Detailed information for compound 257871

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 428.603 | Formula: C24H44O6
  • H donors: 3 H acceptors: 5 LogP: 5.25 Rotable bonds: 14
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCC[C@@H]1CC[C@@H]([C@@H]([C@H]1COC(=O)C(CC)(C)C)CC[C@H](C[C@H](CC(=O)O)O)O)C
  • InChi: 1S/C24H44O6/c1-6-8-17-10-9-16(3)20(12-11-18(25)13-19(26)14-22(27)28)21(17)15-30-23(29)24(4,5)7-2/h16-21,25-26H,6-15H2,1-5H3,(H,27,28)/t16-,17+,18+,19+,20-,21-/m0/s1
  • InChiKey: OCFSRHVZSAWNAA-LPYKTLRWSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens 3-hydroxy-3-methylglutaryl-CoA reductase Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Leishmania mexicana 3-hydroxy-3-methylglutaryl-CoA reductase, putative Get druggable targets OG5_127955 All targets in OG5_127955
Trypanosoma cruzi 3-hydroxy-3-methylglutaryl-CoA reductase, putative Get druggable targets OG5_127955 All targets in OG5_127955
Schistosoma mansoni hydroxymethylglutaryl-CoA reductase (NADPH) Get druggable targets OG5_127955 All targets in OG5_127955
Leishmania major 3-hydroxy-3-methylglutaryl-CoA reductase Get druggable targets OG5_127955 All targets in OG5_127955
Trypanosoma brucei gambiense 3-hydroxy-3-methylglutaryl-CoA reductase, putative Get druggable targets OG5_127955 All targets in OG5_127955
Echinococcus multilocularis hydroxymethylglutaryl coenzyme A reductase Get druggable targets OG5_127955 All targets in OG5_127955
Mycobacterium ulcerans hydroxymethylglutaryl-coenzyme a (HMG-CoA) reductase Get druggable targets OG5_127955 All targets in OG5_127955
Candida albicans hydroxymethylglutaryl-CoA reductase (ergosterol biosynthesis) Get druggable targets OG5_127955 All targets in OG5_127955
Leishmania braziliensis 3-hydroxy-3-methylglutaryl-CoA reductase, putative Get druggable targets OG5_127955 All targets in OG5_127955
Trypanosoma cruzi 3-hydroxy-3-methylglutaryl-CoA reductase Get druggable targets OG5_127955 All targets in OG5_127955
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127955 All targets in OG5_127955
Brugia malayi Hydroxymethylglutaryl-coenzyme A reductase family protein Get druggable targets OG5_127955 All targets in OG5_127955
Candida albicans hydroxymethylglutaryl-CoA reductase (ergosterol biosynthesis) Get druggable targets OG5_127955 All targets in OG5_127955
Trypanosoma brucei 3-hydroxy-3-methylglutaryl-CoA reductase, putative Get druggable targets OG5_127955 All targets in OG5_127955
Echinococcus granulosus hydroxymethylglutaryl coenzyme A reductase Get druggable targets OG5_127955 All targets in OG5_127955
Leishmania infantum 3-hydroxy-3-methylglutaryl-CoA reductase, putative Get druggable targets OG5_127955 All targets in OG5_127955
Leishmania donovani 3-hydroxy-3-methylglutaryl-CoA reductase, putative Get druggable targets OG5_127955 All targets in OG5_127955
Schistosoma japonicum ko:K00021 3-hydroxy-3-methylglutaryl-CoA reductase [EC1.1.1.34], putative Get druggable targets OG5_127955 All targets in OG5_127955
Trypanosoma congolense 3-hydroxy-3-methylglutaryl-CoA reductase, putative Get druggable targets OG5_127955 All targets in OG5_127955
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus Dipeptidyl peptidase 9 0.0133 0.3027 0.3027
Onchocerca volvulus Dipeptidyl peptidase family member 1 homolog 0.0394 1 1
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.0031 0.0328 0.0328
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0085 0.1756 0.2705
Echinococcus multilocularis hydroxymethylglutaryl coenzyme A reductase 0.0165 0.39 0.39
Brugia malayi prolyl oligopeptidase family protein 0.0031 0.0328 0.0328
Onchocerca volvulus 0.0053 0.0906 0.0906
Schistosoma mansoni acylaminoacyl-peptidase (S09 family) 0.0031 0.0328 0.0328
