TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 414.576 | Formula: C23H42O6
H donors: 3 H acceptors: 5 LogP: 5 Rotable bonds: 14
Rule of 5 violations (Lipinski): 1
SMILES: CCC[C@@H]1CCC[C@@H]([C@H]1COC(=O)C(CC)(C)C)CC[C@H](C[C@H](CC(=O)O)O)O
InChi: 1S/C23H42O6/c1-5-8-16-9-7-10-17(11-12-18(24)13-19(25)14-21(26)27)20(16)15-29-22(28)23(3,4)6-2/h16-20,24-25H,5-15H2,1-4H3,(H,26,27)/t16-,17-,18-,19-,20+/m1/s1
InChiKey: NEKAZEXAFPCIDR-WAPOTWQKSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	3-hydroxy-3-methylglutaryl-CoA reductase	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Leishmania mexicana	3-hydroxy-3-methylglutaryl-CoA reductase, putative	Get druggable targets OG5_127955	All targets in OG5_127955
Trypanosoma brucei gambiense	3-hydroxy-3-methylglutaryl-CoA reductase, putative	Get druggable targets OG5_127955	All targets in OG5_127955
Schistosoma mansoni	hydroxymethylglutaryl-CoA reductase (NADPH)	Get druggable targets OG5_127955	All targets in OG5_127955
Trypanosoma cruzi	3-hydroxy-3-methylglutaryl-CoA reductase	Get druggable targets OG5_127955	All targets in OG5_127955
Leishmania major	3-hydroxy-3-methylglutaryl-CoA reductase	Get druggable targets OG5_127955	All targets in OG5_127955
Echinococcus multilocularis	hydroxymethylglutaryl coenzyme A reductase	Get druggable targets OG5_127955	All targets in OG5_127955
Brugia malayi	Hydroxymethylglutaryl-coenzyme A reductase family protein	Get druggable targets OG5_127955	All targets in OG5_127955
Candida albicans	hydroxymethylglutaryl-CoA reductase (ergosterol biosynthesis)	Get druggable targets OG5_127955	All targets in OG5_127955
Mycobacterium ulcerans	hydroxymethylglutaryl-coenzyme a (HMG-CoA) reductase	Get druggable targets OG5_127955	All targets in OG5_127955
Leishmania braziliensis	3-hydroxy-3-methylglutaryl-CoA reductase, putative	Get druggable targets OG5_127955	All targets in OG5_127955
Candida albicans	hydroxymethylglutaryl-CoA reductase (ergosterol biosynthesis)	Get druggable targets OG5_127955	All targets in OG5_127955
Trypanosoma cruzi	3-hydroxy-3-methylglutaryl-CoA reductase, putative	Get druggable targets OG5_127955	All targets in OG5_127955
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_127955	All targets in OG5_127955
Trypanosoma brucei	3-hydroxy-3-methylglutaryl-CoA reductase, putative	Get druggable targets OG5_127955	All targets in OG5_127955
Echinococcus granulosus	hydroxymethylglutaryl coenzyme A reductase	Get druggable targets OG5_127955	All targets in OG5_127955
Leishmania infantum	3-hydroxy-3-methylglutaryl-CoA reductase, putative	Get druggable targets OG5_127955	All targets in OG5_127955
Leishmania donovani	3-hydroxy-3-methylglutaryl-CoA reductase, putative	Get druggable targets OG5_127955	All targets in OG5_127955
Schistosoma japonicum	ko:K00021 3-hydroxy-3-methylglutaryl-CoA reductase [EC1.1.1.34], putative	Get druggable targets OG5_127955	All targets in OG5_127955
Trypanosoma congolense	3-hydroxy-3-methylglutaryl-CoA reductase, putative	Get druggable targets OG5_127955	All targets in OG5_127955

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trypanosoma brucei	Silent information regulator 2 related protein 1	0.0085	0.1756	0.3998
Mycobacterium tuberculosis	Conserved protein	0.0039	0.0533	0.0354
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.0029	0.0269	0.0269
Trypanosoma cruzi	prolyl endopeptidase	0.0031	0.0328	0.0841
Schistosoma mansoni	hypothetical protein	0.0183	0.438	0.438
Mycobacterium tuberculosis	Probable esterase/lipase LipP	0.0039	0.0533	0.0354
Brugia malayi	Trypsin family protein	0.0053	0.0906	0.0906
Loa Loa (eye worm)	hypothetical protein	0.0053	0.0906	0.0906
Mycobacterium leprae	Probable lipase LipE	0.0039	0.0533	1
Brugia malayi	prolyl oligopeptidase family protein	0.0133	0.3027	0.3027
