Detailed information for compound 2196870

Basic information

Technical information
  • TDR Targets ID: 2196870
  • Name: 4-[(4-hydroxy-3-methoxyphenyl)methyl]-2-metho xyphenol
  • MW: 260.105 | Formula: C15H16O4
  • H donors: 2 H acceptors: 2 LogP: 2.74 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 0
  • SMILES: COc1cc(ccc1O)Cc1ccc(c(c1)OC)O
  • InChi: InChI=1S/C15H16O4/c1-18-14-8-10(3-5-12(14)16)7-11-4-6-13(17)15(9-11)19-2/h3-6,8-9,16-17H,7H2,1-2H3
  • InChiKey: NTZWJMKBBBBUGE-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 4-[(4-hydroxy-3-methoxy-phenyl)methyl]-2-methoxy-phenol
  • 4-(4-hydroxy-3-methoxy-benzyl)-2-methoxy-phenol
  • 3888-22-0
  • NSC36672

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi hypothetical protein 0.0037 0.023 0.1242
Echinococcus granulosus lysosomal alpha glucosidase 0.0174 0.1849 1
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0049 0.0375 0.203
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.0562 1
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.023 0.4093
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0039 0.0255 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.0562 1
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0037 0.023 0.0814
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0019 0.0025 0.0438
Trichomonas vaginalis alpha-glucosidase, putative 0.0039 0.0255 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0049 0.0375 0.203
Echinococcus multilocularis lysosomal alpha glucosidase 0.0174 0.1849 0.1849
Leishmania major cathepsin L-like protease 0.0065 0.0562 1
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.023 0.9026
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.0562 1
Echinococcus multilocularis lysosomal alpha glucosidase 0.0174 0.1849 0.1849
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0019 0.0025 0.0438
Trichomonas vaginalis sucrase-isomaltase, putative 0.0039 0.0255 1
Schistosoma mansoni alpha-glucosidase 0.015 0.1564 1
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0233 0.2547 1
Schistosoma mansoni hypothetical protein 0.0037 0.023 0.1468
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.0025 0.0133
Schistosoma mansoni alpha-glucosidase 0.015 0.1564 1
Mycobacterium ulcerans hypothetical protein 0.0037 0.023 1
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0037 0.023 0.0814
Onchocerca volvulus 0.0037 0.023 0.1821
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0025 0.0967
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0102 0.1001 0.5413
Leishmania major cathepsin L-like protease 0.0065 0.0562 1
Echinococcus multilocularis jumonji domain containing protein 0.0043 0.031 0.031
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.0025 0.0133
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0019 0.0025 0.5
Mycobacterium ulcerans lipase LipD 0.0037 0.023 1
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0037 0.023 0.147
Brugia malayi beta-lactamase family protein 0.0037 0.023 0.1244
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.023 0.9026
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.0025 0.0133
Trypanosoma cruzi cysteine peptidase, putative 0.0065 0.0562 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0049 0.0375 0.24
Brugia malayi jmjC domain containing protein 0.0038 0.0244 0.1319
Mycobacterium tuberculosis Probable lipase LipD 0.0037 0.023 0.0814
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.0562 1
Onchocerca volvulus Huntingtin homolog 0.0124 0.1263 1
Mycobacterium leprae conserved hypothetical protein 0.0037 0.023 0.5
Onchocerca volvulus 0.0101 0.0985 0.7802
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.0025 0.0025
Trichomonas vaginalis alpha-glucosidase, putative 0.0039 0.0255 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0049 0.0375 0.24
Schistosoma mansoni jumonji domain containing protein 0.0081 0.0754 0.4823
Schistosoma mansoni hypothetical protein 0.0031 0.0167 0.1066
