Detailed information for compound 225819

Basic information

Technical information
  • TDR Targets ID: 225819
  • Name: N-[2-(2-bromo-5-methoxy-1H-indol-3-yl)ethyl]c yclopropanecarboxamide
  • MW: 337.212 | Formula: C15H17BrN2O2
  • H donors: 2 H acceptors: 1 LogP: 3.08 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccc2c(c1)c(CCNC(=O)C1CC1)c([nH]2)Br
  • InChi: 1S/C15H17BrN2O2/c1-20-10-4-5-13-12(8-10)11(14(16)18-13)6-7-17-15(19)9-2-3-9/h4-5,8-9,18H,2-3,6-7H2,1H3,(H,17,19)
  • InChiKey: YDQHNFULFPWERG-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens melatonin receptor 1A References
Homo sapiens melatonin receptor 1B Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi hypothetical protein melatonin receptor 1B 362 aa 329 aa 18.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Onchocerca volvulus 0.0108 0.1181 0.5166
Schistosoma mansoni hypothetical protein 0.0182 0.2455 0.4951
Onchocerca volvulus 0.0053 0.0222 0.0971
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0075 0.0612 0.0952
Echinococcus multilocularis tar DNA binding protein 0.0076 0.0614 0.0957
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0614 0.1239
Brugia malayi jmjC domain containing protein 0.0152 0.1933 0.301
Echinococcus multilocularis peregrin 0.0129 0.1549 0.2412
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0614 0.1239
Trypanosoma brucei DNA polymerase eta, putative 0.0046 0.0099 0.0096
Echinococcus granulosus voltage dependent L type calcium channel subunit|voltage dependent calcium channel 0.0099 0.1013 0.1577
Brugia malayi jmjC domain containing protein 0.004 0.0003 0.0005
Trichomonas vaginalis glucosylceramidase, putative 0.0172 0.2287 0.5733
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0075 0.0612 0.1164
Echinococcus granulosus lysine specific demethylase 5A 0.0152 0.1933 0.301
Schistosoma mansoni cellular tumor antigen P53 0.0053 0.0222 0.0448
Loa Loa (eye worm) hypothetical protein 0.0093 0.0916 0.2379
Brugia malayi acetyltransferase, GNAT family protein 0.0173 0.2305 0.359
Echinococcus granulosus matrix metallopeptidase 7 M10 family 0.0278 0.4121 0.6418
Loa Loa (eye worm) matrix metalloproteinase 0.0076 0.0627 0.1629
Brugia malayi uridine phosphorylase family protein 0.0202 0.281 0.4376
Trypanosoma cruzi Voltage-dependent calcium channel subunit, putative 0.006 0.0343 0.0339
Plasmodium falciparum conserved Plasmodium membrane protein, unknown function 0.0041 0.0012 0.0082
Echinococcus multilocularis sodium channel protein 0.0042 0.0027 0.0043
Schistosoma mansoni high voltage-activated calcium channel Cav1 0.0099 0.1013 0.2043
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel alpha 1 0.0099 0.1013 0.1577
Schistosoma mansoni protein phosphatase 2C 0.004 0.0003 0.0007
Echinococcus granulosus tumor protein p63 0.0362 0.559 0.8704
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0262 0.3851 0.5997
Toxoplasma gondii WD domain, G-beta repeat-containing protein 0.0041 0.0012 0.006
Brugia malayi Voltage-gated calcium channel, L-type, alpha subunit. C. elegans egl-19 ortholog 0.0099 0.1013 0.1577
Echinococcus granulosus JmjC domain containing protein 4 0.004 0.0003 0.0005
Trichomonas vaginalis glucosylceramidase, putative 0.0172 0.2287 0.5733
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0051 0.0185 0.1253
Brugia malayi jmjC domain containing protein 0.004 0.0003 0.0005
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0075 0.0612 0.0608
Echinococcus granulosus phd:f box containing protein 0.004 0.0003 0.0005
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0614 0.1239
Schistosoma mansoni high voltage-activated calcium channel Cav2A 0.0099 0.1013 0.2043