Trypanosoma brucei	serine peptidase, Clan SC, Family S9B	0.0133	0.3027	0.7557
Brugia malayi	TAR-binding protein	0.0061	0.1129	0.1129
Echinococcus multilocularis	histone lysine N methyltransferase SETMAR	0.0029	0.0265	0.0265
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0061	0.1129	0.1129
Leishmania major	silent information regulator 2, putative	0.0085	0.1756	0.4502
Trichomonas vaginalis	D-aminoacylase, putative	0.0039	0.0533	0.0389
Brugia malayi	Stress-activated protein kinase jnk-1	0.0265	0.6561	0.6561
Mycobacterium leprae	conserved hypothetical protein	0.0039	0.0533	1
Trypanosoma cruzi	hypothetical protein, conserved	0.0031	0.0328	0.0841
Giardia lamblia	3-hydroxy-3-methylglutaryl-coenzyme A reductase	0.0078	0.1562	0.864
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0094	0.1994	0.1994
Mycobacterium ulcerans	beta-lactamase	0.0039	0.0533	0.0575
Trypanosoma cruzi	hypothetical protein, conserved	0.0039	0.0533	0.1367
Trypanosoma cruzi	serine peptidase, clan SC, family S9A-like protein, putative	0.0031	0.0328	0.0841
Mycobacterium ulcerans	lipase LipD	0.0039	0.0533	0.0575
Schistosoma mansoni	prolyl oligopeptidase (S09 family)	0.0031	0.0328	0.0328
Trypanosoma cruzi	3-hydroxy-3-methylglutaryl-CoA reductase	0.0165	0.39	1
Trichomonas vaginalis	3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative	0.0078	0.1562	0.2337
Mycobacterium tuberculosis	Conserved protein	0.0039	0.0533	0.0354
Brugia malayi	hypothetical protein	0.0101	0.2194	0.2194
Echinococcus multilocularis	glycoprotein Antigen 5	0.0029	0.0269	0.0269
Schistosoma mansoni	transcription factor LCR-F1	0.0036	0.0449	0.0449
Trichomonas vaginalis	D-aminoacylase, putative	0.0039	0.0533	0.0389
Leishmania major	hypothetical protein, conserved	0.0039	0.0533	0.1367
Loa Loa (eye worm)	prolyl oligopeptidase	0.0031	0.0328	0.0328
Trypanosoma cruzi	dipeptidyl-peptidase 8-like serine peptidase	0.0133	0.3027	0.7762
Trichomonas vaginalis	penicillin-binding protein, putative	0.0039	0.0533	0.0389
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0533	0.0533
Trypanosoma cruzi	Silent information regulator 2 related protein 1	0.0085	0.1756	0.4502
Mycobacterium tuberculosis	Probable conserved lipoprotein	0.0039	0.0533	0.0354
Echinococcus multilocularis	protein patched	0.0068	0.1308	0.1308
Schistosoma mansoni	niemann-pick C1 (NPC1)	0.0068	0.1308	0.1308
Schistosoma mansoni	tar DNA-binding protein	0.0061	0.1129	0.1129
Schistosoma mansoni	chromatin regulatory protein sir2	0.0085	0.1756	0.1756
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0029	0.0265	0.0265
Onchocerca volvulus		0.0029	0.0265	0.0265
Echinococcus multilocularis	Niemann Pick C1 protein	0.0068	0.1308	0.1308
Trichomonas vaginalis	set domain proteins, putative	0.0229	0.5606	1
Entamoeba histolytica	Sir2 family transcriptional regulator, putative	0.0085	0.1756	1
Echinococcus granulosus	Protein patched homolog 1	0.0068	0.1308	0.1308
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0039	0.0533	0.0533
Echinococcus multilocularis	NAD dependent deacetylase sirtuin 3	0.0085	0.1756	0.1756
Loa Loa (eye worm)	hypothetical protein	0.0053	0.0906	0.0906
Trichomonas vaginalis	esterase, putative	0.0039	0.0533	0.0389
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0094	0.1994	0.1994
Trypanosoma cruzi	oligopeptidase b	0.0031	0.0328	0.0841
Onchocerca volvulus	Prolyl endopeptidase homolog	0.0031	0.0328	0.0328
Entamoeba histolytica	hypothetical protein	0.0036	0.0449	0.0848
Onchocerca volvulus		0.0039	0.0533	0.0533
Onchocerca volvulus		0.0042	0.0617	0.0617
Trypanosoma cruzi	3-hydroxy-3-methylglutaryl-CoA reductase, putative	0.0165	0.39	1
Schistosoma mansoni	patched 1	0.0068	0.1308	0.1308
Echinococcus multilocularis	dipeptidyl aminopeptidaseprotein	0.0394	1	1
Brugia malayi	follicle stimulating hormone receptor	0.0244	0.5989	0.5989
