Detailed information for compound 26198

Basic information

Technical information
  • TDR Targets ID: 26198
  • Name: 2-[[amino(hydrazinyl)methylidene]amino]acetic acid
  • MW: 132.121 | Formula: C3H8N4O2
  • H donors: 4 H acceptors: 2 LogP: -3.97 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: NNC(=N)NCC(=O)O
  • InChi: 1S/C3H8N4O2/c4-3(7-5)6-1-2(8)9/h1,5H2,(H,8,9)(H3,4,6,7)
  • InChiKey: XJHZGOPHYCNIAO-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-[[amino(hydrazino)methylene]amino]acetic acid
  • 2-[[azanyl(hydrazinyl)methylidene]amino]ethanoic acid

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0145 0.167 0.1652
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.083 1 1
Loa Loa (eye worm) isocitrate dehydrogenase 0.0015 0.0089 0.0069
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.083 1 1
Trichomonas vaginalis glutamine synthetase-bacteria, putative 0.0195 0.2273 0.8169
Loa Loa (eye worm) hypothetical protein 0.0392 0.4666 0.4655
Trypanosoma brucei glutamine synthetase, putative 0.0773 0.9297 1
Brugia malayi Nuclear hormone receptor family member nhr-25 0.083 1 1
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.083 1 1
Echinococcus granulosus Nuclear hormone receptor HR96 0.0392 0.4666 0.4666
Entamoeba histolytica glutamine synthetase, putative 0.0195 0.2273 1
Loa Loa (eye worm) hypothetical protein 0.0392 0.4666 0.4655
Schistosoma mansoni nuclear receptor nhr-48 0.0392 0.4666 0.4666
Loa Loa (eye worm) hypothetical protein 0.0392 0.4666 0.4655
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.001 0.0021 0.0021
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.003 0.0263 0.0263
Brugia malayi Steroid receptor seven-up type 2 0.083 1 1
Brugia malayi tailless protein 0.0392 0.4666 0.4655
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.083 1 1
Echinococcus granulosus nuclear receptor 2DBD gamma 0.083 1 1
Echinococcus multilocularis neuropeptide s receptor 0.045 0.5372 0.5372
Brugia malayi Nuclear hormone receptor E75 0.0392 0.4666 0.4655
Loa Loa (eye worm) hypothetical protein 0.0145 0.167 0.1652
Plasmodium vivax SET domain protein, putative 0.003 0.0263 0.0297
Trypanosoma cruzi glutamine synthetase, putative 0.0773 0.9297 1
Brugia malayi Nuclear hormone receptor family member nhr-19 0.083 1 1
Brugia malayi Muscleblind-like protein 0.0145 0.167 0.1653
Brugia malayi hypothetical protein 0.0439 0.5237 0.5228
Echinococcus granulosus GPCR family 2 0.0015 0.0089 0.0089
Entamoeba histolytica glutamine synthetase, putative 0.0195 0.2273 1
Brugia malayi Nuclear hormone receptor family member nhr-31 0.083 1 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0263 0.0263
Echinococcus granulosus thyroid hormone receptor alpha 0.0392 0.4666 0.4666
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0028 0.0243 0.0243
Brugia malayi Nuclear hormone receptor family member nhr-25 0.083 1 1
Brugia malayi Pre-SET motif family protein 0.003 0.0263 0.0244
Loa Loa (eye worm) hypothetical protein 0.083 1 1
Brugia malayi glutamine synthetase 0.0276 0.3255 0.3242
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0015 0.0089 0.0089
Schistosoma mansoni nuclear hormone receptor 0.0392 0.4666 0.4666
Trichomonas vaginalis glutamine synthetase, putative 0.0195 0.2273 0.8169
Loa Loa (eye worm) hypothetical protein 0.0048 0.0492 0.0473
Onchocerca volvulus 0.083 1 1
Schistosoma mansoni Tr4/Tr2 (homologue) 0.083 1 1
Echinococcus granulosus Nuclear hormone receptor HR96 0.0392 0.4666 0.4666
Echinococcus granulosus retinoic acid receptor rxr beta a 0.083 1 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.083 1 1
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0392 0.4666 0.4655
Schistosoma mansoni cpg binding protein 0.0028 0.0242 0.0242
Loa Loa (eye worm) hypothetical protein 0.0392 0.4666 0.4655
Schistosoma mansoni nuclear hormone receptor 0.083 1 1
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0048 0.0492 0.0473
Echinococcus granulosus histone lysine methyltransferase setb 0.003 0.0263 0.0263
