Detailed information for compound 261372

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 328.298 | Formula: C16H13FN4O3
  • H donors: 3 H acceptors: 3 LogP: 2.34 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: COC(=O)Nc1[nH]c2c(n1)cc(cc2)NC(=O)c1ccccc1F
  • InChi: 1S/C16H13FN4O3/c1-24-16(23)21-15-19-12-7-6-9(8-13(12)20-15)18-14(22)10-4-2-3-5-11(10)17/h2-8H,1H3,(H,18,22)(H2,19,20,21,23)
  • InChiKey: CFUKSJYRQIZEQA-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0593 0.0739 0.0735
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0052 0.0029 0.0029
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0252 0.0292 0.0292
Entamoeba histolytica hypothetical protein 0.005 0.0027 0.4799
Trypanosoma cruzi GUP1, putative 0.005 0.0027 0.0246
Trichomonas vaginalis conserved hypothetical protein 0.0088 0.0076 1
Toxoplasma gondii dgat2l1-prov protein 0.0852 0.108 1
Echinococcus granulosus raf serine:threonine protein kinase 0.0665 0.0834 0.0829
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0101 0.0094 0.0784
Brugia malayi TAR-binding protein 0.0252 0.0292 0.0286
Loa Loa (eye worm) hypothetical protein 0.005 0.0027 0.0027
Trichomonas vaginalis conserved hypothetical protein 0.0088 0.0076 1
Brugia malayi RNA recognition motif domain containing protein 0.0252 0.0292 0.0286
Brugia malayi hypothetical protein 0.0152 0.016 0.0153
Trypanosoma brucei glycerol uptake protein, putative 0.005 0.0027 0.0246
Schistosoma mansoni sterol O-acyltransferase 1 0.005 0.0027 0.0022
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.005 0.0027 0.1695
Schistosoma mansoni o-acyltransferase (membrane bound) domain containing protein 0.005 0.0027 0.0022
Echinococcus granulosus protein cysteine N palmitoyltransferase 0.005 0.0027 0.0022
Toxoplasma gondii diacylglycerol acyltransferase 0.0189 0.0209 0.189
Loa Loa (eye worm) hypothetical protein 0.0067 0.0049 0.0049
Loa Loa (eye worm) membrane bound O-acyltransferase domain containing 1 0.005 0.0027 0.0027
Toxoplasma gondii acyl-CoA:cholesterol acyltransferase alpha ACAT1-alpha 0.0299 0.0354 0.3238
Loa Loa (eye worm) glutathione reductase 0.0037 0.001 0.001
Schistosoma mansoni hypothetical protein 0.0035 0.0007 0.0002
Brugia malayi Calcitonin receptor-like protein seb-1 0.0052 0.0029 0.0022
Plasmodium vivax acyl-CoA synthetase, putative 0.005 0.0027 0.0487
Leishmania major 4-coumarate:coa ligase-like protein 0.0067 0.0049 0.0364
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0095 0.0085 0.7602
Brugia malayi MBOAT family protein 0.005 0.0027 0.002
Loa Loa (eye worm) raf kinase 0.0662 0.083 0.083
Plasmodium falciparum ataxin-2 like protein, putative 0.0075 0.0059 0.1427
Toxoplasma gondii acyl-CoA:diacylglycerol acyltransferase 1-related enzyme 0.0299 0.0354 0.3238
Toxoplasma gondii hypothetical protein 0.005 0.0027 0.0197
Trypanosoma cruzi glycerol uptake protein, putative 0.005 0.0027 0.0246
Echinococcus multilocularis sterol O acyltransferase 1 0.005 0.0027 0.0022
Echinococcus multilocularis o acyltransferase (membrane bound) domain 0.005 0.0027 0.0022
Onchocerca volvulus 0.0152 0.016 0.1264
Echinococcus multilocularis protein cysteine N palmitoyltransferase 0.005 0.0027 0.0022
Loa Loa (eye worm) hhat protein 0.005 0.0027 0.0027
Leishmania major hypothetical protein, conserved 0.0075 0.0059 0.0458
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0035 0.0007 0.0002
Brugia malayi Hhat protein 0.005 0.0027 0.002
Trypanosoma cruzi diacylglycerol acyltransferase, putative 0.0852 0.108 1
Trichomonas vaginalis conserved hypothetical protein 0.0053 0.0031 0.0846
Trypanosoma brucei diacylglycerol acyltransferase, putative 0.0189 0.0209 0.1931