Trypanosoma cruzi cysteine peptidase, putative 0.0065 0.0562 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0049 0.0375 0.203
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0039 0.0255 1
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0025 0.1071
Treponema pallidum ATP-binding protein (ylxH-1) 0.0533 0.6075 1
Trichomonas vaginalis alpha-glucosidase, putative 0.0039 0.0255 1
Trypanosoma cruzi cruzipain precursor, putative 0.0065 0.0562 1
Trypanosoma cruzi cysteine peptidase, putative 0.0065 0.0562 1
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0049 0.0375 0.203
Giardia lamblia PHD finger protein 15 0.0031 0.0167 1
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0059 0.0496 0.8824
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0039 0.0255 0.1378
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0174 0.1849 1
Mycobacterium tuberculosis Probable hydrolase 0.0037 0.023 0.0814
Entamoeba histolytica hypothetical protein 0.0037 0.023 0.9013
Echinococcus multilocularis PHD finger protein rhinoceros 0.0031 0.0167 0.0167
Toxoplasma gondii exonuclease III APE 0.0019 0.0025 0.0967
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0039 0.0255 1
Mycobacterium leprae Probable lipase LipE 0.0037 0.023 0.5
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0039 0.0255 1
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0039 0.0255 1
Trichomonas vaginalis alpha-glucosidase, putative 0.0039 0.0255 1
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0037 0.023 0.147
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0019 0.0025 0.0967
Trypanosoma cruzi hypothetical protein, conserved 0.0039 0.0255 0.4535
Schistosoma mansoni jumonji/arid domain-containing protein 0.0038 0.0244 0.156
Entamoeba histolytica hypothetical protein 0.0037 0.023 0.9013
Plasmodium vivax hypothetical protein, conserved 0.0037 0.023 1
Loa Loa (eye worm) hypothetical protein 0.0037 0.023 0.1244
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.0562 1
Onchocerca volvulus 0.0037 0.023 0.1821
Loa Loa (eye worm) beta-lactamase 0.0037 0.023 0.1244
Toxoplasma gondii ABC1 family protein 0.0037 0.023 0.9026
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.0562 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0049 0.0375 0.0375
Echinococcus granulosus lysine specific demethylase 5A 0.0038 0.0244 0.1319
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0037 0.023 0.1244
Loa Loa (eye worm) hypothetical protein 0.0037 0.023 0.1244
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.0562 1
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0019 0.0025 0.0438
Onchocerca volvulus Alhambra homolog 0.0031 0.0167 0.132
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0037 0.023 0.1244
Trypanosoma brucei glucosidase, putative 0.0039 0.0255 0.4285
Schistosoma mansoni jumonji/arid domain-containing protein 0.0038 0.0244 0.156
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0031 0.0167 0.1066
Mycobacterium tuberculosis Conserved protein 0.0037 0.023 0.0814
Schistosoma mansoni alpha glucosidase 0.0039 0.0255 0.1629
Echinococcus granulosus peregrin 0.0031 0.0167 0.0902
Trypanosoma cruzi hypothetical protein, conserved 0.0039 0.0255 0.4535
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0049 0.0375 0.0375
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0037 0.023 0.1242
Mycobacterium tuberculosis Conserved protein 0.0037 0.023 0.0814
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0102 0.1001 0.1001
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.0562 1
Loa Loa (eye worm) hypothetical protein 0.0037 0.023 0.1244
Loa Loa (eye worm) hypothetical protein 0.0037 0.023 0.1244
Brugia malayi Glycosyl hydrolases family 31 protein 0.0174 0.1849 1
Brugia malayi jmjC domain containing protein 0.0102 0.1001 0.5413
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.023 0.4093
Echinococcus granulosus jumonji domain containing protein 0.0043 0.031 0.1678
