TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 446.924 | Formula: C15H6Cl6O3
H donors: 0 H acceptors: 2 LogP: 6.92 Rotable bonds: 5
Rule of 5 violations (Lipinski): 1
SMILES: Clc1cc(Cl)c(c(c1)Cl)CC(=O)C(=O)Oc1c(Cl)cc(cc1Cl)Cl
InChi: 1S/C15H6Cl6O3/c16-6-1-9(18)8(10(19)2-6)5-13(22)15(23)24-14-11(20)3-7(17)4-12(14)21/h1-4H,5H2
InChiKey: AHNWLWUINYRJBM-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	hypothetical protein	0.0096	0.0243	0.0243
Loa Loa (eye worm)	hypothetical protein	0.0096	0.0243	0.0243
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0096	0.0243	0.0243
Onchocerca volvulus		0.0096	0.0243	0.0663
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.0135	0.0377	0.0377
Loa Loa (eye worm)	hypothetical protein	0.0096	0.0243	0.0243
Plasmodium vivax	mitogen-activated protein kinase phosphatase 1, putative	0.0025	0	0.5
Trichomonas vaginalis	m-phase inducer phosphatase, putative	0.0323	0.1024	1
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.0096	0.0243	0.0243
Entamoeba histolytica	protein tyrosine phosphatase, putative	0.0096	0.0243	0.2371
Entamoeba histolytica	rodhanase-like domain containing protein	0.0323	0.1024	1
Loa Loa (eye worm)	hypothetical protein	0.0096	0.0243	0.0243
Onchocerca volvulus		0.0096	0.0243	0.0663
Echinococcus multilocularis	hypothetical protein	0.0096	0.0243	0.0243
Brugia malayi	hypothetical protein	0.0096	0.0243	0.0243
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0096	0.0243	0.0243
Giardia lamblia	Protein tyrosine phosphatase	0.0096	0.0243	1
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0096	0.0243	0.0243
Trypanosoma cruzi	tyrosine specific protein phosphatase, putative	0.0125	0.0342	1
Loa Loa (eye worm)	hypothetical protein	0.0096	0.0243	0.0243
Brugia malayi	Matrix metalloprotease, N-terminal domain containing protein	0.0079	0.0185	0.0185
Onchocerca volvulus		0.0323	0.1024	0.2795
Loa Loa (eye worm)	hypothetical protein	0.0096	0.0243	0.0243
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0096	0.0243	0.0243
Schistosoma mansoni	receptor tyrosine phosphatase type r2a	0.0096	0.0243	0.0243
Brugia malayi	hypothetical protein	0.0096	0.0243	0.0243
Echinococcus multilocularis	protein tyrosine phosphatase n9	0.0096	0.0243	0.0243
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0096	0.0243	0.0243
Onchocerca volvulus	Matrix metalloproteinase homolog	0.0144	0.0409	0.1117
Onchocerca volvulus		0.0096	0.0243	0.0663
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0096	0.0243	0.0243
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.0096	0.0243	0.0243
Schistosoma mansoni	non-receptor protein-tyrosine phosphatase	0.0096	0.0243	0.0243
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0096	0.0243	0.0243
Schistosoma mansoni	rgs-gaip interacting protein gipc	0.0096	0.0243	0.0243
Echinococcus granulosus	Receptor type tyrosine protein phosphatase O	0.0096	0.0243	0.0243
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0096	0.0243	0.0243
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0096	0.0243	0.0243
Schistosoma mansoni	receptor protein tyrosine phosphatase n (ia2)	0.0096	0.0243	0.0243
Onchocerca volvulus		0.0125	0.0342	0.0933
Loa Loa (eye worm)	hypothetical protein	0.0096	0.0243	0.0243
Onchocerca volvulus		0.0096	0.0243	0.0663
Trichomonas vaginalis	cdc25b, putative	0.0323	0.1024	1
Schistosoma mansoni	m-phase inducer phosphatase(cdc25)	0.0323	0.1024	0.1024
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.0096	0.0243	0.0243
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0096	0.0243	0.0243
Loa Loa (eye worm)	hypothetical protein	0.0298	0.0937	0.0937
Echinococcus multilocularis		0.0096	0.0243	0.0243
Schistosoma mansoni	hypothetical protein	0.0092	0.023	0.023
Echinococcus granulosus	receptor type tyrosine protein phosphatase zeta	0.0102	0.0262	0.0262
Entamoeba histolytica	protein tyrosine phosphatase, putative	0.0096	0.0243	0.2371
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0096	0.0243	0.0243
Loa Loa (eye worm)	hypothetical protein	0.0096	0.0243	0.0243
Loa Loa (eye worm)	hypothetical protein	0.0096	0.0243	0.0243
Onchocerca volvulus		0.0096	0.0243	0.0663
Trichomonas vaginalis	cdc25b, putative	0.0323	0.1024	1
Schistosoma mansoni	protein-tyrosine phosphatase n9	0.0096	0.0243	0.0243
