TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 380.217 | Formula: C14H10BrN3O3S
H donors: 3 H acceptors: 5 LogP: 2.64 Rotable bonds: 4
Rule of 5 violations (Lipinski): 1
SMILES: Brc1cc(CNC(=O)c2cccs2)c2c(c1)nc(c(n2)O)O
InChi: 1S/C14H10BrN3O3S/c15-8-4-7(6-16-12(19)10-2-1-3-22-10)11-9(5-8)17-13(20)14(21)18-11/h1-5H,6H2,(H,16,19)(H,17,20)(H,18,21)
InChiKey: QAKGVBTUMLAEFY-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Rattus norvegicus	Glutamate (NMDA) receptor subunit zeta 1	Starlite/ChEMBL	References
Rattus norvegicus	Glutamate receptor ionotropic, AMPA	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Schistosoma mansoni	glutamate receptor NMDA	Get druggable targets OG5_133478	All targets in OG5_133478
Schistosoma japonicum	expressed protein	Get druggable targets OG5_133478	All targets in OG5_133478
Echinococcus multilocularis	glutamate receptor NMDA	Get druggable targets OG5_133478	All targets in OG5_133478
Echinococcus granulosus	nmda type glutamate receptor	Get druggable targets OG5_133478	All targets in OG5_133478
Echinococcus granulosus	glutamate receptor NMDA	Get druggable targets OG5_133478	All targets in OG5_133478
Schistosoma japonicum	Glutamate [NMDA] receptor subunit zeta-1 precursor, putative	Get druggable targets OG5_133478	All targets in OG5_133478
Schistosoma japonicum	Glutamate [NMDA] receptor subunit zeta-1 precursor, putative	Get druggable targets OG5_133478	All targets in OG5_133478
Echinococcus multilocularis	nmda type glutamate receptor	Get druggable targets OG5_133478	All targets in OG5_133478
Echinococcus granulosus	nmda type glutamate receptor	Get druggable targets OG5_133478	All targets in OG5_133478
Echinococcus multilocularis	nmda type glutamate receptor	Get druggable targets OG5_133478	All targets in OG5_133478
Schistosoma japonicum	Glutamate [NMDA] receptor subunit zeta-1 precursor, putative	Get druggable targets OG5_133478	All targets in OG5_133478

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Echinococcus multilocularis	glutamate receptor 2	Glutamate receptor ionotropic, AMPA	907 aa	868 aa	30.4 %
Drosophila melanogaster	Glutamate receptor IA	Glutamate (NMDA) receptor subunit zeta 1	938 aa	979 aa	23.7 %
Schistosoma mansoni	glutamate receptor kainate	Glutamate receptor ionotropic, AMPA	907 aa	753 aa	33.2 %
Echinococcus multilocularis	glutamate receptor, ionotrophic, AMPA 3	Glutamate receptor ionotropic, AMPA	907 aa	959 aa	30.9 %
Echinococcus granulosus	Glutamate receptor ionotropic kainate 2	Glutamate receptor ionotropic, AMPA	907 aa	809 aa	34.1 %
Drosophila melanogaster	NMDA receptor 2	Glutamate (NMDA) receptor subunit zeta 1	938 aa	878 aa	27.4 %
Onchocerca volvulus		Glutamate receptor ionotropic, AMPA	907 aa	796 aa	40.5 %
Echinococcus granulosus	glutamate receptor ionotrophic AMPA 3	Glutamate receptor ionotropic, AMPA	907 aa	948 aa	30.6 %
Echinococcus multilocularis	Glutamate receptor, ionotropic kainate 2	Glutamate receptor ionotropic, AMPA	907 aa	809 aa	33.6 %
Echinococcus granulosus	Glutamate receptor ionotropic kainate 2	Glutamate receptor ionotropic, AMPA	907 aa	888 aa	34.0 %
Drosophila melanogaster	Glutamate receptor IIB	Glutamate receptor ionotropic, AMPA	907 aa	863 aa	27.8 %
Echinococcus granulosus	glutamate receptor 2	Glutamate receptor ionotropic, AMPA	907 aa	875 aa	30.4 %
Echinococcus multilocularis	Glutamate receptor, ionotropic kainate 2	Glutamate receptor ionotropic, AMPA	907 aa	886 aa	34.2 %
Onchocerca volvulus	Putative 39S ribosomal protein L45, mitochondrial	Glutamate receptor ionotropic, AMPA	907 aa	799 aa	37.7 %
Echinococcus multilocularis	glutamate (NMDA) receptor subunit	Glutamate (NMDA) receptor subunit zeta 1	938 aa	822 aa	23.2 %
Echinococcus granulosus	Glutamate receptor ionotropic kainate 2	Glutamate receptor ionotropic, AMPA	907 aa	779 aa	33.4 %
