Detailed information for compound 258535

Basic information

Technical information
  • TDR Targets ID: 258535
  • Name: 3-(1-benzofuran-5-yl)-1-[2-hydroxy-6-[3,4,5-t rihydroxy-6-(hydroxymethyl)oxan-2-yl]oxypheny l]propan-1-one
  • MW: 444.431 | Formula: C23H24O9
  • H donors: 5 H acceptors: 6 LogP: 1.94 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: OCC1OC(Oc2cccc(c2C(=O)CCc2ccc3c(c2)cco3)O)C(C(C1O)O)O
  • InChi: 1S/C23H24O9/c24-11-18-20(27)21(28)22(29)23(32-18)31-17-3-1-2-14(25)19(17)15(26)6-4-12-5-7-16-13(10-12)8-9-30-16/h1-3,5,7-10,18,20-25,27-29H,4,6,11H2
  • InChiKey: ZKBXROQWLPBHFI-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 3-(benzofuran-5-yl)-1-[2-hydroxy-6-[3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydropyran-2-yl]oxy-phenyl]propan-1-one
  • 3-(5-benzofuranyl)-1-[2-hydroxy-6-[[3,4,5-trihydroxy-6-(hydroxymethyl)-2-tetrahydropyranyl]oxy]phenyl]-1-propanone
  • 3-(1-benzofuran-5-yl)-1-[2-hydroxy-6-[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-phenyl]propan-1-one
  • 3-(benzofuran-5-yl)-1-[2-hydroxy-6-(3,4,5-trihydroxy-6-methylol-tetrahydropyran-2-yl)oxy-phenyl]propan-1-one
  • 3-(5-benzofuranyl)-1-[2-hydroxy-6-[[3,4,5-trihydroxy-6-(hydroxymethyl)-2-tetrahydropyranyl]oxy]phenyl]propan-1-one

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0062 0.015 0.0342
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0047 0.0049 0.011
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0601 0.3816 0.3816
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0144 0.0709 0.1626
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0601 0.3816 0.3816
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0073 0.0226 0.0515
Onchocerca volvulus 0.0202 0.1104 0.1104
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0078 0.0256 0.0249
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0144 0.0709 0.1626
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0073 0.0226 0.055
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0073 0.0226 0.0515
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0073 0.0226 0.0515
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0078 0.0256 0.0585
Onchocerca volvulus 0.004 0.0002 0.0002
Mycobacterium leprae Probable inosine-5'-monophosphate dehydrogenase GuaB3 (IMP dehydrogenase 2) (inosinic acid dehydrogenase) (inosinate dehydrogena 0.0356 0.2152 0.4951
Trypanosoma cruzi trypanothione reductase, putative 0.0073 0.0226 0.0515
Mycobacterium tuberculosis Probable inosine-5'-monophosphate dehydrogenase GuaB2 (imp dehydrogenase) (inosinic acid dehydrogenase) (inosinate dehydrogenase 0.0679 0.4346 1
Echinococcus multilocularis chromobox protein 1 0.0071 0.0213 0.0487
Loa Loa (eye worm) jmjC domain-containing protein 0.0149 0.0743 0.0848
Echinococcus multilocularis lysosomal alpha glucosidase 0.035 0.2108 0.4848
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0062 0.015 0.0342
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0073 0.0226 0.0515
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0294 0.1725 0.3966
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0601 0.3816 0.3816
Trypanosoma cruzi trypanothione reductase, putative 0.0211 0.1164 0.2676
Loa Loa (eye worm) hypothetical protein 0.004 0.0002 0.0002
Giardia lamblia NADH oxidase lateral transfer candidate 0.0073 0.0226 0.0586
Plasmodium falciparum inosine-5'-monophosphate dehydrogenase 0.0639 0.4072 1
Echinococcus multilocularis PHD finger protein rhinoceros 0.0123 0.0566 0.1299
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0073 0.0226 0.055
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0064 0.0165 0.0375
Echinococcus granulosus chromobox protein 1 0.0071 0.0213 0.0487
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0144 0.0709 0.1626
Brugia malayi inosine-5'-monophosphate dehydrogenase family protein 0.0679 0.4346 0.4965
Mycobacterium ulcerans inosine 5'-monophosphate dehydrogenase 0.0679 0.4346 1
Brugia malayi Pre-SET motif family protein 0.019 0.1022 0.1168