Mycobacterium leprae probable uridine phosphorylase 0.0202 0.281 1
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0075 0.0612 0.0608
Schistosoma mansoni hypothetical protein 0.0125 0.1476 0.2976
Plasmodium falciparum JmjC domain-containing protein, putative 0.004 0.0003 0.0022
Brugia malayi jmjC domain containing protein 0.004 0.0003 0.0005
Plasmodium vivax hypothetical protein, conserved 0.0041 0.0012 0.0082
Trichomonas vaginalis glucosylceramidase, putative 0.0172 0.2287 0.5733
Loa Loa (eye worm) jmjC domain-containing protein 0.0152 0.1933 0.5019
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0173 0.2305 0.359
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0041 0.0012 0.0024
Trichomonas vaginalis glucosylceramidase, putative 0.0181 0.2447 0.6171
Schistosoma mansoni jumonji/arid domain-containing protein 0.0152 0.1933 0.3898
Trypanosoma cruzi DNA polymerase eta, putative 0.0046 0.0099 0.0096
Loa Loa (eye worm) RNA binding protein 0.0076 0.0614 0.1595
Echinococcus multilocularis amyloid beta A4 protein 0.007 0.0525 0.0817
Brugia malayi Hemopexin family protein 0.0108 0.1181 0.1839
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0075 0.0612 0.0952
Loa Loa (eye worm) hypothetical protein 0.0125 0.1476 0.3831
Loa Loa (eye worm) hypothetical protein 0.0099 0.1013 0.263
Echinococcus multilocularis dna polymerase eta 0.0046 0.0099 0.0154
Schistosoma mansoni hypothetical protein 0.0041 0.0012 0.0024
Brugia malayi Matrix metalloprotease, N-terminal domain containing protein 0.0093 0.0916 0.1427
Brugia malayi RNA recognition motif domain containing protein 0.0076 0.0614 0.0957
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0075 0.0612 0.1164
Loa Loa (eye worm) hypothetical protein 0.0076 0.0627 0.1629
Mycobacterium tuberculosis Conserved hypothetical protein 0.0325 0.4937 1
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.0099 0.1013 0.1577
Brugia malayi Matrixin family protein 0.0076 0.0627 0.0977
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.0099 0.1013 0.1577
Loa Loa (eye worm) hypothetical protein 0.0076 0.0627 0.1629
Echinococcus multilocularis geminin 0.0182 0.2455 0.3823
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0075 0.0612 0.0952
Loa Loa (eye worm) uridine phosphorylase 0.0202 0.281 0.7296
Loa Loa (eye worm) X11 protein 0.007 0.0525 0.1362
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0075 0.0612 0.0952
Onchocerca volvulus Alhambra homolog 0.0125 0.1476 0.6452
Echinococcus multilocularis lysine specific demethylase 6a 0.004 0.0003 0.0005
Echinococcus granulosus PHD finger protein rhinoceros 0.0125 0.1476 0.2298
Trichomonas vaginalis glucosylceramidase, putative 0.0172 0.2287 0.5733
Echinococcus multilocularis PHD finger protein rhinoceros 0.0125 0.1476 0.2298
Schistosoma mansoni voltage-gated cation channel 0.0099 0.1013 0.2043
Echinococcus granulosus tar DNA binding protein 0.0076 0.0614 0.0957
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0292 0.4365 0.4363
Loa Loa (eye worm) hypothetical protein 0.0051 0.0189 0.0491
Brugia malayi ImpB/MucB/SamB family protein 0.0046 0.0099 0.0154
Trichomonas vaginalis glucosylceramidase, putative 0.0181 0.2447 0.6171
Schistosoma mansoni lipoxygenase 0.0105 0.1117 0.2253
Loa Loa (eye worm) hypothetical protein 0.0068 0.0477 0.1238
Schistosoma mansoni jumonji domain containing protein 0.004 0.0003 0.0007
Echinococcus granulosus uridine phosphorylase 1 0.0202 0.281 0.4376
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.0099 0.1013 0.1577
Brugia malayi Matrixin family protein 0.0076 0.0627 0.0977
Echinococcus multilocularis voltage dependent calcium channel 0.0099 0.1013 0.1577
Echinococcus granulosus voltage dependent calcium channel 0.0099 0.1013 0.1577