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0096	0.0243	0.0243
Schistosoma mansoni	protein tyrosine phosphatase	0.0096	0.0243	0.0243
Echinococcus multilocularis	Receptor type tyrosine protein phosphatase O	0.0125	0.0342	0.0342
Loa Loa (eye worm)	hypothetical protein	0.0096	0.0243	0.0243
Onchocerca volvulus		0.0096	0.0243	0.0663
Echinococcus granulosus	Receptor type tyrosine protein phosphatase O	0.0096	0.0243	0.0243
Onchocerca volvulus		0.0323	0.1024	0.2795
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0096	0.0243	0.0243
Loa Loa (eye worm)	hypothetical protein	0.0096	0.0243	0.0243
Loa Loa (eye worm)	fibronectin type III domain-containing protein	0.013	0.0361	0.0361
Echinococcus multilocularis	m phase inducer phosphatase(cdc25)	0.0323	0.1024	0.1024
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0096	0.0243	0.0243
Schistosoma mansoni	receptor protein tyrosine phosphatase n (ia2)	0.0096	0.0243	0.0243
Trypanosoma cruzi	tyrosine specific protein phosphatase, putative	0.0096	0.0243	0.7107
Onchocerca volvulus	Matrilysin homolog	0.0144	0.0409	0.1117
Onchocerca volvulus		0.0096	0.0243	0.0663
Loa Loa (eye worm)	hypothetical protein	0.0065	0.0137	0.0137
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0096	0.0243	0.0243
Onchocerca volvulus		0.0096	0.0243	0.0663
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0096	0.0243	0.0243
Trichomonas vaginalis	pten, drome, putative	0.0096	0.0243	0.2371
Loa Loa (eye worm)	hypothetical protein	0.0096	0.0243	0.0243
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0096	0.0243	0.0243
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.0096	0.0243	0.0243
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0096	0.0243	0.0243
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0096	0.0243	0.0243
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0096	0.0243	0.0243
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.0135	0.0377	0.0377
Onchocerca volvulus		0.0096	0.0243	0.0663
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0096	0.0243	0.0243
Brugia malayi	hypothetical protein	0.0096	0.0243	0.0243
Onchocerca volvulus		0.0096	0.0243	0.0663
Schistosoma mansoni	protein tyrosine phosphatase n11 (shp2)	0.0096	0.0243	0.0243
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0032	0.0032
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0096	0.0243	0.0243
Trypanosoma cruzi	tyrosine specific protein phosphatase, putative	0.0125	0.0342	1
Loa Loa (eye worm)	hypothetical protein	0.0065	0.0137	0.0137
Schistosoma mansoni	pcd6 interacting protein-related	0.0096	0.0243	0.0243
Trichomonas vaginalis	mitotic inducer phosphatase CDC25, putative	0.0323	0.1024	1
Schistosoma mansoni	receptor protein tyrosine phosphatase r (pcptp1)	0.0096	0.0243	0.0243
Plasmodium falciparum	mitogen-activated protein kinase phosphatase 1, putative	0.0025	0	0.5
Onchocerca volvulus	4.1 G protein, putative homolog	0.0096	0.0243	0.0663
Mycobacterium ulcerans	hydrolase	0.0079	0.0185	1
Onchocerca volvulus		0.0096	0.0243	0.0663
Onchocerca volvulus		0.1092	0.3662	1
Leishmania major	tyrosine specific protein phosphatase, putative	0.0125	0.0342	1
Loa Loa (eye worm)	hypothetical protein	0.0096	0.0243	0.0243
Schistosoma mansoni	receptor tyrosine phosphatase type r2a	0.013	0.0361	0.0361
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0096	0.0243	0.0243
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0096	0.0243	0.0243
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0096	0.0243	0.0243
Echinococcus multilocularis	matrix metallopeptidase 7 (M10 family)	0.0237	0.0726	0.0726
Brugia malayi	Matrixin family protein	0.0065	0.0137	0.0137
Onchocerca volvulus		0.0096	0.0243	0.0663
Onchocerca volvulus	Matrilysin homolog	0.0065	0.0137	0.0373
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0096	0.0243	0.0243
Onchocerca volvulus		0.0096	0.0243	0.0663
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0096	0.0243	0.0243
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0096	0.0243	0.0243
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0096	0.0243	0.0243
Brugia malayi	Protein-tyrosine phosphatase	0.0096	0.0243	0.0243
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0096	0.0243	0.0243
