Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | fatty acid desaturase | 0.0032 | 0.0126 | 0.0128 |
Brugia malayi | Delta5 fatty acid desaturase | 0.0032 | 0.0126 | 0.0128 |
Echinococcus multilocularis | Fatty acid desaturase, type 1 | 0.0032 | 0.0126 | 1 |
Loa Loa (eye worm) | FAT-3 protein | 0.0032 | 0.0126 | 0.0128 |
Mycobacterium ulcerans | electron transfer protein FdxB | 0.0032 | 0.0126 | 0.5 |
Plasmodium falciparum | stearoyl-CoA desaturase | 0.1534 | 0.9791 | 1 |
Mycobacterium ulcerans | linoleoyl-CoA desaturase, DesA3 | 0.0032 | 0.0126 | 0.5 |
Mycobacterium ulcerans | linoleoyl-CoA desaturase, DesA3 | 0.0032 | 0.0126 | 0.5 |
Echinococcus granulosus | Sphingolipid delta4 desaturase DES1 | 0.0032 | 0.0126 | 1 |
Mycobacterium ulcerans | linoleoyl-CoA desaturase, DesA3_2 | 0.0032 | 0.0126 | 0.5 |
Toxoplasma gondii | sphingolipid delta 4 desaturase/c-4 hydroxylase protein des2 family protein | 0.0032 | 0.0126 | 1 |
Trypanosoma cruzi | fatty acid desaturase, putative | 0.1534 | 0.9791 | 0.9789 |
Schistosoma mansoni | fatty acid desaturase | 0.0032 | 0.0126 | 1 |
Echinococcus multilocularis | Peptidase M, neutral zinc metallopeptidases, zinc binding site | 0.0032 | 0.0126 | 1 |
Mycobacterium tuberculosis | Possible electron transfer protein FdxB | 0.0032 | 0.0126 | 0.5 |
Brugia malayi | Fatty acid desaturase family protein | 0.0032 | 0.0126 | 0.0128 |
Mycobacterium tuberculosis | Probable conserved membrane protein | 0.0032 | 0.0126 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.0126 | 0.0128 |
Onchocerca volvulus | 0.0032 | 0.0126 | 0.0126 | |
Trypanosoma brucei | fatty acid desaturase, putative | 0.1567 | 1 | 1 |
Chlamydia trachomatis | DNA topoisomerase I | 0.0013 | 0 | 0.5 |
Chlamydia trachomatis | SWIB complex protein | 0.0013 | 0 | 0.5 |
Onchocerca volvulus | 0.1567 | 1 | 1 | |
Echinococcus granulosus | Fatty acid desaturase type 1 | 0.0032 | 0.0126 | 1 |
Echinococcus multilocularis | Peptidase M, neutral zinc metallopeptidases, zinc binding site | 0.0032 | 0.0126 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0013 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable transmembrane alkane 1-monooxygenase AlkB (alkane 1-hydroxylase) (lauric acid omega-hydroxylase) (omega-hydroxylase) (f | 0.0032 | 0.0126 | 0.5 |
Trypanosoma cruzi | fatty acid desaturase, putative | 0.1534 | 0.9791 | 0.9789 |
Loa Loa (eye worm) | fatty acid desaturase | 0.0032 | 0.0126 | 0.0128 |
Trypanosoma cruzi | fatty acid desaturase, putative | 0.1567 | 1 | 1 |
Brugia malayi | Fatty acid desaturase family protein | 0.0032 | 0.0126 | 0.0128 |
Mycobacterium ulcerans | hypothetical protein | 0.0032 | 0.0126 | 0.5 |
Brugia malayi | acyl-CoA desaturase | 0.1534 | 0.9791 | 1 |
Mycobacterium ulcerans | hypothetical protein | 0.0032 | 0.0126 | 0.5 |
Mycobacterium ulcerans | transmembrane alkane 1-monooxygenase AlkB | 0.0032 | 0.0126 | 0.5 |
Leishmania major | fatty-acid desaturase, putative | 0.1567 | 1 | 1 |
Loa Loa (eye worm) | acyl-CoA desaturase | 0.1534 | 0.9791 | 1 |
Onchocerca volvulus | 0.1567 | 1 | 1 | |
Plasmodium vivax | stearoyl-CoA desaturase (acyl-CoA desaturase, faty acid desaturase), putative | 0.1534 | 0.9791 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 5.5 nM | Homogenous Time-Resolved Fluorescence Assay (HTRF2 Assay) | BINDINGDB. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.