Detailed information for compound 21747

Basic information

Technical information
  • TDR Targets ID: 21747
  • Name: N-(1-adamantyl)-4,6-dimethylpyridin-2-amine
  • MW: 256.386 | Formula: C17H24N2
  • H donors: 1 H acceptors: 1 LogP: 4.61 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: Cc1cc(nc(c1)C)NC12CC3CC(C2)CC(C1)C3
  • InChi: 1S/C17H24N2/c1-11-3-12(2)18-16(4-11)19-17-8-13-5-14(9-17)7-15(6-13)10-17/h3-4,13-15H,5-10H2,1-2H3,(H,18,19)
  • InChiKey: MQKSYCZTUUVJGS-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-(1-adamantyl)-4,6-dimethyl-pyridin-2-amine
  • N-(1-adamantyl)-4,6-dimethyl-2-pyridinamine
  • 1-adamantyl-(4,6-dimethyl-2-pyridyl)amine

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0034 0.0133 0.0117
Mycobacterium tuberculosis Ribonucleoside-diphosphate reductase (beta chain) NrdB (ribonucleotide reductase small chain) 0.0135 0.1369 0.2838
Leishmania major metacaspase, putative 0.0174 0.1849 0.3352
Mycobacterium ulcerans transcriptional regulator NrdR 0.0031 0.0106 0.0157
Trichomonas vaginalis DEAD box ATP-dependent RNA helicase, putative 0.0097 0.0905 0.1746
Schistosoma mansoni hypothetical protein 0.0026 0.0035 0.0018
Trypanosoma brucei ubiquitin-conjugating enzyme E2, putative 0.0051 0.0342 0.0136
Plasmodium falciparum ribonucleoside-diphosphate reductase small chain, putative 0.0046 0.0279 0.0303
Echinococcus multilocularis ribonucleoside diphosphate reductase subunit 0.0135 0.1369 0.2746
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0047 0.0291 0.0275
Schistosoma mansoni ATP-binding cassette transporter 0.0036 0.0156 0.0139
Echinococcus granulosus integrin beta 2 0.0224 0.2465 0.4972
Plasmodium vivax ribonucleoside-diphosphate reductase small chain, putative 0.0135 0.1369 0.257
Trichomonas vaginalis conserved hypothetical protein 0.0174 0.1849 0.3881
Brugia malayi Kelch motif family protein 0.0046 0.0283 0.0507
Brugia malayi Guanylate kinase family protein 0.0027 0.0047 0.0025
Trichomonas vaginalis conserved hypothetical protein 0.0174 0.1849 0.3881
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0174 0.1849 0.3569
Trypanosoma brucei metacaspase MCA3 0.0174 0.1849 0.3368
Echinococcus multilocularis glutamate receptor 2 0.0036 0.0156 0.0282
Schistosoma mansoni glutamate receptor NMDA 0.0036 0.0156 0.0139
Echinococcus granulosus glutamate receptor ionotrophic AMPA 3 0.0036 0.0156 0.0282
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0167 0.1761 0.3543
Brugia malayi Eukaryotic aspartyl protease family protein 0.0034 0.0133 0.0201
Schistosoma mansoni adam (A disintegrin and metalloprotease 0.0057 0.0424 0.0408
Echinococcus granulosus kelch ECH associated protein 1 like 0.0094 0.0875 0.1744
Loa Loa (eye worm) hypothetical protein 0.0034 0.0133 0.027
Loa Loa (eye worm) ribonucleotide reductase M2 B 0.0135 0.1369 0.277
Loa Loa (eye worm) hypothetical protein 0.0026 0.0035 0.007
Treponema pallidum ribonucleotide-diphosphate reductase subunit beta 0.0135 0.1369 0.1148
Trypanosoma cruzi ubiquitin-conjugating enzyme E2, putative 0.0051 0.0342 0.0111
Schistosoma mansoni hypothetical protein 0.0095 0.0879 0.0863
Loa Loa (eye worm) hypothetical protein 0.0044 0.0258 0.0522
Trypanosoma cruzi metacaspase 5, putative 0.0174 0.1849 0.3352
Trypanosoma cruzi ubiquitin-conjugating enzyme E2, putative 0.0051 0.0342 0.0111