Toxoplasma gondii	dipeptidyl peptidase iv (dpp iv) n-terminal region domain-containing protein	0.0133	0.3027	1
Echinococcus granulosus	Niemann Pick C1 protein	0.0068	0.1308	0.1308
Trichomonas vaginalis	D-aminoacylase, putative	0.0039	0.0533	0.0389
Mycobacterium tuberculosis	Probable esterase LipL	0.0039	0.0533	0.0354
Echinococcus multilocularis	tar DNA binding protein	0.0061	0.1129	0.1129
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0533	0.0533
Brugia malayi	beta-lactamase family protein	0.0039	0.0533	0.0533
Schistosoma mansoni	tar DNA-binding protein	0.0061	0.1129	0.1129
Echinococcus multilocularis	Dipeptidyl peptidase 9	0.0133	0.3027	0.3027
Mycobacterium tuberculosis	Probable lipase LipE	0.0039	0.0533	0.0354
Echinococcus multilocularis	protein dispatched 1	0.0068	0.1308	0.1308
Trypanosoma cruzi	oligopeptidase B-like protein, putative	0.0031	0.0328	0.0841
Trypanosoma brucei	3-hydroxy-3-methylglutaryl-CoA reductase, putative	0.0165	0.39	1
Brugia malayi	RNA recognition motif domain containing protein	0.0061	0.1129	0.1129
Loa Loa (eye worm)	CMGC/MAPK/JNK protein kinase	0.0265	0.6561	0.6561
Brugia malayi	Pre-SET motif family protein	0.0029	0.0265	0.0265
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0328	0.0328
Echinococcus granulosus	prolyl endopeptidase	0.0031	0.0328	0.0328
Brugia malayi	prolyl oligopeptidase family protein	0.0031	0.0328	0.0328
Toxoplasma gondii	hypothetical protein	0.0031	0.0328	0.1083
Brugia malayi	prolyl oligopeptidase family protein	0.0031	0.0328	0.0328
Brugia malayi	beta-lactamase family protein	0.0039	0.0533	0.0533
Echinococcus multilocularis	sterol regulatory element binding protein	0.0068	0.1308	0.1308
Mycobacterium tuberculosis	Probable lipase LipD	0.0039	0.0533	0.0354
Leishmania major	3-hydroxy-3-methylglutaryl-CoA reductase	0.0165	0.39	1
Loa Loa (eye worm)	abnormal chemotaxis protein 14	0.0068	0.1308	0.1308
Onchocerca volvulus		0.0039	0.0533	0.0533
Trypanosoma brucei	hypothetical protein, conserved	0.0039	0.0533	0.0575
Brugia malayi	RNA binding protein	0.0061	0.1129	0.1129
Toxoplasma gondii	ABC1 family protein	0.0039	0.0533	0.1761
Loa Loa (eye worm)	hypothetical protein	0.0165	0.39	0.39
Schistosoma mansoni	hypothetical protein	0.0183	0.438	0.438
Echinococcus granulosus	sterol regulatory element binding protein	0.0068	0.1308	0.1308
Plasmodium vivax	hypothetical protein, conserved	0.0039	0.0533	1
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0039	0.0533	0.0533
Trichomonas vaginalis	3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative	0.0078	0.1562	0.2337
Leishmania major	oligopeptidase b	0.0031	0.0328	0.0841
Trichomonas vaginalis	conserved hypothetical protein	0.0068	0.1308	0.1858
Trichomonas vaginalis	3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative	0.0078	0.1562	0.2337
Echinococcus multilocularis	c Jun NH2 terminal kinase	0.0265	0.6561	0.6561
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0039	0.0533	0.0533
Echinococcus granulosus	chromatin regulatory protein sir2	0.0085	0.1756	0.1756
Echinococcus granulosus	glycoprotein Antigen 5	0.0029	0.0269	0.0269
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0036	0.0449	0.0449
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0265	0.0265
Onchocerca volvulus		0.0229	0.5606	0.5606
Entamoeba histolytica	hypothetical protein	0.0036	0.0449	0.0848
Schistosoma mansoni	hypothetical protein	0.0036	0.0449	0.0449
Schistosoma mansoni	hydroxymethylglutaryl-CoA reductase (NADPH)	0.0165	0.39	0.39
Echinococcus granulosus	hydroxymethylglutaryl coenzyme A reductase	0.0165	0.39	0.39
Schistosoma mansoni	subfamily S9B unassigned peptidase (S09 family)	0.0394	1	1
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0029	0.0265	0.0265
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0533	0.0533
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.0249	0.6126	1