Onchocerca volvulus		0.1092	0.3662	1
Schistosoma mansoni	receptor protein tyrosine phosphatase	0.0102	0.0262	0.0262
Brugia malayi	Protein-tyrosine phosphatase	0.0102	0.0262	0.0262
Loa Loa (eye worm)	hypothetical protein	0.0079	0.0185	0.0185
Brugia malayi	protein-tyrosine phosphatase Lar-like precursor, putative	0.0125	0.0342	0.0342
Echinococcus multilocularis	receptor type tyrosine protein phosphatase protein tyrosine phosphatase receptor type	0.0096	0.0243	0.0243
Loa Loa (eye worm)	hypothetical protein	0.0096	0.0243	0.0243
Schistosoma mansoni	receptor tyrosine phosphatase type r2a	0.013	0.0361	0.0361
Loa Loa (eye worm)	hypothetical protein	0.0096	0.0243	0.0243
Echinococcus granulosus	m phase inducer phosphatasecdc25	0.0323	0.1024	0.1024
Echinococcus multilocularis	receptor type tyrosine protein phosphatase protein tyrosine phosphatase receptor type	0.013	0.0361	0.0361
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0096	0.0243	0.0243
Trichomonas vaginalis	cdc25c, putative	0.0323	0.1024	1
Brugia malayi	Matrixin family protein	0.0065	0.0137	0.0137
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0096	0.0243	0.0243
Plasmodium falciparum	rhodanese like protein, putative	0.0025	0	0.5
Schistosoma mansoni	protein tyrosine phosphatase	0.0102	0.0262	0.0262
Loa Loa (eye worm)	matrix metalloproteinase	0.0065	0.0137	0.0137
Loa Loa (eye worm)	matrixin family protein	0.0144	0.0409	0.0409
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0096	0.0243	0.0243
Mycobacterium leprae	PROBABLE HYDROLASE	0.0079	0.0185	1
Entamoeba histolytica	rodhanase-like domain containing protein	0.0323	0.1024	1
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0135	0.0377	0.0377
Entamoeba histolytica	rodhanase-like domain containing protein	0.0323	0.1024	1
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0096	0.0243	0.0243
Echinococcus multilocularis	Receptor type tyrosine protein phosphatase O	0.0125	0.0342	0.0342
Brugia malayi	Protein-tyrosine phosphatase 1	0.0096	0.0243	0.0243
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.2938	1	1
Loa Loa (eye worm)	hypothetical protein	0.0096	0.0243	0.0243
Brugia malayi	Rhodanese-like domain containing protein	0.0323	0.1024	0.1024
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0096	0.0243	0.0243
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0096	0.0243	0.0243
Brugia malayi	Matrixin family protein	0.0065	0.0137	0.0137
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0096	0.0243	0.0243
Echinococcus multilocularis	sortilin receptor	0.0029	0.0012	0.0012
Onchocerca volvulus		0.0096	0.0243	0.0663
Loa Loa (eye worm)	hypothetical protein	0.0096	0.0243	0.0243
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0096	0.0243	0.0243
Loa Loa (eye worm)	protein-tyrosine-phosphatase	0.0096	0.0243	0.0243
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0135	0.0377	0.0377
Schistosoma mansoni	protein tyrosine phosphatase	0.0096	0.0243	0.0243
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0028	0.0028
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0096	0.0243	0.0243
Toxoplasma gondii	rhodanese family domain-containing protein	0.0025	0	0.5
Loa Loa (eye worm)	protein-tyrosine phosphatase 1	0.0096	0.0243	0.0243
Onchocerca volvulus		0.0065	0.0137	0.0373
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0096	0.0243	0.0243
Echinococcus multilocularis	receptor type tyrosine protein phosphatase zeta	0.0096	0.0243	0.0243
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0096	0.0243	0.0243
Echinococcus granulosus	matrix metallopeptidase 7 M10 family	0.0237	0.0726	0.0726
Onchocerca volvulus		0.0096	0.0243	0.0663
Echinococcus multilocularis	receptor type tyrosine protein phosphatase H	0.0096	0.0243	0.0243
Onchocerca volvulus		0.0092	0.023	0.0628
Loa Loa (eye worm)	hypothetical protein	0.0096	0.0243	0.0243
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0096	0.0243	0.0243
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.1092	0.3662	0.3662
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.2938	1	1
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.2938	1	1
Brugia malayi	Hemopexin family protein	0.0092	0.023	0.023
Brugia malayi	hypothetical protein	0.0096	0.0243	0.0243