Schistosoma mansoni chromatin regulatory protein sir2 0.0085 0.1756 0.1756
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0201 0.4864 0.4864
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0094 0.1994 0.1994
Loa Loa (eye worm) hypothetical protein 0.0039 0.0533 0.0533
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0094 0.1994 0.1994
Echinococcus multilocularis Mastin 0.0029 0.0269 0.0269
Entamoeba histolytica hypothetical protein 0.0036 0.0449 0.0848
Onchocerca volvulus 0.0039 0.0533 0.0533
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0265 0.0265
Loa Loa (eye worm) RNA binding protein 0.0061 0.1129 0.1129
Schistosoma mansoni dipeptidyl-peptidase 9 (S09 family) 0.0133 0.3027 0.3027
Loa Loa (eye worm) prolyl oligopeptidase 0.0394 1 1
Echinococcus multilocularis chromatin regulatory protein sir2 0.0085 0.1756 0.1756
Mycobacterium ulcerans hypothetical protein 0.0039 0.0533 0.0575
Echinococcus granulosus Mastin 0.0029 0.0269 0.0269
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0039 0.0533 0.0575
Echinococcus granulosus enteropeptidase 0.0029 0.0269 0.0269
Plasmodium vivax SET domain protein, putative 0.0029 0.0265 0.4978
Entamoeba histolytica Sir2 family transcriptional regulator, putative 0.0085 0.1756 1
Echinococcus multilocularis enteropeptidase 0.0029 0.0269 0.0269
Giardia lamblia Hypothetical protein 0.0085 0.1756 1
Loa Loa (eye worm) TAR-binding protein 0.0061 0.1129 0.1129
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0039 0.0533 0.0354
Entamoeba histolytica hypothetical protein 0.0036 0.0449 0.0848
Echinococcus granulosus histone lysine methyltransferase setb 0.0029 0.0265 0.0265
Trypanosoma cruzi hypothetical protein, conserved 0.0031 0.0328 0.0841
Loa Loa (eye worm) hypothetical protein 0.0101 0.2194 0.2194
Trypanosoma cruzi Silent information regulator 2 related protein 1 0.0085 0.1756 0.4502
Echinococcus granulosus acylamino acid releasing enzyme 0.0031 0.0328 0.0328
Schistosoma mansoni serine/threonine protein kinase 0.0265 0.6561 0.6561
Schistosoma mansoni chromatin regulatory protein sir2 0.0085 0.1756 0.1756
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0053 0.0906 0.0906
Trypanosoma cruzi oligopeptidase b 0.0031 0.0328 0.0841
Echinococcus multilocularis geminin 0.0183 0.438 0.438
Plasmodium falciparum peptidase, putative 0.0031 0.0328 1
Echinococcus multilocularis prolyl endopeptidase 0.0031 0.0328 0.0328
Loa Loa (eye worm) beta-lactamase 0.0039 0.0533 0.0533
Leishmania major oligopeptidase B-like protein,serine peptidase, clan SC, family S9A-like protein 0.0031 0.0328 0.0841
Mycobacterium ulcerans hydroxymethylglutaryl-coenzyme a (HMG-CoA) reductase 0.0165 0.39 1
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0036 0.0449 0.0449
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0053 0.0906 0.0906
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0029 0.0265 0.0877
Loa Loa (eye worm) hypothetical protein 0.0068 0.1308 0.1308
Entamoeba histolytica hypothetical protein 0.0036 0.0449 0.0848
Loa Loa (eye worm) hypothetical protein 0.0029 0.0265 0.0265
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0036 0.0449 0.0449
Onchocerca volvulus 0.0229 0.5606 0.5606
Echinococcus granulosus glycoprotein Antigen 5 0.0029 0.0269 0.0269
Echinococcus granulosus chromatin regulatory protein sir2 0.0085 0.1756 0.1756
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0039 0.0533 0.0533
Echinococcus multilocularis c Jun NH2 terminal kinase 0.0265 0.6561 0.6561
Trichomonas vaginalis 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative 0.0078 0.1562 0.2337
Trichomonas vaginalis conserved hypothetical protein 0.0068 0.1308 0.1858
Leishmania major oligopeptidase b 0.0031 0.0328 0.0841
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0039 0.0533 0.0533
