Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | Serotonin 2 (5-HT2) receptor | Starlite/ChEMBL | References |
Rattus norvegicus | Dopamine D1 receptor | Starlite/ChEMBL | References |
Rattus norvegicus | Dopamine D2 receptor | Starlite/ChEMBL | References |
Rattus norvegicus | Muscarinic acetylcholine receptor | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Schistosoma japonicum | 5-hydroxytryptamine receptor 1, putative | Get druggable targets OG5_132667 | All targets in OG5_132667 |
Schistosoma japonicum | 5-hydroxytryptamine receptor, putative | Get druggable targets OG5_132667 | All targets in OG5_132667 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0143 | 0.0043 | 0.08 |
Echinococcus granulosus | matrix metallopeptidase 7 M10 family | 0.0424 | 0.0321 | 1 |
Echinococcus multilocularis | endothelin converting enzyme 1 | 0.0189 | 0.0088 | 0.2744 |
Trypanosoma cruzi | Peptide deformylase 2, putative | 0.3884 | 0.3754 | 0.5 |
Loa Loa (eye worm) | matrixin family protein | 0.0259 | 0.0157 | 0.4324 |
Loa Loa (eye worm) | hypothetical protein | 0.0143 | 0.0043 | 0.08 |
Loa Loa (eye worm) | hypothetical protein | 0.0143 | 0.0043 | 0.08 |
Treponema pallidum | polypeptide deformylase (def) | 1.0179 | 1 | 0.5 |
Mycobacterium tuberculosis | Probable zinc metalloprotease Zmp1 | 0.0189 | 0.0088 | 0.0047 |
Brugia malayi | Matrixin family protein | 0.0282 | 0.018 | 1 |
Onchocerca volvulus | Matrilysin homolog | 0.0259 | 0.0157 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0143 | 0.0043 | 0.08 |
Echinococcus multilocularis | adam 17 protease | 0.0212 | 0.0111 | 0.345 |
Loa Loa (eye worm) | hypothetical protein | 0.0143 | 0.0043 | 0.08 |
Plasmodium vivax | peptide deformylase, putative | 1.0179 | 1 | 0.5 |
Onchocerca volvulus | 0.0165 | 0.0065 | 0.3431 | |
Onchocerca volvulus | Matrix metalloproteinase homolog | 0.0259 | 0.0157 | 1 |
Echinococcus granulosus | endothelin converting enzyme 1 | 0.0189 | 0.0088 | 0.2744 |
Loa Loa (eye worm) | hypothetical protein | 0.014 | 0.0039 | 0.07 |
Mycobacterium ulcerans | zinc metalloprotease | 0.0189 | 0.0088 | 0.0047 |
Plasmodium falciparum | peptide deformylase | 1.0179 | 1 | 0.5 |
Brugia malayi | Hypothetical zinc metalloproteinase T16A9.4 | 0.0189 | 0.0088 | 0.4886 |
Brugia malayi | Matrixin family protein | 0.0117 | 0.0016 | 0.0912 |
Schistosoma mansoni | matrix metallopeptidase-7 (M10 family) | 0.0117 | 0.0016 | 0.1485 |
Wolbachia endosymbiont of Brugia malayi | peptide deformylase | 1.0179 | 1 | 0.5 |
Mycobacterium ulcerans | peptide deformylase | 1.0179 | 1 | 1 |
Brugia malayi | Matrixin family protein | 0.0117 | 0.0016 | 0.0912 |
Mycobacterium tuberculosis | Probable polypeptide deformylase Def (PDF) (formylmethionine deformylase) | 1.0179 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.014 | 0.0039 | 0.07 |
Toxoplasma gondii | hypothetical protein | 1.0179 | 1 | 1 |
Echinococcus granulosus | Blood coagulation inhibitor Disintegrin | 0.0133 | 0.0033 | 0.1015 |
Loa Loa (eye worm) | hypothetical protein | 0.0189 | 0.0088 | 0.2201 |
Schistosoma mansoni | hypothetical protein | 0.0165 | 0.0065 | 0.5844 |
Brugia malayi | Matrixin family protein | 0.0117 | 0.0016 | 0.0912 |
Mycobacterium tuberculosis | Possible exported protein | 0.1539 | 0.1428 | 0.1392 |
Loa Loa (eye worm) | hypothetical protein | 0.014 | 0.0039 | 0.07 |
Leishmania major | polypeptide deformylase-like protein, putative | 0.3884 | 0.3754 | 0.5 |
