Detailed information for compound 254679

Basic information

Technical information
  • TDR Targets ID: 254679
  • Name: 2,5-diethyl-4-[(5-methyl-1H-imidazol-4-yl)met hyl]-1,3-thiazole
  • MW: 235.348 | Formula: C12H17N3S
  • H donors: 1 H acceptors: 2 LogP: 3.15 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCc1sc(nc1Cc1[nH]cnc1C)CC
  • InChi: 1S/C12H17N3S/c1-4-11-10(15-12(5-2)16-11)6-9-8(3)13-7-14-9/h7H,4-6H2,1-3H3,(H,13,14)
  • InChiKey: UGBRWRATXNXMJY-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2,5-diethyl-4-[(5-methyl-1H-imidazol-4-yl)methyl]thiazole

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Rattus norvegicus Adrenergic receptor alpha-2 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Schistosoma mansoni amine GPCR Adrenergic receptor alpha-2   450 aa 439 aa 29.2 %
Echinococcus multilocularis fmrfamide receptor Adrenergic receptor alpha-2   450 aa 366 aa 19.9 %
Echinococcus granulosus alpha 1A adrenergic receptor Adrenergic receptor alpha-2   450 aa 476 aa 21.0 %
Onchocerca volvulus Adrenergic receptor alpha-2   450 aa 420 aa 19.8 %
Loa Loa (eye worm) TYRA-2 protein Adrenergic receptor alpha-2   450 aa 488 aa 23.8 %
Schistosoma mansoni biogenic amine (5HT) receptor Adrenergic receptor alpha-2   450 aa 433 aa 27.9 %
Echinococcus multilocularis neuropeptides capa receptor Adrenergic receptor alpha-2   450 aa 486 aa 20.6 %
Onchocerca volvulus Adrenergic receptor alpha-2   450 aa 467 aa 25.1 %
Echinococcus multilocularis serotonin receptor Adrenergic receptor alpha-2   450 aa 426 aa 31.9 %
Schistosoma japonicum ko:K04145 dopamine receptor D2, putative Adrenergic receptor alpha-2   450 aa 473 aa 24.1 %
Schistosoma japonicum ko:K04207 neuropeptide Y receptor Y5, putative Adrenergic receptor alpha-2   450 aa 378 aa 20.9 %
Echinococcus granulosus biogenic amine 5HT receptor Adrenergic receptor alpha-2   450 aa 423 aa 31.7 %
Echinococcus multilocularis alpha 1A adrenergic receptor Adrenergic receptor alpha-2   450 aa 478 aa 20.7 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Entamoeba histolytica tubulin family protein 0.0091 0.0397 0.0383
Leishmania major carbonic anhydrase-like protein 0.0804 0.7957 0.8342
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0368 0.3334 0.4166
Mycobacterium tuberculosis Beta-carbonic anhydrase 0.064 0.6218 1
Loa Loa (eye worm) hypothetical protein 0.0336 0.2994 0.3737
Loa Loa (eye worm) beta-tubulin 0.0091 0.0397 0.046
Schistosoma mansoni nuclear hormone receptor 0.0159 0.1112 0.1136
Schistosoma mansoni nuclear hormone receptor 0.0336 0.2994 0.3117
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0336 0.2994 0.3737
Loa Loa (eye worm) hypothetical protein 0.0159 0.1112 0.1362
Trypanosoma brucei GMP reductase 0.0057 0.0036 0.0004
Echinococcus multilocularis Tubulin beta 2C chain 0.0091 0.0397 0.046
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0159 0.1112 0.1362
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0336 0.2994 0.3737
Schistosoma mansoni carbonic anhydrase-related 0.0368 0.3334 0.3475
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0336 0.2994 0.3737
Echinococcus granulosus tissue type plasminogen activator 0.0074 0.0219 0.0235
Schistosoma mansoni hypothetical protein 0.0368 0.3334 0.3475
Echinococcus granulosus FTZ F1 alpha 0.0336 0.2994 0.3737
Trypanosoma cruzi inosine-5'-monophosphate dehydrogenase, putative 0.0057 0.0036 0.0004
Leishmania major beta tubulin 0.0091 0.0397 0.0383
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0336 0.2994 0.3737
Trichomonas vaginalis tubulin, putative 0.0091 0.0397 0.0365
Echinococcus granulosus Tubulin beta 2C chain 0.0091 0.0397 0.046
Schistosoma mansoni hypothetical protein 0.0074 0.0219 0.0196
