Detailed information for compound 257727

Basic information

Technical information
  • TDR Targets ID: 257727
  • Name: 5-(2-fluorophenyl)-1,3-dihydro-1,4-benzodiaze pin-2-one
  • MW: 254.259 | Formula: C15H11FN2O
  • H donors: 1 H acceptors: 1 LogP: 2.51 Rotable bonds: 1
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C1CN=C(c2c(N1)cccc2)c1ccccc1F
  • InChi: 1S/C15H11FN2O/c16-12-7-3-1-5-10(12)15-11-6-2-4-8-13(11)18-14(19)9-17-15/h1-8H,9H2,(H,18,19)
  • InChiKey: ZFYAQIQNROJRTO-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0063 0.0295 0.4203
Echinococcus granulosus survival motor neuron protein 1 0.026 0.1722 1
Schistosoma mansoni histamine h1 receptor 0.0063 0.0295 0.4203
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0063 0.0295 1
Loa Loa (eye worm) hypothetical protein 0.0063 0.0295 0.0295
Echinococcus granulosus 7tm_1 domain containing protein 0.0063 0.0295 0.1641
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0025 0.0015 0.0217
Toxoplasma gondii PAN domain-containing protein 0.0672 0.4708 1
Schistosoma mansoni neuropeptide f receptor 76f 0.0063 0.0295 0.4203
Loa Loa (eye worm) G-protein coupled receptor 0.0063 0.0295 0.0295
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0063 0.0295 0.4203
Toxoplasma gondii hypothetical protein 0.0043 0.0149 0.0171
Loa Loa (eye worm) hypothetical protein 0.0063 0.0295 0.0295
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0066 0.0312 0.1737
Brugia malayi PAN domain containing protein 0.0043 0.0149 0.0115
Echinococcus multilocularis fmrfamide receptor 0.0063 0.0295 0.1641
Echinococcus granulosus neuropeptides capa receptor 0.0063 0.0295 0.1641
Echinococcus multilocularis somatostatin receptor 0.0063 0.0295 0.1641
Brugia malayi hypothetical protein 0.0063 0.0295 0.0262
Echinococcus multilocularis neuropeptide receptor 0.0063 0.0295 0.1641
Onchocerca volvulus 0.0063 0.0295 1
Brugia malayi hypothetical protein 0.026 0.1722 0.1693
Echinococcus multilocularis fmrfamide receptor 0.0063 0.0295 0.1641
Giardia lamblia Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit 0.0032 0.007 0.5
Echinococcus granulosus rhodopsin orphan GPCR 0.0063 0.0295 0.1641
Echinococcus multilocularis rhodopsin orphan GPCR 0.0063 0.0295 0.1641
Brugia malayi hypothetical protein 0.0063 0.0295 0.0262
Loa Loa (eye worm) hypothetical protein 0.0063 0.0295 0.0295
Onchocerca volvulus 0.0063 0.0295 1
Schistosoma mansoni biogenic amine receptor 0.0063 0.0295 0.4203
Schistosoma mansoni amine GPCR 0.0063 0.0295 0.4203
Loa Loa (eye worm) hypothetical protein 0.0063 0.0295 0.0295
Echinococcus granulosus biogenic amine 5HT receptor 0.0063 0.0295 0.1641
Loa Loa (eye worm) hypothetical protein 0.0063 0.0295 0.0295
Schistosoma mansoni amine GPCR 0.0063 0.0295 0.4203
Onchocerca volvulus 0.0063 0.0295 1
Echinococcus granulosus 7TM GPCR rhodopsin 0.0063 0.0295 0.1641
Schistosoma mansoni amine GPCR 0.0063 0.0295 0.4203
Entamoeba histolytica phosphofructokinase, putative 0.012 0.0702 1
Loa Loa (eye worm) neuropeptide F receptor 0.0063 0.0295 0.0295
Loa Loa (eye worm) hypothetical protein 0.0063 0.0295 0.0295
Brugia malayi PAN domain containing protein 0.0043 0.0149 0.0115
Schistosoma mansoni hypothetical protein 0.0063 0.0295 0.4203
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0063 0.0295 0.0262
Echinococcus granulosus rhodopsin orphan GPCR 0.0063 0.0295 0.1641
Brugia malayi 6-phosphofructokinase 0.012 0.0702 0.0671
