Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | solute carrier family 18 (vesicular acetylcholine transporter), member 3 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Loa Loa (eye worm) | vesicular acetylcholine transporter unc-17 | Get druggable targets OG5_133283 | All targets in OG5_133283 |
Brugia malayi | vesicular acetylcholine transporter unc-17 | Get druggable targets OG5_133283 | All targets in OG5_133283 |
Schistosoma mansoni | vesicular acetylcholine transporter | Get druggable targets OG5_133283 | All targets in OG5_133283 |
Onchocerca volvulus | Vesicular acetylcholine transporter homolog | Get druggable targets OG5_133283 | All targets in OG5_133283 |
Echinococcus granulosus | vesicular acetylcholine transporter | Get druggable targets OG5_133283 | All targets in OG5_133283 |
Echinococcus multilocularis | vesicular acetylcholine transporter | Get druggable targets OG5_133283 | All targets in OG5_133283 |
Schistosoma japonicum | ko:K08155 MFS transporter, DHA1 family, solute carrier family 18 (vesicular, putative | Get druggable targets OG5_133283 | All targets in OG5_133283 |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | Abnormal catecholamine distribution protein 1 | solute carrier family 18 (vesicular acetylcholine transporter), member 3 | 532 aa | 504 aa | 34.3 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | peptidyl-prolyl cis-trans isomerase, putative | 0.0053 | 0.0669 | 1 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease | 0.0018 | 0.0147 | 0.1547 |
Mycobacterium ulcerans | FK-506 binding protein, peptidyl-prolyl cis-trans isomerase | 0.0053 | 0.0669 | 1 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease, putative | 0.0018 | 0.0147 | 0.1547 |
Schistosoma mansoni | immunophilin FK506 binding protein FKBP12 | 0.0053 | 0.0669 | 0.053 |
Loa Loa (eye worm) | hypothetical protein | 0.0046 | 0.0559 | 0.1436 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0012 | 0.0052 | 0.0133 |
Plasmodium vivax | 70 kDa peptidylprolyl isomerase, putative | 0.0053 | 0.0669 | 1 |
Entamoeba histolytica | peptidyl-prolyl cis-trans isomerase, FKBP-type , putative | 0.0053 | 0.0669 | 1 |
Trypanosoma cruzi | peptidyl-prolyl cis-trans isomerase, putative | 0.0053 | 0.0669 | 1 |
Leishmania major | fk506-binding protein 1-like protein | 0.0053 | 0.0669 | 1 |
Loa Loa (eye worm) | CYP4Cod1 | 0.0012 | 0.0052 | 0.0133 |
Treponema pallidum | peptidyl-prolyl cis-trans isomerase, FKBP-type, 22 kDa (fklB) | 0.0053 | 0.0669 | 1 |
Echinococcus multilocularis | peptidyl prolyl cis trans isomerase FKBP4 | 0.0053 | 0.0669 | 0.053 |
Loa Loa (eye worm) | FKBP-type peptidyl-prolyl cis-trans isomerase-12 | 0.0053 | 0.0669 | 0.1718 |
Loa Loa (eye worm) | exodeoxyribonuclease III family protein | 0.0018 | 0.0147 | 0.0379 |
Wolbachia endosymbiont of Brugia malayi | exonuclease III | 0.0018 | 0.0147 | 0.5 |
Schistosoma mansoni | immunophilin | 0.0053 | 0.0669 | 0.053 |
Leishmania major | peptidylprolyl isomerase-like protein | 0.0053 | 0.0669 | 1 |
Trypanosoma brucei | peptidyl-prolyl cis-trans isomerase, putative | 0.0053 | 0.0669 | 1 |
Echinococcus multilocularis | fk506 binding protein | 0.0053 | 0.0669 | 0.053 |
Trichomonas vaginalis | fk506-binding protein, putative | 0.0053 | 0.0669 | 1 |
Leishmania major | apurinic/apyrimidinic endonuclease-redox protein | 0.0018 | 0.0147 | 0.1547 |