Toxoplasma gondii hypothetical protein 0.0368 0.3334 1
Toxoplasma gondii PAN domain-containing protein 0.0296 0.2564 0.767
Leishmania major beta tubulin 0.0091 0.0397 0.0383
Toxoplasma gondii PAN domain-containing protein 0.0296 0.2564 0.767
Loa Loa (eye worm) hypothetical protein 0.0336 0.2994 0.3737
Schistosoma mansoni thyroid hormone receptor 0.0336 0.2994 0.3117
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0336 0.2994 0.3737
Echinococcus multilocularis Tubulin beta 2C chain 0.0091 0.0397 0.046
Echinococcus multilocularis nuclear receptor nhr 48 0.0159 0.1112 0.1362
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0336 0.2994 0.3737
Mycobacterium leprae CARBONIC ANHYDRASE (CARBONATE DEHYDRATASE) (CARBONIC DEHYDRATASE) 0.0953 0.9532 1
Leishmania major beta tubulin 0.0091 0.0397 0.0383
Echinococcus granulosus Tubulin beta 2C chain 0.0091 0.0397 0.046
Leishmania major beta tubulin 0.0091 0.0397 0.0383
Echinococcus multilocularis tubulin beta 1 chain 0.0091 0.0397 0.046
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0159 0.1112 0.3218
Loa Loa (eye worm) hypothetical protein 0.0336 0.2994 0.3737
Brugia malayi hypothetical protein 0.0178 0.1313 0.1616
Mycobacterium tuberculosis Probable conserved transmembrane protein 0.0155 0.1077 0.1684
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.0804 0.7957 0.8342
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0336 0.2994 0.3737
Echinococcus granulosus Nuclear hormone receptor HR96 0.0159 0.1112 0.1362
Onchocerca volvulus Bile acid receptor homolog 0.0336 0.2994 1
Trichomonas vaginalis tubulin epsilon chain, putative 0.0091 0.0397 0.0365
Loa Loa (eye worm) tubulin beta chain 0.0091 0.0397 0.046
Echinococcus multilocularis carbonic anhydrase II 0.0804 0.7957 1
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0336 0.2994 0.3117
Onchocerca volvulus 0.0159 0.1112 0.3218
Trichomonas vaginalis conserved hypothetical protein 0.0997 1 1
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0336 0.2994 0.3737
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0336 0.2994 0.3737
Loa Loa (eye worm) hypothetical protein 0.0336 0.2994 0.3737
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0336 0.2994 0.3737
Echinococcus granulosus tubulin beta 4A class IVa 0.0091 0.0397 0.046
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0336 0.2994 0.3737
Loa Loa (eye worm) hypothetical protein 0.0159 0.1112 0.1362
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0159 0.1112 0.1136
Echinococcus granulosus inosine 5' monophosphate dehydrogenase 2 0.0057 0.0036 0.0004
Plasmodium falciparum alpha tubulin 1 0.0057 0.0032 0.0097
Echinococcus multilocularis Tubulin beta 2C chain 0.0091 0.0397 0.046
Brugia malayi beta-tubulin, identical 0.0091 0.0397 0.046
Schistosoma mansoni carbonic anhydrase 0.0953 0.9532 1
Loa Loa (eye worm) hypothetical protein 0.0159 0.1112 0.1362
Trypanosoma brucei beta tubulin 0.0091 0.0397 0.046
Schistosoma mansoni carbonic anhydrase-related 0.0368 0.3334 0.3475
Loa Loa (eye worm) nuclear receptor NHR-67 0.0159 0.1112 0.1362
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0336 0.2994 0.3737
Giardia lamblia Beta tubulin 0.0091 0.0397 1
Mycobacterium tuberculosis Probable transmembrane carbonic anhydrase (carbonate dehydratase) (carbonic dehydratase) 0.0512 0.4859 0.7803
Schistosoma mansoni steroid hormone receptor ad4bp 0.0336 0.2994 0.3117
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0368 0.3334 0.4166
Loa Loa (eye worm) carbonic anhydrase 3 0.0804 0.7957 1
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0336 0.2994 0.3737
Schistosoma mansoni tubulin subunit beta 0.0091 0.0397 0.0383
