TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 542.301 | Formula: C31H38N6O3
H donors: 0 H acceptors: 4 LogP: 5.1 Rotable bonds: 9
Rule of 5 violations (Lipinski): 2
SMILES: COc1ccc(cc1OCCCCn1cnc2c1cncn2)C1=NN(C2CCCCCC2)C(=O)[C@H]2[C@@H]1CC=CC2
InChi: InChI=1S/C31H38N6O3/c1-39-27-15-14-22(18-28(27)40-17-9-8-16-36-21-34-30-26(36)19-32-20-33-30)29-24-12-6-7-13-25(24)31(38)37(35-29)23-10-4-2-3-5-11-23/h6-7,14-15,18-21,23-25H,2-5,8-13,16-17H2,1H3/t24-,25+/m0/s1
InChiKey: FZHQFKLHOFLUQF-LOSJGSFVSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	phosphodiesterase 4B, cAMP-specific		References
Trypanosoma brucei gambiense	cAMP-specific phosphodiesterase, putative		References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Trichomonas vaginalis	cyclic nucleotide phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Schistosoma mansoni	camp/cgmp cyclic nucleotide phosphodiesterase	Get druggable targets OG5_127318	All targets in OG5_127318
Echinococcus multilocularis	cAMP specific 3',5' cyclic phosphodiesterase	Get druggable targets OG5_128242	All targets in OG5_128242
Trichomonas vaginalis	cyclic nucleotide phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Schistosoma japonicum	cAMP-specific 3',5'-cyclic phosphodiesterase 4D, putative	Get druggable targets OG5_128242	All targets in OG5_128242
Brugia malayi	Probable 3',5'-cyclic phosphodiesterase R153.1, putative	Get druggable targets OG5_128242	All targets in OG5_128242
Trichomonas vaginalis	cGMP-specific 3,5-cyclic phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Echinococcus multilocularis	cAMP specific 3',5' cyclic phosphodiesterase	Get druggable targets OG5_128242	All targets in OG5_128242
Trichomonas vaginalis	conserved hypothetical protein	Get druggable targets OG5_127318	All targets in OG5_127318
Schistosoma japonicum	cAMP-specific 3',5'-cyclic phosphodiesterase, isoform F, putative	Get druggable targets OG5_128242	All targets in OG5_128242
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Leishmania mexicana	cAMP specific phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Echinococcus granulosus	cAMP specific 3'5' cyclic phosphodiesterase	Get druggable targets OG5_128242	All targets in OG5_128242
Candida albicans	similar to S. cerevisiae PDE2 (YOR360C) cAMP phosphodiesterase	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	cGMP-dependent 3,5-cyclic phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	conserved hypothetical protein	Get druggable targets OG5_127318	All targets in OG5_127318
Echinococcus multilocularis	cAMP specific 3',5' cyclic phosphodiesterase	Get druggable targets OG5_128242	All targets in OG5_128242
Schistosoma mansoni	camp-specific 35-cyclic phosphodiesterase	Get druggable targets OG5_128242	All targets in OG5_128242
Trichomonas vaginalis	rod cGMP-specific 3,5-cyclic phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Cryptosporidium parvum	membrane associated HD superfamily cyclic nucleotide phosphodiesterase domain containing protein	Get druggable targets OG5_128242	All targets in OG5_128242
Trypanosoma brucei	cAMP-specific phosphodiesterase	Get druggable targets OG5_127318	All targets in OG5_127318
Schistosoma japonicum	expressed protein	Get druggable targets OG5_127318	All targets in OG5_127318
Echinococcus multilocularis	dual 3',5' cyclic AMP and GMP phosphodiesterase	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	cAMP/cGMP cyclic nucleotide phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Leishmania mexicana	cAMP specific phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Echinococcus granulosus	cAMP specific 3'5' cyclic phosphodiesterase	Get druggable targets OG5_128242	All targets in OG5_128242
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	Get druggable targets OG5_128242	All targets in OG5_128242
Schistosoma japonicum	Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	cGMP-specific 3,5-cyclic phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trypanosoma congolense	cAMP-specific phosphodiesterase	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Echinococcus granulosus	dual 3'5' cyclic AMP and GMP phosphodiesterase	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	cone cGMP-specific 3,5-cyclic phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	conserved hypothetical protein	Get druggable targets OG5_127318	All targets in OG5_127318
Candida albicans	similar to S. cerevisiae PDE2 (YOR360C) cAMP phosphodiesterase	Get druggable targets OG5_127318	All targets in OG5_127318
Trypanosoma brucei	cAMP-specific phosphodiesterase	Get druggable targets OG5_127318	All targets in OG5_127318
Giardia lamblia	CAMP-specific 3,5-cyclic phosphodiesterase 4B	Get druggable targets OG5_128242	All targets in OG5_128242