Schistosoma mansoni jumonji/arid domain-containing protein 0.0149 0.0743 0.1705
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0073 0.0226 0.055
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0601 0.3816 0.3816
Mycobacterium tuberculosis Probable reductase 0.0482 0.3005 0.6912
Brugia malayi Thioredoxin reductase 0.0211 0.1164 0.133
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0536 0.337 0.7754
Loa Loa (eye worm) IMP dehydrogenase 1 0.0679 0.4346 0.4965
Brugia malayi loechrig isoform VII 0.004 0.0002 0.0002
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.1327 0.8753 1
Brugia malayi PHD-finger family protein 0.0123 0.0566 0.0647
Echinococcus multilocularis lysine specific demethylase 5A 0.0149 0.0743 0.1705
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0078 0.0256 0.0256
Plasmodium falciparum glutathione reductase 0.0211 0.1164 0.2856
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0073 0.0226 0.0515
Schistosoma mansoni jumonji domain containing protein 0.0321 0.1909 0.4391
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0073 0.0226 0.0515
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0482 0.3005 0.6912
Toxoplasma gondii thioredoxin reductase 0.0211 0.1164 0.2676
Schistosoma mansoni alpha glucosidase 0.0078 0.0256 0.0585
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0601 0.3816 0.3816
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0078 0.0256 0.0256
Trichomonas vaginalis alpha-glucosidase, putative 0.0078 0.0256 0.0256
Brugia malayi ancient conserved domain protein 4 0.004 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.0211 0.1165 0.1331
Echinococcus multilocularis jumonji domain containing protein 0.0172 0.0895 0.2055
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0073 0.0226 0.0258
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0073 0.0226 0.0515
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0073 0.0226 0.0515
Echinococcus granulosus lysine specific demethylase 5A 0.0149 0.0743 0.1705
Echinococcus multilocularis neutral alpha glucosidase AB 0.0078 0.0256 0.0585
Trichomonas vaginalis maltase-glucoamylase, putative 0.0078 0.0256 0.0256
Trichomonas vaginalis mercuric reductase, putative 0.0073 0.0226 0.0226
Plasmodium vivax hypothetical protein, conserved 0.0123 0.0566 0.1387
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0064 0.0165 0.0188
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0249 0.1422 0.327
Schistosoma mansoni hypothetical protein 0.0165 0.085 0.1952
Toxoplasma gondii IMP dehydrogenas 0.0679 0.4346 1
Loa Loa (eye worm) hypothetical protein 0.0123 0.0566 0.0647
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0073 0.0226 0.0515
Echinococcus granulosus chromobox protein 1 0.0071 0.0213 0.0487
Loa Loa (eye worm) hypothetical protein 0.004 0.0002 0.0002
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0078 0.0256 0.0249
Plasmodium vivax inosine-5'-monophosphate dehydrogenase, putative 0.0639 0.4072 1
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0404 0.2474 0.569
Echinococcus multilocularis geminin 0.0165 0.085 0.1952
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0482 0.3005 0.6912
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0144 0.0709 0.1627
Trichomonas vaginalis chromobox protein, putative 0.0043 0.0021 0.0021
Mycobacterium ulcerans inosine 5-monophosphate dehydrogenase 0.0639 0.4072 0.9369
Trypanosoma cruzi inosine-5'-monophosphate dehydrogenase, putative 0.0679 0.4346 1
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0211 0.1164 0.2676
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0073 0.0226 0.0515
Brugia malayi glutaminase DH11.1 0.0313 0.186 0.2125
Plasmodium vivax thioredoxin reductase, putative 0.0211 0.1164 0.2856
Trichomonas vaginalis alpha-glucosidase, putative 0.0078 0.0256 0.0256
Toxoplasma gondii PHD-finger domain-containing protein 0.0123 0.0566 0.1299
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0601 0.3816 1
Loa Loa (eye worm) chloride channel protein 7 0.004 0.0002 0.0002