Toxoplasma gondii PAN domain-containing protein 0.0043 0.0149 0.0171
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0063 0.0295 0.1641
Loa Loa (eye worm) hypothetical protein 0.0063 0.0295 0.0295
Schistosoma mansoni opsin-like receptor 0.0063 0.0295 0.4203
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.012 0.0702 0.5
Loa Loa (eye worm) hypothetical protein 0.0063 0.0295 0.0295
Schistosoma mansoni growth hormone secretagogue receptor 0.0063 0.0295 0.4203
Loa Loa (eye worm) hypothetical protein 0.0063 0.0295 0.0295
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0063 0.0295 0.1641
Brugia malayi GnHR receptor homolog 0.0063 0.0295 0.0262
Loa Loa (eye worm) neuropeptide F receptor 0.0063 0.0295 0.0295
Schistosoma mansoni myosin xvIII 0.0063 0.0295 0.4203
Echinococcus granulosus fmrfamide receptor 0.0063 0.0295 0.1641
Loa Loa (eye worm) phosphofructokinase 0.012 0.0702 0.0702
Echinococcus multilocularis g protein coupled receptor 0.0063 0.0295 0.1641
Echinococcus granulosus neuropeptide Y receptor 0.0063 0.0295 0.1641
Loa Loa (eye worm) hypothetical protein 0.0063 0.0295 0.0295
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0063 0.0295 0.4203
Onchocerca volvulus 0.0063 0.0295 1
Loa Loa (eye worm) G-protein coupled receptor 0.0063 0.0295 0.0295
Echinococcus granulosus neuropeptide s receptor 0.0063 0.0295 0.1641
Loa Loa (eye worm) hypothetical protein 0.0063 0.0295 0.0295
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0063 0.0295 0.1641
Toxoplasma gondii hypothetical protein 0.0043 0.0149 0.0171
Loa Loa (eye worm) hypothetical protein 0.1401 1 1
Brugia malayi follicle stimulating hormone receptor 0.0063 0.0295 0.0262
Echinococcus granulosus tm gpcr rhodopsin 0.0063 0.0295 0.1641
Schistosoma mansoni hypothetical protein 0.0063 0.0295 0.4203
Brugia malayi PAN domain containing protein 0.0043 0.0149 0.0115
Onchocerca volvulus 0.0063 0.0295 1
Onchocerca volvulus 0.0063 0.0295 1
Trichomonas vaginalis phosphofructokinase, putative 0.012 0.0702 1
Onchocerca volvulus 0.0063 0.0295 1
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0032 0.007 0.5
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0063 0.0295 0.0295
Loa Loa (eye worm) hypothetical protein 0.0063 0.0295 0.0295
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0063 0.0295 0.0262
Schistosoma mansoni biogenic amine receptor 0.0063 0.0295 0.4203
Brugia malayi RE15519p 0.0063 0.0295 0.0262
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0063 0.0295 0.1641
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0063 0.0295 0.1641
Echinococcus granulosus neuropeptide receptor 0.0063 0.0295 0.1641
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0063 0.0295 0.4203
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0063 0.0295 0.1641
Loa Loa (eye worm) hypothetical protein 0.0043 0.0149 0.0149
Echinococcus granulosus hypothetical protein 0.0063 0.0295 0.1641
Entamoeba histolytica phosphofructokinase, putative 0.012 0.0702 1
Brugia malayi larval opioid receptor 0.0063 0.0295 0.0262
Echinococcus multilocularis 6 phosphofructokinase 0.012 0.0702 0.4027
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0063 0.0295 0.4203
Schistosoma mansoni hypothetical protein 0.0063 0.0295 0.4203
Echinococcus granulosus g protein coupled receptor 0.0063 0.0295 0.1641
Brugia malayi Bromodomain containing protein 0.0082 0.0434 0.0401