Trichomonas vaginalis	cone cGMP-specific 3,5-cyclic phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trypanosoma cruzi	cAMP specific phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	rod cGMP-specific 3,5-cyclic phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	cAMP-specific phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trypanosoma cruzi	cAMP specific phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Neospora caninum	cAMP-specific phosphodiesterase, putative	Get druggable targets OG5_128242	All targets in OG5_128242
Trichomonas vaginalis	cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trypanosoma brucei gambiense	cAMP-specific phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Leishmania braziliensis	cAMP specific phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	cAMP-specific phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Leishmania braziliensis	cAMP specific phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trypanosoma brucei gambiense	cAMP-specific phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	cGMP-specific 3,5-cyclic phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Leishmania infantum	cAMP specific phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Cryptosporidium hominis	hypothetical protein	Get druggable targets OG5_128242	All targets in OG5_128242
Loa Loa (eye worm)	cyclic AMP specific phosphodiesterase PDE4D5A	Get druggable targets OG5_128242	All targets in OG5_128242
Schistosoma japonicum	IPR002073,3'5'-cyclic nucleotide phosphodiesterase,domain-containing	Get druggable targets OG5_128242	All targets in OG5_128242
Echinococcus granulosus	cAMP specific 3'5' cyclic phosphodiesterase	Get druggable targets OG5_128242	All targets in OG5_128242
Leishmania infantum	cAMP specific phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	cGMP-inhibited 3,5-cyclic phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trypanosoma congolense	cAMP-specific phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Schistosoma japonicum	Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	conserved hypothetical protein	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trypanosoma cruzi	cAMP specific phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	cGMP-dependent 3,5-cyclic phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Schistosoma japonicum	cAMP-specific 3',5'-cyclic phosphodiesterase 4D, putative	Get druggable targets OG5_128242	All targets in OG5_128242
Trichomonas vaginalis	cAMP-specific 3,5-cyclic phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	cAMP-specific 3,5-cyclic phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Toxoplasma gondii	hypothetical protein	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	rod cGMP-specific 3,5-cyclic phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	cyclic nucleotide phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_128242	All targets in OG5_128242
Leishmania donovani	cAMP specific phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trypanosoma cruzi	cAMP specific phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	cAMP-specific phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Schistosoma japonicum	Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Schistosoma japonicum	cAMP-specific 3',5'-cyclic phosphodiesterase 4C, putative	Get druggable targets OG5_128242	All targets in OG5_128242

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Brugia malayi	3'5'-cyclic nucleotide phosphodiesterase family protein	0.0073	0.1108	0.1095
Loa Loa (eye worm)	hypothetical protein	0.0073	0.1108	0.1108
Schistosoma mansoni	camp-specific cyclic nucleotide phosphodiesterase	0.005	0.067	0.152
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0175	0.0175
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.005	0.067	0.1253
Trypanosoma brucei	glucose transporter, putative	0.0032	0.0345	0.1775
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0053	0.0735	0.0721
Trypanosoma cruzi	hypothetical protein, conserved	0.005	0.067	0.3522
Trichomonas vaginalis	rod cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0114	0.1876	1
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0278	0.0278
Plasmodium falciparum	calcium-dependent protein kinase 4	0.0032	0.0338	0.0404
Trypanosoma cruzi	prolyl-tRNA synthetase, putative	0.0037	0.0422	0.2189
Brugia malayi	Probable 3',5'-cyclic phosphodiesterase C32E12.2, putative	0.0073	0.1108	0.1095
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.005	0.067	0.1253
Entamoeba histolytica	protein kinase, putative	0.0032	0.0337	1
Trichomonas vaginalis	conserved hypothetical protein	0.0065	0.0946	0.5006
Loa Loa (eye worm)	major facilitator superfamily transporter	0.0015	0.0014	0.0014