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.019 0.1022 0.2349
Trichomonas vaginalis alpha-glucosidase, putative 0.0078 0.0256 0.0256
Leishmania major inosine-5-monophosphate dehydrogenase 0.0679 0.4346 1
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0073 0.0226 0.0515
Mycobacterium tuberculosis Probable dehydrogenase 0.0482 0.3005 0.6912
Loa Loa (eye worm) hypothetical protein 0.004 0.0002 0.0002
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0123 0.0566 0.1299
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0482 0.3005 0.6912
Loa Loa (eye worm) hypothetical protein 0.019 0.1022 0.1168
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0073 0.0226 0.0515
Echinococcus granulosus jumonji domain containing protein 0.0172 0.0895 0.2055
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0294 0.1725 0.3966
Brugia malayi CBS domain containing protein 0.004 0.0002 0.0002
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0073 0.0226 0.0515
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0073 0.0226 0.0515
Brugia malayi chloride channel protein 7 0.004 0.0002 0.0002
Loa Loa (eye worm) heterochromatin protein 1 0.0071 0.0213 0.0244
Brugia malayi jmjC domain containing protein 0.0149 0.0743 0.0848
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0144 0.0709 0.1626
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0062 0.015 0.0342
Loa Loa (eye worm) jmjC domain-containing protein 0.0255 0.1459 0.1667
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0054 0.0093 0.0107
Echinococcus granulosus histone lysine methyltransferase setb 0.019 0.1022 0.2349
Schistosoma mansoni alpha-glucosidase 0.0301 0.1776 0.4085
Loa Loa (eye worm) chloride channel 3 0.004 0.0002 0.0002
Giardia lamblia Fructose-bisphosphate aldolase 0.0601 0.3816 1
Toxoplasma gondii NADPH-glutathione reductase 0.0073 0.0226 0.0515
Brugia malayi Heterochromatin protein 1 0.0071 0.0213 0.0244
Plasmodium falciparum thioredoxin reductase 0.0211 0.1164 0.2856
Treponema pallidum NADH oxidase 0.0073 0.0226 0.0586
Mycobacterium tuberculosis Probable inosine-5'-monophosphate dehydrogenase GuaB3 (imp dehydrogenase) (inosinic acid dehydrogenase) (inosinate dehydrogenase 0.0356 0.2152 0.4951
Brugia malayi AF-10 protein 0.004 0.0002 0.0002
Mycobacterium tuberculosis Probable oxidoreductase 0.0536 0.337 0.7754
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0073 0.0226 0.0515
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0536 0.337 0.7754
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0294 0.1725 0.3966
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0202 0.1102 0.2532
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0482 0.3005 0.6912
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.019 0.1022 0.2349
Brugia malayi GMP reductase 0.0282 0.1647 0.1882
Loa Loa (eye worm) glutaminase 0.0313 0.186 0.2125
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0073 0.0226 0.0515
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0078 0.0256 0.0292
Leishmania major alpha glucosidase II subunit, putative 0.0078 0.0256 0.0585
Brugia malayi glutathione reductase 0.0211 0.1164 0.133
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0064 0.0165 0.0375
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0064 0.0165 0.0188
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0144 0.0709 0.1627
Echinococcus granulosus PHD finger protein rhinoceros 0.0123 0.0566 0.1299
Schistosoma mansoni chromobox protein 0.0071 0.0213 0.0487
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0073 0.0226 0.055
Echinococcus granulosus geminin 0.0165 0.085 0.1952
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0536 0.337 0.7754
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0073 0.0226 0.0515
Loa Loa (eye worm) loechrig isoform VII 0.004 0.0002 0.0002
Trichomonas vaginalis glutaminase, putative 0.0313 0.186 0.186
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.019 0.1022 0.2349
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0601 0.3816 0.3816