Echinococcus granulosus diacylglycerol O acyltransferase 1 0.0299 0.0354 0.0349
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0593 0.0739 0.0733
Leishmania major diacylglycerol acyltransferase, putative 0.0189 0.0209 0.1859
Trypanosoma cruzi diacylglycerol acyltransferase, putative 0.0189 0.0209 0.1931
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0593 0.0739 0.0735
Trichomonas vaginalis conserved hypothetical protein 0.0088 0.0076 1
Brugia malayi MBOAT family protein 0.005 0.0027 0.002
Loa Loa (eye worm) hhat protein 0.005 0.0027 0.0027
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0035 0.0007 0.0002
Schistosoma mansoni diacylglycerol O-acyltransferase 0.0189 0.0209 0.0204
Treponema pallidum alginate O-acetylation protein (algI) 0.005 0.0027 0.5
Entamoeba histolytica membrane-bound O-acyltransferase (MBOAT ) family protein 0.005 0.0027 0.4799
Brugia malayi MBOAT family protein 0.005 0.0027 0.002
Brugia malayi Raf kinase 0.0642 0.0804 0.0797
Echinococcus multilocularis o acyltransferase (membrane bound) domain 0.005 0.0027 0.0022
Trypanosoma cruzi diacylglycerol acyltransferase, putative 0.0189 0.0209 0.1931
Brugia malayi AMP-binding enzyme family protein 0.0067 0.0049 0.0042
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0214 0.0242 0.2234
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0067 0.0049 0.122
Schistosoma mansoni serine/threonine protein kinase 0.0665 0.0834 0.0829
Mycobacterium tuberculosis Probable reductase 0.0085 0.0073 0.6342
Loa Loa (eye worm) hypothetical protein 0.005 0.0027 0.0027
Brugia malayi hypothetical protein 0.0075 0.0059 0.0052
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0593 0.0739 0.0735
Schistosoma mansoni leukocyte receptor cluster (lrc) member 4 protein 0.005 0.0027 0.0022
Loa Loa (eye worm) hypothetical protein 0.0075 0.0059 0.0059
Toxoplasma gondii hypothetical protein 0.0034 0.0006 0.0003
Loa Loa (eye worm) hypothetical protein 0.005 0.0027 0.0027
Schistosoma mansoni diacylglycerol O-acyltransferase 0.0189 0.0209 0.0204
Brugia malayi AMP-binding enzyme family protein 0.0067 0.0049 0.0042
Trypanosoma cruzi glycerol uptake protein, putative 0.005 0.0027 0.0246
Schistosoma mansoni hypothetical protein 0.005 0.0027 0.0022
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0593 0.0739 0.0735
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0085 0.0073 0.6342
Loa Loa (eye worm) hypothetical protein 0.005 0.0027 0.0027
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0047 0.0023 0.1332
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0101 0.0094 0.0865
Plasmodium falciparum diacylglycerol O-acyltransferase 0.0299 0.0354 1
Loa Loa (eye worm) hypothetical protein 0.005 0.0027 0.0027
Trypanosoma brucei diacylglycerol acyltransferase, putative 0.0852 0.108 1
Leishmania major hypothetical protein, conserved 0.005 0.0027 0.016
Leishmania major 4-coumarate:coa ligase-like protein 0.0067 0.0049 0.0364
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0593 0.0739 0.0735
Loa Loa (eye worm) diacylglycerol acyltransferase 0.0299 0.0354 0.0354
Brugia malayi hypothetical protein 0.0048 0.0024 0.0017
Loa Loa (eye worm) MBOAT family protein 0.005 0.0027 0.0027
Loa Loa (eye worm) hypothetical protein 0.7648 1 1
Schistosoma mansoni tar DNA-binding protein 0.0252 0.0292 0.0287
Loa Loa (eye worm) diacylglycerol acyltransferase 0.0852 0.108 0.108
Entamoeba histolytica vacuolar protein sorting 26 0.005 0.0027 0.4799
Echinococcus granulosus o acyltransferase membrane bound domain 0.005 0.0027 0.0022
Onchocerca volvulus 0.0067 0.0049 0.0208
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0067 0.0049 0.3944