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0268	0.0268
Trichomonas vaginalis	cAMP-specific 3,5-cyclic phosphodiesterase, putative	0.0114	0.1876	1
Trypanosoma brucei	glucose transporter, putative	0.0032	0.0345	0.1775
Brugia malayi	Isocitrate dehydrogenase	0.0017	0.0056	0.0041
Trypanosoma brucei	glucose transporter 2A	0.0032	0.0345	0.1775
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type	0.0032	0.0337	0.0779
Schistosoma mansoni	camp-specific 35-cyclic phosphodiesterase	0.005	0.067	0.152
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0017	0.0055	0.0127
Schistosoma mansoni	hypothetical protein	0.0017	0.0055	0.0094
Echinococcus granulosus	solute carrier family 22	0.0015	0.0014	0.0033
Leishmania major	hypothetical protein, conserved	0.005	0.067	0.3522
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	0.0114	0.1876	1
Toxoplasma gondii	hypothetical protein	0.0023	0.0178	0.0313
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0114	0.1876	1
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.005	0.067	0.1253
Trichomonas vaginalis	CAMK family protein kinase	0.0032	0.0337	0.1734
Echinococcus granulosus	lysyl tRNA synthetase	0.0023	0.0175	0.0405
Trypanosoma brucei	3', 5'-cyclic nucleotide phosphodiesterase, putative	0.005	0.067	0.3522
Loa Loa (eye worm)	hypothetical protein	0.0036	0.042	0.042
Trichomonas vaginalis	conserved hypothetical protein	0.0104	0.1689	0.8998
Echinococcus multilocularis	Sugar transporter ERD6 protein	0.0015	0.0014	0.0033
Echinococcus multilocularis	solute carrier family 2 facilitated glucose	0.0104	0.1689	0.3902
Plasmodium falciparum	3',5'-cyclic nucleotide phosphodiesterase, putative	0.005	0.067	0.082
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0032	0.0337	0.0779
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.005	0.067	0.1253
Plasmodium vivax	calcium-dependent protein kinase 1, putative	0.0032	0.0338	0.0404
Mycobacterium leprae	conserved hypothetical protein	0.0023	0.0178	0.3186
Trichomonas vaginalis	calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase, putative	0.005	0.067	0.3522
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0073	0.1108	0.5875
Trichomonas vaginalis	cGMP-dependent 3,5-cyclic phosphodiesterase, putative	0.0114	0.1876	1
Trichomonas vaginalis	cyclic nucleotide phosphodiesterase, putative	0.0114	0.1876	1
Trichomonas vaginalis	sugar transporter, putative	0.0032	0.0345	0.1775
Loa Loa (eye worm)	hypothetical protein	0.0246	0.4329	0.4329
Plasmodium falciparum	calcium-dependent protein kinase 1	0.0032	0.0338	0.0404
Trypanosoma brucei	THT1 - hexose transporter, putative	0.0032	0.0345	0.1775
Trichomonas vaginalis	lysyl-tRNA synthetase, putative	0.0023	0.0175	0.0865
Loa Loa (eye worm)	hypothetical protein	0.055	1	1
Trichomonas vaginalis	cGMP-inhibited 3,5-cyclic phosphodiesterase, putative	0.005	0.067	0.3522
Brugia malayi	Cam kinase protein 1	0.0032	0.0337	0.0323
Trichomonas vaginalis	conserved hypothetical protein	0.0032	0.0345	0.1775
Trichomonas vaginalis	cGMP-inhibited 3,5-cyclic phosphodiesterase, putative	0.0114	0.1876	1
Loa Loa (eye worm)	major facilitator superfamily transporter	0.0015	0.0014	0.0014
Echinococcus granulosus	calcium:calmodulin dependent 3'5' cyclic	0.005	0.067	0.1548
Leishmania major	cAMP phosphodiesterase A, putative;with=GeneDB:LinJ18_V3.1100	0.005	0.067	0.3522
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0246	0.4329	0.8246
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0014	0.0014
Schistosoma mansoni	hypothetical protein	0.0017	0.0055	0.0094
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type	0.0032	0.0337	0.0779
Schistosoma mansoni	lamin	0.0029	0.0278	0.0612
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0337	0.0337
Giardia lamblia	Prolyl-tRNA synthetase	0.0031	0.0325	0.072
Trypanosoma brucei	calcium/calmodulin-dependent protein kinase, putative	0.0032	0.0337	0.1734
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0055	0.0055
Plasmodium vivax	calcium-dependent protein kinase, putative	0.0032	0.0338	0.0404
Toxoplasma gondii	protein kinase, putative	0.0295	0.5247	1
Brugia malayi	cytoplasmic intermediate filament protein	0.0015	0.0029	0.0014
Echinococcus multilocularis	high affinity cAMP specific 3',5' cyclic	0.005	0.067	0.1548
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0014	0.0014
Echinococcus multilocularis	isocitrate dehydrogenase 2 (NADP+)	0.0017	0.0056	0.0128
Trypanosoma brucei	glucose transporter, putative	0.0032	0.0345	0.1775
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0014	0.0014
Leishmania major	glucose transporter, lmgt1	0.0032	0.0345	0.1775
Trichomonas vaginalis	glucose transporter, putative	0.0032	0.0345	0.1775
Trichomonas vaginalis	conserved hypothetical protein	0.005	0.067	0.3522
