Detailed information for compound 255438

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 317.446 | Formula: C18H23NO2S
  • H donors: 1 H acceptors: 2 LogP: 3.56 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: CNC(=O)C(c1ccc2c(c1)SCC1C(C2=O)CCCC1)C
  • InChi: 1S/C18H23NO2S/c1-11(18(21)19-2)12-7-8-15-16(9-12)22-10-13-5-3-4-6-14(13)17(15)20/h7-9,11,13-14H,3-6,10H2,1-2H3,(H,19,21)
  • InChiKey: XECATCVHJFZVHH-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) aspartic protease BmAsp-2 0.0048 0.0077 0.0077
Echinococcus granulosus glutamate receptor ionotrophic AMPA 3 0.0127 0.0268 0.0418
Schistosoma mansoni hypothetical protein 0.0213 0.048 0.074
Trichomonas vaginalis DNA polymerase eta, putative 0.0087 0.0172 0.3992
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0127 0.0268 0.0418
Plasmodium falciparum ribonucleoside-diphosphate reductase small chain, putative 0.0066 0.0119 0.2533
Echinococcus granulosus disks large 3 0.0047 0.0073 0.0112
Onchocerca volvulus Eukaryotic initiation factor 4A homolog 0.005 0.008 0.332
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0127 0.0268 0.0418
Trypanosoma brucei DNA polymerase kappa, putative 0.0066 0.012 0.2557
Echinococcus multilocularis integrin alpha ps 0.1195 0.2879 0.4502
Echinococcus multilocularis tyrosine kinase 0.0023 0.0016 0.0023
Trichomonas vaginalis hypothetical protein 0.0115 0.0239 0.5545
Trypanosoma brucei DNA polymerase kappa, putative 0.0087 0.0172 0.3671
Echinococcus granulosus nmda type glutamate receptor 0.0021 0.001 0.0014
Plasmodium falciparum plasmepsin IV 0.0048 0.0077 0.162
Loa Loa (eye worm) hypothetical protein 0.0048 0.0077 0.0077
Trypanosoma brucei Eukaryotic initiation factor 4A-1 0.005 0.008 0.1693
Plasmodium vivax ribonucleoside-diphosphate reductase small chain, putative 0.0066 0.0119 0.2533
Plasmodium falciparum plasmepsin VI 0.0048 0.0077 0.162
Loa Loa (eye worm) RGC/RGC protein kinase 0.0068 0.0124 0.0124
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0048 0.0077 0.0117
Brugia malayi polk-prov protein 0.0066 0.012 0.0138
Loa Loa (eye worm) glutamate receptor 1 0.0106 0.0217 0.0217
Mycobacterium tuberculosis Ribonucleoside-diphosphate reductase (beta chain) NrdB (ribonucleotide reductase small chain) 0.0066 0.0119 0.01
Brugia malayi ImpB/MucB/SamB family protein 0.0031 0.0034 0.0038
Echinococcus granulosus metabotropic glutamate receptor 2 0.0021 0.001 0.0014
Brugia malayi latrophilin 2 splice variant baaae 0.0213 0.048 0.0554
Echinococcus multilocularis cathepsin d (lysosomal aspartyl protease) 0.0048 0.0077 0.0118
Echinococcus multilocularis eukaryotic initiation factor 4A 0.005 0.008 0.0123
Echinococcus multilocularis cpg binding protein 0.003 0.0032 0.0048
Echinococcus multilocularis ribonucleoside diphosphate reductase subunit 0.0066 0.0119 0.0185
Loa Loa (eye worm) hypothetical protein 0.0066 0.012 0.012
Brugia malayi Latrophilin receptor protein 2 0.0099 0.02 0.023
Echinococcus multilocularis metabotropic glutamate receptor 5 0.0021 0.001 0.0014
Echinococcus granulosus kelch ECH associated protein 1 like 0.0093 0.0186 0.0289
Echinococcus multilocularis integrin alpha ps 0.1195 0.2879 0.4502