Echinococcus granulosus adam 0.0067 0.0543 0.107
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0026 0.0035 0.0018
Trypanosoma brucei ribonucleoside-diphosphate reductase small chain 0.0135 0.1369 0.2337
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.02 0.2172 0.4357
Plasmodium vivax RNA helicase-1, putative 0.0097 0.0905 0.1606
Echinococcus multilocularis enteropeptidase 0.0026 0.0035 0.0037
Echinococcus granulosus eukaryotic initiation factor 4A III 0.0097 0.0905 0.1805
Echinococcus granulosus ribonucleoside diphosphate reductase large 0.0426 0.4941 1
Toxoplasma gondii ubiquitin-conjugating enzyme subfamily protein 0.0051 0.0342 0.0435
Brugia malayi hypothetical protein 0.0034 0.0133 0.0201
Leishmania major ribonucleoside-diphosphate reductase small chain, putative 0.0135 0.1369 0.2318
Mycobacterium ulcerans ribonucleotide-diphosphate reductase subunit beta 0.0046 0.0279 0.0541
Trypanosoma brucei cysteine peptidase C (CPC) 0.0047 0.0291 0.0025
Plasmodium falciparum subtilisin-like protease 1 0.0175 0.1868 0.3608
Loa Loa (eye worm) reprolysin 0.0044 0.0258 0.0522
Brugia malayi hypothetical protein 0.0046 0.0283 0.0507
Trichomonas vaginalis DEAD box ATP-dependent RNA helicase, putative 0.0097 0.0905 0.1746
Chlamydia trachomatis ribonucleoside-diphosphate reductase subunit alpha 0.0426 0.4941 1
Toxoplasma gondii ribonucleoside-diphosphate reductase small subunit 0.0135 0.1369 0.257
Echinococcus granulosus Peptidase S1 S6 chymotrypsin Hap 0.0026 0.0035 0.0037
Trichomonas vaginalis conserved hypothetical protein 0.0174 0.1849 0.3881
Brugia malayi Reprolysin 0.0026 0.0035 0.0001
Loa Loa (eye worm) glutamate receptor 2 0.0036 0.0156 0.0315
Brugia malayi hypothetical protein 0.0046 0.0287 0.0515
Plasmodium falciparum ribonucleoside-diphosphate reductase large subunit, putative 0.0426 0.4941 1
Loa Loa (eye worm) integrin beta-2 0.0303 0.3425 0.6932
Chlamydia trachomatis ribonucleoside-diphosphate reductase subunit beta 0.0135 0.1369 0.2612
Schistosoma mansoni caspase-7 (C14 family) 0.041 0.474 0.4731
Brugia malayi ribonucleotide reductase 2 0.0135 0.1369 0.2719
Plasmodium falciparum ribonucleoside-diphosphate reductase small chain, putative 0.0135 0.1369 0.257
Echinococcus granulosus caspase 2 0.022 0.2416 0.4873
Loa Loa (eye worm) hypothetical protein 0.0046 0.0287 0.0581
Brugia malayi Glutamate receptor 1 precursor 0.0036 0.0156 0.0247
Echinococcus multilocularis apoptotic protease activating factor 1 0.0046 0.0287 0.055
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0174 0.1849 0.3569
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0026 0.0035 0.0018
Loa Loa (eye worm) hypothetical protein 0.0033 0.012 0.0242
Echinococcus granulosus enteropeptidase 0.0026 0.0035 0.0037
Trypanosoma brucei ribonucleoside-diphosphate reductase small chain 0.0135 0.1369 0.2337
Schistosoma mansoni subfamily M12B unassigned peptidase (M12 family) 0.0044 0.0258 0.0242
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.0141 0.1449 0.1435
Schistosoma mansoni cercarial elastase (S01 family) 0.0026 0.0035 0.0018
Plasmodium vivax metacaspase 1, putative 0.0174 0.1849 0.3569
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0141 0.1449 0.1435
Loa Loa (eye worm) cathepsin B 0.0047 0.0291 0.0589