Echinococcus multilocularis	Glutamate receptor, ionotropic kainate 2	Glutamate receptor ionotropic, AMPA	907 aa	779 aa	33.4 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Plasmodium falciparum	ataxin-2 like protein, putative	0.0027	0.0484	1
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.0018	0.011	0.0045
Echinococcus multilocularis	glutamate receptor subunit protein glur	0.002	0.0193	0.0178
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.0018	0.011	0.0053
Schistosoma mansoni	glutamate receptor NMDA	0.0145	0.5398	1
Leishmania major	hypothetical protein, conserved	0.0027	0.0484	1
Brugia malayi	Steroid receptor seven-up type 2	0.0018	0.011	0.0127
Brugia malayi	Pre-SET motif family protein	0.0224	0.8707	1
Echinococcus multilocularis	ecdysone induced protein 78C	0.0018	0.011	0.0045
Loa Loa (eye worm)	hypothetical protein	0.0018	0.011	0.0127
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0084	0.2854	0.4438
Echinococcus multilocularis	glutamate (NMDA) receptor subunit	0.0039	0.099	0.1453
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.0018	0.011	0.0127
Brugia malayi	photoreceptor-specific nuclear receptor	0.0018	0.011	0.0127
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0084	0.2854	0.3278
Echinococcus multilocularis	nmda type glutamate receptor	0.0167	0.6328	1
Echinococcus multilocularis	GPCR, family 2	0.0047	0.1307	0.1961
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0018	0.011	0.0045
Echinococcus multilocularis	Ribosomal protein S1, RNA binding domain	0.002	0.0193	0.0178
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0018	0.011	0.0127
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0032	0.0693	0.1149
Brugia malayi	Pre-SET motif family protein	0.0032	0.0693	0.0795
Echinococcus granulosus	glutamate receptor ionotrophic AMPA 3	0.005	0.1422	0.2145
Schistosoma mansoni	hypothetical protein	0.0047	0.1307	0.2305
Echinococcus granulosus	nmda type glutamate receptor	0.0106	0.3758	0.5886
Schistosoma mansoni	thyroid hormone receptor	0.0018	0.011	0.0053
Brugia malayi	MH2 domain containing protein	0.0129	0.4718	0.5418
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0148	0.5534	0.6356
Brugia malayi	ecdysteroid receptor	0.0018	0.011	0.0127
Echinococcus granulosus	intermediate filament protein	0.0029	0.0563	0.077
Schistosoma mansoni	hypothetical protein	0.0047	0.1307	0.2305
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0148	0.5534	0.6356
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.0018	0.011	0.0127
Plasmodium vivax	ataxin-2 like protein, putative	0.0027	0.0484	0.658
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.0018	0.011	0.0053
Wolbachia endosymbiont of Brugia malayi	exonuclease III	0.0018	0.0082	0.5
Brugia malayi	Glutamate receptor 1 precursor	0.0039	0.099	0.1137
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.0018	0.011	0.0127
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0018	0.011	0.0045
Echinococcus multilocularis	lamin	0.0029	0.0563	0.077
Schistosoma mansoni	hypothetical protein	0.0047	0.1307	0.2305
Echinococcus granulosus	FTZ F1 alpha	0.0018	0.011	0.0045
Schistosoma mansoni	intermediate filament proteins	0.0029	0.0563	0.0905
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0047	0.1307	0.1961
Schistosoma mansoni	lamin	0.0029	0.0563	0.0905
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0693	0.0795
Brugia malayi	hypothetical protein	0.0034	0.0781	0.0897
Onchocerca volvulus		0.0029	0.0563	0.0458
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.0018	0.011	0.0045
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0047	0.1307	0.1961
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0018	0.011	0.0127
Loa Loa (eye worm)	hypothetical protein	0.0148	0.5534	0.6356
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0018	0.011	0.0127