Echinococcus granulosus	geminin	0.0183	0.438	0.438
Trichomonas vaginalis	penicillin-binding protein, putative	0.0039	0.0533	0.0389
Trichomonas vaginalis	chromatin regulatory protein sir2, putative	0.0085	0.1756	0.2705
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0094	0.1994	0.1994
Trypanosoma cruzi	hypothetical protein, conserved	0.0039	0.0533	0.1367
Brugia malayi	Pre-SET motif family protein	0.0201	0.4864	0.4864
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0094	0.1994	0.1994
Echinococcus granulosus	tar DNA binding protein	0.0061	0.1129	0.1129
Trypanosoma cruzi	serine peptidase, Clan SC, Family S9B	0.0133	0.3027	0.7762
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0094	0.1994	0.1994
Schistosoma mansoni	tar DNA-binding protein	0.0061	0.1129	0.1129
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0039	0.0533	0.0533
Echinococcus multilocularis	acylamino acid releasing enzyme	0.0031	0.0328	0.0328
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0533	0.0533
Plasmodium vivax	hypothetical protein, conserved	0.0031	0.0328	0.615
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0244	0.5989	0.5989
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0328	0.0328
Brugia malayi	beta-lactamase	0.0039	0.0533	0.0533
Schistosoma mansoni	histone-lysine n-methyltransferase suv9	0.0029	0.0265	0.0265
Schistosoma mansoni	tar DNA-binding protein	0.0061	0.1129	0.1129
Brugia malayi	transcriptional regulator, Sir2 family protein	0.0085	0.1756	0.1756
Mycobacterium tuberculosis	Probable hydrolase	0.0039	0.0533	0.0354
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0094	0.1994	0.1994
Echinococcus multilocularis	histone lysine methyltransferase setb histone lysine methyltransferase eggless	0.0029	0.0265	0.0265
Trypanosoma brucei	Dipeptidyl-peptidase 8-like, putative	0.0133	0.3027	0.7557
Toxoplasma gondii	prolyl endopeptidase	0.0031	0.0328	0.1083
Echinococcus granulosus	dipeptidyl aminopeptidaseprotein	0.0394	1	1
Schistosoma mansoni	prolyl oligopeptidase (S09 family)	0.0031	0.0328	0.0328
Echinococcus granulosus	5'partial\|histone lysine N methyltransferase SETDB2	0.0028	0.0237	0.0237
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0533	0.0533
Mycobacterium ulcerans	esterase/lipase LipP	0.0039	0.0533	0.0575
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0328	0.0328
Echinococcus granulosus	c-Jun N-terminal kinases	0.0265	0.6561	0.6561
Schistosoma mansoni	tar DNA-binding protein	0.0061	0.1129	0.1129
Loa Loa (eye worm)	transcriptional regulator	0.0085	0.1756	0.1756
Leishmania major	dipeptidyl-peptidase 8-like serine peptidase, putative,serine peptidase, Clan SC, Family S9B	0.0133	0.3027	0.7762
Brugia malayi	hypothetical protein	0.0036	0.0449	0.0449
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0039	0.0533	0.0533
Brugia malayi	Hydroxymethylglutaryl-coenzyme A reductase family protein	0.0165	0.39	0.39
Toxoplasma gondii	acylaminoacyl-peptidase, putative	0.0031	0.0328	0.1083
Mycobacterium tuberculosis	Conserved protein	0.0039	0.0533	0.0354
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0094	0.1994	0.1994
Echinococcus granulosus	beta LACTamase domain containing family member	0.0039	0.0533	0.0533
Brugia malayi	CHE-14 protein	0.0068	0.1308	0.1308
Echinococcus granulosus	NAD dependent deacetylase sirtuin 3	0.0085	0.1756	0.1756
Leishmania major	prolyl oligopeptidase, putative,serine peptidase clan SC, family S9A, putative	0.0031	0.0328	0.0841
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0094	0.1994	0.1994
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.0201	0.4864	0.4864
Schistosoma mansoni	chromatin regulatory protein sir2	0.0085	0.1756	0.1756
Schistosoma mansoni	acylaminoacyl-peptidase (S09 family)	0.0031	0.0328	0.0328
Brugia malayi	prolyl oligopeptidase family protein	0.0031	0.0328	0.0328