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0015 0.0089 0.0089
Schistosoma mansoni glutamine synthetase bacteria 0.0195 0.2273 0.2273
Brugia malayi orphan nuclear receptor NR2E1 0.0392 0.4666 0.4655
Brugia malayi nuclear receptor NHR-88 0.083 1 1
Loa Loa (eye worm) hypothetical protein 0.0392 0.4666 0.4655
Loa Loa (eye worm) hypothetical protein 0.0392 0.4666 0.4655
Brugia malayi isocitrate dehydrogenase 0.0015 0.0089 0.007
Trypanosoma cruzi transcription factor btf3, putative 0.0034 0.0316 0.0246
Brugia malayi latrophilin 2 splice variant baaae 0.0033 0.0306 0.0287
Loa Loa (eye worm) Gln-2 protein 0.0497 0.5945 0.5936
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.083 1 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0263 0.0263
Brugia malayi nuclear receptor NHR-67 0.0392 0.4666 0.4655
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0015 0.0089 0.0089
Onchocerca volvulus 0.0392 0.4666 0.4533
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.083 1 1
Brugia malayi nuclear hormone receptor family member odr-7 0.0392 0.4666 0.4655
Onchocerca volvulus Protein ultraspiracle homolog 0.083 1 1
Brugia malayi steroid hormone receptor 0.083 1 1
Echinococcus multilocularis ecdysone induced protein 78C 0.083 1 1
Echinococcus granulosus glutamine synthetase 0.0773 0.9297 0.9297
Loa Loa (eye worm) hypothetical protein 0.0033 0.0306 0.0286
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0015 0.0089 0.007
Echinococcus multilocularis cpg binding protein 0.003 0.0262 0.0262
Brugia malayi Nuclear hormone receptor family member nhr-19 0.083 1 1
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0015 0.0089 0.0089
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.083 1 1
Loa Loa (eye worm) hypothetical protein 0.083 1 1
Mycobacterium ulcerans glutamine synthetase 0.0497 0.5945 1
Echinococcus granulosus dnaJ subfamily B 0.0398 0.4741 0.4741
Brugia malayi beta-NAC-like protein 0.0034 0.0316 0.0297
Schistosoma mansoni hypothetical protein 0.0033 0.0306 0.0306
Brugia malayi Nuclear hormone receptor family member nhr-1 0.083 1 1
Wolbachia endosymbiont of Brugia malayi glutamine synthetase 0.0195 0.2273 0.5
Leishmania major basic transcription factor 3a, putative 0.0034 0.0316 0.0246
Onchocerca volvulus 0.0392 0.4666 0.4533
Echinococcus granulosus neuropeptide receptor A26 0.045 0.5372 0.5372
Loa Loa (eye worm) hypothetical protein 0.0439 0.5237 0.5227
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.083 1 1
Brugia malayi Nuclear hormone receptor E75 0.0392 0.4666 0.4655
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0789 0.9494 0.9494
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0439 0.5237 0.5227
Loa Loa (eye worm) hypothetical protein 0.0439 0.5237 0.5227
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.083 1 1
Echinococcus granulosus ecdysone induced protein 78C 0.083 1 1
Loa Loa (eye worm) hypothetical protein 0.0439 0.5237 0.5227
Brugia malayi conserved hypotetical protein 0.0392 0.4666 0.4655
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0015 0.0089 0.0089
Plasmodium vivax basic transcription factor 3b, putative 0.0034 0.0316 0.0387
Schistosoma mansoni hypothetical protein 0.0015 0.0089 0.0089
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0263 0.0263
Brugia malayi Pre-SET motif family protein 0.0203 0.2372 0.2357
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0392 0.4666 0.4666
Echinococcus multilocularis muscleblind protein 1 0.0145 0.167 0.167
Loa Loa (eye worm) hypothetical protein 0.0392 0.4666 0.4655
Schistosoma mansoni hypothetical protein 0.0398 0.4741 0.4741
Brugia malayi hypothetical protein 0.0392 0.4666 0.4655
Loa Loa (eye worm) nuclear receptor NHR-67 0.0392 0.4666 0.4655
Brugia malayi nuclear hormone receptor 0.0392 0.4666 0.4655
Echinococcus multilocularis isocitrate dehydrogenase 0.0015 0.0089 0.0089
Loa Loa (eye worm) hypothetical protein 0.0439 0.5237 0.5227