Echinococcus granulosus carbonic anhydrase 0.0368 0.3334 0.4166
Trypanosoma cruzi inosine-5'-monophosphate dehydrogenase, putative 0.0057 0.0036 0.0004
Echinococcus multilocularis Tubulin beta 2C chain 0.0091 0.0397 0.046
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0336 0.2994 0.3737
Plasmodium vivax tubulin alpha chain, putative 0.0057 0.0032 0.0816
Brugia malayi hypothetical protein 0.0159 0.1112 0.1362
Echinococcus multilocularis tubulin subunit beta 0.0091 0.0397 0.046
Brugia malayi nuclear receptor NHR-88 0.0336 0.2994 0.3737
Trypanosoma brucei beta tubulin 0.0091 0.0397 0.046
Trypanosoma brucei carbonic anhydrase-like protein 0.0804 0.7957 1
Echinococcus multilocularis thyroid hormone receptor alpha 0.0336 0.2994 0.3737
Brugia malayi nuclear receptor NHR-88 0.0159 0.1112 0.1362
Leishmania major beta tubulin 0.0091 0.0397 0.0383
Brugia malayi Nuclear hormone receptor E75 0.0159 0.1112 0.1362
Loa Loa (eye worm) hypothetical protein 0.0159 0.1112 0.1362
Echinococcus multilocularis FTZ F1 alpha 0.0336 0.2994 0.3737
Onchocerca volvulus 0.0336 0.2994 1
Leishmania major guanosine monophosphate reductase 0.0057 0.0036 0.0004
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0336 0.2994 0.3737
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0178 0.1313 0.1616
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0336 0.2994 0.3737
Trypanosoma brucei beta tubulin 0.0091 0.0397 0.046
Schistosoma mansoni inosine-5-monophosphate dehydrogenase 0.0057 0.0036 0.0004
Loa Loa (eye worm) tubulin beta-1 chain 0.0091 0.0397 0.046
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.0804 0.7957 0.8342
Toxoplasma gondii IMP dehydrogenas 0.0057 0.0036 0.0011
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.0368 0.3334 0.4166
Plasmodium falciparum cysteine repeat modular protein 1 0.0074 0.0219 0.0657
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0368 0.3334 0.4166
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0336 0.2994 0.3117
Brugia malayi nuclear hormone receptor 0.0336 0.2994 0.3737
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0159 0.1112 0.1362
Schistosoma mansoni tubulin subunit beta 0.0091 0.0397 0.0383
Echinococcus multilocularis beta tubulin 0.0091 0.0397 0.046
Loa Loa (eye worm) BEN-1 protein 0.0091 0.0397 0.046
Trypanosoma cruzi carbonic anhydrase-like protein, putative 0.0804 0.7957 1
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0159 0.1112 0.1362
Loa Loa (eye worm) tubulin beta-4 chain 0.0091 0.0397 0.046
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0336 0.2994 0.3737
Leishmania major beta tubulin 0.0091 0.0397 0.0383
Leishmania major beta tubulin 0.0091 0.0397 0.0383
Giardia lamblia Beta tubulin 0.0091 0.0397 1
Schistosoma mansoni tubulin subunit beta 0.0091 0.0397 0.0383
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0336 0.2994 0.3117
Loa Loa (eye worm) hypothetical protein 0.0368 0.3334 0.4166
Brugia malayi inosine-5'-monophosphate dehydrogenase family protein 0.0057 0.0036 0.0004
Echinococcus multilocularis Tubulin beta 2C chain 0.0091 0.0397 0.046
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0336 0.2994 0.3737
Brugia malayi hypothetical protein 0.0159 0.1112 0.1362
Leishmania major beta tubulin 0.0091 0.0397 0.0383
Brugia malayi nuclear receptor RXR 0.0159 0.1112 0.1362
Loa Loa (eye worm) hypothetical protein 0.0159 0.1112 0.1362
Onchocerca volvulus 0.0134 0.0856 0.2297
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0336 0.2994 0.3737
Brugia malayi nuclear hormone receptor 0.0159 0.1112 0.1362
Schistosoma mansoni carbonic anhydrase 0.0368 0.3334 0.3475
Leishmania major beta tubulin 0.0091 0.0397 0.0383
Mycobacterium ulcerans carbonic anhydrase 0.0953 0.9532 0.9532
