TDR Targets

Basic information

Technical information

TDR Targets ID: 255036
Name: 2-[4-[(2R)-2-(benzenesulfonamido)-3-(4-hydrox yphenyl)propoxy]carbonyl-2,6-dihydroxybenzoyl ]-3-hydroxybenzoic acid
MW: 607.585 | Formula: C30H25NO11S
H donors: 6 H acceptors: 10 LogP: 4.46 Rotable bonds: 12
Rule of 5 violations (Lipinski): 3
SMILES: Oc1ccc(cc1)C[C@@H](NS(=O)(=O)c1ccccc1)COC(=O)c1cc(O)c(c(c1)O)C(=O)c1c(O)cccc1C(=O)O
InChi: 1S/C30H25NO11S/c32-20-11-9-17(10-12-20)13-19(31-43(40,41)21-5-2-1-3-6-21)16-42-30(39)18-14-24(34)27(25(35)15-18)28(36)26-22(29(37)38)7-4-8-23(26)33/h1-12,14-15,19,31-35H,13,16H2,(H,37,38)/t19-/m1/s1
InChiKey: PQWWKDOKHDWZBH-LJQANCHMSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

2-[4-[(2R)-2-(benzenesulfonamido)-3-(4-hydroxyphenyl)propoxy]carbonyl-2,6-dihydroxy-benzoyl]-3-hydroxy-benzoic acid
2-[[4-[[(2R)-2-(benzenesulfonamido)-3-(4-hydroxyphenyl)propoxy]-oxomethyl]-2,6-dihydroxyphenyl]-oxomethyl]-3-hydroxybenzoic acid
2-[2,6-dihydroxy-4-[(2R)-3-(4-hydroxyphenyl)-2-(phenylsulfonylamino)propoxy]carbonyl-phenyl]carbonyl-3-hydroxy-benzoic acid
2-[2,6-dihydroxy-4-[(2R)-3-(4-hydroxyphenyl)-2-(phenylsulfonylamino)propoxy]carbonylbenzoyl]-3-hydroxybenzoic acid
2-[2,6-dihydroxy-4-[(2R)-3-(4-hydroxyphenyl)-2-(phenylsulfonylamino)propoxy]carbonyl-benzoyl]-3-hydroxy-benzoic acid
2-[[2,6-dihydroxy-4-[[(2R)-3-(4-hydroxyphenyl)-2-(phenylsulfonylamino)propoxy]-oxomethyl]phenyl]-oxomethyl]-3-hydroxybenzoic acid
Acyclic Balanol Analog 12b(R)

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	protein kinase C, delta	Starlite/ChEMBL	References
Homo sapiens	protein kinase C, gamma	Starlite/ChEMBL	References
Homo sapiens	protein kinase C, beta	Starlite/ChEMBL	References
Homo sapiens	protein kinase C, eta	Starlite/ChEMBL	References
Homo sapiens	protein kinase C, alpha	Starlite/ChEMBL	References
Homo sapiens	protein kinase C, epsilon	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Echinococcus multilocularis	RNA directed DNA polymerase	Get druggable targets OG5_129482	All targets in OG5_129482
Echinococcus multilocularis	telomerase reverse transcriptase subunit	Get druggable targets OG5_129482	All targets in OG5_129482
Loa Loa (eye worm)	AGC/PKC/ETA protein kinase	Get druggable targets OG5_129314	All targets in OG5_129314
Candida albicans	protein kinase C similar to S. cerevisiae PKC1 (YBL105C)	Get druggable targets OG5_129482	All targets in OG5_129482
Schistosoma japonicum	IPR000477,RNA-directed DNA polymerase (Reverse transcriptase),domain-containing	Get druggable targets OG5_129482	All targets in OG5_129482
Schistosoma mansoni	serine/threonine protein kinase	Get druggable targets OG5_129482	All targets in OG5_129482
Schistosoma japonicum	Protein kinase C alpha type, putative	Get druggable targets OG5_129482	All targets in OG5_129482
Onchocerca volvulus		Get druggable targets OG5_132502	All targets in OG5_132502
Echinococcus granulosus	RNA directed DNA polymerase	Get druggable targets OG5_129482	All targets in OG5_129482
Schistosoma mansoni	serine/threonine protein kinase	Get druggable targets OG5_129482	All targets in OG5_129482
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_129482	All targets in OG5_129482
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_132502	All targets in OG5_132502