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0018	0.011	0.0045
Schistosoma mansoni	glutamate receptor kainate	0.0039	0.099	0.1708
Brugia malayi	hypothetical protein	0.0027	0.0484	0.0556
Echinococcus multilocularis	glutamate receptor 2	0.005	0.1422	0.2145
Schistosoma mansoni	glutamate receptor NMDA	0.0039	0.099	0.1708
Schistosoma mansoni	hypothetical protein	0.0101	0.3577	0.6576
Echinococcus multilocularis	glutamate receptor 2	0.0029	0.0579	0.0796
Brugia malayi	latrophilin 2 splice variant baaae	0.0101	0.3577	0.4109
Entamoeba histolytica	hypothetical protein	0.0034	0.0781	1
Echinococcus multilocularis	glutamate receptor, ionotrophic, AMPA 3	0.005	0.1422	0.2145
Loa Loa (eye worm)	hypothetical protein	0.0018	0.011	0.0127
Loa Loa (eye worm)	hypothetical protein	0.0018	0.011	0.0127
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0563	0.0646
Loa Loa (eye worm)	hypothetical protein	0.0018	0.011	0.0127
Schistosoma mansoni	coup transcription factor	0.0018	0.011	0.0053
Loa Loa (eye worm)	exodeoxyribonuclease III family protein	0.0018	0.0082	0.0094
Echinococcus multilocularis	Glutamate receptor, ionotropic kainate 2	0.005	0.1422	0.2145
Loa Loa (eye worm)	hypothetical protein	0.0018	0.011	0.0127
Toxoplasma gondii	histone lysine methyltransferase SET/SUV39	0.0032	0.0693	1
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.0018	0.011	0.0045
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.0018	0.011	0.0045
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0148	0.5534	0.6356
Mycobacterium tuberculosis	Probable glutamine-binding lipoprotein GlnH (GLNBP)	0.0052	0.151	1
Brugia malayi	nuclear receptor NHR-88	0.0018	0.011	0.0127
Schistosoma mansoni	steroid hormone receptor ad4bp	0.0018	0.011	0.0053
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0032	0.0693	0.1149
Echinococcus granulosus	ecdysone induced protein 78C	0.0018	0.011	0.0045
Giardia lamblia	Endonuclease/Exonuclease/phosphatase	0.0018	0.0082	0.5
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0047	0.1307	0.1961
Brugia malayi	Latrophilin receptor protein 2	0.0047	0.1307	0.1501
Entamoeba histolytica	hypothetical protein	0.0034	0.0781	1
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.0018	0.011	0.0127
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.0018	0.011	0.0045
Trypanosoma cruzi	PAB1-binding protein , putative	0.0027	0.0484	1
Schistosoma mansoni	thyroid hormone receptor	0.0018	0.011	0.0053
Echinococcus multilocularis	histone lysine N methyltransferase SETMAR	0.0032	0.0693	0.0978
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0084	0.2854	0.3278
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	0.0029	0.0563	0.0646
Echinococcus multilocularis	histone lysine methyltransferase setb histone lysine methyltransferase eggless	0.0032	0.0693	0.0978
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0084	0.2854	0.4438
Echinococcus multilocularis	glutamate receptor ionotropic kainate	0.002	0.0193	0.0178
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.0018	0.011	0.0127
Schistosoma mansoni	retinoic acid receptor RXR	0.0018	0.011	0.0053
Loa Loa (eye worm)	hypothetical protein	0.0018	0.011	0.0127
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0084	0.2854	0.5215
Schistosoma mansoni	glutamate receptor AMPA	0.0039	0.099	0.1708
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.0018	0.011	0.0127
Schistosoma mansoni	nuclear hormone receptor	0.0018	0.011	0.0053
Brugia malayi	Glutamate receptor 2 precursor	0.0039	0.099	0.1137
Echinococcus multilocularis	Glutamate receptor, ionotropic kainate 2	0.005	0.1422	0.2145
Entamoeba histolytica	hypothetical protein	0.0034	0.0781	1
Echinococcus multilocularis	lamin dm0	0.0029	0.0563	0.077
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0018	0.011	0.0127
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.0018	0.011	0.0127