Schistosoma mansoni glutamate receptor kainate 0.0106 0.0217 0.0333
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0312 0.0721 0.0721
Loa Loa (eye worm) hypothetical protein 0.1271 0.3066 0.3066
Loa Loa (eye worm) hypothetical protein 0.2093 0.5073 0.5073
Echinococcus granulosus fibrillin 2 0.0115 0.0239 0.0371
Echinococcus multilocularis fibrillin 2 0.0115 0.0239 0.0371
Loa Loa (eye worm) apoptosis regulator protein 0.0062 0.011 0.011
Leishmania major ribonucleoside-diphosphate reductase small chain, putative 0.0066 0.0119 0.2533
Giardia lamblia Tenascin precursor 0.0115 0.0239 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0066 0.012 0.2557
Giardia lamblia Neurogenic locus Notch protein precursor 0.0115 0.0239 1
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.1058 0.2545 0.3979
Loa Loa (eye worm) guanylate kinase 0.0039 0.0053 0.0053
Echinococcus multilocularis kelch ECH associated protein 1 0.0093 0.0186 0.0289
Schistosoma mansoni glutamate receptor NMDA 0.0106 0.0217 0.0333
Echinococcus granulosus glutamate NMDA receptor subunit 0.0106 0.0217 0.0337
Schistosoma mansoni terminal deoxycytidyl transferase 0.0031 0.0034 0.0051
Leishmania major DNA polymerase kappa, putative 0.0045 0.0068 0.1439
Schistosoma mansoni bcl-2 homologous antagonist/killer (bak) 0.0062 0.011 0.0169
Brugia malayi Receptor family ligand binding region containing protein 0.0021 0.001 0.001
Echinococcus multilocularis glutamate receptor 2 0.0088 0.0173 0.0268
Brugia malayi eukaryotic initiation factor 4A 0.005 0.008 0.0091
Mycobacterium ulcerans adenylylate/guanylate cyclase 0.0044 0.0067 0.0063
Echinococcus granulosus cathepsin d lysosomal aspartyl protease 0.0048 0.0077 0.0118
Trypanosoma cruzi DNA polymerase kappa, putative 0.0087 0.0172 0.3671
Trypanosoma brucei ribonucleoside-diphosphate reductase small chain 0.0066 0.0119 0.2533
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0099 0.02 0.0311
Mycobacterium tuberculosis Ribonucleoside-diphosphate reductase (beta chain) NrdF1 (ribonucleotide reductase small subunit) (R2F protein) 0.0066 0.0119 0.01
Echinococcus multilocularis Kelch repeat type 1 0.0093 0.0187 0.029
Giardia lamblia High cysteine protein 0.0115 0.0239 1
Trypanosoma cruzi Eukaryotic initiation factor 4A-1 0.005 0.008 0.1693
Trypanosoma brucei unspecified product 0.0073 0.0138 0.2934
Brugia malayi Integrin beta pat-3 precursor 0.3554 0.8644 1
Plasmodium falciparum ribonucleoside-diphosphate reductase large subunit, putative 0.0208 0.0467 1
Plasmodium falciparum eukaryotic initiation factor 4A 0.005 0.008 0.1693
Schistosoma mansoni ribonucleoside-diphosphate reductase alpha subunit 0.0208 0.0467 0.072
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 3 0.0039 0.0054 0.0083
Echinococcus granulosus glutamate receptor subunit protein glur 0.0039 0.0054 0.0083
Loa Loa (eye worm) hypothetical protein 0.005 0.008 0.008
Brugia malayi hypothetical protein 0.0021 0.001 0.001
Loa Loa (eye worm) hypothetical protein 0.0115 0.0239 0.0239
Echinococcus multilocularis ribonucleoside diphosphate reductase large 0.0208 0.0467 0.0729
Echinococcus multilocularis integrin beta 2 0.2633 0.6393 1
Onchocerca volvulus 0.0021 0.001 0.0374
Echinococcus granulosus glutamate receptor 2 0.0088 0.0173 0.0268