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0292 0.4365 0.4363
Loa Loa (eye worm) hypothetical protein 0.0215 0.3029 0.7864
Toxoplasma gondii PHD-finger domain-containing protein 0.0125 0.1476 1
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0292 0.4365 0.4363
Schistosoma mansoni hypothetical protein 0.0108 0.1181 0.2382
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0051 0.0189 0.0491
Loa Loa (eye worm) PHD-finger family protein 0.0125 0.1476 0.3831
Trypanosoma brucei PHD-zinc-finger like domain containing protein, putative 0.0041 0.0012 0.0009
Onchocerca volvulus Matrilysin homolog 0.0169 0.2242 0.9803
Plasmodium vivax JmjC domain containing protein 0.004 0.0003 0.0022
Loa Loa (eye worm) hypothetical protein 0.0046 0.0099 0.0257
Echinococcus multilocularis voltage dependent calcium channel 0.0099 0.1013 0.1577
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0075 0.0612 0.0608
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0051 0.0185 0.1234
Echinococcus multilocularis lysine specific demethylase 5A 0.0152 0.1933 0.301
Onchocerca volvulus Glucosylceramidase homolog 0.0172 0.2287 1
Brugia malayi Calcitonin receptor-like protein seb-1 0.0051 0.0189 0.0295
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0051 0.0185 0.1234
Loa Loa (eye worm) hypothetical protein 0.0041 0.0012 0.0031
Echinococcus multilocularis ubiquitin specific protease 41 0.0075 0.0612 0.0952
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0125 0.1476 0.2976
Echinococcus granulosus jumonji domain containing protein 0.0174 0.2327 0.3624
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.041 0.6422 1
Schistosoma mansoni hypothetical protein 0.0182 0.2455 0.4951
Brugia malayi jmjC domain containing protein 0.004 0.0003 0.0005
Loa Loa (eye worm) calcium channel 0.0099 0.1013 0.263
Echinococcus granulosus muscleblind protein 0.0153 0.1961 0.3054
Echinococcus granulosus dna polymerase eta 0.0046 0.0099 0.0154
Trypanosoma brucei Voltage-dependent calcium channel subunit, putative 0.006 0.0343 0.0339
Echinococcus multilocularis uridine phosphorylase 1 0.0202 0.281 0.4376
Plasmodium vivax hypothetical protein, conserved 0.0125 0.1476 1
Echinococcus granulosus ubiquitin specific protease 41 0.0075 0.0612 0.0952
Loa Loa (eye worm) matrixin family protein 0.0169 0.2242 0.5821
Schistosoma mansoni lipoxygenase 0.0177 0.2374 0.4788
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0616 1 1
Trichomonas vaginalis glucosylceramidase, putative 0.0262 0.3851 1
Plasmodium falciparum phd finger protein, putative 0.0125 0.1476 1
Loa Loa (eye worm) matrixin family protein 0.0185 0.2507 0.6509
Echinococcus granulosus histone acetyltransferase KAT2B 0.0168 0.2221 0.3459
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.041 0.6422 1
Brugia malayi hypothetical protein 0.0068 0.0477 0.0742
Schistosoma mansoni phosphatidylserine receptor 0.004 0.0003 0.0007
Echinococcus multilocularis tumor protein p63 0.0362 0.559 0.8704
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0616 1 1
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0075 0.0612 0.0608
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0087 0.0806 0.0803
Schistosoma mansoni phd/f-box containing protein 0.004 0.0003 0.0007
Schistosoma mansoni jumonji domain containing protein 0.0326 0.4958 1
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel|voltage dependent L type calcium channel subu 0.0099 0.1013 0.1577
Schistosoma mansoni matrix metallopeptidase-9 (M10 family) 0.0081 0.0701 0.1414
Loa Loa (eye worm) hypothetical protein 0.0076 0.0627 0.1629
Schistosoma mansoni amyloid beta A4 protein related 0.007 0.0525 0.1058