Leishmania major beta tubulin 0.0091 0.0397 0.0383
Toxoplasma gondii kringle domain-containing protein 0.0074 0.0219 0.0565
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0336 0.2994 0.3737
Brugia malayi Putative carbonic anhydrase 5 precursor 0.0804 0.7957 1
Trypanosoma cruzi carbonic anhydrase-like protein, putative 0.0804 0.7957 1
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0159 0.1112 0.3218
Echinococcus multilocularis ecdysone induced protein 78C 0.0336 0.2994 0.3737
Trypanosoma brucei inosine-5'-monophosphate dehydrogenase 0.0057 0.0036 0.0004
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0336 0.2994 0.3117
Giardia lamblia Beta tubulin 0.0091 0.0397 1
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0159 0.1112 0.1362
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0178 0.1313 0.1348
Brugia malayi Protein kinase domain containing protein 0.0074 0.0219 0.0235
Mycobacterium tuberculosis Beta-carbonic anhydrase CanB 0.0596 0.575 0.9243
Schistosoma mansoni RAR-like nuclear receptor 0.0336 0.2994 0.3117
Echinococcus multilocularis carbonic anhydrase 0.0368 0.3334 0.4166
Loa Loa (eye worm) hypothetical protein 0.0178 0.1313 0.1616
Brugia malayi Nuclear hormone receptor-like 1 0.0178 0.1313 0.1616
Echinococcus granulosus Nuclear hormone receptor HR96 0.0159 0.1112 0.1362
Leishmania major beta tubulin 0.0091 0.0397 0.0383
Trichomonas vaginalis tubulin epsilon chain, putative 0.0091 0.0397 0.0365
Mycobacterium ulcerans inosine 5'-monophosphate dehydrogenase 0.0057 0.0036 0.0036
Schistosoma mansoni tubulin subunit beta 0.0091 0.0397 0.0383
Brugia malayi tailless protein 0.0159 0.1112 0.1362
Loa Loa (eye worm) hypothetical protein 0.0074 0.0219 0.0235
Brugia malayi Kringle domain containing protein 0.0074 0.0219 0.0235
Echinococcus granulosus carbonic anhydrase II 0.0804 0.7957 1
Loa Loa (eye worm) hypothetical protein 0.0336 0.2994 0.3737
Loa Loa (eye worm) hypothetical protein 0.0178 0.1313 0.1616
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0159 0.1112 0.1362
Loa Loa (eye worm) hypothetical protein 0.0178 0.1313 0.1616
Loa Loa (eye worm) hypothetical protein 0.0159 0.1112 0.1362
Brugia malayi hypothetical protein 0.0178 0.1313 0.1616
Schistosoma mansoni coup transcription factor 0.0336 0.2994 0.3117
Echinococcus granulosus Tubulin beta 2C chain 0.0091 0.0397 0.046
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0336 0.2994 0.3117
Plasmodium vivax cysteine repeat modular protein 1, putative 0.0074 0.0219 0.5521
Schistosoma mansoni thyroid hormone receptor 0.0336 0.2994 0.3117
Trichomonas vaginalis conserved hypothetical protein 0.0997 1 1
Brugia malayi Carbonic anhydrase like protein 2 precursor 0.0368 0.3334 0.4166
Echinococcus granulosus Tubulin beta 2C chain 0.0091 0.0397 0.046
Plasmodium vivax tubulin alpha chain, putative 0.0057 0.0032 0.0816
Brugia malayi Nuclear hormone receptor E75 0.0159 0.1112 0.1362
Loa Loa (eye worm) IMP dehydrogenase 1 0.0057 0.0036 0.0004
Leishmania major beta tubulin 0.0091 0.0397 0.0383
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0336 0.2994 0.3737
Echinococcus granulosus Tubulin beta 2C chain 0.0091 0.0397 0.046
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0336 0.2994 0.3737
Loa Loa (eye worm) hypothetical protein 0.0159 0.1112 0.1362
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0336 0.2994 0.3117
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0159 0.1112 0.1362
Leishmania major beta tubulin 0.0091 0.0397 0.0383
Echinococcus granulosus tubulin beta 1 chain 0.0091 0.0397 0.046
Entamoeba histolytica carbonic anhydrase, putative 0.0953 0.9532 1
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0159 0.1112 0.1362
