TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 257.288 | Formula: C14H15N3O2
H donors: 1 H acceptors: 2 LogP: 1.39 Rotable bonds: 5
Rule of 5 violations (Lipinski): 1
SMILES: OC(=O)CCCn1nc(ccc1=N)c1ccccc1
InChi: 1S/C14H15N3O2/c15-13-9-8-12(11-5-2-1-3-6-11)16-17(13)10-4-7-14(18)19/h1-3,5-6,8-9,15H,4,7,10H2,(H,18,19)
InChiKey: MCGRKKMCGKMHHG-UHFFFAOYSA-N

Network

Hover on a compound node to display the structore

Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

This is a work in progress. Come back soon to try this features!

Clustering layers

This is a work in progress. Come back soon to try this features!

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	gamma-aminobutyric acid (GABA) A receptor, alpha 2	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	gamma-aminobutyric acid (GABA) A receptor, alpha 2	451 aa	393 aa	25.9 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Onchocerca volvulus		0.0029	0.02	0.0466
Plasmodium falciparum	kinesin-5	0.0026	0.0152	0.3314
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0044	0.0434	0.0434
Trypanosoma brucei	DNA polymerase beta thumb, putative	0.0041	0.0385	0.0911
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0345	0.1058
Echinococcus multilocularis	kinesin family 1	0.0199	0.2799	0.2799
Toxoplasma gondii	hypothetical protein	0.0047	0.0477	1
Mycobacterium leprae	DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE	0.0116	0.1536	1
Onchocerca volvulus		0.0038	0.0345	0.0917
Schistosoma mansoni	rab6-interacting	0.0019	0.0049	0.0049
Schistosoma mansoni	hypothetical protein	0.0173	0.2404	0.2404
Onchocerca volvulus		0.0038	0.0345	0.0917
Trypanosoma brucei	mitochondrial DNA polymerase beta-PAK	0.0138	0.1871	0.4429
Mycobacterium tuberculosis	Probable lipase LipE	0.0038	0.0345	0.0982
Trichomonas vaginalis	D-aminoacylase, putative	0.0038	0.0345	0.1055
Mycobacterium tuberculosis	NADPH-dependent mycothiol reductase Mtr	0.0046	0.0459	0.1304
Trypanosoma cruzi	PAB1-binding protein , putative	0.0027	0.0169	0.04
Echinococcus granulosus	lipoxygenase domain containing protein	0.0019	0.0049	0.0049
Loa Loa (eye worm)	hypothetical protein	0.0028	0.019	0.0501
Schistosoma mansoni	hypothetical protein	0.0031	0.0228	0.0228
Echinococcus multilocularis	arachidonate 5 lipoxygenase	0.0054	0.0576	0.0576
Brugia malayi	beta-lactamase family protein	0.0038	0.0345	0.1214
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0031	0.0228	0.0228
Plasmodium vivax	kinesin-5	0.0026	0.0152	0.3314
Echinococcus granulosus	lipoxygenase domain containing protein	0.0019	0.0049	0.0049
Brugia malayi	hypothetical protein	0.0027	0.0169	0.0593
Echinococcus multilocularis	histone lysine N methyltransferase SETMAR	0.0029	0.02	0.02
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0038	0.0345	0.0345
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0038	0.0345	0.1058
Mycobacterium tuberculosis	Probable reductase	0.0105	0.1358	0.386
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0031	0.0228	0.0228
Schistosoma mansoni	polycystin 1-related	0.0019	0.0049	0.0049
Trypanosoma cruzi	mitochondrial DNA polymerase beta-PAK, putative	0.0041	0.0385	0.0911
Schistosoma mansoni	3-hydroxyacyl-CoA dehydrogenase	0.0059	0.0666	0.0666
Brugia malayi	Pre-SET motif family protein	0.0029	0.02	0.0702
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0031	0.0228	0.0228