Echinococcus granulosus subfamily M12B unassigned peptidase 0.0044 0.0258 0.049
Trypanosoma cruzi metacaspase 5, putative 0.0174 0.1849 0.3352
Leishmania major ribonucleoside-diphosphate reductase small chain, putative 0.0135 0.1369 0.2318
Echinococcus granulosus Mastin 0.0026 0.0035 0.0037
Echinococcus granulosus transmembrane protease serine 3 0.0026 0.0035 0.0037
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0034 0.0133 0.0117
Loa Loa (eye worm) hypothetical protein 0.0026 0.0035 0.007
Trypanosoma cruzi Eukaryotic initiation factor 4A-1 0.0097 0.0905 0.1321
Echinococcus multilocularis ubiquitin conjugating enzyme e2 i 0.0051 0.0342 0.0661
Toxoplasma gondii eukaryotic initiation factor-4A, putative 0.0097 0.0905 0.1606
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0047 0.0291 0.0356
Schistosoma mansoni glutamate receptor NMDA 0.0036 0.0156 0.0139
Loa Loa (eye worm) trypsin family protein 0.0026 0.0035 0.007
Loa Loa (eye worm) hypothetical protein 0.0046 0.0283 0.0573
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0036 0.0156 0.0282
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0036 0.0156 0.0282
Brugia malayi cathepsin B-like cysteine proteinase 0.0141 0.1449 0.2883
Schistosoma mansoni aminopeptidase PILS (M01 family) 0.0026 0.0035 0.0018
Giardia lamblia UBC3 0.0051 0.0342 0.0838
Brugia malayi ube2i2 protein 0.0051 0.0342 0.0627
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0174 0.1849 0.3881
Schistosoma mansoni glutamate receptor AMPA 0.0036 0.0156 0.0139
Brugia malayi Integrin beta pat-3 precursor 0.0303 0.3425 0.6911
Echinococcus multilocularis subfamily M12B unassigned peptidase 0.0044 0.0258 0.049
Echinococcus granulosus caspase 0.041 0.474 0.9592
Echinococcus granulosus glutamate receptor 2 0.0036 0.0156 0.0282
Onchocerca volvulus Eukaryotic initiation factor 4A homolog 0.0097 0.0905 0.3656
Schistosoma mansoni ribonucleoside-diphosphate reductase alpha subunit 0.0426 0.4941 0.4932
Brugia malayi aspartic protease BmAsp-2, identical 0.0034 0.0133 0.0201
Echinococcus multilocularis eukaryotic initiation factor 4A III 0.0097 0.0905 0.1805
Plasmodium vivax hypothetical protein, conserved 0.0174 0.1849 0.3569
Trichomonas vaginalis ribonucleoside-diphosphate reductase alpha chain, putative 0.0395 0.4555 1
Echinococcus granulosus subfamily S1A unassigned peptidase S01 family 0.0026 0.0035 0.0037
Loa Loa (eye worm) hypothetical protein 0.0026 0.0035 0.007
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0034 0.0133 0.0117
Wolbachia endosymbiont of Brugia malayi ribonucleotide-diphosphate reductase subunit alpha 0.0395 0.4555 1
Schistosoma mansoni cercarial elastase (S01 family) 0.0026 0.0035 0.0018
Treponema pallidum ribonucleotide-diphosphate reductase subunit alpha 0.0426 0.4941 1
Leishmania major ubiquitin-conjugating enzyme e2, putative 0.0051 0.0342 0.0111
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0174 0.1849 0.3881
Plasmodium falciparum metacaspase-like protein 0.0174 0.1849 0.3569
Mycobacterium leprae RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE (ALPHA CHAIN) NRDE (RIBONUCLEOTIDE REDUCTASE SMALL SUBUNIT) (R1F PROTEIN) 0.0395 0.4555 1
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0034 0.0133 0.0117
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0026 0.0035 0.0018
