Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | aspartic protease BmAsp-2 | 0.0398 | 0.3164 | 1 |
Plasmodium vivax | glutathione reductase, putative | 0.0063 | 0.0279 | 0.0881 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0138 | 0.0923 | 0.0938 |
Echinococcus multilocularis | glycoprotein Antigen 5 | 0.0138 | 0.0923 | 0.0923 |
Loa Loa (eye worm) | hypothetical protein | 0.0138 | 0.0923 | 0.2916 |
Plasmodium falciparum | plasmepsin IV | 0.0398 | 0.3164 | 1 |
Echinococcus granulosus | transmembrane protease serine 3 | 0.0138 | 0.0923 | 0.0923 |
Schistosoma mansoni | subfamily A1A unassigned peptidase (A01 family) | 0.0094 | 0.0548 | 0.0557 |
Onchocerca volvulus | 0.0138 | 0.0923 | 1 | |
Trypanosoma cruzi | trypanothione reductase, putative | 0.0063 | 0.0279 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0138 | 0.0923 | 0.2916 |
Echinococcus granulosus | cathepsin d lysosomal aspartyl protease | 0.0398 | 0.3164 | 0.3164 |
Toxoplasma gondii | eukaryotic aspartyl protease superfamily protein | 0.0094 | 0.0548 | 0.1731 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0138 | 0.0923 | 0.0938 |
Echinococcus multilocularis | calpain A | 0.0055 | 0.0212 | 0.0212 |
Echinococcus granulosus | enteropeptidase | 0.0138 | 0.0923 | 0.0923 |
Plasmodium falciparum | plasmepsin II | 0.0398 | 0.3164 | 1 |
Plasmodium vivax | thioredoxin reductase, putative | 0.0063 | 0.0279 | 0.0881 |
Loa Loa (eye worm) | hypothetical protein | 0.0138 | 0.0923 | 0.2916 |
Schistosoma mansoni | subfamily A1A unassigned peptidase (A01 family) | 0.0094 | 0.0548 | 0.0557 |
Schistosoma mansoni | family C2 unassigned peptidase (C02 family) | 0.0053 | 0.0191 | 0.0195 |
Brugia malayi | aspartic protease BmAsp-2, identical | 0.0094 | 0.0548 | 0.5936 |
Plasmodium vivax | aspartyl protease, putative | 0.0094 | 0.0548 | 0.1731 |
Brugia malayi | Thioredoxin reductase | 0.0063 | 0.0279 | 0.302 |
Loa Loa (eye worm) | trypsin family protein | 0.0138 | 0.0923 | 0.2916 |
Plasmodium falciparum | plasmepsin V | 0.0094 | 0.0548 | 0.1731 |
Trichomonas vaginalis | Clan AA, family A1, cathepsin D-like aspartic peptidase | 0.0398 | 0.3164 | 1 |
Schistosoma mansoni | family C2 unassigned peptidase (C02 family) | 0.0055 | 0.0212 | 0.0215 |
Schistosoma mansoni | family C2 unassigned peptidase (C02 family) | 0.0055 | 0.0212 | 0.0215 |
Brugia malayi | Eukaryotic aspartyl protease family protein | 0.0094 | 0.0548 | 0.5936 |
Schistosoma mansoni | subfamily A1A unassigned peptidase (A01 family) | 0.0094 | 0.0548 | 0.0557 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0138 | 0.0923 | 0.0938 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0411 | 0.3273 | 1 |
Toxoplasma gondii | aspartyl protease | 0.0094 | 0.0548 | 0.1731 |
Trypanosoma brucei | trypanothione reductase | 0.0063 | 0.0279 | 0.3428 |
Echinococcus multilocularis | Peptidase S1 S6, chymotrypsin Hap | 0.0138 | 0.0923 | 0.0923 |
Mycobacterium ulcerans | hypothetical protein | 0.0411 | 0.3273 | 1 |
Brugia malayi | aspartic protease BmAsp-1, identical | 0.0094 | 0.0548 | 0.5936 |
Echinococcus granulosus | glycoprotein Antigen 5 | 0.0138 | 0.0923 | 0.0923 |
Echinococcus multilocularis | tachykinin peptides receptor 99D | 0.1193 | 1 | 1 |
Echinococcus multilocularis | subfamily S1A unassigned peptidase (S01 family) | 0.0138 | 0.0923 | 0.0923 |
Leishmania major | calcium channel protein, putative,ion transporter, putative | 0.0036 | 0.0051 | 0.1843 |
Brugia malayi | calpain family protein 1 | 0.0053 | 0.0191 | 0.2075 |
Echinococcus multilocularis | calpain family protein 1, d | 0.0039 | 0.0072 | 0.0072 |
Loa Loa (eye worm) | glutathione reductase | 0.0063 | 0.0279 | 0.0881 |
Plasmodium falciparum | glutathione reductase | 0.0063 | 0.0279 | 0.0881 |
Brugia malayi | Trypsin family protein | 0.0138 | 0.0923 | 1 |
Toxoplasma gondii | thioredoxin reductase | 0.0063 | 0.0279 | 0.0881 |
Plasmodium falciparum | plasmepsin VII | 0.0094 | 0.0548 | 0.1731 |