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0063 0.0295 0.1641
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.012 0.0702 0.5
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0053 0.022 0.0187
Schistosoma mansoni neuropeptide receptor 0.0063 0.0295 0.4203
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0063 0.0295 0.1641
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0063 0.0295 0.0295
Schistosoma mansoni hypothetical protein 0.0037 0.0107 0.1527
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0063 0.0295 0.4203
Brugia malayi G-protein coupled receptor 0.0063 0.0295 0.0262
Loa Loa (eye worm) hypothetical protein 0.0078 0.04 0.04
Brugia malayi putative neuropeptide receptor NPR1 0.0063 0.0295 0.0262
Schistosoma mansoni bromodomain containing protein 0.007 0.034 0.4843
Loa Loa (eye worm) hypothetical protein 0.0063 0.0295 0.0295
Echinococcus granulosus neuropeptides capa receptor 0.0063 0.0295 0.1641
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0063 0.0295 0.4203
Echinococcus multilocularis rhodopsin orphan GPCR 0.0063 0.0295 0.1641
Loa Loa (eye worm) hypothetical protein 0.0063 0.0295 0.0295
Loa Loa (eye worm) hypothetical protein 0.0063 0.0295 0.0295
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0063 0.0295 0.4203
Toxoplasma gondii microneme protein MIC17A 0.0043 0.0149 0.0171
Schistosoma mansoni opsin-like receptor 0.0063 0.0295 0.4203
Echinococcus granulosus rhodopsin orphan GPCR 0.0063 0.0295 0.1641
Brugia malayi 6-phosphofructokinase 0.012 0.0702 0.0671
Brugia malayi Dopamine receptor 0.0063 0.0295 0.0262
Brugia malayi latrophilin 2 splice variant baaae 0.0037 0.0107 0.0073
Loa Loa (eye worm) hypothetical protein 0.0063 0.0295 0.0295
Toxoplasma gondii microneme protein MIC17B 0.0043 0.0149 0.0171
Loa Loa (eye worm) melatonin receptor type 1A 0.0063 0.0295 0.0295
Loa Loa (eye worm) hypothetical protein 0.0043 0.0149 0.0149
Loa Loa (eye worm) 6-phosphofructokinase 0.012 0.0702 0.0702
Loa Loa (eye worm) hypothetical protein 0.0063 0.0295 0.0295
Loa Loa (eye worm) hypothetical protein 0.0043 0.0149 0.0149
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0063 0.0295 0.4203
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0063 0.0295 0.0262
Brugia malayi Serotonin receptor 0.0063 0.0295 0.0262
Loa Loa (eye worm) hypothetical protein 0.0043 0.0149 0.0149
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0063 0.0295 0.4203
Loa Loa (eye worm) hypothetical protein 0.0063 0.0295 0.0295
Schistosoma mansoni hypothetical protein 0.0063 0.0295 0.4203
Onchocerca volvulus 0.0063 0.0295 1
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0063 0.0295 0.0262
Onchocerca volvulus 0.0063 0.0295 1
Loa Loa (eye worm) hypothetical protein 0.0063 0.0295 0.0295
Echinococcus multilocularis rhodopsin orphan GPCR 0.0063 0.0295 0.1641
Echinococcus multilocularis rhodopsin orphan GPCR 0.0063 0.0295 0.1641
Loa Loa (eye worm) hypothetical protein 0.0043 0.0149 0.0149
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.004 0.0122 0.0626
Loa Loa (eye worm) hypothetical protein 0.0063 0.0295 0.0295
Schistosoma mansoni 6-phosphofructokinase 0.012 0.0702 1
Echinococcus multilocularis dro:myosuppressin receptor 0.0063 0.0295 0.1641
Echinococcus granulosus peptide allatostatin:somatostatin 0.0063 0.0295 0.1641
Loa Loa (eye worm) hypothetical protein 0.0043 0.0149 0.0149