Loa Loa (eye worm) jmjC domain-containing protein 0.004 0.0003 0.0008
Echinococcus multilocularis matrix metallopeptidase 7 (M10 family) 0.0278 0.4121 0.6418
Leishmania major DNA polymerase eta, putative 0.0046 0.0099 0.0096
Loa Loa (eye worm) jmjC domain-containing protein 0.0259 0.379 0.9842
Loa Loa (eye worm) jmjC domain-containing protein 0.004 0.0003 0.0008
Trichomonas vaginalis glucosylceramidase, putative 0.0172 0.2287 0.5733
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0075 0.0612 1
Trichomonas vaginalis conserved hypothetical protein 0.0075 0.0612 0.1164
Echinococcus granulosus voltage gated sodium channel Nav1 alpha subunit 0.0042 0.0027 0.0043
Brugia malayi AF-10 protein 0.0041 0.0012 0.0019
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0106 0.1135 0.1132
Trypanosoma brucei PHD-zinc-finger like domain containing protein, putative 0.0041 0.0012 0.0009
Echinococcus multilocularis jumonji domain containing 1A 0.004 0.0003 0.0005
Loa Loa (eye worm) hypothetical protein 0.004 0.0003 0.0008
Plasmodium falciparum histone acetyltransferase GCN5 0.0047 0.0111 0.0754
Loa Loa (eye worm) hypothetical protein 0.0053 0.0222 0.0576
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0087 0.0806 0.0803
Brugia malayi Matrixin family protein 0.0076 0.0627 0.0977
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0075 0.0612 0.1233
Toxoplasma gondii PHD-finger domain-containing protein 0.0125 0.1476 1
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0262 0.3851 1
Giardia lamblia PHD finger protein 15 0.0125 0.1476 1
Loa Loa (eye worm) acetyltransferase 0.0173 0.2305 0.5986
Brugia malayi Matrixin family protein 0.0076 0.0627 0.0977
Mycobacterium ulcerans hypothetical protein 0.0325 0.4937 1
Schistosoma mansoni uridine phosphorylase 0.0202 0.281 0.5667
Onchocerca volvulus 0.0076 0.0627 0.2743
Brugia malayi PHD-finger family protein 0.0041 0.0012 0.0019
Echinococcus granulosus amyloid beta A4 protein 0.007 0.0525 0.0817
Trichomonas vaginalis glucosylceramidase, putative 0.0262 0.3851 1
Loa Loa (eye worm) hypothetical protein 0.0153 0.1961 0.5093
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.004 0.0003 0.0007
Brugia malayi abnormal cell lineage protein 10 (Protein lin-10), putative 0.0063 0.0395 0.0616
Echinococcus multilocularis jumonji domain containing protein 0.0174 0.2327 0.3624
Trichomonas vaginalis glucosylceramidase, putative 0.0262 0.3851 1
Loa Loa (eye worm) hypothetical protein 0.0075 0.0612 0.1588
Loa Loa (eye worm) hypothetical protein 0.004 0.0003 0.0008
Loa Loa (eye worm) hypothetical protein 0.0153 0.1961 0.5093
Trichomonas vaginalis glucosylceramidase, putative 0.0262 0.3851 1
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0173 0.2305 0.4649
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0075 0.0612 0.1233
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0616 1 1
Trichomonas vaginalis glucosylceramidase, putative 0.0172 0.2287 0.5733
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0177 0.2374 0.3697
Onchocerca volvulus Matrilysin homolog 0.0076 0.0627 0.2743
Echinococcus multilocularis phd:f box containing protein 0.004 0.0003 0.0005
Trichomonas vaginalis glucosylceramidase, putative 0.0262 0.3851 1
Trichomonas vaginalis glucosylceramidase, putative 0.0262 0.3851 1
Echinococcus granulosus geminin 0.0182 0.2455 0.3823
Loa Loa (eye worm) jmjC domain-containing protein 0.004 0.0003 0.0008
Echinococcus multilocularis muscleblind protein 0.0153 0.1961 0.3054
Brugia malayi jmjC domain containing protein 0.041 0.6422 1
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0614 0.1239
Brugia malayi RNA binding protein 0.0076 0.0614 0.0957
