (eye worm) TAR-binding protein 0.0066 0.0208 0.0301
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.005 0.0013 0.0017
Echinococcus granulosus thyroid hormone receptor alpha 0.007 0.0252 0.0323
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.006 0.0129 0.0169
Echinococcus granulosus nuclear factor of activated T cells 5 0.0246 0.2295 0.2942
Schistosoma mansoni hypothetical protein 0.012 0.0835 0.1071
Loa Loa (eye worm) hypothetical protein 0.0149 0.1165 0.1685
Brugia malayi Nuclear hormone receptor E75 0.007 0.0252 0.0347

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 0.51 uM Binding affinity for Group II Metabotropic glutamate receptor was measured using [3H]-glutamate in rat forebrain membranes ChEMBL. 9464367

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

No external resources registered for this compound

Bibliographic References

1 literature reference was collected for this gene.

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