Echinococcus granulosus	protein kinase C gamma type	Get druggable targets OG5_129482	All targets in OG5_129482
Brugia malayi	protein kinase C II.	Get druggable targets OG5_129314	All targets in OG5_129314
Echinococcus granulosus	serine:threonine protein kinase N2	Get druggable targets OG5_129314	All targets in OG5_129314
Entamoeba histolytica	PH domain containing protein kinase, putative	Get druggable targets OG5_129314	All targets in OG5_129314
Candida albicans	protein kinase C similar to S. cerevisiae PKC1 (YBL105C)	Get druggable targets OG5_129482	All targets in OG5_129482
Brugia malayi	Protein kinase c protein 2	Get druggable targets OG5_129482	All targets in OG5_129482
Schistosoma japonicum	Protein kinase C alpha type, putative	Get druggable targets OG5_129482	All targets in OG5_129482
Schistosoma mansoni	serine/threonine protein kinase	Get druggable targets OG5_129314	All targets in OG5_129314
Echinococcus multilocularis	serine threonine protein kinase	Get druggable targets OG5_129482	All targets in OG5_129482
Echinococcus multilocularis	protein kinase c epsilon type	Get druggable targets OG5_129314	All targets in OG5_129314
Schistosoma japonicum	Calcium-dependent protein kinase C, putative	Get druggable targets OG5_129482	All targets in OG5_129482
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_129482	All targets in OG5_129482
Schistosoma japonicum	Protein kinase C gamma type, putative	Get druggable targets OG5_129482	All targets in OG5_129482
Echinococcus granulosus	protein kinase c epsilon type	Get druggable targets OG5_129314	All targets in OG5_129314
Echinococcus multilocularis	Protein kinase C, brain isozyme	Get druggable targets OG5_129482	All targets in OG5_129482
Schistosoma japonicum	Protein kinase C epsilon type, putative	Get druggable targets OG5_129314	All targets in OG5_129314
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_132502	All targets in OG5_132502
Echinococcus multilocularis	serine:threonine protein kinase N2	Get druggable targets OG5_129314	All targets in OG5_129314
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_132502	All targets in OG5_132502
Schistosoma japonicum	ko:K06068 novel protein kinase C, putative	Get druggable targets OG5_129314	All targets in OG5_129314
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_132502	All targets in OG5_132502
Loa Loa (eye worm)	AGC/PKC/ALPHA protein kinase	Get druggable targets OG5_129482	All targets in OG5_129482
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_132502	All targets in OG5_132502
Echinococcus granulosus	Protein kinase C brain isozyme	Get druggable targets OG5_129482	All targets in OG5_129482

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus granulosus	guanine nucleotide exchange factor VAV2	0.005	0.0249	0.0423
Echinococcus multilocularis	serine:threonine protein kinase N2	0.0233	0.4616	0.784
Echinococcus granulosus	ribosomal protein s6 kinase beta 1	0.0066	0.0632	0.1073
Plasmodium falciparum	cAMP-dependent protein kinase catalytic subunit	0.0147	0.2571	0.5
Echinococcus multilocularis	ribosomal protein s6 kinase beta 1	0.0066	0.0632	0.1073
Loa Loa (eye worm)	hypothetical protein	0.0046	0.014	0.011
Echinococcus granulosus	protein kinase C gamma type	0.0217	0.4228	0.7181