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.005	0.067	0.1253
Trichomonas vaginalis	conserved hypothetical protein	0.0023	0.0178	0.0881
Mycobacterium tuberculosis	Two component sensor histidine kinase DosT	0.0023	0.0178	1
Echinococcus granulosus	cAMP specific 3'5' cyclic phosphodiesterase	0.0196	0.3399	0.7852
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.005	0.067	0.1253
Trichomonas vaginalis	lysyl-tRNA synthetase, putative	0.002	0.0122	0.0577
Leishmania major	protein kinase, putative	0.0032	0.0337	0.1734
Mycobacterium ulcerans	putative regulatory protein	0.0023	0.0178	1
Trichomonas vaginalis	cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative	0.0091	0.1438	0.7647
Toxoplasma gondii	GAF domain-containing protein	0.0023	0.0178	0.0313
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.005	0.067	0.1253
Schistosoma mansoni	protein kinase	0.0032	0.0337	0.0748
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	0.0114	0.1876	1
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0014	0.0014
Echinococcus multilocularis	General substrate transporter	0.009	0.1415	0.3269
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0017	0.0055	0.0055
Echinococcus granulosus	intermediate filament protein	0.0029	0.0278	0.0643
Trichomonas vaginalis	conserved hypothetical protein	0.0065	0.0946	0.5006
Trypanosoma brucei	glucose transporter 1E	0.0032	0.0345	0.1775
Trichomonas vaginalis	cone cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0114	0.1876	1
Echinococcus granulosus	dual 3'5' cyclic AMP and GMP phosphodiesterase	0.0114	0.1876	0.4334
Schistosoma mansoni	cgmp-dependent 35-cyclic phosphodiesterase	0.0073	0.1108	0.2535
Plasmodium falciparum	protein kinase 6	0.0443	0.8012	1
Plasmodium vivax	isocitrate dehydrogenase [NADP], mitochondrial, putative	0.0017	0.0056	0.0051
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.005	0.067	0.1253
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0104	0.1689	0.3902
Echinococcus granulosus	Sugar transporter ERD6 protein	0.0015	0.0014	0.0033
Brugia malayi	bifunctional aminoacyl-tRNA synthetase	0.0031	0.0325	0.0311
Trypanosoma cruzi	cyclic nucleotide phosphodiesterase	0.005	0.067	0.3522
Trichomonas vaginalis	cAMP-specific phosphodiesterase, putative	0.0091	0.1438	0.7647
Brugia malayi	Calcium/calmodulin-dependent protein kinase type II alpha chain	0.0032	0.0337	0.0323
Echinococcus multilocularis	isocitrate dehydrogenase	0.0017	0.0056	0.0128
Echinococcus multilocularis	musashi	0.0029	0.0278	0.0643
Schistosoma mansoni	lamin	0.0029	0.0278	0.0612
Echinococcus multilocularis	calcium:calmodulin dependent 3',5' cyclic	0.005	0.067	0.1548
Trypanosoma cruzi	isocitrate dehydrogenase, putative	0.0017	0.0056	0.0221
Loa Loa (eye worm)	cyclic AMP specific phosphodiesterase PDE4D5A	0.0196	0.3399	0.3399
Echinococcus multilocularis	lamin	0.0029	0.0278	0.0643
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0014	0.0014
Trypanosoma cruzi	cAMP specific phosphodiesterase, putative	0.0114	0.1876	1
Trypanosoma cruzi	hypothetical protein, conserved	0.005	0.067	0.3522
Toxoplasma gondii	hypothetical protein	0.0023	0.0178	0.0313
Schistosoma mansoni	glucose transport protein	0.0104	0.1689	0.3882
Trichomonas vaginalis	cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0114	0.1876	1
Schistosoma mansoni	hypothetical protein	0.0017	0.0055	0.0094
Schistosoma mansoni	calcium/calmodulin-dependent 35-cyclic nucleotide phosphodiesterase	0.005	0.067	0.152
Loa Loa (eye worm)	hypothetical protein	0.005	0.067	0.067
Wolbachia endosymbiont of Brugia malayi	major facilitator superfamily permease	0.0015	0.0014	0.5
Echinococcus granulosus	lamin	0.0029	0.0278	0.0643
Trypanosoma cruzi	cAMP specific phosphodiesterase, putative	0.0114	0.1876	1
Echinococcus granulosus	calcium dependent protein kinase	0.003	0.03	0.0694
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0014	0.0014
Toxoplasma gondii	hypothetical protein	0.0065	0.0946	0.1781
Echinococcus multilocularis	solute carrier family 22	0.0015	0.0014	0.0033
Trichomonas vaginalis	cyclic nucleotide phosphodiesterase, putative	0.005	0.067	0.3522
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.005	0.067	0.1253
Trypanosoma brucei	glucose transporter, putative	0.0032	0.0345	0.1775
Echinococcus granulosus	synaptic vesicle 2 protein	0.0015	0.0014	0.0033
Schistosoma mansoni	protein kinase	0.0032	0.0337	0.0748
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0014	0.0014
Leishmania major	lysyl-tRNA synthetase, putative	0.0023	0.0175	0.0865
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0014	0.0014
Trichomonas vaginalis	sugar transporter, putative	0.0032	0.0345	0.1775
Toxoplasma gondii	cell-cycle-associated protein kinase MAPK, putative	0.0169	0.289	0.5495
Loa Loa (eye worm)	sugar transporter	0.0015	0.0014	0.0014