Loa Loa (eye worm) hypothetical protein 0.0622 0.1479 0.1479
Schistosoma mansoni cpg binding protein 0.0028 0.0028 0.0041
Trypanosoma cruzi Eukaryotic initiation factor 4A-1 0.005 0.008 0.1693
Echinococcus granulosus kelch ECH associated protein 1 0.0093 0.0186 0.0289
Loa Loa (eye worm) hypothetical protein 0.0062 0.011 0.011
Echinococcus multilocularis glutamate receptor 2 0.0106 0.0217 0.0337
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0031 0.0034 0.0034
Schistosoma mansoni hypothetical protein 0.0062 0.011 0.0169
Trichomonas vaginalis Clan AA, family A1, cathepsin D-like aspartic peptidase 0.0048 0.0077 0.1762
Schistosoma mansoni metabotropic glutamate receptor 0.0021 0.001 0.0014
Loa Loa (eye worm) hypothetical protein 0.0032 0.0037 0.0037
Chlamydia trachomatis ribonucleoside-diphosphate reductase subunit alpha 0.0208 0.0467 1
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0031 0.0034 0.0051
Loa Loa (eye worm) hypothetical protein 0.054 0.1278 0.1278
Trypanosoma brucei DNA polymerase kappa, putative 0.0035 0.0045 0.0938
Schistosoma mansoni tyrosine kinase 0.0023 0.0016 0.0023
Trichomonas vaginalis DEAD box ATP-dependent RNA helicase, putative 0.005 0.008 0.1841
Brugia malayi metabotropic GABA-B receptor subtype 2 0.0021 0.001 0.001
Loa Loa (eye worm) kelch domain-containing protein family protein 0.0546 0.1294 0.1294
Schistosoma mansoni mixed-lineage leukemia protein mll 0.006 0.0105 0.0161
Mycobacterium ulcerans imidazoleglycerol-phosphate dehydratase 0.3527 0.8578 1
Schistosoma mansoni DNA polymerase eta 0.0031 0.0034 0.0051
Trypanosoma brucei DNA polymerase eta, putative 0.0031 0.0034 0.0703
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0031 0.0034 0.0051
Schistosoma mansoni cathepsin D (A01 family) 0.0142 0.0306 0.0472
Brugia malayi EGF-like domain containing protein 0.0115 0.0239 0.0275
Echinococcus multilocularis atrial natriuretic peptide receptor 0.006 0.0105 0.0163
Trypanosoma brucei unspecified product 0.0021 0.0011 0.0201
Plasmodium vivax RNA helicase-1, putative 0.005 0.008 0.1693
Echinococcus multilocularis protein jagged 2 0.0115 0.0239 0.0371
Loa Loa (eye worm) hypothetical protein 0.0031 0.0034 0.0034
Schistosoma mansoni DEAD box ATP-dependent RNA helicase 0.005 0.008 0.0122
Echinococcus granulosus atrial natriuretic peptide receptor 0.006 0.0105 0.0163
Brugia malayi EGF-like domain containing protein 0.0115 0.0239 0.0275
Trypanosoma cruzi extracellular receptor, putative 0.0021 0.001 0.0191
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0127 0.0268 0.0418
Trichomonas vaginalis teneurin and N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase, putative 0.0115 0.0239 0.5545
Brugia malayi Glutamate receptor 1 precursor 0.0106 0.0217 0.0249
Trypanosoma brucei DNA polymerase IV, putative 0.0087 0.0172 0.3671
Brugia malayi EGF-like domain containing protein 0.0115 0.0239 0.0275
Echinococcus granulosus GPCR family 2 0.0099 0.02 0.0311
Mycobacterium tuberculosis Probable cold-shock DeaD-box protein A homolog DeaD (ATP-dependent RNA helicase dead homolog) 0.005 0.008 0.0054
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0127 0.0268 0.0418
