Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | Oxytocin receptor | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Echinococcus multilocularis | allatostatin A receptor | Oxytocin receptor | 388 aa | 311 aa | 21.9 % |
Onchocerca volvulus | Phospholipase d-related homolog | Oxytocin receptor | 388 aa | 330 aa | 20.0 % |
Echinococcus multilocularis | orexin receptor type 2 | Oxytocin receptor | 388 aa | 332 aa | 23.2 % |
Echinococcus granulosus | neuropeptide receptor | Oxytocin receptor | 388 aa | 324 aa | 21.9 % |
Onchocerca volvulus | Mitochondrial inner membrane protein homolog | Oxytocin receptor | 388 aa | 346 aa | 24.0 % |
Onchocerca volvulus | Oxytocin receptor | 388 aa | 327 aa | 23.9 % | |
Schistosoma japonicum | ko:K04135 adrenergic receptor, alpha 1a, putative | Oxytocin receptor | 388 aa | 349 aa | 22.9 % |
Echinococcus multilocularis | neuropeptide receptor | Oxytocin receptor | 388 aa | 324 aa | 21.6 % |
Schistosoma japonicum | ko:K04209 neuropeptide Y receptor, invertebrate, putative | Oxytocin receptor | 388 aa | 327 aa | 19.3 % |
Echinococcus granulosus | orexin receptor type 2 | Oxytocin receptor | 388 aa | 338 aa | 24.3 % |
Schistosoma japonicum | ko:K04134 cholinergic receptor, invertebrate, putative | Oxytocin receptor | 388 aa | 323 aa | 21.7 % |
Echinococcus granulosus | allatostatin A receptor | Oxytocin receptor | 388 aa | 313 aa | 23.6 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Toxoplasma gondii | oxidoreductase, 2OG-Fe(II) oxygenase family protein | 0.0044 | 0.5 | 0.5 |
Toxoplasma gondii | oxidoreductase, 2OG-Fe(II) oxygenase family protein | 0.0044 | 0.5 | 0.5 |
Trypanosoma cruzi | 2OG-Fe(II) oxygenase superfamily, putative | 0.0044 | 0.5 | 0.5 |
Toxoplasma gondii | hypoxia- inducible factor prolyl hydroxylase (phd2), putative | 0.0044 | 0.5 | 0.5 |
Toxoplasma gondii | tetratricopeptide repeat-containing protein | 0.0044 | 0.5 | 0.5 |
Trypanosoma cruzi | 2OG-Fe(II) oxygenase superfamily, putative | 0.0044 | 0.5 | 0.5 |
Schistosoma mansoni | prolyl 4-hydroxylase alpha subunit 1 | 0.0044 | 0.5 | 0.5 |
Trypanosoma brucei | 2OG-Fe(II) oxygenase superfamily, putative | 0.0044 | 0.5 | 0.5 |
Leishmania major | hypothetical protein, conserved | 0.0044 | 0.5 | 0.5 |
Onchocerca volvulus | 0.0044 | 0.5 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0044 | 0.5 | 0.5 |
Echinococcus multilocularis | prolyl 4 hydroxylase subunit alpha 1 | 0.0044 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0044 | 0.5 | 0.5 |
Leishmania major | hypothetical protein, unknown function | 0.0044 | 0.5 | 0.5 |
Loa Loa (eye worm) | prolyl 4-hydroxylase 2 | 0.0044 | 0.5 | 0.5 |
Echinococcus granulosus | prolyl 4 hydroxylase subunit alpha 1 | 0.0044 | 0.5 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 16 uM | Half-maximal inhibition of binding of [3H]-Oxytocin to OT receptor in rat uterine tissue | ChEMBL. | 1331449 |
IC50 (binding) | = 16 uM | Half-maximal inhibition of binding of [3H]-Oxytocin to OT receptor in rat uterine tissue | ChEMBL. | 1331449 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.