Echinococcus multilocularis	solute carrier family 22	0.0015	0.0014	0.0033
Plasmodium falciparum	cGMP-specific phosphodiesterase	0.005	0.067	0.082
Plasmodium falciparum	calcium-dependent protein kinase 2	0.0032	0.0338	0.0404
Trichomonas vaginalis	cyclic nucleotide phosphodiesterase, putative	0.005	0.067	0.3522
Schistosoma mansoni	lysyl-tRNA synthetase	0.0023	0.0175	0.0373
Loa Loa (eye worm)	calcium/calmodulin-stimulated cyclic nucleotide phosphodiesterase	0.005	0.067	0.067
Trypanosoma cruzi	hypothetical protein, conserved	0.005	0.067	0.3522
Toxoplasma gondii	prolyl-tRNA synthetase (ProRS)	0.0037	0.0422	0.0779
Schistosoma mansoni	camp-specific 35-cyclic phosphodiesterase	0.0246	0.4329	1
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	0.0114	0.1876	1
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.005	0.067	0.1253
Echinococcus multilocularis	high affinity cgmp specific 3' 5' cyclic	0.005	0.067	0.1548
Trypanosoma cruzi	hexose transporter, putative	0.0018	0.0071	0.0303
Trypanosoma cruzi	prolyl-tRNA synthetase, putative	0.0037	0.0422	0.2189
Onchocerca volvulus		0.0029	0.0278	1
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0053	0.0735	0.0735
Trichomonas vaginalis	cAMP/cGMP cyclic nucleotide phosphodiesterase, putative	0.0114	0.1876	1
Plasmodium falciparum	protein kinase 7	0.0295	0.5247	0.6542
Giardia lamblia	Lysyl-tRNA synthetase	0.0023	0.0175	0.0373
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0104	0.1689	0.3902
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	0.0073	0.1108	0.5875
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0017	0.0055	0.0127
Plasmodium vivax	CDK-related protein kinase 6, putative	0.0443	0.8012	1
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0017	0.0055	0.0041
Schistosoma mansoni	hypothetical protein	0.0036	0.042	0.094
Plasmodium falciparum	phosphodiesterase delta, putative	0.005	0.067	0.082
Trypanosoma cruzi	hexose transporter, putative	0.0032	0.0345	0.1775
Trichomonas vaginalis	cyclic nucleotide phosphodiesterase, putative	0.0114	0.1876	1
Toxoplasma gondii	isocitrate dehydrogenase	0.0017	0.0056	0.0079
Echinococcus multilocularis	solute carrier family 2 facilitated glucose	0.0104	0.1689	0.3902
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	0.0029	0.0278	0.0278
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.005	0.067	0.3522
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0014	0.0014
Plasmodium falciparum	isocitrate dehydrogenase [NADP], mitochondrial	0.0017	0.0056	0.0051
Plasmodium falciparum	lysine--tRNA ligase	0.0023	0.0175	0.0201
Schistosoma mansoni	camp-specific 35-cyclic phosphodiesterase	0.005	0.067	0.152
Leishmania major	hypothetical protein, conserved	0.005	0.067	0.3522
Echinococcus multilocularis	synaptic vesicle 2 protein	0.0015	0.0014	0.0033
Plasmodium vivax	phosphodiesterase gamma, putative	0.005	0.067	0.082
Trypanosoma brucei	lysyl-tRNA synthetase, putative	0.0023	0.0175	0.0865
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0053	0.0735	0.0721
Brugia malayi	Probable 3',5'-cyclic phosphodiesterase R153.1, putative	0.005	0.067	0.0657
Plasmodium falciparum	cGMP-specific phosphodiesterase	0.005	0.067	0.082
Trypanosoma cruzi	cAMP phosphodiesterase A, putative	0.005	0.067	0.3522
Echinococcus granulosus	solute carrier family 22	0.0015	0.0014	0.0033
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	0.0017	0.0056	0.0128
Schistosoma mansoni	serine/threonine protein kinase	0.0032	0.0337	0.0748
Plasmodium vivax	3',5'-cyclic nucleotide phosphodiesterase, putative	0.005	0.067	0.082
Leishmania major	glucose transporter, lmgt2	0.0032	0.0345	0.1775
Plasmodium falciparum	GAF domain-related protein, putative	0.0023	0.0178	0.0205
Brugia malayi	lysyl-tRNA synthetase	0.0023	0.0175	0.0161
Trypanosoma cruzi	cAMP phosphodiesterase A, putative	0.005	0.067	0.3522
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.005	0.067	0.1253
Trypanosoma brucei	cAMP-specific phosphodiesterase	0.0114	0.1876	1
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0325	0.0325
Trypanosoma brucei	cAMP phosphodiesterase A, putative	0.005	0.067	0.3522
Mycobacterium tuberculosis	Lysyl-tRNA synthetase 2 LysX	0.002	0.011	0.5818
Echinococcus multilocularis	GPCR, family 2	0.0017	0.0055	0.0127
Schistosoma mansoni	glucose transport protein	0.0104	0.1689	0.3882
Brugia malayi	Bifunctional aminoacyl-tRNA synthetase	0.0031	0.0325	0.0311
Echinococcus multilocularis	calcium dependent protein kinase	0.003	0.03	0.0694
Plasmodium vivax	3',5'-cyclic nucleotide phosphodiesterase, putative	0.005	0.067	0.082
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0032	0.0337	0.0779
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0014	0.0014
Trypanosoma brucei	glucose transporter, putative	0.0032	0.0345	0.1775