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0055 0.0233 0.02
Brugia malayi Dopamine receptor protein 2 0.0063 0.0295 0.0262
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0063 0.0295 0.4203
Loa Loa (eye worm) PAN domain-containing protein 0.0043 0.0149 0.0149
Loa Loa (eye worm) hypothetical protein 0.0063 0.0295 0.0295
Echinococcus granulosus tm gpcr rhodopsin 0.0063 0.0295 0.1641
Onchocerca volvulus 0.0063 0.0295 1
Loa Loa (eye worm) hypothetical protein 0.0063 0.0295 0.0295
Echinococcus granulosus g protein coupled receptor 0.0063 0.0295 0.1641
Brugia malayi PAN domain containing protein 0.0043 0.0149 0.0115
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0063 0.0295 0.1641
Echinococcus granulosus biogenic amine 5HT receptor 0.0063 0.0295 0.1641
Echinococcus granulosus neuropeptide FF receptor 2 0.0063 0.0295 0.1641
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0063 0.0295 0.4203
Brugia malayi PAN domain containing protein 0.0043 0.0149 0.0115
Onchocerca volvulus 0.0053 0.022 0.4865
Echinococcus multilocularis G-protein coupled receptor, putative 0.0063 0.0295 0.1641
Toxoplasma gondii PAN/Apple domain-containing protein 0.0043 0.0149 0.0171
Brugia malayi AKH receptor 0.0063 0.0295 0.0262
Schistosoma mansoni biogenic amine (5HT) receptor 0.0063 0.0295 0.4203
Loa Loa (eye worm) hypothetical protein 0.0063 0.0295 0.0295
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0055 0.0233 0.0233
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0063 0.0295 0.1641
Echinococcus multilocularis neuropeptide receptor 0.0063 0.0295 0.1641
Loa Loa (eye worm) hypothetical protein 0.0055 0.0233 0.0233
Brugia malayi neuropeptide F receptor 0.0063 0.0295 0.0262
Echinococcus multilocularis neuropeptide FF receptor 2 0.0063 0.0295 0.1641
Echinococcus multilocularis sex peptide receptor 0.0063 0.0295 0.1641
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0063 0.0295 0.1641
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0063 0.0295 0.4203
Loa Loa (eye worm) hypothetical protein 0.0063 0.0295 0.0295
Leishmania major ATP-dependent phosphofructokinase 0.012 0.0702 0.5
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0063 0.0295 0.1641
Toxoplasma gondii PAN domain-containing protein 0.0043 0.0149 0.0171
Echinococcus granulosus neuropeptide receptor 0.0063 0.0295 0.1641
Brugia malayi Melatonin receptor type 1A 0.0063 0.0295 0.0262
Schistosoma mansoni 6-phosphofructokinase 0.012 0.0702 1
Loa Loa (eye worm) hypothetical protein 0.0063 0.0295 0.0295
Loa Loa (eye worm) hypothetical protein 0.0063 0.0295 0.0295
Plasmodium vivax 6-phosphofructokinase, putative 0.0032 0.007 0.5
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0032 0.007 0.5
Echinococcus multilocularis neuropeptide s receptor 0.0063 0.0295 0.1641
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0063 0.0295 0.0295
Schistosoma mansoni amine GPCR 0.0063 0.0295 0.4203
Brugia malayi hypothetical protein 0.0063 0.0295 0.0262
Mycobacterium ulcerans 6-phosphofructokinase 0.012 0.0702 0.5
Echinococcus multilocularis allatostatin A receptor 0.0063 0.0295 0.1641
Loa Loa (eye worm) hypothetical protein 0.0063 0.0295 0.0295
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0063 0.0295 0.1641
Loa Loa (eye worm) hypothetical protein 0.026 0.1722 0.1722
Toxoplasma gondii microneme protein MIC17C 0.0043 0.0149 0.0171
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0063 0.0295 0.1641