Trichomonas vaginalis 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative 0.0078 0.1562 0.2337
Plasmodium vivax hypothetical protein, conserved 0.0039 0.0533 1
Echinococcus granulosus sterol regulatory element binding protein 0.0068 0.1308 0.1308
Schistosoma mansoni hypothetical protein 0.0183 0.438 0.438
Loa Loa (eye worm) hypothetical protein 0.0165 0.39 0.39
Toxoplasma gondii ABC1 family protein 0.0039 0.0533 0.1761
Brugia malayi RNA binding protein 0.0061 0.1129 0.1129
Loa Loa (eye worm) hypothetical protein 0.0039 0.0533 0.0533
Echinococcus multilocularis acylamino acid releasing enzyme 0.0031 0.0328 0.0328
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0039 0.0533 0.0533
Schistosoma mansoni tar DNA-binding protein 0.0061 0.1129 0.1129
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0094 0.1994 0.1994
Trypanosoma cruzi serine peptidase, Clan SC, Family S9B 0.0133 0.3027 0.7762
Echinococcus granulosus tar DNA binding protein 0.0061 0.1129 0.1129
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0094 0.1994 0.1994
Brugia malayi Pre-SET motif family protein 0.0201 0.4864 0.4864
Trypanosoma cruzi hypothetical protein, conserved 0.0039 0.0533 0.1367
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0094 0.1994 0.1994
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0085 0.1756 0.2705
Trichomonas vaginalis penicillin-binding protein, putative 0.0039 0.0533 0.0389
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0249 0.6126 1
Echinococcus granulosus geminin 0.0183 0.438 0.438
Loa Loa (eye worm) hypothetical protein 0.0039 0.0533 0.0533
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0265 0.0265
Echinococcus granulosus hydroxymethylglutaryl coenzyme A reductase 0.0165 0.39 0.39
Schistosoma mansoni subfamily S9B unassigned peptidase (S09 family) 0.0394 1 1
Schistosoma mansoni hypothetical protein 0.0036 0.0449 0.0449
Schistosoma mansoni hydroxymethylglutaryl-CoA reductase (NADPH) 0.0165 0.39 0.39
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0029 0.0265 0.0265
Trypanosoma brucei Dipeptidyl-peptidase 8-like, putative 0.0133 0.3027 0.7557
Toxoplasma gondii prolyl endopeptidase 0.0031 0.0328 0.1083
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0094 0.1994 0.1994
Mycobacterium tuberculosis Probable hydrolase 0.0039 0.0533 0.0354
Brugia malayi transcriptional regulator, Sir2 family protein 0.0085 0.1756 0.1756
Schistosoma mansoni tar DNA-binding protein 0.0061 0.1129 0.1129
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0029 0.0265 0.0265
Brugia malayi beta-lactamase 0.0039 0.0533 0.0533
Loa Loa (eye worm) hypothetical protein 0.0031 0.0328 0.0328
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0244 0.5989 0.5989
Plasmodium vivax hypothetical protein, conserved 0.0031 0.0328 0.615
Leishmania major prolyl oligopeptidase, putative,serine peptidase clan SC, family S9A, putative 0.0031 0.0328 0.0841
Echinococcus granulosus NAD dependent deacetylase sirtuin 3 0.0085 0.1756 0.1756
Brugia malayi CHE-14 protein 0.0068 0.1308 0.1308
Echinococcus granulosus beta LACTamase domain containing family member 0.0039 0.0533 0.0533
Mycobacterium tuberculosis Conserved protein 0.0039 0.0533 0.0354
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0094 0.1994 0.1994
Toxoplasma gondii acylaminoacyl-peptidase, putative 0.0031 0.0328 0.1083
Echinococcus multilocularis beta LACTamase domain containing family member 0.0039 0.0533 0.0533
Brugia malayi Hydroxymethylglutaryl-coenzyme A reductase family protein 0.0165 0.39 0.39
Brugia malayi hypothetical protein 0.0036 0.0449 0.0449
Leishmania major dipeptidyl-peptidase 8-like serine peptidase, putative,serine peptidase, Clan SC, Family S9B 0.0133 0.3027 0.7762
Loa Loa (eye worm) transcriptional regulator 0.0085 0.1756 0.1756