Loa Loa (eye worm)	calcium/calmodulin-dependent protein kinase ID	0.0032	0.0337	0.0337
Trypanosoma brucei	3', 5'-cyclic nucleotide phosphodiesterase, putative	0.005	0.067	0.3522
Toxoplasma gondii	calcium-dependent protein kinase CDPK2B	0.0032	0.0338	0.0617
Trypanosoma brucei	cAMP-specific phosphodiesterase, putative	0.005	0.067	0.3522
Leishmania major	prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative	0.0037	0.0422	0.2189
Schistosoma mansoni	high-affinity cgmp-specific 35-cyclic phosphodiesterase	0.005	0.067	0.152
Toxoplasma gondii	lysine-tRNA ligase	0.0023	0.0175	0.0308
Mycobacterium ulcerans	two component sensor histidine kinase DevS	0.0023	0.0178	1
Echinococcus multilocularis	cAMP and cAMP inhibited cGMP 3',5' cyclic	0.0073	0.1108	0.256
Brugia malayi	Probable 3',5'-cyclic phosphodiesterase R153.1, putative	0.0196	0.3399	0.339
Echinococcus granulosus	General substrate transporter	0.009	0.1415	0.3269
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.005	0.067	0.1253
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type	0.0032	0.0337	0.0779
Plasmodium falciparum	calcium-dependent protein kinase 3	0.0032	0.0338	0.0404
Echinococcus granulosus	lamin dm0	0.0029	0.0278	0.0643
Trichomonas vaginalis	sugar transporter, putative	0.0032	0.0345	0.1775
Brugia malayi	latrophilin 2 splice variant baaae	0.0036	0.042	0.0406
Schistosoma mansoni	camp-specific 35-cyclic phosphodiesterase	0.005	0.067	0.152
Trypanosoma brucei	cAMP-specific phosphodiesterase	0.0114	0.1876	1
Leishmania major	glucose transporter, lmgt3	0.0032	0.0345	0.1775
Mycobacterium tuberculosis	Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP)	0.0017	0.0056	0.2508
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0032	0.0337	0.0779
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0104	0.1689	0.3902
Brugia malayi	Sugar transporter family protein	0.0104	0.1689	0.1677
Trichomonas vaginalis	conserved hypothetical protein	0.005	0.067	0.3522
Echinococcus granulosus	NADP dependent isocitrate dehydrogenase	0.0017	0.0056	0.0128
Mycobacterium tuberculosis	Two component sensor histidine kinase DevS	0.0023	0.0178	1
Plasmodium vivax	cyclic nucleotide phosphodiesterase, putative	0.005	0.067	0.082
Onchocerca volvulus		0.0029	0.0278	1
Leishmania major	cAMP-specific phosphodiesterase, putative	0.005	0.067	0.3522
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0014	0.0014
Chlamydia trachomatis	lysine--tRNA ligase	0.0023	0.0175	0.5
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0114	0.1876	1
Plasmodium vivax	calcium-dependent protein kinase 4, putative	0.0032	0.0338	0.0404
Entamoeba histolytica	prolyl-tRNA synthetase, putative	0.0031	0.0325	0.9253
Mycobacterium leprae	Possible lysyl-tRNA synthetase 2 LysX	0.0023	0.0175	0.3046
Trypanosoma brucei	THT1 - hexose transporter, putative	0.0032	0.0345	0.1775
Echinococcus multilocularis	lysyl tRNA synthetase	0.0023	0.0175	0.0405
Schistosoma mansoni	intermediate filament proteins	0.0029	0.0278	0.0612
Trypanosoma brucei	glucose transporter, putative	0.0032	0.0345	0.1775
Trichomonas vaginalis	cAMP-specific phosphodiesterase, putative	0.0114	0.1876	1
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.005	0.067	0.1253
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0325	0.0325
Mycobacterium leprae	Probable prolyl tRNA synthetase ProS	0.0031	0.0325	1
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	0.0114	0.1876	1
Brugia malayi	intermediate filament protein	0.0029	0.0278	0.0264
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.005	0.067	0.1253
Trypanosoma cruzi	cAMP-specific phosphodiesterase, putative	0.005	0.067	0.3522
Leishmania major	glucose transporter/membrane transporter D2, putative	0.0032	0.0345	0.1775
Toxoplasma gondii	calcium-dependent protein kinase CDPK2A	0.0032	0.0338	0.0617
Echinococcus granulosus	cAMP and cAMP inhibited cGMP 3'5' cyclic	0.0073	0.1108	0.256
Echinococcus multilocularis	calcium:calmodulin dependent 3',5' cyclic	0.005	0.067	0.1548
Trypanosoma cruzi	hypothetical protein, conserved	0.005	0.067	0.3522
Schistosoma mansoni	glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs)	0.0031	0.0325	0.072
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.005	0.067	0.1253
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.005	0.067	0.1253
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	0.0017	0.0056	0.0128
Plasmodium vivax	calcium-dependent protein kinase 3, putative	0.0032	0.0338	0.0404
Echinococcus multilocularis	dual 3',5' cyclic AMP and GMP phosphodiesterase	0.0114	0.1876	0.4334
Trichomonas vaginalis	cGMP-dependent 3,5-cyclic phosphodiesterase, putative	0.005	0.067	0.3522
Mycobacterium ulcerans	lysyl-tRNA synthetase	0.0023	0.0175	0.9816
Schistosoma mansoni	camp/cgmp cyclic nucleotide phosphodiesterase	0.0114	0.1876	0.4315