Loa Loa (eye worm) hypothetical protein 0.0021 0.001 0.001
Leishmania major extracellular receptor, putative 0.0021 0.001 0.0191
Plasmodium vivax ribonucleoside-diphosphate reductase large chain, putative 0.0208 0.0467 1
Echinococcus granulosus integrin alpha ps 0.0573 0.1358 0.2123
Echinococcus multilocularis integrin alpha 3 0.2043 0.4952 0.7746
Loa Loa (eye worm) glutamate receptor 0.0021 0.001 0.001
Echinococcus granulosus integrin beta 2 0.2633 0.6393 1
Echinococcus multilocularis adam 0.0115 0.0239 0.0371
Trichomonas vaginalis DEAD box ATP-dependent RNA helicase, putative 0.005 0.008 0.1841
Onchocerca volvulus 0.0029 0.0029 0.118
Brugia malayi Integrin alpha cytoplasmic region family protein 0.2016 0.4886 0.5652
Trichomonas vaginalis DEAD box ATP-dependent RNA helicase, putative 0.005 0.008 0.1841
Trypanosoma cruzi ribonucleoside-diphosphate reductase small chain, putative 0.0066 0.0119 0.2533
Entamoeba histolytica deoxycytidyl transferase, putative 0.0031 0.0034 0.3409
Treponema pallidum ribonucleotide-diphosphate reductase subunit beta 0.0066 0.0119 0.1011
Echinococcus granulosus eukaryotic initiation factor 4A III 0.005 0.008 0.0123
Schistosoma mansoni cpg binding protein 0.003 0.0032 0.0047
Loa Loa (eye worm) lethal(1)discs large-1 tumor suppressor 0.0044 0.0066 0.0066
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0127 0.0268 0.0418
Echinococcus granulosus dna polymerase eta 0.0031 0.0034 0.0051
Schistosoma mansoni hypothetical protein 0.0062 0.011 0.0169
Trypanosoma brucei ribonucleoside-diphosphate reductase small chain 0.0066 0.0119 0.2533
Schistosoma mansoni hypothetical protein 0.0119 0.025 0.0384
Loa Loa (eye worm) integrin beta-2 0.3554 0.8644 0.8644
Trypanosoma cruzi ribonucleoside-diphosphate reductase large chain, putative 0.0208 0.0467 1
Loa Loa (eye worm) latrophilin receptor protein 2 0.0099 0.02 0.02
Schistosoma mansoni hypothetical protein 0.0093 0.0187 0.0287
Schistosoma mansoni glutamate receptor AMPA 0.0106 0.0217 0.0333
Schistosoma mansoni cathepsin D (A01 family) 0.0142 0.0306 0.0472
Onchocerca volvulus Atrial natriuretic peptide receptor 3 homolog 0.0068 0.0124 0.5193
Loa Loa (eye worm) hypothetical protein 0.0021 0.001 0.001
Echinococcus granulosus cpg binding protein 0.003 0.0032 0.0048
Brugia malayi Peripheral plasma membrane protein CASK 0.002 0.0008 0.0008
Loa Loa (eye worm) glutamate receptor 2 0.0106 0.0217 0.0217
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.1271 0.3066 0.3546
Schistosoma mansoni glutamate receptor kainate 0.0106 0.0217 0.0333
Trypanosoma cruzi ribonucleoside-diphosphate reductase small chain, putative 0.0066 0.0119 0.2533
Wolbachia endosymbiont of Brugia malayi ribonucleotide-diphosphate reductase subunit alpha 0.0193 0.0429 1
Echinococcus granulosus ribonucleoside diphosphate reductase large 0.0208 0.0467 0.0729
Echinococcus multilocularis glutamate receptor ionotropic kainate 0.0039 0.0054 0.0083
Mycobacterium ulcerans DNA polymerase IV 0.0087 0.0172 0.0186
Mycobacterium leprae Probable imidazole glycerol-phosphate dehydratase HisB 0.174 0.421 1
Plasmodium vivax ribonucleotide reductase small subunit, putative 0.0022 0.0013 0.0255
Onchocerca volvulus 0.0115 0.0239 1