Echinococcus granulosus c-Jun N-terminal kinases 0.0265 0.6561 0.6561
Schistosoma mansoni tar DNA-binding protein 0.0061 0.1129 0.1129
Loa Loa (eye worm) hypothetical protein 0.0031 0.0328 0.0328
Mycobacterium ulcerans esterase/lipase LipP 0.0039 0.0533 0.0575
Loa Loa (eye worm) hypothetical protein 0.0039 0.0533 0.0533
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.0031 0.0328 0.0328
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0028 0.0237 0.0237
Echinococcus granulosus dipeptidyl aminopeptidaseprotein 0.0394 1 1
Onchocerca volvulus 0.0042 0.0617 0.0617
Onchocerca volvulus 0.0039 0.0533 0.0533
Entamoeba histolytica hypothetical protein 0.0036 0.0449 0.0848
Onchocerca volvulus Prolyl endopeptidase homolog 0.0031 0.0328 0.0328
Trypanosoma cruzi oligopeptidase b 0.0031 0.0328 0.0841
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0094 0.1994 0.1994
Trichomonas vaginalis esterase, putative 0.0039 0.0533 0.0389
Mycobacterium tuberculosis Probable lipase LipE 0.0039 0.0533 0.0354
Echinococcus multilocularis Dipeptidyl peptidase 9 0.0133 0.3027 0.3027
Schistosoma mansoni tar DNA-binding protein 0.0061 0.1129 0.1129
Brugia malayi beta-lactamase family protein 0.0039 0.0533 0.0533
Loa Loa (eye worm) hypothetical protein 0.0039 0.0533 0.0533
Trichomonas vaginalis D-aminoacylase, putative 0.0039 0.0533 0.0389
Echinococcus multilocularis tar DNA binding protein 0.0061 0.1129 0.1129
Mycobacterium tuberculosis Probable esterase LipL 0.0039 0.0533 0.0354
Echinococcus granulosus Niemann Pick C1 protein 0.0068 0.1308 0.1308
Toxoplasma gondii dipeptidyl peptidase iv (dpp iv) n-terminal region domain-containing protein 0.0133 0.3027 1
Echinococcus multilocularis dipeptidyl aminopeptidaseprotein 0.0394 1 1
Brugia malayi follicle stimulating hormone receptor 0.0244 0.5989 0.5989
Schistosoma mansoni patched 1 0.0068 0.1308 0.1308
Trypanosoma cruzi 3-hydroxy-3-methylglutaryl-CoA reductase, putative 0.0165 0.39 1
Loa Loa (eye worm) hypothetical protein 0.0031 0.0328 0.0328
Brugia malayi Pre-SET motif family protein 0.0029 0.0265 0.0265
Trypanosoma brucei 3-hydroxy-3-methylglutaryl-CoA reductase, putative 0.0165 0.39 1
Loa Loa (eye worm) CMGC/MAPK/JNK protein kinase 0.0265 0.6561 0.6561
Brugia malayi RNA recognition motif domain containing protein 0.0061 0.1129 0.1129
Trypanosoma cruzi oligopeptidase B-like protein, putative 0.0031 0.0328 0.0841
Echinococcus multilocularis protein dispatched 1 0.0068 0.1308 0.1308
Trypanosoma brucei hypothetical protein, conserved 0.0039 0.0533 0.0575
Onchocerca volvulus 0.0039 0.0533 0.0533
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0068 0.1308 0.1308
Leishmania major 3-hydroxy-3-methylglutaryl-CoA reductase 0.0165 0.39 1
Mycobacterium tuberculosis Probable lipase LipD 0.0039 0.0533 0.0354
Echinococcus multilocularis sterol regulatory element binding protein 0.0068 0.1308 0.1308
Brugia malayi beta-lactamase family protein 0.0039 0.0533 0.0533
Brugia malayi prolyl oligopeptidase family protein 0.0031 0.0328 0.0328
Toxoplasma gondii hypothetical protein 0.0031 0.0328 0.1083
Brugia malayi prolyl oligopeptidase family protein 0.0031 0.0328 0.0328
Echinococcus granulosus prolyl endopeptidase 0.0031 0.0328 0.0328
Trichomonas vaginalis D-aminoacylase, putative 0.0039 0.0533 0.0389
Leishmania major silent information regulator 2, putative 0.0085 0.1756 0.4502
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0061 0.1129 0.1129
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0029 0.0265 0.0265
Brugia malayi TAR-binding protein 0.0061 0.1129 0.1129
Trypanosoma brucei serine peptidase, Clan SC, Family S9B 0.0133 0.3027 0.7557
Mycobacterium leprae Probable lipase LipE 0.0039 0.0533 1
Loa Loa (eye worm) hypothetical protein 0.0053 0.0906 0.0906