Schistosoma mansoni glutamate receptor AMPA 0.0036 0.0156 0.0139
Trypanosoma cruzi metacaspase, putative 0.0174 0.1849 0.3352
Plasmodium vivax SUMO-conjugating enzyme UBC9, putative 0.0051 0.0342 0.0435
Echinococcus granulosus apoptotic protease activating factor 1 0.0046 0.0287 0.055
Echinococcus multilocularis transmembrane protease serine 3 0.0026 0.0035 0.0037
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0026 0.0035 0.0018
Echinococcus multilocularis eukaryotic initiation factor 4A 0.0097 0.0905 0.1805
Entamoeba histolytica DEAD/DEAH box helicase, putative 0.0097 0.0905 1
Schistosoma mansoni cercarial elastase (S01 family) 0.0026 0.0035 0.0018
Trypanosoma brucei Eukaryotic initiation factor 4A-1 0.0097 0.0905 0.1343
Echinococcus granulosus eukaryotic initiation factor 4A 0.0097 0.0905 0.1805
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0036 0.0156 0.0282
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0034 0.0133 0.0117
Onchocerca volvulus 0.0034 0.0133 0.0414
Echinococcus granulosus cathepsin d lysosomal aspartyl protease 0.0034 0.0133 0.0237
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0174 0.1849 0.3881
Trypanosoma brucei metacaspase MCA2 0.0174 0.1849 0.3368
Loa Loa (eye worm) ube2i2 protein 0.0051 0.0342 0.0693
Loa Loa (eye worm) hypothetical protein 0.0097 0.0905 0.1832
Echinococcus multilocularis glutamate (NMDA) receptor subunit 0.0036 0.0156 0.0282
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0174 0.1849 0.3881
Trichomonas vaginalis conserved hypothetical protein 0.0174 0.1849 0.3881
Loa Loa (eye worm) hypothetical protein 0.0026 0.0035 0.007
Trypanosoma brucei ribonucleoside-diphosphate reductase small chain, putative 0.0135 0.1369 0.2337
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0167 0.1761 0.3543
Trypanosoma cruzi ribonucleoside-diphosphate reductase large chain, putative 0.0121 0.1204 0.1963
Schistosoma mansoni cathepsin D (A01 family) 0.0034 0.0133 0.0117
Loa Loa (eye worm) hypothetical protein 0.0026 0.0035 0.007
Echinococcus multilocularis Kelch repeat type 1 0.0095 0.0879 0.1751
Schistosoma mansoni hypothetical protein 0.0046 0.0287 0.0271
Trypanosoma cruzi metacaspase, putative 0.0174 0.1849 0.3352
Brugia malayi eukaryotic initiation factor 4A 0.0097 0.0905 0.1774
Loa Loa (eye worm) hypothetical protein 0.02 0.2172 0.4397
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0141 0.1449 0.1435
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0036 0.0156 0.0282
Schistosoma mansoni cercarial elastase (S01 family) 0.0026 0.0035 0.0018
Echinococcus multilocularis caspase 3, apoptosis cysteine peptidase 0.041 0.474 0.9592
Giardia lamblia Translation initiation factor eIF-4A, putative 0.0097 0.0905 1
Echinococcus multilocularis kelch ECH associated protein 1 0.0094 0.0875 0.1744
Echinococcus granulosus caspase 8 0.0174 0.1849 0.3722
Loa Loa (eye worm) hypothetical protein 0.0174 0.1849 0.3743
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0034 0.0133 0.0117
Brugia malayi latrophilin 2 splice variant baaae 0.0034 0.0132 0.0198
Echinococcus multilocularis caspase 2 0.022 0.2416 0.4873
Trypanosoma cruzi ribonucleoside-diphosphate reductase small chain, putative 0.0135 0.1369 0.2318
Plasmodium falciparum eukaryotic initiation factor 4A 0.0097 0.0905 0.1606