Leishmania major carbonic anhydrase family protein, putative 0.0953 0.9532 1
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0336 0.2994 1
Leishmania major beta tubulin 0.0091 0.0397 0.0383
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0336 0.2994 0.3737
Schistosoma mansoni retinoic acid receptor RXR 0.0336 0.2994 0.3117
Plasmodium falciparum tubulin beta chain 0.0091 0.0397 0.119
Plasmodium falciparum carbonic anhydrase 0.0368 0.3334 1
Echinococcus granulosus carbonic anhydrase 0.0368 0.3334 0.4166
Brugia malayi ecdysone receptor 0.0159 0.1112 0.1362
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0159 0.1112 0.1362
Schistosoma mansoni zinc finger protein 0.0159 0.1112 0.1136
Onchocerca volvulus 0.0159 0.1112 0.3218
Onchocerca volvulus Putative sulfate transporter 0.0134 0.0856 0.2297
Brugia malayi conserved hypotetical protein 0.0159 0.1112 0.1362
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0336 0.2994 0.3737
Wolbachia endosymbiont of Brugia malayi IMP dehydrogenase 0.0057 0.0036 0.5
Brugia malayi nuclear hormone receptor family member odr-7 0.0159 0.1112 0.1362
Echinococcus granulosus nuclear receptor nhr 48 0.0159 0.1112 0.1362
Echinococcus multilocularis beta tubulin 0.0091 0.0397 0.046
Schistosoma mansoni nuclear hormone receptor 0.0159 0.1112 0.1136
Loa Loa (eye worm) BEN-1 protein 0.0091 0.0397 0.046
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0159 0.1112 0.1136
Echinococcus multilocularis carbonic anhydrase 0.0368 0.3334 0.4166
Brugia malayi Tubulin beta-1 chain 0.0091 0.0397 0.046
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0336 0.2994 0.3737
Toxoplasma gondii beta tubulin 0.0091 0.0397 0.1103
Toxoplasma gondii beta-1 tubulin, putative 0.0091 0.0397 0.1103
Schistosoma mansoni carbonic anhydrase-related 0.0368 0.3334 0.3475
Mycobacterium leprae Probable transmembrane transport protein 0.0155 0.1077 0.1096
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0336 0.2994 0.3737
Loa Loa (eye worm) hypothetical protein 0.0159 0.1112 0.1362
Echinococcus multilocularis tubulin, beta 4A class IVa 0.0091 0.0397 0.046
Loa Loa (eye worm) steroid hormone receptor 0.0336 0.2994 0.3737
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0178 0.1313 0.1616
Loa Loa (eye worm) hypothetical protein 0.0368 0.3334 0.4166
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0336 0.2994 0.3737
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0159 0.1112 0.1362
Brugia malayi steroid hormone receptor 0.0336 0.2994 0.3737
Trichomonas vaginalis tubulin alpha chain, putative 0.0091 0.0397 0.0365
Leishmania major inosine-5-monophosphate dehydrogenase 0.0057 0.0036 0.0004
Schistosoma mansoni tubulin subunit beta 0.0091 0.0397 0.0383
Trichomonas vaginalis tubulin beta chain, putative 0.0091 0.0397 0.0365
Brugia malayi photoreceptor-specific nuclear receptor 0.0336 0.2994 0.3737
Loa Loa (eye worm) hypothetical protein 0.0159 0.1112 0.1362
Loa Loa (eye worm) nuclear hormone receptor 0.0159 0.1112 0.1362
Trichomonas vaginalis tubulin gamma chain, putative 0.0091 0.0397 0.0365
Trypanosoma cruzi inosine-5'-monophosphate dehydrogenase, putative 0.0057 0.0036 0.0004
Echinococcus multilocularis tissue type plasminogen activator 0.0074 0.0219 0.0235
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0336 0.2994 0.3737
Trypanosoma cruzi GMP reductase 0.0057 0.0036 0.0004
Schistosoma mansoni nuclear receptor nhr-48 0.0159 0.1112 0.1136
Trypanosoma cruzi beta tubulin, putative 0.0091 0.0397 0.046
Brugia malayi ecdysteroid receptor 0.0336 0.2994 0.3737
Loa Loa (eye worm) hypothetical protein 0.0159 0.1112 0.1362
Loa Loa (eye worm) hypothetical protein 0.0178 0.1313 0.1616
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0336 0.2994 0.3737