Brugia malayi prolyl oligopeptidase family protein 0.0133 0.3027 0.3027
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0039 0.0533 0.0354
Brugia malayi Trypsin family protein 0.0053 0.0906 0.0906
Schistosoma mansoni hypothetical protein 0.0183 0.438 0.438
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0029 0.0269 0.0269
Trypanosoma cruzi prolyl endopeptidase 0.0031 0.0328 0.0841
Mycobacterium tuberculosis Conserved protein 0.0039 0.0533 0.0354
Trypanosoma brucei Silent information regulator 2 related protein 1 0.0085 0.1756 0.3998
Mycobacterium ulcerans lipase LipD 0.0039 0.0533 0.0575
Trypanosoma cruzi serine peptidase, clan SC, family S9A-like protein, putative 0.0031 0.0328 0.0841
Trypanosoma cruzi hypothetical protein, conserved 0.0039 0.0533 0.1367
Mycobacterium ulcerans beta-lactamase 0.0039 0.0533 0.0575
Giardia lamblia 3-hydroxy-3-methylglutaryl-coenzyme A reductase 0.0078 0.1562 0.864
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0094 0.1994 0.1994
Trypanosoma cruzi hypothetical protein, conserved 0.0031 0.0328 0.0841
Mycobacterium leprae conserved hypothetical protein 0.0039 0.0533 1
Brugia malayi Stress-activated protein kinase jnk-1 0.0265 0.6561 0.6561
Trypanosoma cruzi dipeptidyl-peptidase 8-like serine peptidase 0.0133 0.3027 0.7762
Trichomonas vaginalis penicillin-binding protein, putative 0.0039 0.0533 0.0389
Loa Loa (eye worm) prolyl oligopeptidase 0.0031 0.0328 0.0328
Leishmania major hypothetical protein, conserved 0.0039 0.0533 0.1367
Trichomonas vaginalis D-aminoacylase, putative 0.0039 0.0533 0.0389
Schistosoma mansoni transcription factor LCR-F1 0.0036 0.0449 0.0449
Echinococcus multilocularis glycoprotein Antigen 5 0.0029 0.0269 0.0269
Mycobacterium tuberculosis Conserved protein 0.0039 0.0533 0.0354
Brugia malayi hypothetical protein 0.0101 0.2194 0.2194
Trichomonas vaginalis 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative 0.0078 0.1562 0.2337
Trypanosoma cruzi 3-hydroxy-3-methylglutaryl-CoA reductase 0.0165 0.39 1
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.0031 0.0328 0.0328
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0039 0.0533 0.0533
Echinococcus multilocularis NAD dependent deacetylase sirtuin 3 0.0085 0.1756 0.1756
Loa Loa (eye worm) hypothetical protein 0.0053 0.0906 0.0906
Echinococcus granulosus Protein patched homolog 1 0.0068 0.1308 0.1308
Entamoeba histolytica Sir2 family transcriptional regulator, putative 0.0085 0.1756 1
Trichomonas vaginalis set domain proteins, putative 0.0229 0.5606 1
Echinococcus multilocularis Niemann Pick C1 protein 0.0068 0.1308 0.1308
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0265 0.0265
Onchocerca volvulus 0.0029 0.0265 0.0265
Schistosoma mansoni chromatin regulatory protein sir2 0.0085 0.1756 0.1756
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0068 0.1308 0.1308
Schistosoma mansoni tar DNA-binding protein 0.0061 0.1129 0.1129
Echinococcus multilocularis protein patched 0.0068 0.1308 0.1308
Loa Loa (eye worm) hypothetical protein 0.0039 0.0533 0.0533
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0039 0.0533 0.0354
Trypanosoma cruzi Silent information regulator 2 related protein 1 0.0085 0.1756 0.4502

Activities

Activity type Activity value Assay description Source Reference
I50 (binding) = 0.008 uM Compound was evaluated in vitro for its ability to inhibit HMG-CoA reductase ChEMBL. No reference
IC50 (binding) = 0.008 uM Compound was evaluated in vitro for its ability to inhibit HMG-CoA reductase ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

No external resources registered for this compound

Bibliographic References

No literature references available for this target.

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