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0067 0.0049 0.122
Trypanosoma cruzi diacylglycerol acyltransferase, putative 0.0189 0.0209 0.1931
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0067 0.0049 0.122
Echinococcus granulosus microtubule associated protein 2 0.0953 0.1211 0.1207
Toxoplasma gondii thioredoxin reductase 0.0037 0.001 0.0038
Loa Loa (eye worm) TAR-binding protein 0.0252 0.0292 0.0292
Echinococcus multilocularis thioredoxin glutathione reductase 0.0037 0.001 0.0005
Echinococcus granulosus alpha 16 mannosyl glycoprotein 0.7648 1 1
Loa Loa (eye worm) hypothetical protein 0.005 0.0027 0.0027
Plasmodium falciparum ataxin-2 like protein, putative 0.0075 0.0059 0.1427
Loa Loa (eye worm) TKL/RAF/RAF protein kinase 0.0377 0.0456 0.0456
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0593 0.0739 0.0739
Mycobacterium ulcerans acyl-CoA synthetase 0.0067 0.0049 0.122
Mycobacterium tuberculosis Probable dehydrogenase 0.0085 0.0073 0.6342
Brugia malayi AMP-binding enzyme family protein 0.0067 0.0049 0.0042
Trypanosoma cruzi PAB1-binding protein , putative 0.0075 0.0059 0.0542
Loa Loa (eye worm) thioredoxin reductase 0.0037 0.001 0.001
Schistosoma mansoni hypothetical protein 0.0035 0.0007 0.0002
Leishmania major mitochondrial DNA polymerase beta 0.0214 0.0242 0.2165
Loa Loa (eye worm) hypothetical protein 0.0052 0.0029 0.0029
Schistosoma mansoni zinc finger protein 0.005 0.0027 0.0022
Loa Loa (eye worm) MBOAT family protein 0.005 0.0027 0.0027
Loa Loa (eye worm) hypothetical protein 0.0067 0.0049 0.0049
Leishmania major glycerol uptake protein, putative 0.005 0.0027 0.016
Plasmodium vivax ataxin-2 like protein, putative 0.0075 0.0059 0.1427
Mycobacterium tuberculosis Probable oxidoreductase 0.0095 0.0085 0.7602
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0095 0.0085 1
Loa Loa (eye worm) MBOAT family protein 0.005 0.0027 0.0027
Schistosoma mansoni tar DNA-binding protein 0.0252 0.0292 0.0287
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0052 0.0029 0.0022
Schistosoma mansoni tar DNA-binding protein 0.0252 0.0292 0.0287
Brugia malayi N-terminal motif family protein 0.0539 0.0669 0.0662
Schistosoma mansoni diacylglycerol O-acyltransferase 1 0.0852 0.108 0.1076
Trichomonas vaginalis conserved hypothetical protein 0.0088 0.0076 1
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0211 0.0238 0.0233
Schistosoma mansoni o-acyltransferase (membrane bound) domain containing protein 0.005 0.0027 0.0022
Schistosoma mansoni hypothetical protein 0.0189 0.0209 0.0204
Echinococcus granulosus Membrane bound O acyl transferase MBOAT 0.005 0.0027 0.0022
Trichomonas vaginalis conserved hypothetical protein 0.0088 0.0076 1
Entamoeba histolytica membrane-bound O-acyltransferase (MBOAT ) family protein 0.005 0.0027 0.4799
Trichomonas vaginalis conserved hypothetical protein 0.0088 0.0076 1
Loa Loa (eye worm) hypothetical protein 0.005 0.0027 0.0027
Mycobacterium ulcerans acyl-CoA synthetase 0.0067 0.0049 0.122
Loa Loa (eye worm) hypothetical protein 0.005 0.0027 0.0027
Leishmania major glycerol uptake protein, putative 0.005 0.0027 0.016
Echinococcus multilocularis o acyltransferase (membrane bound) domain 0.005 0.0027 0.0022
Toxoplasma gondii mono- or diacylglycerol acyltransferase 0.0189 0.0209 0.189
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0593 0.0739 0.0735
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0539 0.0669 0.6094
Echinococcus multilocularis lysophospholipid acyltransferase 7 0.005 0.0027 0.0022
Echinococcus multilocularis membrane bound acyltransferase:hhat 0.005 0.0027 0.0022