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0026 0.0035 0.0018
Loa Loa (eye worm) hypothetical protein 0.0034 0.0133 0.027
Loa Loa (eye worm) hypothetical protein 0.0034 0.0132 0.0266
Echinococcus multilocularis caspase 8 0.0174 0.1849 0.3722
Plasmodium vivax ribonucleotide reductase small subunit, putative 0.0046 0.0279 0.0303
Echinococcus granulosus glutamate NMDA receptor subunit 0.0036 0.0156 0.0282
Schistosoma mansoni caspase-3 (C14 family) 0.041 0.474 0.4731
Leishmania major ribonucleoside-diphosphate reductase large chain, putative 0.0426 0.4941 1
Schistosoma mansoni glutamate receptor kainate 0.0036 0.0156 0.0139
Schistosoma mansoni ribonucleoside-diphosphate reductase small chain 0.0135 0.1369 0.1354
Schistosoma mansoni subfamily C14A unassigned peptidase (C14 family) 0.0174 0.1849 0.1836
Brugia malayi hypothetical protein 0.0057 0.0424 0.0793
Echinococcus granulosus cathepsin b 0.0141 0.1449 0.2909
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0026 0.0035 0.0018
Schistosoma mansoni hypothetical protein 0.0026 0.0035 0.0018
Plasmodium vivax subtilisin-like protease 1 0.0175 0.1868 0.3608
Trypanosoma brucei metacaspase 0.0174 0.1849 0.3368
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0036 0.0156 0.0282
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0141 0.1449 0.1435
Echinococcus multilocularis caspase 3 0.0236 0.2611 0.5269
Trypanosoma brucei metacaspase 5, putative 0.0174 0.1849 0.3368
Trichomonas vaginalis ubiquitin-conjugating enzyme rad6, putative 0.0051 0.0342 0.0473
Echinococcus multilocularis kelch ECH associated protein 1 0.0094 0.0875 0.1744
Mycobacterium tuberculosis Ribonucleoside-diphosphate reductase (beta chain) NrdF1 (ribonucleotide reductase small subunit) (R2F protein) 0.0135 0.1369 0.2838
Trypanosoma cruzi Eukaryotic initiation factor 4A-1 0.0097 0.0905 0.1321
Echinococcus multilocularis glutamate receptor 2 0.0036 0.0156 0.0282
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0141 0.1449 0.2491
Brugia malayi Pepsin A precursor 0.0034 0.0133 0.0201
Mycobacterium tuberculosis Probable ribonucleoside-diphosphate reductase (large subunit) NrdZ (ribonucleotide reductase) 0.0142 0.1459 0.3041
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0174 0.1849 0.3881
Echinococcus multilocularis cathepsin b 0.0141 0.1449 0.2909
Loa Loa (eye worm) aspartic protease BmAsp-1 0.0034 0.0133 0.027
Echinococcus granulosus cathepsin b 0.0141 0.1449 0.2909
Trichomonas vaginalis DEAD box ATP-dependent RNA helicase, putative 0.0097 0.0905 0.1746
Schistosoma mansoni glutamate receptor kainate 0.0036 0.0156 0.0139
Echinococcus multilocularis adam 0.0067 0.0543 0.107
Trichomonas vaginalis conserved hypothetical protein 0.0174 0.1849 0.3881
Loa Loa (eye worm) kelch domain-containing protein family protein 0.0046 0.0283 0.0573
Brugia malayi aspartic protease BmAsp-1, identical 0.0034 0.0133 0.0201
Echinococcus multilocularis glycoprotein Antigen 5 0.0026 0.0035 0.0037
Echinococcus granulosus kelch ECH associated protein 1 0.0094 0.0875 0.1744
Brugia malayi Glutamate receptor 2 precursor 0.0036 0.0156 0.0247
Mycobacterium tuberculosis Ribonucleoside-diphosphate reductase (alpha chain) NrdE (ribonucleotide reductase small subunit) (R1F protein) 0.0395 0.4555 1