Schistosoma mansoni	diacylglycerol kinase theta	0.0046	0.014	0.0006
Brugia malayi	Protein kinase domain containing protein	0.0066	0.0632	0.0603
Brugia malayi	RhoGEF domain containing protein	0.0046	0.014	0.011
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0045	0.0136	0.0232
Toxoplasma gondii	AGC kinase	0.0147	0.2571	1
Echinococcus multilocularis	cAMP dependent protein kinase catalytic subunit	0.0147	0.2571	0.4366
Trypanosoma cruzi	cAMP-dependent protein kinase catalytic subunit 2	0.0147	0.2571	0.5
Brugia malayi	diacylglycerol kinase	0.0046	0.014	0.011
Echinococcus granulosus	NDR protein kinase	0.0066	0.0632	0.1073
Echinococcus multilocularis	myotubularin protein 13	0.0046	0.014	0.0238
Loa Loa (eye worm)	hypothetical protein	0.0046	0.014	0.011
Brugia malayi	Protein kinase domain containing protein	0.0066	0.0632	0.0603
Echinococcus multilocularis	Rac GTPase activating protein 1	0.0046	0.014	0.0238
Echinococcus multilocularis	tyrosine protein kinase Fgr	0.0045	0.0136	0.0232
Schistosoma mansoni	unc-13 (munc13)	0.0053	0.0321	0.0322
Echinococcus multilocularis	guanine nucleotide exchange factor VAV2	0.005	0.0249	0.0423
Brugia malayi	hypothetical protein	0.005	0.0251	0.0221
Echinococcus granulosus	Ribosomal protein S6 kinase beta 2	0.0066	0.0632	0.1073
Schistosoma mansoni	serine/threonine protein kinase	0.0066	0.0632	0.0862
Brugia malayi	SRC-1	0.0045	0.0136	0.0106
Echinococcus granulosus	proto oncogene tyrosine protein kinase LCK	0.0045	0.0136	0.0232
Echinococcus multilocularis	Ribosomal protein S6 kinase beta 2	0.0066	0.0632	0.1073
Echinococcus granulosus	protein kinase c iota type	0.0112	0.1722	0.2926
Loa Loa (eye worm)	AGC/PKA protein kinase	0.0147	0.2571	0.2548
Echinococcus multilocularis	protein kinase c iota type	0.0112	0.1722	0.2926
Loa Loa (eye worm)	AGC/RSK/RSK protein kinase	0.0066	0.0632	0.0603
Loa Loa (eye worm)	AGC/RSK/P70 protein kinase	0.0066	0.0632	0.0603
Loa Loa (eye worm)	integrin beta-2	0.0331	0.6955	0.6945
Onchocerca volvulus		0.0053	0.0321	0.0626
Entamoeba histolytica	PH domain containing protein kinase, putative	0.017	0.3107	1
Echinococcus multilocularis	cAMP dependent protein kinase catalytic subunit	0.0147	0.2571	0.4366
Schistosoma mansoni	serine/threonine protein kinase	0.0262	0.5319	0.901
Leishmania major	protein kinase A catalytic subunit isoform 2	0.0147	0.2571	0.5
Toxoplasma gondii	protein kinase, cAMP-dependent, catalytic chain	0.0147	0.2571	1
Echinococcus granulosus	C2 calcium dependent membrane targeting	0.0053	0.0321	0.0546
Schistosoma mansoni	lipoxygenase	0.0081	0.0979	0.1465
Schistosoma mansoni	lipoxygenase	0.0115	0.1809	0.2909
Entamoeba histolytica	protein kinase, putative	0.0066	0.0632	0.1658
Echinococcus multilocularis	cAMP dependent protein kinase catalytic subunit	0.0147	0.2571	0.4366
Echinococcus multilocularis	C2 calcium dependent membrane targeting	0.0053	0.0321	0.0546
Echinococcus multilocularis	integrin beta 2	0.0245	0.4906	0.8332
Loa Loa (eye worm)	hypothetical protein	0.0046	0.014	0.011
Loa Loa (eye worm)	hypothetical protein	0.0046	0.014	0.011
Loa Loa (eye worm)	hypothetical protein	0.0046	0.014	0.011
Trichomonas vaginalis	AGC family protein kinase	0.0066	0.0632	0.0364
Brugia malayi	Protein kinase domain containing protein	0.0049	0.0213	0.0183