Mycobacterium leprae Probable inosine-5'-monophosphate dehydrogenase GuaB2 (IMP dehydrogenase) (IMPDH) (IMPD) 0.0679 0.4346 1
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.035 0.2108 0.2408
Brugia malayi Pre-SET motif family protein 0.1327 0.8753 1
Loa Loa (eye worm) GMP reductase 0.0282 0.1647 0.1882
Trichomonas vaginalis set domain proteins, putative 0.151 1 1
Plasmodium vivax glutathione reductase, putative 0.0211 0.1164 0.2856
Schistosoma mansoni chromobox protein 0.0071 0.0213 0.0487
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0073 0.0226 0.0515
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0073 0.0226 0.0515
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0054 0.0093 0.0107
Loa Loa (eye worm) transcription factor SMAD2 0.0116 0.0518 0.0592
Trypanosoma cruzi hypothetical protein, conserved 0.0078 0.0256 0.0585
Trichomonas vaginalis chromobox protein, putative 0.0043 0.0021 0.0021
Plasmodium falciparum phd finger protein, putative 0.0123 0.0566 0.1387
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0144 0.0709 0.0809
Brugia malayi Voltage gated chloride channel family protein 0.004 0.0002 0.0002
Brugia malayi Bromodomain containing protein 0.0123 0.0566 0.0647
Wolbachia endosymbiont of Brugia malayi IMP dehydrogenase 0.0679 0.4346 1
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0073 0.0226 0.0515
Giardia lamblia PHD finger protein 15 0.0123 0.0566 0.1479
Echinococcus multilocularis peregrin 0.0123 0.0566 0.1299
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0144 0.0709 0.1627
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0073 0.0226 0.0515
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0601 0.3816 0.3816
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0064 0.0165 0.0375
Echinococcus multilocularis lysosomal alpha glucosidase 0.035 0.2108 0.4848
Echinococcus multilocularis thioredoxin glutathione reductase 0.0213 0.1179 0.271
Echinococcus multilocularis chromobox protein 1 0.0071 0.0213 0.0487
Loa Loa (eye worm) glutathione reductase 0.0211 0.1164 0.133
Echinococcus granulosus inosine 5' monophosphate dehydrogenase 2 0.0679 0.4346 1
Trypanosoma cruzi GMP reductase 0.0679 0.4346 1
Leishmania major trypanothione reductase 0.0211 0.1164 0.2676
Echinococcus granulosus neutral alpha glucosidase AB 0.0078 0.0256 0.0585
Brugia malayi jmjC domain containing protein 0.0404 0.2474 0.2826
Brugia malayi PHD-finger family protein 0.004 0.0002 0.0002
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0073 0.0226 1
Onchocerca volvulus Putative GMP reductase 0.0282 0.1647 0.1647
Trichomonas vaginalis chromobox protein, putative 0.0071 0.0213 0.0213
Toxoplasma gondii PHD-finger domain-containing protein 0.0123 0.0566 0.1299
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.019 0.1022 0.2349
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0058 0.0122 0.0139
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0183 0.0975 0.2239
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0073 0.0226 0.0515
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0064 0.0165 0.0375
Schistosoma mansoni alpha-glucosidase 0.0301 0.1776 0.4085
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0062 0.015 0.0342
Trichomonas vaginalis glutathione reductase, putative 0.0073 0.0226 0.0226
Schistosoma mansoni glutaminase 0.0313 0.186 0.4277
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0144 0.0709 0.0809
Trichomonas vaginalis alpha-glucosidase, putative 0.0078 0.0256 0.0256
Trypanosoma cruzi inosine-5'-monophosphate dehydrogenase, putative 0.0679 0.4346 1
Trichomonas vaginalis sucrase-isomaltase, putative 0.0078 0.0256 0.0256
Loa Loa (eye worm) hypothetical protein 0.004 0.0002 0.0002
Schistosoma mansoni hypothetical protein 0.0165 0.085 0.1952
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.019 0.1022 0.2349
Plasmodium falciparum thioredoxin reductase 0.0073 0.0226 0.055
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0482 0.3005 0.6912
Trypanosoma cruzi hypothetical protein, conserved 0.0078 0.0256 0.0585