Leishmania major	prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative	0.0037	0.0422	0.2189
Trichomonas vaginalis	cGMP-dependent 3,5-cyclic phosphodiesterase, putative	0.0114	0.1876	1
Echinococcus granulosus	solute carrier family 22	0.0015	0.0014	0.0033
Trichomonas vaginalis	cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0114	0.1876	1
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	0.005	0.067	0.3522
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	0.0114	0.1876	1
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.005	0.067	0.1253
Mycobacterium tuberculosis	Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase)	0.002	0.011	0.5818
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0215	0.0215
Trypanosoma cruzi	cAMP specific phosphodiesterase, putative	0.0114	0.1876	1
Mycobacterium ulcerans	lysyl-tRNA synthetase	0.0023	0.0175	0.9816
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0178	0.0178
Plasmodium vivax	mitogen-activated protein kinase 2, putative	0.0169	0.289	0.3595
Trypanosoma brucei	isocitrate dehydrogenase, putative	0.0017	0.0056	0.0221
Plasmodium falciparum	calcium-dependent protein kinase 5	0.0032	0.0338	0.0404
Plasmodium falciparum	proline--tRNA ligase	0.0037	0.0422	0.051
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0014	0.0014
Toxoplasma gondii	isocitrate dehydrogenase	0.0017	0.0056	0.0079
Brugia malayi	Intermediate filament tail domain containing protein	0.0029	0.0278	0.0264
Loa Loa (eye worm)	cytoplasmic intermediate filament protein	0.0015	0.0029	0.0029
Echinococcus granulosus	high affinity cAMP specific 3'5' cyclic	0.005	0.067	0.1548
Giardia lamblia	Hypothetical protein	0.005	0.067	0.152
Loa Loa (eye worm)	intermediate filament protein	0.0029	0.0278	0.0278
Brugia malayi	3'5'-cyclic nucleotide phosphodiesterase family protein	0.005	0.067	0.0657
Trypanosoma cruzi	hexose transporter, putative	0.0032	0.0345	0.1775
Echinococcus multilocularis	glutamyl tRNA synthetase cytoplasmic	0.0031	0.0325	0.0751
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0017	0.0055	0.0127
Echinococcus granulosus	calcium:calmodulin dependent 3'5' cyclic	0.005	0.067	0.1548
Brugia malayi	isocitrate dehydrogenase	0.0017	0.0056	0.0041
Trichomonas vaginalis	cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0114	0.1876	1
Echinococcus multilocularis	cAMP specific 3',5' cyclic phosphodiesterase	0.0246	0.4329	1
Giardia lamblia	hypothetical protein	0.005	0.067	0.152
Echinococcus multilocularis	solute carrier family 22	0.0015	0.0014	0.0033
Loa Loa (eye worm)	hypothetical protein	0.0053	0.0735	0.0735
Trichomonas vaginalis	cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative	0.005	0.067	0.3522
Plasmodium vivax	hypothetical protein, conserved	0.0023	0.0178	0.0205
Trichomonas vaginalis	cyclic nucleotide phosphodiesterase, putative	0.0114	0.1876	1
Plasmodium vivax	hexose transporter	0.0104	0.1689	0.2094
Schistosoma mansoni	high-affinity cgmp-specific 35-cyclic phosphodiesterase	0.005	0.067	0.152
Trypanosoma cruzi	cAMP specific phosphodiesterase, putative	0.0091	0.1438	0.7647
Schistosoma mansoni	high-affinity cgmp-specific 35-cyclic phosphodiesterase	0.005	0.067	0.152
Trypanosoma brucei	bifunctional aminoacyl-tRNA synthetase, putative	0.0037	0.0422	0.2189
Trypanosoma brucei	glucose transporter, putative	0.0032	0.0345	0.1775
Plasmodium falciparum	phosphodiesterase gamma, putative	0.005	0.067	0.082
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0014	0.0014
Trypanosoma brucei	glucose transporter, putative	0.0032	0.0345	0.1775
Trypanosoma cruzi	isocitrate dehydrogenase [NADP], mitochondrial precursor, putative	0.0017	0.0056	0.0221
Trichomonas vaginalis	conserved hypothetical protein	0.0114	0.1876	1
Mycobacterium ulcerans	putative regulatory protein	0.0023	0.0178	1
Schistosoma mansoni	NADP-specific isocitrate dehydrogenase	0.0017	0.0056	0.0095
Trichomonas vaginalis	conserved hypothetical protein	0.0065	0.0946	0.5006
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0014	0.0014
Trichomonas vaginalis	cGMP-dependent 3,5-cyclic phosphodiesterase, putative	0.0073	0.1108	0.5875
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0014	0.0014
Trichomonas vaginalis	rod cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0114	0.1876	1
Plasmodium falciparum	hexose transporter	0.0104	0.1689	0.2094
Trypanosoma brucei	isocitrate dehydrogenase [NADP], mitochondrial precursor, putative	0.0017	0.0056	0.0221
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.005	0.067	0.3522
Echinococcus granulosus	cAMP specific 3'5' cyclic phosphodiesterase	0.0246	0.4329	1
Schistosoma mansoni	hypothetical protein	0.0104	0.1689	0.3882
Brugia malayi	Latrophilin receptor protein 2	0.0017	0.0055	0.0041