Trypanosoma cruzi | Peptide deformylase 2, putative | 0.3884 | 0.3754 | 0.5 |
Trypanosoma cruzi | polypeptide deformylase-like protein, putative | 0.3884 | 0.3754 | 0.5 |
Loa Loa (eye worm) | peptidase family M13 containing protein | 0.014 | 0.0039 | 0.07 |
Trypanosoma cruzi | polypeptide deformylase-like protein, putative | 0.3884 | 0.3754 | 0.5 |
Schistosoma mansoni | ADAM17 peptidase (M12 family) | 0.0212 | 0.0111 | 1 |
Echinococcus granulosus | adam 17 protease | 0.0233 | 0.0132 | 0.4102 |
Mycobacterium leprae | PROBABLE POLYPEPTIDE DEFORMYLASE DEF (PDF) (FORMYLMETHIONINE DEFORMYLASE) | 1.0179 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0445 | 0.0342 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.014 | 0.0039 | 0.07 |
Mycobacterium leprae | probable zinc metalloprotease | 0.0189 | 0.0088 | 0.0047 |
Loa Loa (eye worm) | peptidase family M13 containing protein | 0.014 | 0.0039 | 0.07 |
Schistosoma mansoni | family M13 unassigned peptidase (M13 family) | 0.0189 | 0.0088 | 0.7952 |
Brugia malayi | Matrixin family protein | 0.0117 | 0.0016 | 0.0912 |
Brugia malayi | Matrix metalloprotease, N-terminal domain containing protein | 0.0142 | 0.0042 | 0.2309 |
Trypanosoma brucei | Polypeptide deformylase 1 | 0.3884 | 0.3754 | 0.5 |
Brugia malayi | Peptidase family M13 containing protein | 0.0189 | 0.0088 | 0.4886 |
Loa Loa (eye worm) | hypothetical protein | 0.0142 | 0.0042 | 0.0774 |
Loa Loa (eye worm) | hypothetical protein | 0.0189 | 0.0088 | 0.2201 |
Brugia malayi | Hemopexin family protein | 0.0165 | 0.0065 | 0.3591 |
Loa Loa (eye worm) | matrixin family protein | 0.0282 | 0.018 | 0.5034 |
Echinococcus multilocularis | Blood coagulation inhibitor, Disintegrin | 0.0133 | 0.0033 | 0.1015 |
Echinococcus multilocularis | matrix metallopeptidase 7 (M10 family) | 0.0424 | 0.0321 | 1 |
Trypanosoma brucei | Peptide deformylase 2 | 0.3884 | 0.3754 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0189 | 0.0088 | 0.2201 |
Loa Loa (eye worm) | hypothetical protein | 0.0143 | 0.0043 | 0.08 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
-Log Ki (binding) | = 5.09 | Binding affinity against dopamine receptor D1 | ChEMBL. | 7907148 |
-Log Ki (binding) | = 5.18 | Binding affinity against dopamine D2 receptor | ChEMBL. | 7907148 |
-Log Ki (binding) | = 5.94 | Binding affinity against serotonin 5-hydroxytryptamine 2 receptor | ChEMBL. | 7907148 |
-Log Ki (binding) | = 6.13 | Binding affinity against muscarinic (M) receptor | ChEMBL. | 7907148 |
Inhibition (functional) | = 0 % | Inhibitory activity in apomorphine antagonism test at a dose of 20mg/kg,sc | ChEMBL. | 7907148 |
Ki (binding) | = 5.09 | Binding affinity against dopamine receptor D1 | ChEMBL. | 7907148 |
Ki (binding) | = 5.18 | Binding affinity against dopamine D2 receptor | ChEMBL. | 7907148 |
Ki (binding) | = 5.94 | Binding affinity against serotonin 5-hydroxytryptamine 2 receptor | ChEMBL. | 7907148 |
Ki (binding) | = 6.13 | Binding affinity against muscarinic (M) receptor | ChEMBL. | 7907148 |
Ratio (binding) | = 0.84 | Ratio of binding affinity towards D2 to muscarinic receptor (M) was measured | ChEMBL. | 7907148 |
Ratio (binding) | = 1.02 | Ratio of binding affinity towards D2 to D1 receptor was measured | ChEMBL. | 7907148 |
Ratio (binding) | = 1.15 | Ratio of binding affinity towards 5-HT2 to D2 receptor was measured | ChEMBL. | 7907148 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.