Echinococcus multilocularis glutamate receptor subunit protein glur 0.0039 0.0054 0.0083
Toxoplasma gondii ribonucleoside-diphosphate reductase large chain 0.0208 0.0467 1
Echinococcus multilocularis dna polymerase eta 0.0031 0.0034 0.0051
Echinococcus granulosus EGFP:Bcl2 fusion protein 0.0778 0.186 0.2908
Leishmania major DNA polymerase eta, putative 0.0031 0.0034 0.0703
Toxoplasma gondii aspartyl proteinase (eimepsin), putative 0.0048 0.0077 0.162
Brugia malayi Probable ATP-dependent helicase DHX35 0.0032 0.0037 0.0041
Schistosoma mansoni integrin alpha-ps 0.0622 0.1479 0.2284
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0127 0.0268 0.0418
Trypanosoma brucei DNA polymerase kappa, putative 0.0087 0.0172 0.3671
Mycobacterium ulcerans DNA polymerase IV 0.0087 0.0172 0.0186
Echinococcus multilocularis glutamate receptor, ionotrophic, AMPA 3 0.0127 0.0268 0.0418
Giardia lamblia Tenascin-like 0.0115 0.0239 1
Loa Loa (eye worm) hypothetical protein 0.1471 0.3552 0.3552
Trypanosoma brucei DNA polymerase kappa, putative 0.0087 0.0172 0.3671
Trypanosoma brucei DNA polymerase kappa, putative 0.0045 0.0068 0.1439
Echinococcus multilocularis eukaryotic initiation factor 4A III 0.005 0.008 0.0123
Trypanosoma brucei DNA polymerase kappa, putative 0.0087 0.0172 0.3671
Echinococcus granulosus glutamate receptor ionotropic kainate 0.0039 0.0054 0.0083
Giardia lamblia Translation initiation factor eIF-4A, putative 0.005 0.008 0.0693
Trypanosoma brucei DNA polymerase kappa, putative 0.0035 0.0045 0.0938
Echinococcus multilocularis Bcl 2 ous antagonist:killer 0.0062 0.011 0.0171
Leishmania major eukaryotic initiation factor 4a, putative 0.005 0.008 0.1693
Echinococcus granulosus glutamate receptor 2 0.0127 0.0268 0.0418
Loa Loa (eye worm) receptor family ligand binding region containing protein 0.0021 0.001 0.001
Leishmania major eukaryotic initiation factor 4a, putative 0.005 0.008 0.1693
Trypanosoma brucei DNA polymerase IV, putative 0.0073 0.0138 0.2934
Echinococcus multilocularis fibrillin 1 0.0115 0.0239 0.0371
Trypanosoma brucei DNA polymerase kappa, putative 0.0087 0.0172 0.3671
Mycobacterium tuberculosis Ribonucleoside-diphosphate reductase (alpha chain) NrdE (ribonucleotide reductase small subunit) (R1F protein) 0.0193 0.0429 0.0463
Schistosoma mansoni hypothetical protein 0.0039 0.0054 0.0082
Trypanosoma cruzi DNA polymerase kappa, putative 0.0087 0.0172 0.3671
Brugia malayi ribonucleoside-diphosphate reductase large chain, putative 0.0208 0.0467 0.0539
Echinococcus multilocularis integrin alpha ps 0.0573 0.1358 0.2123
Echinococcus multilocularis dna polymerase kappa 0.0087 0.0172 0.0267
Loa Loa (eye worm) hypothetical protein 0.0021 0.001 0.001
Treponema pallidum ribonucleotide-diphosphate reductase subunit alpha 0.0208 0.0467 1
Echinococcus multilocularis Ribosomal protein S1, RNA binding domain 0.0039 0.0054 0.0083
Brugia malayi Kelch motif family protein 0.0546 0.1294 0.1496
Trypanosoma brucei DNA polymerase kappa, putative 0.0087 0.0172 0.3671
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0031 0.0034 0.0051
Schistosoma mansoni ATP-binding cassette transporter 0.0106 0.0217 0.0333
Loa Loa (eye worm) hypothetical protein 0.0021 0.001 0.001