Onchocerca volvulus		0.0053	0.0906	0.0906
Echinococcus multilocularis	hydroxymethylglutaryl coenzyme A reductase	0.0165	0.39	0.39
Trichomonas vaginalis	chromatin regulatory protein sir2, putative	0.0085	0.1756	0.2705
Schistosoma mansoni	prolyl oligopeptidase (S09 family)	0.0031	0.0328	0.0328
Onchocerca volvulus	Dipeptidyl peptidase family member 1 homolog	0.0394	1	1
Echinococcus granulosus	Dipeptidyl peptidase 9	0.0133	0.3027	0.3027
Mycobacterium ulcerans	fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE	0.0039	0.0533	0.0575
Echinococcus granulosus	Mastin	0.0029	0.0269	0.0269
Mycobacterium ulcerans	hypothetical protein	0.0039	0.0533	0.0575
Echinococcus multilocularis	chromatin regulatory protein sir2	0.0085	0.1756	0.1756
Loa Loa (eye worm)	prolyl oligopeptidase	0.0394	1	1
Schistosoma mansoni	dipeptidyl-peptidase 9 (S09 family)	0.0133	0.3027	0.3027
Loa Loa (eye worm)	RNA binding protein	0.0061	0.1129	0.1129
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0029	0.0265	0.0265
Onchocerca volvulus		0.0039	0.0533	0.0533
Entamoeba histolytica	hypothetical protein	0.0036	0.0449	0.0848
Echinococcus multilocularis	Mastin	0.0029	0.0269	0.0269
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0533	0.0533
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0094	0.1994	0.1994
Trypanosoma cruzi	Silent information regulator 2 related protein 1	0.0085	0.1756	0.4502
Loa Loa (eye worm)	hypothetical protein	0.0101	0.2194	0.2194
Trypanosoma cruzi	hypothetical protein, conserved	0.0031	0.0328	0.0841
Echinococcus granulosus	histone lysine methyltransferase setb	0.0029	0.0265	0.0265
Entamoeba histolytica	hypothetical protein	0.0036	0.0449	0.0848
Mycobacterium tuberculosis	Possible conserved lipoprotein LpqK	0.0039	0.0533	0.0354
Loa Loa (eye worm)	TAR-binding protein	0.0061	0.1129	0.1129
Echinococcus multilocularis	enteropeptidase	0.0029	0.0269	0.0269
Giardia lamblia	Hypothetical protein	0.0085	0.1756	1
Entamoeba histolytica	Sir2 family transcriptional regulator, putative	0.0085	0.1756	1
Plasmodium vivax	SET domain protein, putative	0.0029	0.0265	0.4978
Echinococcus granulosus	enteropeptidase	0.0029	0.0269	0.0269
Loa Loa (eye worm)	hypothetical protein	0.0068	0.1308	0.1308
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.0053	0.0906	0.0906
Toxoplasma gondii	histone lysine methyltransferase SET/SUV39	0.0029	0.0265	0.0877
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0036	0.0449	0.0449
Mycobacterium ulcerans	hydroxymethylglutaryl-coenzyme a (HMG-CoA) reductase	0.0165	0.39	1
Leishmania major	oligopeptidase B-like protein,serine peptidase, clan SC, family S9A-like protein	0.0031	0.0328	0.0841
Loa Loa (eye worm)	beta-lactamase	0.0039	0.0533	0.0533
Echinococcus multilocularis	prolyl endopeptidase	0.0031	0.0328	0.0328
Plasmodium falciparum	peptidase, putative	0.0031	0.0328	1
Echinococcus multilocularis	geminin	0.0183	0.438	0.438
Trypanosoma cruzi	oligopeptidase b	0.0031	0.0328	0.0841
Schistosoma mansoni	chromatin regulatory protein sir2	0.0085	0.1756	0.1756
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.0053	0.0906	0.0906
Schistosoma mansoni	serine/threonine protein kinase	0.0265	0.6561	0.6561
Echinococcus granulosus	acylamino acid releasing enzyme	0.0031	0.0328	0.0328

Activities

Activity type	Activity value	Assay description	Source	Reference
I50 (binding)	= 1.7 uM	Compound was evaluated in vitro for its ability to inhibit HMG-CoA reductase	ChEMBL.	No reference
IC50 (binding)	= 1.7 uM	Compound was evaluated in vitro for its ability to inhibit HMG-CoA reductase	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

No external resources registered for this compound

Bibliographic References

No literature references available for this target.

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Detailed information for compound 255764