Echinococcus multilocularis g protein coupled receptor 0.0063 0.0295 0.1641
Echinococcus multilocularis rhodopsin orphan GPCR 0.0063 0.0295 0.1641
Brugia malayi neuropeptide F receptor 0.0063 0.0295 0.0262
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0063 0.0295 0.1641
Echinococcus multilocularis neuropeptide receptor A26 0.0063 0.0295 0.1641
Brugia malayi putative neuropeptide receptor 0.0063 0.0295 0.0262
Loa Loa (eye worm) hypothetical protein 0.0063 0.0295 0.0295
Loa Loa (eye worm) hypothetical protein 0.0063 0.0295 0.0295
Brugia malayi Tachykinin-like peptides receptor 99D 0.0063 0.0295 0.0262
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0063 0.0295 0.4203
Onchocerca volvulus 0.0063 0.0295 1
Echinococcus multilocularis serotonin receptor 0.0063 0.0295 0.1641
Schistosoma mansoni survival motor neuron protein 0.0053 0.022 0.3134
Loa Loa (eye worm) hypothetical protein 0.0037 0.0107 0.0107
Echinococcus multilocularis rhodopsin orphan GPCR 0.0063 0.0295 0.1641
Onchocerca volvulus Neuropeptide F receptor homolog 0.0063 0.0295 1
Loa Loa (eye worm) hypothetical protein 0.0063 0.0295 0.0295
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0063 0.0295 0.0295
Brugia malayi hypothetical protein 0.0063 0.0295 0.0262
Schistosoma mansoni alpha-1 adrenergic receptor 0.0063 0.0295 0.4203
Echinococcus granulosus orexin receptor type 2 0.0063 0.0295 0.1641
Echinococcus granulosus tm gpcr rhodopsin 0.0063 0.0295 0.1641
Echinococcus multilocularis neuropeptides capa receptor 0.0063 0.0295 0.1641
Onchocerca volvulus 0.0063 0.0295 1
Schistosoma mansoni neuropeptide F-like receptor 0.0063 0.0295 0.4203
Trichomonas vaginalis phosphofructokinase, putative 0.012 0.0702 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0063 0.0295 0.1641
Brugia malayi G protein-coupled receptor F59B2.13 0.0063 0.0295 0.0262
Brugia malayi PAN domain containing protein 0.0043 0.0149 0.0115
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.012 0.0702 0.5
Loa Loa (eye worm) hypothetical protein 0.0042 0.0141 0.0141
Loa Loa (eye worm) hypothetical protein 0.0063 0.0295 0.0295
Echinococcus multilocularis rhodopsin orphan GPCR 0.0063 0.0295 0.1641
Loa Loa (eye worm) hypothetical protein 0.0063 0.0295 0.0295
Loa Loa (eye worm) hypothetical protein 0.0063 0.0295 0.0295
Toxoplasma gondii subtilisin SUB12 0.0043 0.0149 0.0171
Loa Loa (eye worm) hypothetical protein 0.0063 0.0295 0.0295
Brugia malayi Serotonin receptor 0.0063 0.0295 0.0262
Onchocerca volvulus 0.0063 0.0295 1
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0063 0.0295 0.0262
Echinococcus multilocularis survival motor neuron protein 1 0.026 0.1722 1
Loa Loa (eye worm) hypothetical protein 0.0047 0.0176 0.0176
Loa Loa (eye worm) TYRA-2 protein 0.0063 0.0295 0.0295
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0063 0.0295 0.4203
Echinococcus granulosus neuropeptide Y receptor 0.0063 0.0295 0.1641
Echinococcus granulosus g protein coupled receptor 0.0063 0.0295 0.1641
Loa Loa (eye worm) PAN domain-containing protein 0.0043 0.0149 0.0149
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0063 0.0295 0.4203
Echinococcus multilocularis g protein coupled receptor 0.0063 0.0295 0.1641
Brugia malayi hypothetical protein 0.0063 0.0295 0.0262
Onchocerca volvulus 0.0063 0.0295 1
Schistosoma mansoni neuropeptide receptor 0.0063 0.0295 0.4203