Echinococcus multilocularis	receptor type tyrosine protein phosphatase zeta	0.0102	0.0262	0.0262
Schistosoma mansoni	matrix metallopeptidase-7 (M10 family)	0.0065	0.0137	0.0137
Onchocerca volvulus		0.0096	0.0243	0.0663
Trichomonas vaginalis	mitotic inducer phosphatase CDC25, putative	0.0323	0.1024	1
Schistosoma mansoni	protein-tyrosine phosphatase non-receptor type nt5	0.0096	0.0243	0.0243
Loa Loa (eye worm)	hypothetical protein	0.0096	0.0243	0.0243
Onchocerca volvulus		0.0096	0.0243	0.0663
Onchocerca volvulus		0.0323	0.1024	0.2795
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0096	0.0243	0.0243
Chlamydia trachomatis	hypothetical protein	0.0025	0	0.5
Onchocerca volvulus		0.0096	0.0243	0.0663
Schistosoma mansoni	receptor tyrosine phosphatase type r2a	0.0102	0.0262	0.0262
Echinococcus multilocularis	receptor type tyrosine protein phosphatase F	0.0135	0.0377	0.0377
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.1092	0.3662	0.3662
Brugia malayi	Matrixin family protein	0.0157	0.0454	0.0454
Loa Loa (eye worm)	hypothetical protein	0.0096	0.0243	0.0243
Schistosoma mansoni	protein tyrosine phosphatase non-receptor type nt1	0.2938	1	1
Loa Loa (eye worm)	matrixin family protein	0.0157	0.0454	0.0454
Loa Loa (eye worm)	hypothetical protein	0.0096	0.0243	0.0243
Loa Loa (eye worm)	hypothetical protein	0.0323	0.1024	0.1024
Schistosoma mansoni	receptor tyrosine phosphatase type r2a	0.0135	0.0377	0.0377
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0102	0.0262	0.0262
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0096	0.0243	0.0243
Loa Loa (eye worm)	hypothetical protein	0.0298	0.0937	0.0937
Brugia malayi	Dual specificity protein phosphatase CDC14B	0.0096	0.0243	0.0243
Loa Loa (eye worm)	protein tyrosine phosphatase	0.0096	0.0243	0.0243
Loa Loa (eye worm)	dual specificity protein phosphatase CDC14B	0.0096	0.0243	0.0243
Echinococcus multilocularis	Receptor type tyrosine protein phosphatase O	0.013	0.0361	0.0361
Loa Loa (eye worm)	hypothetical protein	0.0096	0.0243	0.0243
Onchocerca volvulus		0.0096	0.0243	0.0663
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0096	0.0243	0.0243
Trichomonas vaginalis	m-phase inducer phosphatase, putative	0.0323	0.1024	1
Trichomonas vaginalis	mitotic inducer phosphatase CDC25, putative	0.0323	0.1024	1
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0096	0.0243	0.0243
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0096	0.0243	0.0243
Echinococcus granulosus	protein tyrosine phosphatase n9	0.0096	0.0243	0.0243
Brugia malayi	Rhodanese-like domain containing protein	0.0323	0.1024	0.1024
Onchocerca volvulus		0.0323	0.1024	0.2795
Wolbachia endosymbiont of Brugia malayi	sulfurtransferase	0.0025	0	0.5
Onchocerca volvulus		0.0096	0.0243	0.0663
Loa Loa (eye worm)	hypothetical protein	0.0096	0.0243	0.0243
Loa Loa (eye worm)	hypothetical protein	0.0096	0.0243	0.0243
Plasmodium vivax	rhodanese like protein, putative	0.0025	0	0.5
Echinococcus multilocularis	Receptor type tyrosine protein phosphatase O	0.0125	0.0342	0.0342
Brugia malayi	Matrixin family protein	0.0065	0.0137	0.0137
Leishmania major	protein-tyrosine phosphatase 1-like protein	0.0096	0.0243	0.7107
Trypanosoma brucei	protein tyrosine phosphatase 1	0.0096	0.0243	1
Loa Loa (eye worm)	hypothetical protein	0.0096	0.0243	0.0243
Loa Loa (eye worm)	hypothetical protein	0.0323	0.1024	0.1024
Loa Loa (eye worm)	hypothetical protein	0.0096	0.0243	0.0243
Brugia malayi	hypothetical protein	0.0096	0.0243	0.0243
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0096	0.0243	0.0243
Entamoeba histolytica	Pten 3-phosphoinositide phosphatase, putative	0.0096	0.0243	0.2371
Loa Loa (eye worm)	hypothetical protein	0.0065	0.0137	0.0137
Mycobacterium tuberculosis	Probable peptidoglycan hydrolase	0.0079	0.0185	1
Echinococcus granulosus	receptor type tyrosine protein phosphatase zeta	0.0096	0.0243	0.0243

Activities

Activity type	Activity value	Assay description	Source	Reference
Inhibition (binding)	0 %	In vitro inhibition of farnesyl transferase (FT) by using FT [3H]-SPA kit; IA is inactive	ChEMBL.	10669567

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

No external resources registered for this compound

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 228860