Treponema pallidum	amino acid ABC transporter, periplasmic binding protein (hisJ)	0.0052	0.151	1
Echinococcus granulosus	glutamate receptor NMDA	0.0095	0.3327	0.5194
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0084	0.2854	0.5215
Echinococcus multilocularis	Glutamate receptor, ionotropic kainate 2	0.005	0.1422	0.2145
Trypanosoma cruzi	PAB1-binding protein , putative	0.0027	0.0484	1
Echinococcus granulosus	GPCR family 2	0.0047	0.1307	0.1961
Echinococcus granulosus	glutamate receptor 2	0.005	0.1422	0.2145
Schistosoma mansoni	glutamate receptor kainate	0.0039	0.099	0.1708
Toxoplasma gondii	LsmAD domain-containing protein	0.0027	0.0484	0.658
Schistosoma mansoni	lamin	0.0029	0.0563	0.0905
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.0018	0.011	0.0127
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.0018	0.011	0.0045
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0034	0.0781	0.1119
Schistosoma mansoni	hypothetical protein	0.0034	0.0781	0.1315
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0032	0.0693	0.1149
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.0018	0.011	0.0045
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0047	0.1307	0.1961
Brugia malayi	Nuclear hormone receptor-like 1	0.0018	0.011	0.0127
Brugia malayi	intermediate filament protein	0.0029	0.0563	0.0646
Echinococcus multilocularis	FTZ F1 alpha	0.0018	0.011	0.0045
Echinococcus granulosus	Glutamate receptor ionotropic kainate 2	0.005	0.1422	0.2145
Loa Loa (eye worm)	glutamate receptor 1	0.0039	0.099	0.1137
Schistosoma mansoni	RAR-like nuclear receptor	0.0018	0.011	0.0053
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0047	0.1307	0.1501
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0018	0.011	0.0127
Loa Loa (eye worm)	hypothetical protein	0.0101	0.3577	0.4109
Echinococcus granulosus	glutamate receptor subunit protein glur	0.002	0.0193	0.0178
Brugia malayi	exodeoxyribonuclease III family protein	0.0018	0.0082	0.0094
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.0018	0.011	0.0053
Echinococcus multilocularis	nmda type glutamate receptor	0.0106	0.3758	0.5886
Echinococcus granulosus	glutamate receptor 2	0.0029	0.0579	0.0796
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.0018	0.011	0.0127
Echinococcus multilocularis	glutamate receptor NMDA	0.0095	0.3327	0.5194
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0018	0.011	0.0045
Trichomonas vaginalis	set domain proteins, putative	0.0255	1	1
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0084	0.2854	0.5215
Mycobacterium ulcerans	glutamine-binding lipoprotein GlnH	0.0052	0.151	1
Echinococcus multilocularis	Glutamate receptor, ionotropic kainate 3	0.0072	0.2352	0.3635
Loa Loa (eye worm)	glutamate receptor 2	0.0039	0.099	0.1137
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0084	0.2854	0.4438
Echinococcus multilocularis	NMDA receptor	0.002	0.0193	0.0178
Echinococcus granulosus	lamin	0.0029	0.0563	0.077
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0018	0.011	0.0053
Onchocerca volvulus		0.0029	0.0563	0.0458
Echinococcus multilocularis	glutamate receptor 2	0.0039	0.099	0.1453
Loa Loa (eye worm)	transcription factor SMAD2	0.0129	0.4718	0.5418
Entamoeba histolytica	hypothetical protein	0.0034	0.0781	1
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0484	0.0556
Schistosoma mansoni	ATP-binding cassette transporter	0.0039	0.099	0.1708
Echinococcus granulosus	Ribosomal protein S1 RNA binding domain	0.002	0.0193	0.0178
Schistosoma mansoni	hypothetical protein	0.0047	0.1307	0.2305
Onchocerca volvulus		0.0032	0.0693	0.0589
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0034	0.0781	0.1119
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.0224	0.8707	1
Echinococcus granulosus	Glutamate receptor ionotropic kainate 2	0.005	0.1422	0.2145