Loa Loa (eye worm) hypothetical protein 0.022 0.2416 0.489
Brugia malayi ribonucleoside-diphosphate reductase large chain, putative 0.0426 0.4941 1
Brugia malayi mucosa associated lymphoid tissue lymphoma translocation protein 1 0.0174 0.1849 0.3699
Plasmodium falciparum SUMO-conjugating enzyme UBC9 0.0051 0.0342 0.0435
Schistosoma mansoni caspase-7 (C14 family) 0.022 0.2416 0.2403
Schistosoma mansoni hypothetical protein 0.0034 0.0132 0.0115
Trypanosoma brucei Metacaspase-4 0.0174 0.1849 0.3368
Brugia malayi Cell death protein 3 precursor 0.022 0.2416 0.4854
Plasmodium vivax ribonucleoside-diphosphate reductase large chain, putative 0.0426 0.4941 1
Loa Loa (eye worm) hypothetical protein 0.0141 0.1449 0.2933
Brugia malayi Calcitonin receptor-like protein seb-1 0.0049 0.0322 0.0586
Echinococcus granulosus caspase 3 apoptosis cysteine peptidase 0.041 0.474 0.9592
Schistosoma mansoni DEAD box ATP-dependent RNA helicase 0.0097 0.0905 0.089
Schistosoma mansoni cercarial elastase (S01 family) 0.0026 0.0035 0.0018
Trypanosoma brucei ribonucleoside-diphosphate reductase small chain 0.0135 0.1369 0.2337
Loa Loa (eye worm) DEAH box polypeptide 35 0.0033 0.012 0.0242
Loa Loa (eye worm) ribonucleoside-diphosphate reductase large subunit 0.0426 0.4941 1
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0034 0.0133 0.0117
Schistosoma mansoni glutamate receptor kainate 0.0036 0.0156 0.0139
Schistosoma mansoni cercarial elastase (S01 family) 0.0026 0.0035 0.0018
Trypanosoma cruzi ribonucleoside-diphosphate reductase large chain, putative 0.0426 0.4941 1
Trypanosoma brucei ribonucleoside-diphosphate reductase large chain 0.0426 0.4941 1
Schistosoma mansoni cercarial elastase (S01 family) 0.0026 0.0035 0.0018
Toxoplasma gondii ribonucleoside-diphosphate reductase large chain 0.0426 0.4941 1
Loa Loa (eye worm) hypothetical protein 0.0026 0.0035 0.007
Trypanosoma cruzi metacaspase, putative 0.0174 0.1849 0.3352
Leishmania major eukaryotic initiation factor 4a, putative 0.0097 0.0905 0.1321
Leishmania major eukaryotic initiation factor 4a, putative 0.0097 0.0905 0.1321
Onchocerca volvulus 0.0046 0.0287 0.1061
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0034 0.0133 0.0117
Schistosoma mansoni cercarial elastase (S01 family) 0.0026 0.0035 0.0018
Loa Loa (eye worm) hypothetical protein 0.0026 0.0035 0.007
Schistosoma mansoni cercarial elastase (S01 family) 0.0026 0.0035 0.0018
Loa Loa (eye worm) hypothetical protein 0.0026 0.0035 0.007
Brugia malayi hypothetical protein 0.0034 0.0133 0.0201
Loa Loa (eye worm) aspartic protease BmAsp-2 0.0034 0.0133 0.027
Loa Loa (eye worm) glutamate receptor 1 0.0036 0.0156 0.0315
Echinococcus multilocularis Peptidase S1 S6, chymotrypsin Hap 0.0026 0.0035 0.0037
Echinococcus multilocularis glutamate receptor, ionotrophic, AMPA 3 0.0036 0.0156 0.0282
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0049 0.0322 0.0652
Loa Loa (eye worm) hypothetical protein 0.0034 0.0133 0.027
Echinococcus multilocularis subfamily S1A unassigned peptidase (S01 family) 0.0026 0.0035 0.0037
Echinococcus granulosus caspase 3 0.0236 0.2611 0.5269
Schistosoma mansoni cercarial elastase (S01 family) 0.0026 0.0035 0.0018
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0174 0.1849 0.3881
Echinococcus multilocularis cathepsin b 0.0141 0.1449 0.2909