Trypanosoma cruzi trypanothione reductase, putative 0.0037 0.001 0.0088
Trichomonas vaginalis conserved hypothetical protein 0.0088 0.0076 1
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0095 0.0085 0.7602
Schistosoma mansoni o-acyltransferase (membrane bound) domain containing protein 0.005 0.0027 0.0022
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0047 0.0023 0.1332
Trypanosoma brucei glycerol uptake protein, putative 0.005 0.0027 0.0246
Schistosoma mansoni hypothetical protein 0.0074 0.0058 0.0053
Plasmodium falciparum acyl-CoA synthetase 0.005 0.0027 0.0487
Brugia malayi MH2 domain containing protein 0.0116 0.0113 0.0106
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0047 0.0023 0.1332
Schistosoma mansoni microtubule-associated protein tau 0.0953 0.1211 0.1207
Echinococcus granulosus membrane bound acyltransferase:hhat 0.005 0.0027 0.0022
Trypanosoma brucei trypanothione reductase 0.0037 0.001 0.0088
Schistosoma mansoni tar DNA-binding protein 0.0252 0.0292 0.0287
Schistosoma mansoni diacylglycerol O-acyltransferase 1 0.0299 0.0354 0.0349
Brugia malayi diacylglycerol acyltransferase family protein 0.0852 0.108 0.1074
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0067 0.0049 0.3944
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0214 0.0242 0.2234
Loa Loa (eye worm) hypothetical protein 0.0539 0.0669 0.0669
Echinococcus granulosus sterol O acyltransferase 1 0.005 0.0027 0.0022
Echinococcus multilocularis alpha 1,6 mannosyl glycoprotein 0.7648 1 1
Echinococcus granulosus lysophospholipid acyltransferase 7 0.005 0.0027 0.0022
Echinococcus granulosus tar DNA binding protein 0.0252 0.0292 0.0287
Loa Loa (eye worm) hypothetical protein 0.0249 0.0288 0.0288
Toxoplasma gondii LsmAD domain-containing protein 0.0075 0.0059 0.0494
Echinococcus multilocularis raf serine:threonine protein kinase 0.0665 0.0834 0.0829
Loa Loa (eye worm) hypothetical protein 0.005 0.0027 0.0027
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.005 0.0027 0.5
Trypanosoma brucei PAB1-binding protein , putative 0.0075 0.0059 0.0542
Brugia malayi MBOAT family protein 0.005 0.0027 0.002
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0085 0.0073 0.6342
Brugia malayi RNA binding protein 0.0252 0.0292 0.0286
Schistosoma mansoni transcription factor LCR-F1 0.0035 0.0007 0.0002
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0037 0.0009 0.008
Leishmania major 4-coumarate:coa ligase-like protein 0.0067 0.0049 0.0364
Trypanosoma cruzi diacylglycerol acyltransferase, putative 0.0852 0.108 1
Entamoeba histolytica acyl-coA synthetase, putative 0.0067 0.0049 1
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0085 0.0073 0.6555
Trypanosoma cruzi PAB1-binding protein , putative 0.0075 0.0059 0.0542
Loa Loa (eye worm) hypothetical protein 0.0067 0.0049 0.0049
Entamoeba histolytica acyl-CoA synthetase, putative 0.0067 0.0049 1
Entamoeba histolytica membrane-bound O-acyltransferase (MBOAT ) family protein 0.005 0.0027 0.4799
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0085 0.0073 0.6342
Entamoeba histolytica hypothetical protein, conserved 0.005 0.0027 0.4799
Trypanosoma cruzi glycerol uptake protein, putative 0.005 0.0027 0.0246
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0214 0.0242 0.2234
Leishmania major glycerol uptake protein, putative 0.005 0.0027 0.016
Echinococcus multilocularis Membrane bound O acyl transferase, MBOAT 0.005 0.0027 0.0022
Loa Loa (eye worm) transcription factor SMAD2 0.0116 0.0113 0.0113
Mycobacterium ulcerans hypothetical protein 0.0189 0.0209 1
Leishmania major diacylglycerol acyltransferase, putative 0.0189 0.0209 0.1859