Onchocerca volvulus | 0.0138 | 0.0923 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0053 | 0.0191 | 0.0605 |
Echinococcus granulosus | sodium channel protein | 0.0036 | 0.0051 | 0.0051 |
Echinococcus multilocularis | enteropeptidase | 0.0138 | 0.0923 | 0.0923 |
Echinococcus multilocularis | family C2 unassigned peptidase (C02 family) | 0.0055 | 0.0212 | 0.0212 |
Echinococcus granulosus | thioredoxin glutathione reductase | 0.0063 | 0.0279 | 0.0279 |
Loa Loa (eye worm) | calpain family protein 1 | 0.0053 | 0.0191 | 0.0605 |
Schistosoma mansoni | subfamily A1A unassigned peptidase (A01 family) | 0.0094 | 0.0548 | 0.0557 |
Onchocerca volvulus | 0.0138 | 0.0923 | 1 | |
Plasmodium falciparum | plasmepsin III | 0.0094 | 0.0548 | 0.1731 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0138 | 0.0923 | 0.0938 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0138 | 0.0923 | 0.0938 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0138 | 0.0923 | 0.0938 |
Brugia malayi | glutathione reductase | 0.0063 | 0.0279 | 0.302 |
Plasmodium falciparum | plasmepsin I | 0.0398 | 0.3164 | 1 |
Echinococcus granulosus | voltage gated sodium channel Nav1 alpha subunit | 0.0036 | 0.0051 | 0.0051 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0138 | 0.0923 | 0.0938 |
Loa Loa (eye worm) | aspartic protease BmAsp-1 | 0.0094 | 0.0548 | 0.1731 |
Onchocerca volvulus | 0.0094 | 0.0548 | 0.5845 | |
Loa Loa (eye worm) | hypothetical protein | 0.0094 | 0.0548 | 0.1731 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0138 | 0.0923 | 0.0938 |
Plasmodium vivax | aspartyl proteinase, putative | 0.0094 | 0.0548 | 0.1731 |
Brugia malayi | Trypsin family protein | 0.0138 | 0.0923 | 1 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0138 | 0.0923 | 0.0938 |
Loa Loa (eye worm) | calpain family protein 1 | 0.0039 | 0.0072 | 0.0227 |
Loa Loa (eye worm) | hypothetical protein | 0.0094 | 0.0548 | 0.1731 |
Schistosoma mansoni | hypothetical protein | 0.0138 | 0.0923 | 0.0938 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0138 | 0.0923 | 0.0938 |
Brugia malayi | hypothetical protein | 0.0094 | 0.0548 | 0.5936 |
Giardia lamblia | Hypothetical protein | 0.0031 | 0 | 0.5 |
Schistosoma mansoni | cathepsin D (A01 family) | 0.1174 | 0.9841 | 1 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0138 | 0.0923 | 0.0938 |
Schistosoma mansoni | subfamily A1A unassigned peptidase (A01 family) | 0.0094 | 0.0548 | 0.0557 |
Echinococcus granulosus | Mastin | 0.0138 | 0.0923 | 0.0923 |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.0072 | 0.0227 |
Schistosoma mansoni | hypothetical protein | 0.0138 | 0.0923 | 0.0938 |
Echinococcus granulosus | calpain A | 0.0055 | 0.0212 | 0.0212 |
Plasmodium vivax | aspartyl protease, putative | 0.0094 | 0.0548 | 0.1731 |
Loa Loa (eye worm) | hypothetical protein | 0.0047 | 0.014 | 0.0442 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0138 | 0.0923 | 0.0938 |
Plasmodium vivax | plasmepsin IV, putative | 0.0398 | 0.3164 | 1 |
Onchocerca volvulus | 0.0138 | 0.0923 | 1 | |
Brugia malayi | Trypsin family protein | 0.0138 | 0.0923 | 1 |
Loa Loa (eye worm) | aspartyl protease 6 | 0.0094 | 0.0548 | 0.1731 |
Schistosoma mansoni | subfamily A1A unassigned peptidase (A01 family) | 0.0094 | 0.0548 | 0.0557 |
Brugia malayi | hypothetical protein | 0.0094 | 0.0548 | 0.5936 |
Schistosoma mansoni | subfamily A1A unassigned peptidase (A01 family) | 0.0094 | 0.0548 | 0.0557 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0138 | 0.0923 | 0.0938 |
Echinococcus multilocularis | thioredoxin glutathione reductase | 0.0063 | 0.0279 | 0.0279 |
Entamoeba histolytica | prefoldin subunit 6, putative | 0.0031 | 0 | 0.5 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0138 | 0.0923 | 0.0938 |
Schistosoma mansoni | cathepsin D (A01 family) | 0.1174 | 0.9841 | 1 |
Brugia malayi | Chymotrypsin-like protease CTRL-1 precursor | 0.0138 | 0.0923 | 1 |