Schistosoma mansoni ubiquitin-conjugating enzyme E2 I 0.0051 0.0342 0.0326
Trypanosoma cruzi metacaspase, putative 0.0174 0.1849 0.3352
Schistosoma mansoni integrin beta subunit 0.0178 0.1902 0.1889
Toxoplasma gondii subtilisin SUB1 0.0175 0.1868 0.3608
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0036 0.0156 0.0282
Mycobacterium ulcerans ribonucleotide-diphosphate reductase subunit alpha 0.0395 0.4555 1
Echinococcus granulosus kelch ECH associated protein 1 like 0.0094 0.0875 0.1744
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0174 0.1849 0.3881
Echinococcus granulosus glycoprotein Antigen 5 0.0026 0.0035 0.0037
Echinococcus multilocularis caspase 0.041 0.474 0.9592
Echinococcus multilocularis cathepsin d (lysosomal aspartyl protease) 0.0034 0.0133 0.0237
Echinococcus granulosus ubiquitin conjugating enzyme e2 i 0.0051 0.0342 0.0661
Toxoplasma gondii cathepsin B 0.0047 0.0291 0.0328
Loa Loa (eye worm) hypothetical protein 0.0026 0.0035 0.007
Plasmodium falciparum metacaspase 1 0.0174 0.1849 0.3569
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0174 0.1849 0.3881
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0174 0.1849 0.3881
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0174 0.1849 0.3569
Trichomonas vaginalis conserved hypothetical protein 0.0174 0.1849 0.3881
Schistosoma mansoni DEAD box ATP-dependent RNA helicase 0.0097 0.0905 0.089
Schistosoma mansoni cathepsin D (A01 family) 0.0034 0.0133 0.0117
Mycobacterium tuberculosis Probable cold-shock DeaD-box protein A homolog DeaD (ATP-dependent RNA helicase dead homolog) 0.0097 0.0905 0.1797
Schistosoma mansoni cercarial elastase (S01 family) 0.0026 0.0035 0.0018
Echinococcus multilocularis ribonucleoside diphosphate reductase large 0.0426 0.4941 1
Onchocerca volvulus 0.0034 0.0133 0.0414
Onchocerca volvulus Cell death protein 3 homolog 0.022 0.2416 1
Echinococcus multilocularis Mastin 0.0026 0.0035 0.0037
Trypanosoma cruzi ribonucleoside-diphosphate reductase small chain, putative 0.0135 0.1369 0.2318
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0026 0.0035 0.0018
Brugia malayi Probable ATP-dependent helicase DHX35 0.0033 0.012 0.0173
Loa Loa (eye worm) aspartyl protease 6 0.0034 0.0133 0.027
Echinococcus granulosus ribonucleoside diphosphate reductase subunit 0.0135 0.1369 0.2746
Schistosoma mansoni subfamily M12B unassigned peptidase (M12 family) 0.0044 0.0258 0.0242
Echinococcus multilocularis integrin beta 2 0.0224 0.2465 0.4972
Mycobacterium leprae RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE (BETA CHAIN) NRDF (RIBONUCLEOTIDE REDUCTASE SMALL SUBUNIT) (R2F PROTEIN) 0.0046 0.0279 0.0389
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0034 0.0133 0.0117

Activities

Activity type Activity value Assay description Source Reference
Control (functional) ~ 250 % TNF-alpha stimulatory activity of the compound in B78/TNF/9 melanoma cells evaluated by ELISA method ChEMBL. 11354376
Enhancement (functional) 0 % Tested for the ability to stimulate TNF-alpha production in B78-H1 murine melanoma cells transduced with gene for human TNF-alpha, clone-9 at 10 uM concentration; In active ChEMBL. 11354376

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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