Loa Loa (eye worm) hypothetical protein 0.0152 0.016 0.016
Plasmodium vivax diacylglycerol O-acyltransferase, putative 0.0299 0.0354 1
Echinococcus multilocularis tar DNA binding protein 0.0252 0.0292 0.0287
Leishmania major diacylglycerol acyltransferase, putative 0.0852 0.108 1
Entamoeba histolytica acyl-CoA synthetase, putative 0.0067 0.0049 1
Schistosoma mansoni beta-12-n-acetylglucosaminyltransferase II 0.7648 1 1
Loa Loa (eye worm) MH2 domain-containing protein 0.0116 0.0113 0.0113
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0067 0.0049 0.122
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0593 0.0739 0.0735
Schistosoma mansoni tar DNA-binding protein 0.0252 0.0292 0.0287
Echinococcus granulosus o acyltransferase membrane bound domain 0.005 0.0027 0.0022
Trypanosoma brucei RNA helicase, putative 0.0074 0.0058 0.0535
Brugia malayi Thioredoxin reductase 0.0037 0.001 0.0003
Schistosoma mansoni membrane-bound acyltransferase/hhat 0.005 0.0027 0.0022
Brugia malayi diacylglycerol acyltransferase 0.0299 0.0354 0.0347
Leishmania major hypothetical protein, unknown function,protein, unknown function 0.0189 0.0209 0.1859
Trypanosoma cruzi diacylglycerol acyltransferase, putative 0.0189 0.0209 0.1931
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0085 0.0073 0.6342
Echinococcus granulosus o acyltransferase membrane bound domain 0.005 0.0027 0.0022
Mycobacterium ulcerans hypothetical protein 0.0067 0.0049 0.122
Brugia malayi glutathione reductase 0.0037 0.001 0.0003
Trichomonas vaginalis conserved hypothetical protein 0.0088 0.0076 1
Loa Loa (eye worm) hypothetical protein 0.0035 0.0007 0.0007
Echinococcus multilocularis microtubule associated protein 2 0.0953 0.1211 0.1207
Mycobacterium ulcerans hypothetical protein 0.0113 0.0109 0.4506
Echinococcus multilocularis diacylglycerol O acyltransferase 1 0.0299 0.0354 0.0349
Mycobacterium tuberculosis Conserved hypothetical protein 0.0113 0.0109 1
Onchocerca volvulus 0.0852 0.108 1
Trypanosoma cruzi GUP1, putative 0.005 0.0027 0.0246
Echinococcus granulosus thioredoxin glutathione reductase 0.0037 0.001 0.0005
Leishmania major glycerol uptake protein, putative 0.005 0.0027 0.016
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0101 0.0094 0.0865
Leishmania major glycerol uptake protein, putative 0.005 0.0027 0.016
Brugia malayi MBOAT family protein 0.005 0.0027 0.002
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0047 0.0023 0.1332
Loa Loa (eye worm) RNA binding protein 0.0252 0.0292 0.0292
Mycobacterium ulcerans acyl-CoA synthetase 0.0067 0.0049 0.122

Activities

Activity type Activity value Assay description Source Reference
Control (functional) = 0 % Compound was tested in vitro against L1210 murine leukemia cell growth rate at a concentration of 100 uM ChEMBL. 1738146
Control (functional) = 0 % Compound was tested in vitro against L1210 murine leukemia cell growth rate at a concentration of 100 uM ChEMBL. 1738146
Control (functional) = 116 % Antifilarial activity measured against the adult worms of A. vitae in jirds by subcutaneous administration ChEMBL. 1738146
IC50 (functional) = 14 uM Compound was tested in vitro for its inhibitory activity against L1210 murine leukemia cell growth at a concentration of 100 uM ChEMBL. 1738146
IC50 (functional) = 14 uM Compound was tested in vitro for its inhibitory activity against L1210 murine leukemia cell growth at a concentration of 100 uM ChEMBL. 1738146

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Mus musculus ChEMBL23 1738146

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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