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0044	0.0434	0.0434
Leishmania major	mitochondrial DNA polymerase beta-PAK, putative	0.0138	0.1871	0.4429
Mycobacterium tuberculosis	Conserved protein	0.0038	0.0345	0.0982
Trypanosoma brucei	PAB1-binding protein , putative	0.0027	0.0169	0.04
Toxoplasma gondii	kinesin motor domain-containing protein	0.0026	0.0152	0.3183
Trypanosoma brucei	hypothetical protein, conserved	0.0038	0.0345	0.0818
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.0202	0.2846	1
Trichomonas vaginalis	esterase, putative	0.0038	0.0345	0.1055
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0038	0.0345	0.1214
Echinococcus granulosus	histone lysine methyltransferase setb	0.0029	0.02	0.02
Toxoplasma gondii	LsmAD domain-containing protein	0.0027	0.0169	0.3537
Mycobacterium tuberculosis	Possible conserved lipoprotein LpqK	0.0038	0.0345	0.0982
Echinococcus granulosus	kinesin family 1	0.0199	0.2799	0.2799
Echinococcus granulosus	5'partial\|histone lysine N methyltransferase SETDB2	0.0028	0.0184	0.0184
Echinococcus multilocularis	musashi	0.0029	0.0198	0.0198
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0345	0.1058
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0097	0.1247	0.438
Trypanosoma cruzi	hypothetical protein, conserved	0.0038	0.0345	0.0818
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0044	0.0434	0.1523
Mycobacterium tuberculosis	Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB	0.0105	0.1358	0.386
Onchocerca volvulus		0.0029	0.0198	0.0459
Brugia malayi	hypothetical protein	0.0017	0.0023	0.008
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0044	0.0434	0.1373
Brugia malayi	Latrophilin receptor protein 2	0.0031	0.0228	0.0802
Mycobacterium ulcerans	lipase LipD	0.0038	0.0345	0.1637
Brugia malayi	Thioredoxin reductase	0.0046	0.0459	0.1612
Echinococcus multilocularis	3 hydroxyacyl coenzyme A dehydrogenase type 2	0.0059	0.0666	0.0666
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	0.0059	0.0666	0.3154
Brugia malayi	hypothetical protein	0.0019	0.0049	0.0174
Echinococcus granulosus	Polycystic kidney disease protein	0.0019	0.0049	0.0049
Echinococcus granulosus	geminin	0.0166	0.2306	0.2306
Echinococcus multilocularis	RUN	0.0019	0.0049	0.0049
Mycobacterium ulcerans	hypothetical protein	0.0038	0.0345	0.1637
Schistosoma mansoni	lipoxygenase	0.0019	0.0049	0.0049
Trichomonas vaginalis	penicillin-binding protein, putative	0.0038	0.0345	0.1055
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.0246	0.3518	1
Trypanosoma cruzi	PAB1-binding protein , putative	0.0027	0.0169	0.04
Mycobacterium tuberculosis	Probable short-chain type dehydrogenase/reductase	0.0059	0.0666	0.1892
Schistosoma mansoni	hypothetical protein	0.0031	0.0228	0.0228
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0044	0.0434	0.0434
Trichomonas vaginalis	penicillin-binding protein, putative	0.0038	0.0345	0.1055
Echinococcus multilocularis	histone lysine methyltransferase setb histone lysine methyltransferase eggless	0.0029	0.02	0.02
Mycobacterium ulcerans	beta-lactamase	0.0038	0.0345	0.1637
Loa Loa (eye worm)	hypothetical protein	0.0029	0.02	0.0538
Echinococcus granulosus	thioredoxin glutathione reductase	0.0046	0.0459	0.0459
Entamoeba histolytica	kinesin, putative	0.0026	0.0152	0.5
Loa Loa (eye worm)	hypothetical protein	0.0097	0.1247	0.4281