Loa Loa (eye worm)	AGC/DMPK/GEK protein kinase	0.0066	0.0632	0.0603
Loa Loa (eye worm)	AGC/PKC/ETA protein kinase	0.0286	0.5888	0.5875
Trypanosoma brucei	cAMP-dependent protein kinase catalytic subunit 1	0.0147	0.2571	1
Loa Loa (eye worm)	AGC/PKN protein kinase	0.0066	0.0632	0.0603
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0045	0.0136	0.0232
Loa Loa (eye worm)	AGC/NDR protein kinase	0.0066	0.0632	0.0603
Loa Loa (eye worm)	hypothetical protein	0.0053	0.0321	0.0292
Brugia malayi	cAMP-dependent protein kinase catalytic subunit, putative	0.0147	0.2571	0.2548
Trichomonas vaginalis	AGC family protein kinase	0.0066	0.0632	0.0364
Echinococcus granulosus	RNA directed DNA polymerase	0.0143	0.2465	0.4186
Plasmodium vivax	cAMP-dependent protein kinase catalytic subunit, putative	0.0147	0.2571	0.5
Brugia malayi	Phorbol esters/diacylglycerol binding domain	0.0049	0.0213	0.0183
Echinococcus granulosus	cAMP dependent protein kinase catalytic subunit	0.0147	0.2571	0.4366
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0147	0.2571	0.8192
Echinococcus granulosus	Protein kinase C brain isozyme	0.0262	0.5319	0.9033
Schistosoma mansoni	serine/threonine kinase	0.0066	0.0632	0.0862
Brugia malayi	Protein kinase domain containing protein	0.0066	0.0632	0.0603
Toxoplasma gondii	AGC kinase	0.0066	0.0632	0.2023
Schistosoma mansoni	protein kinase C mu	0.0049	0.0213	0.0134
Schistosoma mansoni	unc-13 (munc13)	0.0053	0.0321	0.0322
Echinococcus granulosus	myotubularin protein 13	0.0046	0.014	0.0238
Loa Loa (eye worm)	AGC/PKC/ALPHA protein kinase	0.0153	0.2719	0.2697
Schistosoma mansoni	serine/threonine protein kinase	0.0047	0.0171	0.0059
Brugia malayi	Ras association domain family 1 isoform A	0.0046	0.014	0.011
Echinococcus multilocularis	Diacylglycerol kinase theta	0.0046	0.014	0.0238
Echinococcus multilocularis	enhancer of mRNA decapping protein 4	0.0144	0.2497	0.4242
Echinococcus granulosus	Rac GTPase activating protein 1	0.0046	0.014	0.0238
Echinococcus granulosus	unc 13 munc13	0.0053	0.0321	0.0546
Echinococcus multilocularis	tyrosine protein kinase Src64B	0.0045	0.0136	0.0232
Trichomonas vaginalis	AGC family protein kinase	0.0066	0.0632	0.0364
Echinococcus multilocularis	tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase	0.0045	0.0136	0.0232
Schistosoma mansoni	serine/threonine protein kinase	0.0066	0.0632	0.0862
Loa Loa (eye worm)	SRC-1	0.0045	0.0136	0.0106
Loa Loa (eye worm)	AGC/AKT protein kinase	0.0066	0.0632	0.0603
Brugia malayi	Pleckstrin Homology Domain	0.0046	0.014	0.011
Entamoeba histolytica	protein kinase, putative	0.0066	0.0632	0.1658
Echinococcus multilocularis	protein kinase c epsilon type	0.0286	0.5888	1
Loa Loa (eye worm)	AGC/RSK/MSK protein kinase	0.0066	0.0632	0.0603
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0045	0.0136	0.0232
Loa Loa (eye worm)	raf kinase	0.0046	0.014	0.011
Echinococcus granulosus	protein kinase c eta type	0.0046	0.014	0.0238
Trichomonas vaginalis	AGC family protein kinase	0.0066	0.0632	0.0364
Trypanosoma cruzi	cAMP-dependent protein kinase catalytic subunit 3	0.0147	0.2571	0.5
Leishmania major	protein kinase A catalytic subunit	0.0147	0.2571	0.5
Brugia malayi	Integrin beta pat-3 precursor	0.0331	0.6955	0.6945
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.0045	0.0136	0.0232