Echinococcus granulosus serotonin receptor 0.0063 0.0295 0.1641
Schistosoma mansoni opsin-like receptor 0.0063 0.0295 0.4203
Loa Loa (eye worm) hypothetical protein 0.0063 0.0295 0.0295
Echinococcus granulosus tachykinin peptides receptor 99D 0.0063 0.0295 0.1641
Echinococcus granulosus G protein coupled receptor 139 0.0063 0.0295 0.1641
Loa Loa (eye worm) hypothetical protein 0.0063 0.0295 0.0295
Brugia malayi hypothetical protein 0.0063 0.0295 0.0262
Echinococcus granulosus somatostatin receptor 0.0063 0.0295 0.1641
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0032 0.007 0.5
Schistosoma mansoni neuropeptide receptor 0.0063 0.0295 0.4203
Echinococcus multilocularis rhodopsin orphan GPCR 0.0063 0.0295 0.1641
Loa Loa (eye worm) 6-phosphofructokinase 0.012 0.0702 0.0702
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0063 0.0295 0.1641
Brugia malayi hypothetical protein 0.0063 0.0295 0.0262
Brugia malayi PAN domain containing protein 0.0043 0.0149 0.0115
Loa Loa (eye worm) PAN domain-containing protein 0.0043 0.0149 0.0149
Loa Loa (eye worm) hypothetical protein 0.0063 0.0295 0.0295
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0066 0.0312 0.1737
Echinococcus multilocularis neuropeptides capa receptor 0.0063 0.0295 0.1641
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0063 0.0295 0.1641
Loa Loa (eye worm) hypothetical protein 0.0063 0.0295 0.0295
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0063 0.0295 0.0295
Toxoplasma gondii PAN domain-containing protein 0.0043 0.0149 0.0171
Trichomonas vaginalis phosphofructokinase, putative 0.012 0.0702 1
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0063 0.0295 0.1641
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0063 0.0295 0.1641
Toxoplasma gondii 1,3(4)-beta-glucanase 0.0043 0.0149 0.0171
Brugia malayi hypothetical protein 0.0063 0.0295 0.0262
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.012 0.0702 0.5
Loa Loa (eye worm) hypothetical protein 0.0063 0.0295 0.0295
Echinococcus granulosus rhodopsin orphan GPCR 0.0063 0.0295 0.1641
Echinococcus granulosus rhodopsin orphan GPCR 0.0063 0.0295 0.1641
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.004 0.0122 0.0626
Schistosoma mansoni neuropeptide receptor 0.0063 0.0295 0.4203
Trichomonas vaginalis phosphofructokinase, putative 0.012 0.0702 1
Brugia malayi G protein-coupled receptor 0.0063 0.0295 0.0262
Toxoplasma gondii microneme protein MIC4 0.0043 0.0149 0.0171
Loa Loa (eye worm) hypothetical protein 0.0043 0.0149 0.0149
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.012 0.0702 1
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0032 0.007 0.5
Brugia malayi G-protein coupled receptor 0.0063 0.0295 0.0262
Echinococcus granulosus 6 phosphofructokinase 0.012 0.0702 0.4027
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0063 0.0295 0.4203
Onchocerca volvulus 0.0063 0.0295 1
Plasmodium vivax 6-phosphofructokinase, putative 0.0032 0.007 0.5
Echinococcus multilocularis G protein coupled receptor 139 0.0063 0.0295 0.1641
Onchocerca volvulus 0.0063 0.0295 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0063 0.0295 0.4203
Echinococcus granulosus sex peptide receptor 0.0063 0.0295 0.1641
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0063 0.0295 0.4203
Loa Loa (eye worm) hypothetical protein 0.0063 0.0295 0.0295
Schistosoma mansoni neuropeptide F-like receptor 0.0063 0.0295 0.4203