Schistosoma mansoni	hypothetical protein	0.0031	0.0228	0.0228
Trypanosoma brucei	trypanothione reductase	0.0046	0.0459	0.1086
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0031	0.0228	0.0802
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0038	0.0345	0.0345
Wolbachia endosymbiont of Brugia malayi	dihydrolipoamide dehydrogenase E3 component	0.0016	0	0.5
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0044	0.0434	0.0434
Plasmodium falciparum	ataxin-2 like protein, putative	0.0027	0.0169	0.3682
Loa Loa (eye worm)	beta-lactamase	0.0038	0.0345	0.1058
Echinococcus multilocularis	GPCR, family 2	0.0031	0.0228	0.0228
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0345	0.1058
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	0.0029	0.0198	0.053
Schistosoma mansoni	lamin	0.0029	0.0198	0.0198
Mycobacterium tuberculosis	Putative ferredoxin reductase	0.0105	0.1358	0.386
Mycobacterium tuberculosis	Probable esterase LipL	0.0038	0.0345	0.0982
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	0.0059	0.0666	0.3154
Echinococcus granulosus	GPCR family 2	0.0031	0.0228	0.0228
Schistosoma mansoni	hypothetical protein	0.0166	0.2306	0.2306
Loa Loa (eye worm)	kinesin-like protein KLP2	0.0026	0.0152	0.0367
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0345	0.1058
Schistosoma mansoni	intermediate filament proteins	0.0029	0.0198	0.0198
Plasmodium vivax	multidomain scavenger receptor, putative	0.0019	0.0049	0.1078
Mycobacterium tuberculosis	Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras	0.0116	0.1536	0.4368
Schistosoma mansoni	hypothetical protein	0.0031	0.0228	0.0228
Schistosoma mansoni	lipoxygenase	0.0054	0.0576	0.0576
Echinococcus granulosus	intermediate filament protein	0.0029	0.0198	0.0198
Brugia malayi	glutathione reductase	0.0046	0.0459	0.1612
Mycobacterium ulcerans	fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE	0.0038	0.0345	0.1637
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0038	0.0345	0.0345
Mycobacterium tuberculosis	Probable dehydrogenase	0.0105	0.1358	0.386
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0044	0.0434	0.0434
Trypanosoma cruzi	trypanothione reductase, putative	0.0046	0.0459	0.1086
Trypanosoma cruzi	hypothetical protein, conserved	0.0038	0.0345	0.0818
Echinococcus multilocularis	lamin dm0	0.0029	0.0198	0.0198
Plasmodium falciparum	LCCL domain-containing protein	0.0019	0.0049	0.1078
Toxoplasma gondii	ABC1 family protein	0.0038	0.0345	0.7235
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0097	0.1247	0.438
Echinococcus granulosus	beta LACTamase domain containing family member	0.0038	0.0345	0.0345
Plasmodium vivax	glutathione reductase, putative	0.0046	0.0459	1
Giardia lamblia	Kinesin-5	0.0026	0.0152	1
Plasmodium vivax	ataxin-2 like protein, putative	0.0027	0.0169	0.3682
Brugia malayi	beta-lactamase family protein	0.0038	0.0345	0.1214
Mycobacterium tuberculosis	Probable oxidoreductase	0.0116	0.1536	0.4368
Brugia malayi	beta-lactamase	0.0038	0.0345	0.1214
Echinococcus granulosus	lamin	0.0029	0.0198	0.0198
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0044	0.0434	0.0434
Loa Loa (eye worm)	3-hydroxyacyl-CoA dehydrogenase type II	0.0052	0.0551	0.1793
Schistosoma mansoni	lamin	0.0029	0.0198	0.0198
Schistosoma mansoni	microtubule-associated protein tau	0.0669	1	1
Mycobacterium tuberculosis	Probable membrane NADH dehydrogenase NdhA	0.0105	0.1358	0.386