Mycobacterium leprae RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE (ALPHA CHAIN) NRDE (RIBONUCLEOTIDE REDUCTASE SMALL SUBUNIT) (R1F PROTEIN) 0.0193 0.0429 0.0992
Schistosoma mansoni integrin beta subunit 0.2093 0.5073 0.7838
Echinococcus granulosus kelch ECH associated protein 1 like 0.0093 0.0186 0.0289
Echinococcus multilocularis metabotropic glutamate receptor 2 0.0021 0.001 0.0014
Echinococcus multilocularis kelch ECH associated protein 1 0.0093 0.0186 0.0289
Mycobacterium tuberculosis Probable imidazole glycerol-phosphate dehydratase HisB 0.3527 0.8578 1
Entamoeba histolytica DEAD/DEAH box helicase, putative 0.005 0.008 1
Schistosoma mansoni integrin alpha 0.2666 0.6473 1
Onchocerca volvulus 0.0028 0.0028 0.1123
Toxoplasma gondii eukaryotic initiation factor-4A, putative 0.005 0.008 0.1693
Loa Loa (eye worm) hypothetical protein 0.0017 0.0001 0.0001
Brugia malayi metabotropic glutamate receptor type 2 0.0021 0.001 0.001
Echinococcus granulosus glutamate receptor ionotropic kainate 3 0.0039 0.0054 0.0083
Loa Loa (eye worm) hypothetical protein 0.0017 0.0001 0.0001
Trypanosoma brucei DNA polymerase kappa, putative 0.0087 0.0172 0.3671
Toxoplasma gondii ribonucleoside-diphosphate reductase small subunit 0.0066 0.0119 0.2533
Trypanosoma brucei ribonucleoside-diphosphate reductase small chain 0.0022 0.0013 0.0255
Plasmodium falciparum ribonucleoside-diphosphate reductase small chain, putative 0.0022 0.0013 0.0255
Loa Loa (eye worm) hypothetical protein 0.0213 0.048 0.048
Giardia lamblia Tenascin-37 0.0115 0.0239 1
Loa Loa (eye worm) RGC/RGC protein kinase 0.0029 0.0029 0.0029
Echinococcus granulosus integrin alpha ps 0.1195 0.2879 0.4502
Trichomonas vaginalis ribonucleoside-diphosphate reductase alpha chain, putative 0.0193 0.0429 1
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0045 0.0068 0.1439
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0087 0.0172 0.3992
Trypanosoma brucei ribonucleoside-diphosphate reductase small chain 0.0066 0.0119 0.2533
Echinococcus multilocularis EGFP:Bcl2 fusion protein 0.0778 0.186 0.2908
Toxoplasma gondii histone lysine methyltransferase SET1 0.0054 0.009 0.1901
Schistosoma mansoni glutamate receptor AMPA 0.0106 0.0217 0.0333
Schistosoma mansoni integrin alpha-ps 0.1195 0.2879 0.4447
Echinococcus multilocularis glutamate (NMDA) receptor subunit 0.0106 0.0217 0.0337
Trypanosoma cruzi DNA polymerase eta, putative 0.0031 0.0034 0.0703
Trypanosoma cruzi ribonucleoside-diphosphate reductase large chain, putative 0.0059 0.0103 0.2188
Echinococcus multilocularis glutamate receptor 2 0.0127 0.0268 0.0418
Plasmodium falciparum plasmepsin II 0.0048 0.0077 0.162
Brugia malayi Guanylate kinase family protein 0.0051 0.0084 0.0096
Loa Loa (eye worm) hypothetical protein 0.0021 0.001 0.001
Loa Loa (eye worm) hypothetical protein 0.0023 0.0016 0.0016
Loa Loa (eye worm) hypothetical protein 0.2016 0.4886 0.4886
Trypanosoma brucei DNA polymerase kappa, putative 0.0087 0.0172 0.3671
Brugia malayi Receptor family ligand binding region containing protein 0.0068 0.0124 0.0143
Echinococcus granulosus receptor type guanylyl cyclase 0.0068 0.0124 0.0193
Schistosoma mansoni DEAD box ATP-dependent RNA helicase 0.005 0.008 0.0122