Echinococcus granulosus	integrin beta 2	0.0245	0.4906	0.8332
Schistosoma mansoni	chimerin-related rho-gtpase-activating protein	0.005	0.0249	0.0195
Trypanosoma cruzi	cAMP-dependent protein kinase catalytic subunit 3	0.0147	0.2571	0.5
Schistosoma mansoni	serine/threonine protein kinase	0.0147	0.2571	0.4232
Echinococcus granulosus	cAMP dependent protein kinase catalytic subunit	0.0147	0.2571	0.4366
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0041	0.0031	0.0052
Schistosoma mansoni	vav2	0.005	0.0249	0.0195
Loa Loa (eye worm)	variant SH3 domain-containing protein	0.0046	0.014	0.011
Echinococcus multilocularis	tyrosine protein kinase lyn tyrosine protein kinase blk	0.0045	0.0136	0.0232
Echinococcus granulosus	ribosomal protein S6 kinase alpha 3	0.0066	0.0632	0.1073
Loa Loa (eye worm)	hypothetical protein	0.0167	0.3034	0.3012
Echinococcus multilocularis	proto oncogene tyrosine protein kinase LCK	0.0045	0.0136	0.0232
Echinococcus multilocularis	serine:threonine protein kinase N2	0.0066	0.0632	0.1073
Loa Loa (eye worm)	hypothetical protein	0.0188	0.3555	0.3535
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0045	0.0136	0.0232
Echinococcus multilocularis	serine:threonine protein kinase 38	0.0066	0.0632	0.1073
Echinococcus granulosus	tyrosine protein kinase Src64B	0.0045	0.0136	0.0232
Loa Loa (eye worm)	hypothetical protein	0.0143	0.2465	0.2441
Trichomonas vaginalis	AGC family protein kinase	0.0066	0.0632	0.0364
Loa Loa (eye worm)	hypothetical protein	0.0212	0.4124	0.4106
Trichomonas vaginalis	AGC family protein kinase	0.0147	0.2571	1
Brugia malayi	Variant SH3 domain containing protein	0.005	0.0249	0.0219
Trypanosoma cruzi	cAMP-dependent protein kinase catalytic subunit 1	0.0147	0.2571	0.5
Schistosoma mansoni	chimerin-related rho-gtpase-activating protein	0.005	0.0249	0.0195
Onchocerca volvulus		0.0167	0.3034	1
Trichomonas vaginalis	AGC family protein kinase	0.0066	0.0632	0.0364
Echinococcus granulosus	raf serine:threonine protein kinase	0.0047	0.0171	0.029
Schistosoma mansoni	serine/threonine protein kinase	0.0147	0.2571	0.4232
Schistosoma mansoni	serine/threonine protein kinase	0.0286	0.5888	1
Loa Loa (eye worm)	hypothetical protein	0.0046	0.014	0.011
Echinococcus granulosus	protein kinase c epsilon type	0.0286	0.5888	1
Brugia malayi	protein kinase C II.	0.0286	0.5888	0.5875
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0147	0.2571	0.8192
Schistosoma mansoni	serine/threonine protein kinase	0.0262	0.5319	0.901
Schistosoma mansoni	protein kinase C	0.0053	0.0321	0.0322
Schistosoma mansoni	protein kinase C mu	0.0046	0.014	0.0006
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0045	0.0136	0.0232
Brugia malayi	RhoGAP domain containing protein	0.005	0.0249	0.0219
Loa Loa (eye worm)	hypothetical protein	0.005	0.0251	0.0221
Loa Loa (eye worm)	kelch domain-containing protein family protein	0.005	0.0251	0.0221
Entamoeba histolytica	protein kinase, putative	0.0066	0.0632	0.1658
Loa Loa (eye worm)	hypothetical protein	0.0046	0.014	0.011
Loa Loa (eye worm)	hypothetical protein	0.0458	1	1
Giardia lamblia	Kinase, AGC PKA	0.0147	0.2571	0.5
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0045	0.0136	0.0232
Schistosoma mansoni	serine/threonine protein kinase	0.0049	0.0213	0.0134