Plasmodium falciparum	thioredoxin reductase	0.0046	0.0459	1
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0097	0.1247	0.4281
Schistosoma mansoni	transient receptor potential cation channel subfamily A member	0.0158	0.218	0.218
Echinococcus multilocularis	lipoxygenase domain containing protein	0.0019	0.0049	0.0049
Echinococcus multilocularis	ankyrin repeat protein	0.0158	0.218	0.218
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0031	0.0228	0.0228
Toxoplasma gondii	thioredoxin reductase	0.0046	0.0459	0.9606
Loa Loa (eye worm)	thioredoxin reductase	0.0046	0.0459	0.1463
Echinococcus granulosus	3 hydroxyacyl coenzyme A dehydrogenase type 2	0.0059	0.0666	0.0666
Echinococcus granulosus	ankyrin repeat protein	0.0158	0.218	0.218
Brugia malayi	latrophilin 2 splice variant baaae	0.0067	0.0775	0.2724
Brugia malayi	Intermediate filament tail domain containing protein	0.0029	0.0198	0.0695
Echinococcus granulosus	transient receptor potential cation channel	0.0163	0.2254	0.2254
Treponema pallidum	NADH oxidase	0.0016	0	0.5
Onchocerca volvulus		0.0029	0.0198	0.0459
Leishmania major	hypothetical protein, conserved	0.0038	0.0345	0.0818
Plasmodium falciparum	glutathione reductase	0.0046	0.0459	1
Echinococcus multilocularis	thioredoxin glutathione reductase	0.0046	0.0459	0.0459
Leishmania major	trypanothione reductase	0.0046	0.0459	0.1086
Schistosoma mansoni	loxhd1	0.0019	0.0049	0.0049
Echinococcus granulosus	arachidonate 5 lipoxygenase	0.0054	0.0576	0.0576
Mycobacterium tuberculosis	Conserved protein	0.0038	0.0345	0.0982
Mycobacterium tuberculosis	Probable esterase/lipase LipP	0.0038	0.0345	0.0982
Trypanosoma cruzi	mitochondrial DNA polymerase beta, putative	0.0292	0.4225	1
Loa Loa (eye worm)	intermediate filament protein	0.0029	0.0198	0.053
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0169	0.0427
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0228	0.0639
Schistosoma mansoni	rab6-interacting	0.0019	0.0049	0.0049
Brugia malayi	hypothetical protein	0.0019	0.0049	0.0174
Schistosoma mansoni	histone-lysine n-methyltransferase suv9	0.0029	0.02	0.02
Plasmodium vivax	hypothetical protein, conserved	0.0038	0.0345	0.7531
Onchocerca volvulus		0.0038	0.0345	0.0917
Leishmania major	hypothetical protein, conserved	0.0027	0.0169	0.04
Wolbachia endosymbiont of Brugia malayi	dihydrolipoamide dehydrogenase E3 component	0.0016	0	0.5
Leishmania major	3-oxoacyl-(acyl-carrier protein) reductase, putative	0.0059	0.0666	0.1575
Echinococcus granulosus	RUN	0.0019	0.0049	0.0049
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0029	0.02	0.02
Toxoplasma gondii	histone lysine methyltransferase SET/SUV39	0.0029	0.02	0.4186
Schistosoma mansoni	kinesin eg-5	0.0026	0.0152	0.0152
Mycobacterium ulcerans	hypothetical protein	0.0154	0.211	1
Mycobacterium ulcerans	esterase/lipase LipP	0.0038	0.0345	0.1637
Brugia malayi	Kinesin motor domain containing protein	0.0026	0.0152	0.0534
Brugia malayi	Doublecortin family protein	0.0019	0.0049	0.0174
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0031	0.0228	0.0639
Echinococcus multilocularis	lipoxygenase domain containing protein	0.0019	0.0049	0.0049
Brugia malayi	Pre-SET motif family protein	0.0202	0.2846	1
Trypanosoma cruzi	mitochondrial DNA polymerase beta-PAK, putative	0.0138	0.1871	0.4429
Brugia malayi	intermediate filament protein	0.0029	0.0198	0.0695