Trichomonas vaginalis	glucose transporter, putative	0.0032	0.0345	0.1775
Echinococcus multilocularis	lamin dm0	0.0029	0.0278	0.0643
Toxoplasma gondii	calcium-dependent protein kinase CDPK3	0.0032	0.0338	0.0617
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0114	0.1876	1
Echinococcus multilocularis	solute carrier family 22	0.0015	0.0014	0.0033
Trypanosoma cruzi	hypothetical protein, conserved	0.005	0.067	0.3522
Plasmodium vivax	proline--tRNA ligase, putative	0.0037	0.0422	0.051
Schistosoma mansoni	glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs)	0.0031	0.0325	0.072
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	0.0017	0.0056	0.0128
Trichomonas vaginalis	rod cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0114	0.1876	1
Trichomonas vaginalis	prolyl-tRNA synthetase, putative	0.0031	0.0325	0.1669
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0032	0.0337	0.0779
Schistosoma mansoni	lysyl-tRNA synthetase	0.0023	0.0175	0.0373
Giardia lamblia	CAMP-specific 3,5-cyclic phosphodiesterase 4B	0.0246	0.4329	1
Plasmodium falciparum	mitogen-activated protein kinase 2	0.0169	0.289	0.3595
Trichomonas vaginalis	cone cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0114	0.1876	1
Trypanosoma cruzi	lysyl-tRNA synthetase, putative	0.0023	0.0175	0.0865
Toxoplasma gondii	facilitative glucose transporter GT1	0.0104	0.1689	0.3201
Loa Loa (eye worm)	isocitrate dehydrogenase	0.0017	0.0056	0.0056
Leishmania major	isocitrate dehydrogenase [NADP], mitochondrial precursor, putative	0.0017	0.0056	0.0221
Echinococcus granulosus	glutamyl tRNA synthetase cytoplasmic	0.0031	0.0325	0.0751
Trichomonas vaginalis	cAMP-specific 3,5-cyclic phosphodiesterase, putative	0.0114	0.1876	1
Schistosoma mansoni	hypothetical protein	0.0017	0.0055	0.0094
Trichomonas vaginalis	cAMP-specific phosphodiesterase, putative	0.0114	0.1876	1
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0114	0.1876	1
Echinococcus multilocularis	cAMP specific 3',5' cyclic phosphodiesterase	0.0246	0.4329	1
Loa Loa (eye worm)	hypothetical protein	0.05	0.907	0.907
Trichomonas vaginalis	conserved hypothetical protein	0.0032	0.0345	0.1775
Echinococcus granulosus	GPCR family 2	0.0017	0.0055	0.0127
Loa Loa (eye worm)	CAMK/CAMK2 protein kinase	0.0032	0.0337	0.0337
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0017	0.0055	0.0127
Echinococcus granulosus	cAMP specific 3'5' cyclic phosphodiesterase	0.0246	0.4329	1
Echinococcus multilocularis	solute carrier family 2, facilitated glucose	0.0104	0.1689	0.3902
Loa Loa (eye worm)	sugar transporter	0.0104	0.1689	0.1689
Plasmodium falciparum	3',5'-cyclic nucleotide phosphodiesterase, putative	0.005	0.067	0.082
Schistosoma mansoni	protein kinase	0.0032	0.0337	0.0748
Trypanosoma brucei	THT1 - hexose transporter, putative	0.0032	0.0345	0.1775
Brugia malayi	Probable 3',5'-cyclic phosphodiesterase T04D3.3, putative	0.005	0.067	0.0657
Trypanosoma cruzi	hexose transporter	0.0032	0.0345	0.1775
Trypanosoma brucei	hypothetical protein, conserved	0.005	0.067	0.3522
Plasmodium vivax	lysine--tRNA ligase, putative	0.0023	0.0175	0.0201
Echinococcus multilocularis	solute carrier family 2 facilitated glucose	0.0104	0.1689	0.3902
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0104	0.1689	0.3902
Trypanosoma cruzi	hexose transporter, putative	0.0032	0.0345	0.1775
Entamoeba histolytica	protein kinase, putative	0.0032	0.0337	1
Trypanosoma cruzi	hypothetical protein, conserved	0.005	0.067	0.3522
Loa Loa (eye worm)	PDE1B protein	0.005	0.067	0.067
Echinococcus multilocularis	cAMP specific 3',5' cyclic phosphodiesterase	0.0196	0.3399	0.7852
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.005	0.067	0.3522
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type 1	0.0032	0.0337	0.0779
Echinococcus granulosus	high affinity cgmp specific 3' 5' cyclic	0.005	0.067	0.1548
Echinococcus granulosus	solute carrier family 22	0.0015	0.0014	0.0033
Schistosoma mansoni	glucose transport protein	0.0104	0.1689	0.3882

Activities

Activity type	Activity value	Assay description	Source	Reference
EC50 (functional)	= 6.7	Antitrypanosomal activity against suramin-sensitive Trypanosoma brucei brucei Squib427 assessed as inhibition of parasite growth	ChEMBL.	26935942
IC50 (binding)	= 7.8	Inhibition of recombinant Trypanosoma brucei PDEB1 using [3H]-cAMP as substrate after 15 mins by scintillation proximity assay	ChEMBL.	26935942
IC50 (binding)	= 8.8	Inhibition of full length human recombinant PDE4B1 using [3H]-cAMP as substrate by scintillation proximity assay	ChEMBL.	26935942

Phenotypes

Whole-cell/tissue/organism interactions

Species name	Source	Reference	Is orphan
Trypanosoma brucei gambiense		26935942

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL3764370

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 2168172