Trypanosoma brucei trypanothione reductase 0.0211 0.1164 0.2676
Brugia malayi ancient conserved domain protein 2 0.004 0.0002 0.0002
Mycobacterium ulcerans inosine 5-monophosphate dehydrogenase 0.0322 0.1921 0.4418
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0062 0.015 0.0342
Loa Loa (eye worm) thioredoxin reductase 0.0211 0.1164 0.133
Trypanosoma brucei inosine-5'-monophosphate dehydrogenase 0.0679 0.4346 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0601 0.3816 0.3816
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0601 0.3816 1
Trypanosoma brucei GMP reductase 0.0679 0.4346 1
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0064 0.0165 0.0375
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0073 0.0226 0.0515
Loa Loa (eye worm) MH2 domain-containing protein 0.0116 0.0518 0.0592
Onchocerca volvulus Alhambra homolog 0.0123 0.0566 0.0566
Mycobacterium leprae PROBABLE INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE GUAB1(IMP DEHYDROGENASE) (IMPDH) (IMPD) 0.0322 0.1921 0.4418
Echinococcus multilocularis inosine 5' monophosphate dehydrogenase 2 0.0679 0.4346 1
Loa Loa (eye worm) glutaminase 2 0.0313 0.186 0.2125
Loa Loa (eye worm) PHD-finger family protein 0.0123 0.0566 0.0647
Loa Loa (eye worm) hypothetical protein 0.004 0.0002 0.0002
Schistosoma mansoni jumonji/arid domain-containing protein 0.0149 0.0743 0.1705
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0062 0.015 0.0342
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0073 0.0226 0.0515
Brugia malayi F/Y-rich N-terminus family protein 0.0047 0.0049 0.0057
Trypanosoma brucei glucosidase, putative 0.0078 0.0256 0.0585
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0064 0.0165 0.0375
Trypanosoma cruzi inosine-5'-monophosphate dehydrogenase, putative 0.0679 0.4346 1
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0073 0.0226 0.0515
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0062 0.015 0.0172
Brugia malayi Glycosyl hydrolases family 31 protein 0.035 0.2108 0.2408
Brugia malayi Glycosyl hydrolases family 31 protein 0.0078 0.0256 0.0292
Plasmodium vivax SET domain protein, putative 0.019 0.1022 0.2508
Leishmania major guanosine monophosphate reductase 0.0679 0.4346 1
Echinococcus granulosus peregrin 0.0123 0.0566 0.1299
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0404 0.2474 0.569
Trichomonas vaginalis alpha-glucosidase, putative 0.0078 0.0256 0.0256
Brugia malayi inosine-5'-monophosphate dehydrogenase 0.0282 0.1647 0.1882
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0043 0.0021 0.0021
Echinococcus granulosus thioredoxin glutathione reductase 0.0213 0.1179 0.271
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0073 0.0226 0.0515
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0064 0.0165 0.0375
Plasmodium falciparum glutathione reductase 0.0073 0.0226 0.055
Schistosoma mansoni inosine-5-monophosphate dehydrogenase 0.0679 0.4346 1
Mycobacterium ulcerans glutaminase 0.0313 0.186 0.4277
Schistosoma mansoni hypothetical protein 0.0123 0.0566 0.1299
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0062 0.015 0.0342
Brugia malayi CLC chloride channel protein 0.004 0.0002 0.0002
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.019 0.1022 0.2349
Brugia malayi inosine-5'-monophosphate dehydrogenase 0.0282 0.1647 0.1882
Trypanosoma cruzi GMP reductase 0.0679 0.4346 1
Echinococcus granulosus lysosomal alpha glucosidase 0.035 0.2108 0.4848
Onchocerca volvulus 0.0202 0.1102 0.1102
Trichomonas vaginalis chromobox protein, putative 0.0071 0.0213 0.0213
Treponema pallidum fructose-bisphosphate aldolase 0.0601 0.3816 1
Brugia malayi MH2 domain containing protein 0.0116 0.0518 0.0592

Activities

Activity type Activity value Assay description Source Reference
Urinary glucose excretion (functional) = 321 Compound was tested for urinary glucose excretion (mg/24 h) at 100 mg/Kg dose of compound given perorally ChEMBL. 10639275

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.