Schistosoma mansoni	hypothetical protein	0.0166	0.2306	0.2306
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0198	0.053
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0345	0.1058
Echinococcus multilocularis	transient receptor potential cation channel	0.0163	0.2258	0.2258
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0044	0.0434	0.0434
Brugia malayi	3-hydroxyacyl-CoA dehydrogenase type II	0.0059	0.0666	0.2339
Mycobacterium tuberculosis	Conserved protein	0.0038	0.0345	0.0982
Trypanosoma cruzi	mitochondrial DNA polymerase beta-PAK, putative	0.005	0.0523	0.1237
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0029	0.02	0.02
Echinococcus multilocularis	lamin	0.0029	0.0198	0.0198
Mycobacterium tuberculosis	NAD(P)H quinone reductase LpdA	0.0116	0.1536	0.4368
Trypanosoma cruzi	DNA polymerase beta thumb, putative	0.0041	0.0385	0.0911
Leishmania major	mitochondrial DNA polymerase beta	0.0292	0.4225	1
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0154	0.211	0.5999
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0345	0.1058
Mycobacterium leprae	PROBABLE NADH DEHYDROGENASE NDH	0.0105	0.1358	0.85
Schistosoma mansoni	hypothetical protein	0.0067	0.0775	0.0775
Trypanosoma cruzi	mitochondrial DNA polymerase beta, putative	0.0292	0.4225	1
Loa Loa (eye worm)	hypothetical protein	0.0067	0.0775	0.2595
Mycobacterium tuberculosis	Probable NADH dehydrogenase Ndh	0.0105	0.1358	0.386
Trypanosoma cruzi	DNA polymerase beta thumb, putative	0.0041	0.0385	0.0911
Plasmodium falciparum	ataxin-2 like protein, putative	0.0027	0.0169	0.3682
Trichomonas vaginalis	D-aminoacylase, putative	0.0038	0.0345	0.1055
Plasmodium vivax	thioredoxin reductase, putative	0.0046	0.0459	1
Mycobacterium tuberculosis	Probable conserved lipoprotein	0.0038	0.0345	0.0982
Mycobacterium tuberculosis	Probable hydrolase	0.0038	0.0345	0.0982
Trichomonas vaginalis	set domain proteins, putative	0.023	0.3273	1
Trichomonas vaginalis	D-aminoacylase, putative	0.0038	0.0345	0.1055
Chlamydia trachomatis	dihydrolipoyl dehydrogenase	0.0016	0	0.5
Echinococcus multilocularis	geminin	0.0166	0.2306	0.2306
Plasmodium vivax	SET domain protein, putative	0.0029	0.02	0.4358
Onchocerca volvulus		0.023	0.3277	1
Echinococcus multilocularis	microtubule associated protein 2	0.0669	1	1
Echinococcus granulosus	lamin dm0	0.0029	0.0198	0.0198
Schistosoma mansoni	hypothetical protein	0.0019	0.0049	0.0049
Trypanosoma brucei	mitochondrial DNA polymerase beta	0.0292	0.4225	1
Loa Loa (eye worm)	glutathione reductase	0.0046	0.0459	0.1463
Echinococcus multilocularis	Polycystic kidney disease protein	0.0019	0.0049	0.0049
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0029	0.02	0.02
Mycobacterium tuberculosis	Probable lipase LipD	0.0038	0.0345	0.0982

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 1200 nM	Binding affinity in vivo for gamma-aminobutyric-acid A receptor measured by its ability to displace [3H]-GABA agonist from rat brain preparations after iv injection.	ChEMBL.	1331456
IC50 (binding)	= 1200 nM	Binding affinity in vivo for gamma-aminobutyric-acid A receptor measured by its ability to displace [3H]-GABA agonist from rat brain preparations after iv injection.	ChEMBL.	1331456

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

No external resources registered for this compound

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 228282