Schistosoma mansoni | subfamily A1A unassigned peptidase (A01 family) | 0.0398 | 0.3164 | 0.3215 |
Loa Loa (eye worm) | hypothetical protein | 0.0398 | 0.3164 | 1 |
Plasmodium vivax | aspartyl proteinase, putative | 0.0398 | 0.3164 | 1 |
Onchocerca volvulus | 0.0094 | 0.0548 | 0.5845 | |
Schistosoma mansoni | memapsin-2 (A01 family) | 0.0094 | 0.0548 | 0.0557 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0138 | 0.0923 | 0.0938 |
Loa Loa (eye worm) | hypothetical protein | 0.0138 | 0.0923 | 0.2916 |
Toxoplasma gondii | aspartyl protease ASP3 | 0.0094 | 0.0548 | 0.1731 |
Plasmodium falciparum | plasmepsin VIII, putative | 0.0094 | 0.0548 | 0.1731 |
Echinococcus multilocularis | transmembrane protease serine 3 | 0.0138 | 0.0923 | 0.0923 |
Echinococcus multilocularis | Mastin | 0.0138 | 0.0923 | 0.0923 |
Plasmodium falciparum | plasmepsin VI | 0.0398 | 0.3164 | 1 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0138 | 0.0923 | 0.0938 |
Leishmania major | trypanothione reductase | 0.0063 | 0.0279 | 1 |
Brugia malayi | calpain family protein 1 | 0.0053 | 0.0191 | 0.2075 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0138 | 0.0923 | 0.0938 |
Brugia malayi | Trypsin family protein | 0.0138 | 0.0923 | 1 |
Echinococcus granulosus | family C2 unassigned peptidase C02 family | 0.0055 | 0.0212 | 0.0212 |
Toxoplasma gondii | aspartyl protease ASP1 | 0.0398 | 0.3164 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0138 | 0.0923 | 0.2916 |
Plasmodium vivax | plasmepsin V, putative | 0.0094 | 0.0548 | 0.1731 |
Schistosoma mansoni | aminopeptidase PILS (M01 family) | 0.0138 | 0.0923 | 0.0938 |
Plasmodium falciparum | plasmepsin X | 0.0094 | 0.0548 | 0.1731 |
Echinococcus granulosus | subfamily S1A unassigned peptidase S01 family | 0.0138 | 0.0923 | 0.0923 |
Plasmodium vivax | aspartyl protease, putative | 0.0094 | 0.0548 | 0.1731 |
Trypanosoma brucei | RNA helicase, putative | 0.0125 | 0.0813 | 1 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0138 | 0.0923 | 0.0938 |
Loa Loa (eye worm) | thioredoxin reductase | 0.0063 | 0.0279 | 0.0881 |
Schistosoma mansoni | subfamily A1A unassigned peptidase (A01 family) | 0.0094 | 0.0548 | 0.0557 |
Plasmodium falciparum | plasmepsin IX | 0.0094 | 0.0548 | 0.1731 |
Onchocerca volvulus | 0.0138 | 0.0923 | 1 | |
Brugia malayi | hypothetical protein | 0.0138 | 0.0923 | 1 |
Brugia malayi | Pepsin A precursor | 0.0094 | 0.0548 | 0.5936 |
Toxoplasma gondii | aspartyl proteinase (eimepsin), putative | 0.0398 | 0.3164 | 1 |
Brugia malayi | Trypsin-like protease protein 5 | 0.0138 | 0.0923 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0125 | 0.0813 | 0.0826 |
Onchocerca volvulus | 0.0138 | 0.0923 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0138 | 0.0923 | 0.2916 |
Loa Loa (eye worm) | hypothetical protein | 0.0138 | 0.0923 | 0.2916 |
Mycobacterium leprae | Conserved hypothetical protein | 0.0411 | 0.3273 | 0.5 |
Echinococcus multilocularis | sodium channel protein | 0.0036 | 0.0051 | 0.0051 |
Plasmodium falciparum | thioredoxin reductase | 0.0063 | 0.0279 | 0.0881 |
Echinococcus multilocularis | cathepsin d (lysosomal aspartyl protease) | 0.0398 | 0.3164 | 0.3164 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.002 | 0.0064 |
Echinococcus granulosus | Peptidase S1 S6 chymotrypsin Hap | 0.0138 | 0.0923 | 0.0923 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = -4.17 | Inhibitory activity against HIV-1 Integrase (HIV-1-IN) | ChEMBL. | 11831895 |
IC50 (binding) | = 68 uM | In vitro inhibitory activity against HIV-1 integrase. | ChEMBL. | 7473544 |
IC50 (binding) | = 68 uM | In vitro inhibitory activity against HIV-1 integrase. | ChEMBL. | 7473544 |
Log IC50 (binding) | = 4.17 | Inhibitory activity against HIV-1 Integrase (HIV-1-IN) | ChEMBL. | 11831895 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
2 literature references were collected for this gene.