Loa Loa (eye worm) hypothetical protein 0.0573 0.1358 0.1358
Schistosoma mansoni hypothetical protein 0.0099 0.02 0.0307
Echinococcus granulosus Ribosomal protein S1 RNA binding domain 0.0039 0.0054 0.0083
Echinococcus multilocularis nmda type glutamate receptor 0.0039 0.0054 0.0083
Loa Loa (eye worm) ribonucleotide reductase M2 B 0.0066 0.0119 0.0119
Schistosoma mansoni metabotropic glutamate receptor 0.0021 0.001 0.0014
Loa Loa (eye worm) hypothetical protein 0.0115 0.0239 0.0239
Echinococcus granulosus metabotropic glutamate receptor 5 0.0021 0.001 0.0014
Brugia malayi Integrin alpha pat-2 precursor 0.2666 0.6473 0.7487
Brugia malayi Apoptosis regulator proteins, Bcl-2 family protein 0.0062 0.011 0.0126
Loa Loa (eye worm) hypothetical protein 0.0021 0.001 0.001
Trypanosoma cruzi DNA polymerase kappa, putative 0.0087 0.0172 0.3671
Loa Loa (eye worm) hypothetical protein 0.0099 0.02 0.02
Loa Loa (eye worm) hypothetical protein 0.0021 0.001 0.001
Echinococcus granulosus Bcl 2 ous antagonist:killer 0.0062 0.011 0.0171
Giardia lamblia Tenascin-X 0.0115 0.0239 1
Schistosoma mansoni hypothetical protein 0.0573 0.1358 0.2097
Trypanosoma brucei DNA polymerase kappa, putative 0.0087 0.0172 0.3671
Brugia malayi ImpB/MucB/SamB family protein 0.0031 0.0034 0.0038
Echinococcus multilocularis receptor type guanylyl cyclase 0.0068 0.0124 0.0193
Loa Loa (eye worm) RGC/RGC protein kinase 0.0068 0.0124 0.0124
Trypanosoma brucei unspecified product 0.0021 0.0011 0.0201
Schistosoma mansoni protein kinase 0.0068 0.0124 0.0191
Schistosoma mansoni glutamate receptor NMDA 0.0127 0.0268 0.0413
Giardia lamblia hypothetical protein 0.0115 0.0239 1
Echinococcus granulosus dna polymerase kappa 0.0087 0.0172 0.0267
Mycobacterium ulcerans ribonucleotide-diphosphate reductase subunit alpha 0.0193 0.0429 0.0486
Plasmodium vivax plasmepsin IV, putative 0.0048 0.0077 0.162
Brugia malayi Guanylyl cyclase protein 23 0.0029 0.0029 0.0032
Schistosoma mansoni cpg binding protein 0.003 0.0032 0.0047
Toxoplasma gondii BRCA1 C Terminus (BRCT) domain-containing protein 0.0024 0.0016 0.0325
Loa Loa (eye worm) hypothetical protein 0.0115 0.0239 0.0239
Trypanosoma brucei ribonucleoside-diphosphate reductase large chain 0.0208 0.0467 1
Echinococcus granulosus fibrillin 1 0.0115 0.0239 0.0371
Schistosoma mansoni apoptosis regulator bax 0.0062 0.011 0.0169
Echinococcus multilocularis nmda type glutamate receptor 0.0021 0.001 0.0014
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0099 0.02 0.023
Schistosoma mansoni tyrosine kinase 0.0023 0.0016 0.0023
Leishmania major ribonucleoside-diphosphate reductase large chain, putative 0.0208 0.0467 1
Schistosoma mansoni hypothetical protein 0.0099 0.02 0.0307
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0045 0.0068 0.004
Loa Loa (eye worm) hypothetical protein 0.0021 0.001 0.001
Leishmania major ribonucleoside-diphosphate reductase small chain, putative 0.0066 0.0119 0.2533
Schistosoma mansoni cell polarity protein 0.0047 0.0073 0.011
Echinococcus granulosus adam 0.0115 0.0239 0.0371
Trypanosoma brucei DNA polymerase IV, putative 0.0087 0.0172 0.3671
Brugia malayi hypothetical protein 0.054 0.1278 0.1478