Loa Loa (eye worm)	MH2 domain-containing protein	0.0129	0.4718	0.5418
Brugia malayi	Intermediate filament tail domain containing protein	0.0029	0.0563	0.0646
Schistosoma mansoni	glutamate receptor kainate	0.0039	0.099	0.1708
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.0018	0.011	0.0045
Echinococcus granulosus	glutamate receptor ionotropic kainate	0.002	0.0193	0.0178
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.0018	0.011	0.0053
Chlamydia trachomatis	glutamine binding protein	0.0052	0.151	0.5
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.0018	0.011	0.0053
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.0018	0.011	0.0045
Treponema pallidum	amino acid ABC transporter, periplasmic binding protein	0.0052	0.151	1
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0541	0.0621
Echinococcus granulosus	nmda type glutamate receptor	0.0167	0.6328	1
Echinococcus granulosus	5'partial\|histone lysine N methyltransferase SETDB2	0.0031	0.0643	0.0899
Echinococcus granulosus	histone lysine methyltransferase setb	0.0032	0.0693	0.0978
Echinococcus multilocularis	musashi	0.0029	0.0563	0.077
Brugia malayi	steroid hormone receptor	0.0018	0.011	0.0127
Plasmodium vivax	SET domain protein, putative	0.0032	0.0693	1
Echinococcus granulosus	glutamate NMDA receptor subunit	0.0039	0.099	0.1453
Plasmodium falciparum	ataxin-2 like protein, putative	0.0027	0.0484	1
Loa Loa (eye worm)	hypothetical protein	0.0018	0.011	0.0127
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0084	0.2854	0.4438
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0047	0.1307	0.1501
Schistosoma mansoni	transcription factor LCR-F1	0.0034	0.0781	0.1315
Loa Loa (eye worm)	intermediate filament protein	0.0029	0.0563	0.0646
Loa Loa (eye worm)	hypothetical protein	0.0018	0.011	0.0127
Schistosoma mansoni	glutamate receptor AMPA	0.0039	0.099	0.1708
Brugia malayi	nuclear hormone receptor	0.0018	0.011	0.0127
Brugia malayi	hypothetical protein	0.0018	0.0082	0.0094
Chlamydia trachomatis	arginine ABC transporter substrate-binding protein ArtJ	0.0052	0.151	0.5
Trypanosoma brucei	PAB1-binding protein , putative	0.0027	0.0484	1
Loa Loa (eye worm)	steroid hormone receptor	0.0018	0.011	0.0127
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0018	0.011	0.0045
Echinococcus granulosus	Glutamate receptor ionotropic kainate 2	0.005	0.1422	0.2145
Echinococcus granulosus	glutamate receptor ionotropic kainate 3	0.002	0.0193	0.0178
Schistosoma mansoni	hypothetical protein	0.002	0.0193	0.0209
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0018	0.011	0.0127
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.0018	0.011	0.0127
Schistosoma mansoni	histone-lysine n-methyltransferase suv9	0.0032	0.0693	0.1149
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.0018	0.011	0.0127
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.0018	0.011	0.0127
Loa Loa (eye worm)	hypothetical protein	0.0047	0.1307	0.1501
Echinococcus granulosus	lamin dm0	0.0029	0.0563	0.077
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.0018	0.011	0.0127
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.0018	0.011	0.0127

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 0.01 uM	In vitro binding assay for the displacement of [3H]-MDL-105,519 from the glycine-site of NMDA receptors	ChEMBL.	9871605
IC50 (binding)	= 0.01 uM	In vitro binding assay for the displacement of [3H]-MDL-105,519 from the glycine-site of NMDA receptors	ChEMBL.	9871605
IC50 (binding)	= 1.6 uM	In vitro binding assay for the displacement of [3H]-AMPA from AMPA receptor	ChEMBL.	9871605
IC50 (binding)	= 1.6 uM	In vitro binding assay for the displacement of [3H]-AMPA from AMPA receptor	ChEMBL.	9871605

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL343863

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 251491