Echinococcus granulosus neuropeptide receptor A26 0.0063 0.0295 0.1641
Brugia malayi PAN domain containing protein 0.0043 0.0149 0.0115
Schistosoma mansoni amine GPCR 0.0063 0.0295 0.4203
Brugia malayi Bromodomain containing protein 0.0042 0.0141 0.0107
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0063 0.0295 0.4203
Echinococcus multilocularis orexin receptor type 2 0.0063 0.0295 0.1641
Echinococcus multilocularis neuropeptide Y receptor 0.0063 0.0295 0.1641
Echinococcus granulosus dro:myosuppressin receptor 0.0063 0.0295 0.1641
Brugia malayi phosphofructokinase 0.012 0.0702 0.0671
Brugia malayi hypothetical protein 0.0063 0.0295 0.0262
Echinococcus multilocularis g-protein coupled receptor 0.0063 0.0295 0.1641
Schistosoma mansoni biogenic amine receptor 0.0063 0.0295 0.4203
Brugia malayi sulfakinin receptor protein 0.0063 0.0295 0.0262
Brugia malayi Calcitonin receptor-like protein seb-1 0.0055 0.0233 0.02
Brugia malayi PAN domain containing protein 0.0043 0.0149 0.0115
Toxoplasma gondii PAN domain-containing protein 0.0043 0.0149 0.0171
Brugia malayi ORL1-like opioid receptor 0.0063 0.0295 0.0262
Loa Loa (eye worm) hypothetical protein 0.0063 0.0295 0.0295
Schistosoma mansoni adenoreceptor 0.0063 0.0295 0.4203
Echinococcus multilocularis serotonin receptor 0.0063 0.0295 0.1641
Entamoeba histolytica phosphofructokinase, putative 0.012 0.0702 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0063 0.0295 0.1641
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0063 0.0295 0.4203
Schistosoma mansoni hypothetical protein 0.0053 0.022 0.3134
Echinococcus multilocularis neuropeptide Y receptor 0.0063 0.0295 0.1641
Toxoplasma gondii microneme protein, putative 0.0043 0.0149 0.0171
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0063 0.0295 0.1641
Loa Loa (eye worm) PAN domain-containing protein 0.0043 0.0149 0.0149
Brugia malayi hypothetical protein 0.0063 0.0295 0.0262
Loa Loa (eye worm) hypothetical protein 0.0045 0.016 0.016
Brugia malayi PAN domain containing protein 0.0043 0.0149 0.0115
Loa Loa (eye worm) PAN domain-containing protein 0.0043 0.0149 0.0149
Echinococcus granulosus g-protein coupled receptor 0.0063 0.0295 0.1641
Loa Loa (eye worm) hypothetical protein 0.0063 0.0295 0.0295
Echinococcus granulosus alpha 1A adrenergic receptor 0.0063 0.0295 0.1641
Loa Loa (eye worm) hypothetical protein 0.0063 0.0295 0.0295
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0063 0.0295 0.4203
Echinococcus granulosus allatostatin A receptor 0.0063 0.0295 0.1641
Loa Loa (eye worm) hypothetical protein 0.0063 0.0295 0.0295
Toxoplasma gondii PAN domain-containing protein 0.0672 0.4708 1
Schistosoma mansoni biogenic amine (5HT) receptor 0.0063 0.0295 0.4203
Onchocerca volvulus 0.0063 0.0295 1

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = -1.322 Binding affinity of compound towards Benzodiazepine receptor in a competition assay ChEMBL. 8978853
IC50 (binding) = -1.322 Binding affinity towards benzodiazepine/GABA A receptor. ChEMBL. 7861419
Log IC50 (binding) = 1.322 Binding affinity of compound towards Benzodiazepine receptor in a competition assay ChEMBL. 8978853
Log IC50 (binding) = 1.322 Binding affinity towards benzodiazepine/GABA A receptor. ChEMBL. 7861419

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

2 literature references were collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.