Echinococcus granulosus	N chimaerin	0.005	0.0249	0.0423
Brugia malayi	p70 ribosomal S6 kinase beta	0.0066	0.0632	0.0603
Brugia malayi	C1-like domain containing protein	0.0049	0.0213	0.0183
Loa Loa (eye worm)	hypothetical protein	0.0147	0.2571	0.2548
Echinococcus multilocularis	N chimaerin	0.005	0.0249	0.0423
Echinococcus granulosus	serine:threonine protein kinase N2	0.017	0.3107	0.5277
Brugia malayi	Hr1 repeat family protein	0.0066	0.0632	0.0603
Schistosoma mansoni	serine/threonine protein kinase	0.0066	0.0632	0.0862
Echinococcus granulosus	cAMP dependent protein kinase catalytic subunit	0.0147	0.2571	0.4366
Brugia malayi	RhoGAP domain containing protein	0.0046	0.014	0.011
Trichomonas vaginalis	AGC family protein kinase	0.0066	0.0632	0.0364
Echinococcus multilocularis	serine threonine protein kinase	0.0217	0.4228	0.7181
Echinococcus multilocularis	Protein kinase C, brain isozyme	0.0262	0.5319	0.9033
Toxoplasma gondii	AGC kinase	0.0147	0.2571	1
Trichomonas vaginalis	AGC family protein kinase	0.0066	0.0632	0.0364
Trichomonas vaginalis	AGC family protein kinase	0.0066	0.0632	0.0364
Schistosoma mansoni	serine/threonine protein kinase	0.0049	0.0213	0.0134
Echinococcus multilocularis	cAMP dependent protein kinase catalytic subunit	0.0147	0.2571	0.4366
Echinococcus granulosus	Serine/threonine-protein kinase Genghis Khan	0.0049	0.0213	0.0362
Loa Loa (eye worm)	AGC/PKA protein kinase	0.0147	0.2571	0.2548
Trypanosoma brucei	cAMP-dependent protein kinase catalytic subunit 2	0.0147	0.2571	1
Echinococcus granulosus	tyrosine protein kinase Src42A	0.0045	0.0136	0.0232
Loa Loa (eye worm)	RasGEF domain-containing protein	0.0046	0.014	0.011
Trichomonas vaginalis	AGC family protein kinase	0.0066	0.0632	0.0364
Echinococcus granulosus	tyrosine kinase\|tyrosine protein kinase Fyn	0.0041	0.0031	0.0052
Echinococcus multilocularis	protein kinase c eta type	0.0046	0.014	0.0238
Brugia malayi	Kelch motif family protein	0.005	0.0251	0.0221
Schistosoma mansoni	serine/threonine protein kinase	0.0066	0.0632	0.0862
Brugia malayi	protein kinase C3,putative	0.0049	0.0213	0.0183
Brugia malayi	Protein kinase c protein 2	0.0199	0.3809	0.3791
Echinococcus multilocularis	ribosomal protein S6 kinase alpha 3	0.0066	0.0632	0.1073
Leishmania major	protein kinase A catalytic subunit isoform 1	0.0147	0.2571	0.5
Brugia malayi	diacylglycerol kinase	0.0046	0.014	0.011
Echinococcus multilocularis	serine:threonine protein kinase MRCK beta	0.0049	0.0213	0.0362
Trypanosoma brucei	protein kinase A catalytic subunit, putative	0.0147	0.2571	1
Echinococcus multilocularis	tyrosine protein kinase Blk	0.0041	0.0031	0.0052
Schistosoma mansoni	diacylglycerol kinase theta	0.0046	0.014	0.0006
Echinococcus granulosus	3'partial\|tyrosine protein kinase Fgr	0.0045	0.0136	0.0232
Loa Loa (eye worm)	Ras association domain family 1 isoform A	0.0046	0.014	0.011
Echinococcus multilocularis	unc 13 (munc13)	0.0053	0.0321	0.0546
Echinococcus multilocularis	RNA directed DNA polymerase	0.0143	0.2465	0.4186
Loa Loa (eye worm)	hypothetical protein	0.0233	0.4616	0.46
Echinococcus multilocularis	raf serine:threonine protein kinase	0.0047	0.0171	0.029
Loa Loa (eye worm)	hypothetical protein	0.0046	0.014	0.011
Echinococcus granulosus	serine:threonine protein kinase N2	0.0066	0.0632	0.1073