Brugia malayi Nuclear hormone receptor family member nhr-3 0.083 1 1
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0392 0.4666 0.4666
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0439 0.5237 0.5237
Schistosoma mansoni mixed-lineage leukemia protein mll 0.006 0.0636 0.0636
Schistosoma mansoni transcription factor btf3 0.0034 0.0316 0.0316
Loa Loa (eye worm) hypothetical protein 0.0392 0.4666 0.4655
Brugia malayi nuclear receptor RXR 0.0392 0.4666 0.4655
Loa Loa (eye worm) hypothetical protein 0.003 0.0263 0.0243
Plasmodium vivax glutamine synthetase, putative 0.0497 0.5945 1
Schistosoma mansoni nuclear hormone receptor 0.0392 0.4666 0.4666
Schistosoma mansoni retinoid-x-receptor (RXR) 0.083 1 1
Loa Loa (eye worm) hypothetical protein 0.0439 0.5237 0.5227
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.083 1 1
Echinococcus multilocularis muscleblind protein 0.0145 0.167 0.167
Loa Loa (eye worm) latrophilin receptor protein 2 0.0015 0.0089 0.0069
Schistosoma mansoni cpg binding protein 0.003 0.0262 0.0262
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0392 0.4666 0.4666
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0015 0.0089 0.0089
Brugia malayi hypothetical protein 0.0439 0.5237 0.5228
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.083 1 1
Echinococcus multilocularis thyroid hormone receptor alpha 0.083 1 1
Schistosoma mansoni coup transcription factor 0.083 1 1
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0015 0.0089 0.0089
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.003 0.0263 0.0297
Toxoplasma gondii NAC domain-containing protein 0.0034 0.0316 0.0387
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0392 0.4666 0.4666
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.083 1 1
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0203 0.2372 0.2356
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.083 1 1
Brugia malayi ecdysone receptor 0.0392 0.4666 0.4655
Onchocerca volvulus Glutamine synthetase homolog 0.0497 0.5945 0.5844
Schistosoma mansoni glutamine synthetase bacteria 0.0195 0.2273 0.2273
Schistosoma mansoni cpg binding protein 0.003 0.0262 0.0262
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0392 0.4666 0.4655
Loa Loa (eye worm) hypothetical protein 0.0015 0.0089 0.0069
Echinococcus granulosus nuclear receptor 2DBD gamma 0.083 1 1
Schistosoma mansoni glutamine synthetase 1 2 (glutamate-amonia ligase) (gs) 0.0773 0.9297 0.9297
Trypanosoma brucei transcription factor BTF3, putative 0.0034 0.0316 0.0246
Loa Loa (eye worm) hypothetical protein 0.083 1 1
Schistosoma mansoni thyroid hormone receptor 0.083 1 1
Loa Loa (eye worm) hypothetical protein 0.083 1 1
Echinococcus granulosus neuropeptide s receptor 0.045 0.5372 0.5372
Mycobacterium leprae PROBABLE GLUTAMINE SYNTHETASE GLNA2 (GLUTAMINE SYNTHASE) (GS-II) 0.0497 0.5945 0.5
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.083 1 1
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.003 0.0263 0.0263
Brugia malayi Nuclear hormone receptor family member nhr-40 0.083 1 1
Schistosoma mansoni steroid hormone receptor ad4bp 0.083 1 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.083 1 1
Trypanosoma cruzi glutamine synthetase, putative 0.0773 0.9297 1
Echinococcus multilocularis geminin 0.0165 0.1907 0.1907
Loa Loa (eye worm) nuclear hormone receptor 0.0392 0.4666 0.4655
Echinococcus multilocularis glutamine synthetase 0.0773 0.9297 0.9297
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0048 0.0492 0.0474
Echinococcus multilocularis nuclear receptor nhr 48 0.0392 0.4666 0.4666
Onchocerca volvulus 0.0231 0.2712 0.2531
Brugia malayi Nuclear hormone receptor-like 1 0.0439 0.5237 0.5228
Brugia malayi hypothetical protein 0.0392 0.4666 0.4655
Trichomonas vaginalis set domain proteins, putative 0.0231 0.2712 1
Echinococcus granulosus geminin 0.0165 0.1907 0.1907
Echinococcus multilocularis dnaJ subfamily B 0.0398 0.4741 0.4741
Toxoplasma gondii histone lysine methyltransferase SET1 0.0054 0.0559 0.0802