Brugia malayi Bromodomain containing protein 0.0031 0.0167 0.0902
Plasmodium falciparum phd finger protein, putative 0.0031 0.0167 1
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0037 0.023 0.0814
Loa Loa (eye worm) PHD-finger family protein 0.0031 0.0167 0.0902
Leishmania major cathepsin L-like protease 0.0065 0.0562 1
Brugia malayi beta-lactamase 0.0037 0.023 0.1244
Echinococcus multilocularis neutral alpha glucosidase AB 0.0039 0.0255 0.0255
Brugia malayi Glycosyl hydrolases family 31 protein 0.0039 0.0255 0.1378
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0049 0.0375 0.24
Loa Loa (eye worm) hypothetical protein 0.0053 0.0429 0.2318
Leishmania major alpha glucosidase II subunit, putative 0.0039 0.0255 0.4535
Echinococcus multilocularis peregrin 0.0031 0.0167 0.0167
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0025 0.0967
Loa Loa (eye worm) hypothetical protein 0.0037 0.023 0.1244
Plasmodium vivax hypothetical protein, conserved 0.0031 0.0167 0.7251
Trichomonas vaginalis penicillin-binding protein, putative 0.0037 0.023 0.9026
Loa Loa (eye worm) hypothetical protein 0.0037 0.023 0.1244
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0037 0.023 0.023
Schistosoma mansoni ap endonuclease 0.0019 0.0025 0.0157
Schistosoma mansoni transcription factor LCR-F1 0.0037 0.023 0.1468
Brugia malayi hypothetical protein 0.0124 0.1263 0.6829
Entamoeba histolytica hypothetical protein 0.0037 0.023 0.9013
Trypanosoma brucei hypothetical protein, conserved 0.0037 0.023 0.3823
Mycobacterium tuberculosis Probable esterase LipL 0.0037 0.023 0.0814
Brugia malayi PHD-finger family protein 0.0031 0.0167 0.0902
Loa Loa (eye worm) jmjC domain-containing protein 0.0064 0.0557 0.3013
Onchocerca volvulus 0.0037 0.023 0.1821
Loa Loa (eye worm) hypothetical protein 0.0031 0.0167 0.0902
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.0562 1
Echinococcus multilocularis lysine specific demethylase 5A 0.0038 0.0244 0.0244
Toxoplasma gondii PHD-finger domain-containing protein 0.0031 0.0167 0.6545
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0025 0.1477
Mycobacterium tuberculosis Conserved protein 0.0037 0.023 0.0814
Trichomonas vaginalis alpha-glucosidase, putative 0.0039 0.0255 1
Trichomonas vaginalis esterase, putative 0.0037 0.023 0.9026
Echinococcus granulosus beta LACTamase domain containing family member 0.0037 0.023 0.1244
Loa Loa (eye worm) hypothetical protein 0.0124 0.1263 0.6829
Entamoeba histolytica hypothetical protein 0.0037 0.023 0.9013
Mycobacterium ulcerans esterase/lipase LipP 0.0037 0.023 1
Trypanosoma cruzi major cysteine proteinase, putative 0.0051 0.0399 0.7098
Schistosoma mansoni ap endonuclease 0.0019 0.0025 0.0157
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.0562 1
Mycobacterium tuberculosis Probable lipase LipE 0.0037 0.023 0.0814
Echinococcus multilocularis beta LACTamase domain containing family member 0.0037 0.023 0.023
Mycobacterium ulcerans beta-lactamase 0.0037 0.023 1
Onchocerca volvulus Huntingtin homolog 0.0124 0.1263 1
Leishmania major hypothetical protein, conserved 0.0037 0.023 0.4093
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.0562 1
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.023 0.9026
Loa Loa (eye worm) hypothetical protein 0.0124 0.1263 0.6829
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0037 0.023 1
Trichomonas vaginalis penicillin-binding protein, putative 0.0037 0.023 0.9026
Trichomonas vaginalis maltase-glucoamylase, putative 0.0039 0.0255 1
Brugia malayi beta-lactamase family protein 0.0037 0.023 0.1244
Echinococcus granulosus PHD finger protein rhinoceros 0.0031 0.0167 0.0902
Loa Loa (eye worm) jmjC domain-containing protein 0.0038 0.0244 0.1319
Echinococcus granulosus neutral alpha glucosidase AB 0.0039 0.0255 0.1378
Toxoplasma gondii PHD-finger domain-containing protein 0.0031 0.0167 0.6545

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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