Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium ulcerans | transmembrane alkane 1-monooxygenase AlkB | 0.0032 | 0.0126 | 0.5 |
Brugia malayi | acyl-CoA desaturase | 0.1534 | 0.9791 | 1 |
Mycobacterium ulcerans | hypothetical protein | 0.0032 | 0.0126 | 0.5 |
Brugia malayi | Fatty acid desaturase family protein | 0.0032 | 0.0126 | 0.0128 |
Mycobacterium ulcerans | hypothetical protein | 0.0032 | 0.0126 | 0.5 |
Leishmania major | fatty-acid desaturase, putative | 0.1567 | 1 | 1 |
Loa Loa (eye worm) | acyl-CoA desaturase | 0.1534 | 0.9791 | 1 |
Plasmodium vivax | stearoyl-CoA desaturase (acyl-CoA desaturase, faty acid desaturase), putative | 0.1534 | 0.9791 | 1 |
Onchocerca volvulus | 0.1567 | 1 | 1 | |
Echinococcus granulosus | Fatty acid desaturase type 1 | 0.0032 | 0.0126 | 1 |
Chlamydia trachomatis | SWIB complex protein | 0.0013 | 0 | 0.5 |
Onchocerca volvulus | 0.1567 | 1 | 1 | |
Brugia malayi | Fatty acid desaturase family protein | 0.0032 | 0.0126 | 0.0128 |
Mycobacterium tuberculosis | Possible electron transfer protein FdxB | 0.0032 | 0.0126 | 0.5 |
Mycobacterium tuberculosis | Probable conserved membrane protein | 0.0032 | 0.0126 | 0.5 |
Chlamydia trachomatis | DNA topoisomerase I | 0.0013 | 0 | 0.5 |
Trypanosoma brucei | fatty acid desaturase, putative | 0.1567 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.0126 | 0.0128 |
Onchocerca volvulus | 0.0032 | 0.0126 | 0.0126 | |
Trypanosoma cruzi | fatty acid desaturase, putative | 0.1567 | 1 | 1 |
Loa Loa (eye worm) | fatty acid desaturase | 0.0032 | 0.0126 | 0.0128 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0013 | 0 | 0.5 |
Echinococcus multilocularis | Peptidase M, neutral zinc metallopeptidases, zinc binding site | 0.0032 | 0.0126 | 1 |
Mycobacterium tuberculosis | Probable transmembrane alkane 1-monooxygenase AlkB (alkane 1-hydroxylase) (lauric acid omega-hydroxylase) (omega-hydroxylase) (f | 0.0032 | 0.0126 | 0.5 |
Trypanosoma cruzi | fatty acid desaturase, putative | 0.1534 | 0.9791 | 0.9789 |
Trypanosoma cruzi | fatty acid desaturase, putative | 0.1534 | 0.9791 | 0.9789 |
Toxoplasma gondii | sphingolipid delta 4 desaturase/c-4 hydroxylase protein des2 family protein | 0.0032 | 0.0126 | 1 |
Mycobacterium ulcerans | linoleoyl-CoA desaturase, DesA3_2 | 0.0032 | 0.0126 | 0.5 |
Echinococcus multilocularis | Peptidase M, neutral zinc metallopeptidases, zinc binding site | 0.0032 | 0.0126 | 1 |
Schistosoma mansoni | fatty acid desaturase | 0.0032 | 0.0126 | 1 |
Brugia malayi | Delta5 fatty acid desaturase | 0.0032 | 0.0126 | 0.0128 |
Echinococcus multilocularis | Fatty acid desaturase, type 1 | 0.0032 | 0.0126 | 1 |
Loa Loa (eye worm) | fatty acid desaturase | 0.0032 | 0.0126 | 0.0128 |
Mycobacterium ulcerans | linoleoyl-CoA desaturase, DesA3 | 0.0032 | 0.0126 | 0.5 |
Plasmodium falciparum | stearoyl-CoA desaturase | 0.1534 | 0.9791 | 1 |
Mycobacterium ulcerans | linoleoyl-CoA desaturase, DesA3 | 0.0032 | 0.0126 | 0.5 |
Echinococcus granulosus | Sphingolipid delta4 desaturase DES1 | 0.0032 | 0.0126 | 1 |
Mycobacterium ulcerans | electron transfer protein FdxB | 0.0032 | 0.0126 | 0.5 |
Loa Loa (eye worm) | FAT-3 protein | 0.0032 | 0.0126 | 0.0128 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 0.5 nM | Homogenous Time-Resolved Fluorescence Assay (HTRF2 Assay) | BINDINGDB. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.