Loa Loa (eye worm) hypothetical protein 0.0392 0.4666 0.4655
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.083 1 1
Loa Loa (eye worm) hypothetical protein 0.0392 0.4666 0.4655
Echinococcus multilocularis neuropeptide receptor A26 0.045 0.5372 0.5372
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0392 0.4666 0.4666
Onchocerca volvulus Bile acid receptor homolog 0.083 1 1
Echinococcus granulosus cpg binding protein 0.003 0.0262 0.0262
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0015 0.0089 0.0089
Echinococcus granulosus nuclear receptor nhr 48 0.0392 0.4666 0.4666
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0439 0.5237 0.5237
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.083 1 1
Loa Loa (eye worm) hypothetical protein 0.083 1 1
Schistosoma mansoni hypothetical protein 0.0015 0.0089 0.0089
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.083 1 1
Brugia malayi nuclear receptor RXR 0.0439 0.5237 0.5228
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.0242 0.0222
Brugia malayi Nuclear hormone receptor family member nhr-41 0.083 1 1
Loa Loa (eye worm) hypothetical protein 0.0392 0.4666 0.4655
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0392 0.4666 0.4666
Brugia malayi Nuclear hormone receptor family member nhr-49 0.083 1 1
Loa Loa (eye worm) steroid hormone receptor 0.083 1 1
Leishmania major glutamine synthetase, putative 0.0773 0.9297 1
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.083 1 1
Echinococcus multilocularis transcription factor btf3 0.0034 0.0316 0.0316
Mycobacterium ulcerans glutamine synthetase GlnA1 0.0497 0.5945 1
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.083 1 1
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0392 0.4666 0.4533
Plasmodium falciparum basic transcription factor 3b, putative 0.0034 0.0316 0.0387
Brugia malayi photoreceptor-specific nuclear receptor 0.083 1 1
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0392 0.4666 0.4666
Brugia malayi Nuclear hormone receptor family member nhr-14 0.083 1 1
Schistosoma mansoni hypothetical protein 0.0165 0.1907 0.1907
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.083 1 1
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0015 0.0089 0.0089
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.003 0.0263 0.0263
Loa Loa (eye worm) hypothetical protein 0.083 1 1
Echinococcus granulosus FTZ F1 alpha 0.083 1 1
Loa Loa (eye worm) ICD-1 protein 0.0034 0.0316 0.0296
Brugia malayi nuclear receptor NHR-88 0.0392 0.4666 0.4655
Brugia malayi Nuclear hormone receptor-like 1 0.0439 0.5237 0.5228
Schistosoma mansoni zinc finger protein 0.0392 0.4666 0.4666
Echinococcus multilocularis GPCR, family 2 0.0015 0.0089 0.0089
Echinococcus granulosus transcription factor btf3 0.0034 0.0316 0.0316
Brugia malayi Isocitrate dehydrogenase 0.0015 0.0089 0.007
Plasmodium falciparum glutamine synthetase, putative 0.0497 0.5945 1
Brugia malayi Calcitonin receptor-like protein seb-1 0.0048 0.0492 0.0474
Schistosoma mansoni thyroid hormone receptor 0.083 1 1
Brugia malayi nuclear hormone receptor 0.083 1 1
Schistosoma mansoni hypothetical protein 0.0015 0.0089 0.0089
Toxoplasma gondii glutamine synthetase, type I, putative 0.0497 0.5945 1
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.083 1 1
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.001 0.0021 0.0021
Loa Loa (eye worm) DR-78 0.0392 0.4666 0.4655
Loa Loa (eye worm) hypothetical protein 0.083 1 1
Echinococcus granulosus muscleblind protein 0.0145 0.167 0.167
Loa Loa (eye worm) hypothetical protein 0.083 1 1
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0392 0.4666 0.4533
Brugia malayi Nuclear hormone receptor-like 1 0.083 1 1
Brugia malayi nuclear hormone receptor family member nhr-6 0.0392 0.4666 0.4655
Schistosoma mansoni nuclear receptor 0.0392 0.4666 0.4666
Schistosoma mansoni hypothetical protein 0.0165 0.1907 0.1907
Brugia malayi CXXC zinc finger family protein 0.0028 0.0242 0.0223