Echinococcus multilocularis	tyrosine protein kinase Srms	0.0041	0.0031	0.0052
Loa Loa (eye worm)	hypothetical protein	0.0046	0.014	0.011
Entamoeba histolytica	protein kinase, putative	0.0066	0.0632	0.1658
Schistosoma mansoni	rac gtpase activating protein	0.0046	0.014	0.0006
Echinococcus granulosus	Diacylglycerol kinase theta	0.0046	0.014	0.0238
Echinococcus granulosus	tyrosine protein kinase Blk	0.0041	0.0031	0.0052
Echinococcus granulosus	enhancer of mRNA decapping protein 4	0.0144	0.2497	0.4242
Schistosoma mansoni	hypothetical protein	0.0046	0.014	0.0006
Schistosoma mansoni	integrin beta subunit	0.0195	0.3704	0.6204
Loa Loa (eye worm)	CAMK/PKD protein kinase	0.0049	0.0213	0.0183
Loa Loa (eye worm)	RhoGAP domain-containing protein	0.005	0.0249	0.0219
Trichomonas vaginalis	AGC family protein kinase	0.0066	0.0632	0.0364
Echinococcus granulosus	tyrosine protein kinase Lyn	0.0049	0.021	0.0356
Echinococcus granulosus	tyrosine kinase	0.0041	0.0031	0.0052
Echinococcus multilocularis	telomerase reverse transcriptase subunit	0.0143	0.2465	0.4186
Schistosoma mansoni	atypical protein kinase C	0.0112	0.1722	0.2758
Loa Loa (eye worm)	hypothetical protein	0.0167	0.3034	0.3012
Loa Loa (eye worm)	AGC/PKC/IOTA protein kinase	0.0049	0.0213	0.0183
Echinococcus multilocularis	arachidonate 5 lipoxygenase	0.0115	0.1809	0.3073
Schistosoma mansoni	serine/threonine protein kinase	0.0147	0.2571	0.4232
Loa Loa (eye worm)	hypothetical protein	0.0167	0.3034	0.3012
Echinococcus granulosus	arachidonate 5 lipoxygenase	0.0115	0.1809	0.3073

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 0.003 uM	Evaluated against recombinant human Protein kinase C delta	ChEMBL.	8978850
IC50 (binding)	= 0.003 uM	Evaluated against recombinant human Protein kinase C nu	ChEMBL.	8978850
IC50 (binding)	= 0.003 uM	Evaluated against recombinant human Protein kinase C delta	ChEMBL.	8978850
IC50 (binding)	= 0.003 uM	Evaluated against recombinant human Protein kinase C nu	ChEMBL.	8978850
IC50 (binding)	= 0.007 uM	Evaluated against recombinant human Protein kinase C beta 2	ChEMBL.	8978850
IC50 (binding)	= 0.007 uM	Evaluated against recombinant human Protein kinase C beta 2	ChEMBL.	8978850
IC50 (binding)	= 0.03 uM	Evaluated against recombinant human Protein kinase C beta 1	ChEMBL.	8978850
IC50 (binding)	= 0.03 uM	Evaluated against recombinant human Protein kinase C beta 1	ChEMBL.	8978850
IC50 (binding)	= 0.21 uM	Evaluated against recombinant human Protein kinase C alpha	ChEMBL.	8978850
IC50 (binding)	= 0.21 uM	Evaluated against recombinant human Protein kinase C alpha	ChEMBL.	8978850
IC50 (binding)	= 0.46 uM	Evaluated against recombinant human Protein kinase C epsilon	ChEMBL.	8978850
IC50 (binding)	= 0.46 uM	Evaluated against recombinant human Protein kinase C epsilon	ChEMBL.	8978850
IC50 (binding)	= 0.47 uM	Evaluated against recombinant human Protein kinase C gamma	ChEMBL.	8978850
IC50 (binding)	= 0.47 uM	Evaluated against recombinant human Protein kinase C gamma	ChEMBL.	8978850
IC50 (binding)	> 50 uM	Evaluated against recombinant human Protein Kinase A (PKA)	ChEMBL.	8978850

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL345767
PubChem: 5327948

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 255036