Schistosoma mansoni matrix metallopeptidase-7 (M10 family) 0.0076 0.0627 0.1265
Echinococcus granulosus histone acetyltransferase KAT2B 0.0051 0.0185 0.0288
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0075 0.0612 0.0952
Echinococcus multilocularis muscleblind protein 1 0.0153 0.1961 0.3054
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0076 0.0614 0.1595
Trichomonas vaginalis glucosylceramidase, putative 0.0172 0.2287 0.5733
Onchocerca volvulus Matrix metalloproteinase homolog 0.0169 0.2242 0.9803
Brugia malayi Muscleblind-like protein 0.0153 0.1961 0.3054
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.004 0.0003 0.0005
Loa Loa (eye worm) TAR-binding protein 0.0076 0.0614 0.1595
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0075 0.0612 0.3667
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.004 0.0003 0.0005
Schistosoma mansoni jumonji/arid domain-containing protein 0.0152 0.1933 0.3898
Echinococcus granulosus peregrin 0.0129 0.1549 0.2412
Echinococcus granulosus jumonji domain containing 1A 0.004 0.0003 0.0005
Toxoplasma gondii PHD-finger domain-containing protein 0.0041 0.0012 0.006
Brugia malayi TAR-binding protein 0.0076 0.0614 0.0957
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0614 0.1239
Toxoplasma gondii hypothetical protein 0.0099 0.1027 0.6954
Brugia malayi Matrixin family protein 0.0185 0.2507 0.3904
Echinococcus granulosus lysine specific demethylase 6a 0.004 0.0003 0.0005
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0087 0.0806 0.0803
Echinococcus multilocularis JmjC domain containing protein 4 0.004 0.0003 0.0005
Brugia malayi PHD-finger family protein 0.0125 0.1476 0.2298
Schistosoma mansoni uridine phosphorylase 0.0202 0.281 0.5667
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0051 0.0189 0.0295
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0087 0.0806 0.0803
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0177 0.2374 0.3697
Brugia malayi Bromodomain containing protein 0.0129 0.1549 0.2412
Brugia malayi F/Y-rich N-terminus family protein 0.0041 0.0012 0.0019
Schistosoma mansoni DNA polymerase eta 0.0046 0.0099 0.0199
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.0099 0.1013 0.1577

Activities

Activity type Activity value Assay description Source Reference
Activity (functional) Compound was tested in vivo for its activity against melatonin receptor in Syrian hamster gonadal regression model; Agonist ChEMBL. 8258829
Activity (functional) Compound was tested in vivo for its activity against melatonin receptor in rabbit parietal cortex model; Agonist ChEMBL. 8258829
Activity (functional) 0 Compound was tested in vivo for its activity against melatonin receptor in Syrian hamster gonadal regression model; Agonist ChEMBL. 8258829
Activity (functional) 0 Compound was tested in vivo for its activity against melatonin receptor in rabbit parietal cortex model; Agonist ChEMBL. 8258829
INH (functional) = 60 % Inhibition of spontaneous firing activity of single cortical neurons in the rabbit parietal cortex model at 1 x 10 e-6 M (agonist) ChEMBL. 8258829
Ka (binding) = 4.6 Inhibition of 2-[125I]-iodomelatonin binding to melatonin receptor in quail brain ChEMBL. 8258829
Ka (binding) = 4.6 Inhibition of 2-[125I]-iodomelatonin binding to melatonin receptor in quail brain ChEMBL. 8258829
Ki (binding) = 0.00000000021 M l-1 Inhibition of 2-[125I]-iodomelatonin binding to melatonin receptor in quail brain as 1/Ka ChEMBL. 8258829
Ki (binding) = 0.00000000021 M l-1 Inhibition of 2-[125I]-iodomelatonin binding to melatonin receptor in quail brain as 1/Ka ChEMBL. 8258829

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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