Loa Loa (eye worm) | FKBP5 protein | 0.0053 | 0.0669 | 0.1718 |
Echinococcus multilocularis | peptidyl prolyl cis trans isomerase FKBP4 | 0.0046 | 0.0559 | 0.0418 |
Echinococcus granulosus | peptidyl prolyl cis trans isomerase FKBP1A | 0.0053 | 0.0669 | 0.053 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0012 | 0.0052 | 0.0133 |
Schistosoma mansoni | vesicular acetylcholine transporter | 0.0267 | 0.3895 | 0.3804 |
Echinococcus multilocularis | microtubule associated protein 2 | 0.0672 | 1 | 1 |
Brugia malayi | vesicular acetylcholine transporter unc-17 | 0.0267 | 0.3895 | 1 |
Schistosoma mansoni | immunophilin | 0.0053 | 0.0669 | 0.053 |
Brugia malayi | exodeoxyribonuclease III family protein | 0.0018 | 0.0147 | 0.0248 |
Trypanosoma brucei | apurinic/apyrimidinic endonuclease, putative | 0.0018 | 0.0147 | 0.1547 |
Trichomonas vaginalis | peptidylprolyl isomerase, putative | 0.0053 | 0.0669 | 1 |
Entamoeba histolytica | peptidyl-prolyl cis-trans isomerase, FKBP-type, putative | 0.0053 | 0.0669 | 1 |
Echinococcus granulosus | peptidyl prolyl cis trans isomerase FKBP4 | 0.0053 | 0.0669 | 0.053 |
Mycobacterium tuberculosis | Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) | 0.0018 | 0.0147 | 0.5 |
Trypanosoma cruzi | FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative | 0.0053 | 0.0669 | 1 |
Trypanosoma brucei | FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative | 0.0053 | 0.0669 | 1 |
Onchocerca volvulus | Vesicular acetylcholine transporter homolog | 0.0267 | 0.3895 | 0.5 |
Brugia malayi | FKBP-type peptidyl-prolyl cis-trans isomerase-59, BmFKBP59 | 0.0053 | 0.0669 | 0.1606 |
Trichomonas vaginalis | immunophilin, putative | 0.0053 | 0.0669 | 1 |
Toxoplasma gondii | exonuclease III APE | 0.0018 | 0.0147 | 0.5 |
Echinococcus granulosus | vesicular acetylcholine transporter | 0.0267 | 0.3895 | 0.3804 |
Trichomonas vaginalis | peptidylprolyl isomerase, putative | 0.0053 | 0.0669 | 1 |
Giardia lamblia | FKBP-type peptidyl-prolyl cis-trans isomerase | 0.0053 | 0.0669 | 1 |
Loa Loa (eye worm) | vesicular acetylcholine transporter unc-17 | 0.0267 | 0.3895 | 1 |
Brugia malayi | FKBP-type peptidyl-prolyl cis-trans isomerase-12, BmFKBP-12 | 0.0053 | 0.0669 | 0.1606 |
Trypanosoma cruzi | FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative | 0.0053 | 0.0669 | 1 |
Schistosoma mansoni | microtubule-associated protein tau | 0.0672 | 1 | 1 |
Giardia lamblia | 70 kDa peptidylprolyl isomerase, putative | 0.0053 | 0.0669 | 1 |
Echinococcus granulosus | peptidyl prolyl cis trans isomerase FKBP4 | 0.0046 | 0.0559 | 0.0418 |
Mycobacterium ulcerans | exodeoxyribonuclease III protein XthA | 0.0018 | 0.0147 | 0.1547 |
Schistosoma mansoni | immunophilin | 0.0046 | 0.0559 | 0.0418 |
Plasmodium falciparum | peptidyl-prolyl cis-trans isomerase FKBP35 | 0.0053 | 0.0669 | 1 |
Echinococcus multilocularis | vesicular acetylcholine transporter | 0.0267 | 0.3895 | 0.3804 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 400 nM | Inhibition of active transport of [3H]-Acetylcholine using purified Torpedo californica synaptic vesicles | ChEMBL. | 2724295 |
IC50 (binding) | = 400 nM | Inhibition of active transport of [3H]-Acetylcholine using purified Torpedo californica synaptic vesicles | ChEMBL. | 2724295 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.