Onchocerca volvulus 0.002 0.0008 0.0279
Echinococcus granulosus integrin alpha 3 0.2043 0.4952 0.7746
Loa Loa (eye worm) ribonucleoside-diphosphate reductase large subunit 0.0208 0.0467 0.0467
Trypanosoma brucei DNA polymerase kappa, putative 0.0035 0.0045 0.0938
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0099 0.02 0.0311
Loa Loa (eye worm) DEAH box polypeptide 35 0.0032 0.0037 0.0037
Giardia lamblia High cysteine protein 0.0115 0.0239 1
Toxoplasma gondii hypothetical protein 0.0115 0.0239 0.5098
Echinococcus granulosus tyrosine kinase 0.0023 0.0016 0.0023
Echinococcus granulosus eukaryotic initiation factor 4A 0.005 0.008 0.0123
Echinococcus multilocularis GPCR, family 2 0.0099 0.02 0.0311
Brugia malayi Calcitonin receptor-like protein seb-1 0.0312 0.0721 0.0833
Giardia lamblia Neurogenic locus notch-like protein 0.0115 0.0239 1
Trypanosoma brucei RNA helicase, putative 0.0119 0.025 0.5342
Brugia malayi EGF-like domain containing protein 0.0115 0.0239 0.0275
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.1058 0.2545 0.3979
Schistosoma mansoni hypothetical protein 0.0099 0.02 0.0307
Schistosoma mansoni hypothetical protein 0.0099 0.02 0.0307
Brugia malayi Metabotropic glutamate receptor precursor. 0.0021 0.001 0.001
Loa Loa (eye worm) metabotropic glutamate receptor 8 0.0021 0.001 0.001
Echinococcus multilocularis NMDA receptor 0.0039 0.0054 0.0083
Brugia malayi Glutamate receptor 2 precursor 0.0106 0.0217 0.0249
Echinococcus multilocularis disks large 3 0.0047 0.0073 0.0112
Brugia malayi ribonucleotide reductase 2 0.0066 0.0119 0.0136
Loa Loa (eye worm) hypothetical protein 0.0115 0.0239 0.0239
Schistosoma mansoni ribonucleoside-diphosphate reductase small chain 0.0066 0.0119 0.0182
Schistosoma mansoni glutamate receptor kainate 0.0106 0.0217 0.0333
Mycobacterium tuberculosis Probable ribonucleoside-diphosphate reductase (large subunit) NrdZ (ribonucleotide reductase) 0.0069 0.0128 0.011
Plasmodium falciparum plasmepsin I 0.0048 0.0077 0.162
Loa Loa (eye worm) metabotropic GABA-B receptor subtype 2 0.0021 0.001 0.001
Schistosoma mansoni hypothetical protein 0.0062 0.011 0.0169
Echinococcus granulosus nmda type glutamate receptor 0.0039 0.0054 0.0083
Brugia malayi CXXC zinc finger family protein 0.0028 0.0028 0.0031
Trypanosoma brucei ribonucleoside-diphosphate reductase small chain, putative 0.0066 0.0119 0.2533
Echinococcus granulosus ribonucleoside diphosphate reductase subunit 0.0066 0.0119 0.0185
Trypanosoma cruzi DNA polymerase kappa, putative 0.0087 0.0172 0.3671
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.0028 0.0028
Toxoplasma gondii aspartyl protease ASP1 0.0048 0.0077 0.162
Plasmodium vivax aspartyl proteinase, putative 0.0048 0.0077 0.162

Activities

Activity type Activity value Assay description Source Reference
Inhibition (functional) = 14.6 % Inhibition of carrageenan hind paw edema in rats after oral administration of a dose of 5 mg/kg ChEMBL. 2299620

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

No external resources registered for this compound

Bibliographic References

1 literature reference was collected for this gene.

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