Loa Loa (eye worm) hypothetical protein 0.0336 0.2994 0.3737
Loa Loa (eye worm) TK/ROR protein kinase 0.0074 0.0219 0.0235
Loa Loa (eye worm) hypothetical protein 0.0178 0.1313 0.1616
Echinococcus granulosus beta tubulin 0.0091 0.0397 0.046
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0336 0.2994 0.3737
Brugia malayi Nuclear hormone receptor-like 1 0.0336 0.2994 0.3737
Trypanosoma cruzi GMP reductase 0.0057 0.0036 0.0004
Toxoplasma gondii beta-tubulin, putative 0.0091 0.0397 0.1103
Leishmania major beta tubulin 0.0091 0.0397 0.0383
Loa Loa (eye worm) hypothetical protein 0.0336 0.2994 0.3737
Echinococcus granulosus carbonic anhydrase 0.0368 0.3334 0.4166
Entamoeba histolytica tubulin family protein 0.0091 0.0397 0.0383
Loa Loa (eye worm) tubulin beta-2A chain 0.0091 0.0397 0.046
Brugia malayi Carbonic anhydrase like protein 2 precursor 0.0368 0.3334 0.4166
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0804 0.7957 1
Loa Loa (eye worm) hypothetical protein 0.0159 0.1112 0.1362
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0336 0.2994 0.3737
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0178 0.1313 0.1616
Schistosoma mansoni nuclear receptor 0.0159 0.1112 0.1136
Echinococcus multilocularis inosine 5' monophosphate dehydrogenase 2 0.0057 0.0036 0.0004
Brugia malayi nuclear receptor RXR 0.0178 0.1313 0.1616
Trypanosoma brucei beta tubulin 0.0091 0.0397 0.046
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0336 0.2994 0.3737
Onchocerca volvulus Protein ultraspiracle homolog 0.0336 0.2994 1
Schistosoma mansoni tubulin subunit beta 0.0091 0.0397 0.0383
Loa Loa (eye worm) hypothetical protein 0.0159 0.1112 0.1362
Leishmania major beta tubulin 0.0091 0.0397 0.0383
Brugia malayi Steroid receptor seven-up type 2 0.0336 0.2994 0.3737
Loa Loa (eye worm) hypothetical protein 0.0368 0.3334 0.4166
Plasmodium falciparum alpha tubulin 2 0.0057 0.0032 0.0097
Leishmania major beta tubulin 0.0091 0.0397 0.0383
Echinococcus granulosus ecdysone induced protein 78C 0.0336 0.2994 0.3737
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.0804 0.7957 1
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0178 0.1313 0.1348
Brugia malayi Nuclear hormone receptor-like 1 0.0178 0.1313 0.1616
Echinococcus granulosus beta tubulin 0.0091 0.0397 0.046
Leishmania major hypothetical protein, conserved 0.0074 0.0219 0.0196
Echinococcus granulosus thyroid hormone receptor alpha 0.0159 0.1112 0.1362
Loa Loa (eye worm) hypothetical protein 0.0159 0.1112 0.1362
Brugia malayi orphan nuclear receptor NR2E1 0.0159 0.1112 0.1362
Leishmania major beta tubulin 0.0091 0.0397 0.0383
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0336 0.2994 0.3737
Brugia malayi nuclear receptor NHR-67 0.0159 0.1112 0.1362
Echinococcus multilocularis carbonic anhydrase 0.0368 0.3334 0.4166
Schistosoma mansoni nuclear receptor 0.0159 0.1112 0.1136
Plasmodium vivax tubulin beta chain, putative 0.0091 0.0397 1
Echinococcus granulosus tubulin subunit beta 0.0091 0.0397 0.046
Loa Loa (eye worm) hypothetical protein 0.0336 0.2994 0.3737
Loa Loa (eye worm) DR-78 0.0159 0.1112 0.1362
Brugia malayi nuclear hormone receptor family member nhr-6 0.0159 0.1112 0.1362
Trypanosoma cruzi hypothetical protein, conserved 0.0074 0.0219 0.0235

Activities

Activity type Activity value Assay description Source Reference
Ki (binding) = 53 nM In vitro binding affinity against alpha-2 adrenergic receptor in rat ChEMBL. 10602691
Ki (binding) = 53 nM In vitro binding affinity against alpha-2 adrenergic receptor in rat ChEMBL. 10602691

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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