Mycobacterium tuberculosis Probable glutamine synthetase GlnA2 (glutamine synthase) (GS-II) 0.0497 0.5945 1
Schistosoma mansoni nuclear receptor 0.0392 0.4666 0.4666
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0392 0.4666 0.4666
Loa Loa (eye worm) hypothetical protein 0.0392 0.4666 0.4655
Loa Loa (eye worm) hypothetical protein 0.0392 0.4666 0.4655
Schistosoma mansoni retinoic acid receptor RXR 0.083 1 1
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0439 0.5237 0.5237
Schistosoma mansoni RAR-like nuclear receptor 0.083 1 1
Echinococcus multilocularis FTZ F1 alpha 0.083 1 1
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0015 0.0089 0.0089
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0392 0.4666 0.4666
Onchocerca volvulus 0.003 0.0263 0.0021
Schistosoma mansoni hypothetical protein 0.0015 0.0089 0.0089
Brugia malayi Latrophilin receptor protein 2 0.0015 0.0089 0.007
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.083 1 1
Mycobacterium tuberculosis Probable glutamine synthetase GlnA3 (glutamine synthase) (GS-I) 0.0195 0.2273 0.373
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0439 0.5237 0.5237
Trypanosoma cruzi transcription factor btf3, putative 0.0034 0.0316 0.0246

Activities

Activity type Activity value Assay description Source Reference
Blood glucose (functional) = 97 mg dl-1 Terminal blood glucose level was determined in ob/ob mice after oral administration for two weeks(control=226+/-29) ChEMBL. 11312923
Blood glucose (functional) = 97 mg dl-1 Terminal blood glucose level was determined in ob/ob mice after oral administration for two weeks(control=226+/-29) ChEMBL. 11312923
Blood glucose (functional) = 227 mg dl-1 Initial blood glucose level was determined in ob/ob mice(control=228+/-19) ChEMBL. 11312923
Blood glucose (functional) = 227 mg dl-1 Initial blood glucose level was determined in ob/ob mice(control=228+/-19) ChEMBL. 11312923
Body weight (functional) = 23 g Terminal lean body weight was determined in ob/ob mice after oral administration for two weeks(control=25+/-1) ChEMBL. 11312923
Body weight (functional) = 23 g Terminal fat body weight was determined in ob/ob mice after oral administration for two weeks(control=28+/-0.9) ChEMBL. 11312923
Body weight (functional) = 23 g Terminal lean body weight was determined in ob/ob mice after oral administration for two weeks(control=25+/-1) ChEMBL. 11312923
Body weight (functional) = 23 g Terminal fat body weight was determined in ob/ob mice after oral administration for two weeks(control=28+/-0.9) ChEMBL. 11312923
Body weight (functional) = 46 g Terminal body weight was determined in ob/ob mice after oral administration for two weeks(control=53+/-1) ChEMBL. 11312923
Body weight (functional) = 46 g Terminal body weight was determined in ob/ob mice after oral administration for two weeks(control=53+/-1) ChEMBL. 11312923
Body weight (functional) = 52 g Initial body weight was determined in ob/ob mice(control=55+/-1) ChEMBL. 11312923
Body weight (functional) = 52 g Initial body weight was determined in ob/ob mice(control=55+/-1) ChEMBL. 11312923
Dose (functional) = 436 mg kg-1 Avarage daily dose was determined in ob/ob mice(control=0) ChEMBL. 11312923
Dose (functional) = 436 mg kg-1 Avarage daily dose was determined in ob/ob mice(control=0) ChEMBL. 11312923
Food intake (functional) = 87 g kg-1 Average daily food consumption was determined in ob/ob mice after oral administration for twoweeks(control=90+/-3) ChEMBL. 11312923
Food intake (functional) = 87 g kg-1 Average daily food consumption was determined in ob/ob mice after oral administration for twoweeks(control=90+/-3) ChEMBL. 11312923
MISS T/C (functional) < 0.51 In vivo blood glucose was determined in obese, hyperglycemic, hyperinsulinemic, insulin-resistant KKAy mice after a dose of 500 mg/kg for 4 days ChEMBL. 11312923

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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