TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 553.435 | Formula: C25H30Cl2N4O6
H donors: 3 H acceptors: 3 LogP: 2.92 Rotable bonds: 11
Rule of 5 violations (Lipinski): 2
SMILES: CCO/C(=C/1\C(=NC(=C(C1c1cccc(c1Cl)Cl)C(=O)OC)C)COCCNC1=NC(=O)C(N1)(C)C)/O
InChi: 1S/C25H30Cl2N4O6/c1-6-37-22(33)19-16(12-36-11-10-28-24-30-23(34)25(3,4)31-24)29-13(2)17(21(32)35-5)18(19)14-8-7-9-15(26)20(14)27/h7-9,18,33H,6,10-12H2,1-5H3,(H2,28,30,31,34)/b22-19+
InChiKey: HYUNCTPYIADDEL-ZBJSNUHESA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Schistosoma mansoni	tyrosine kinase	0.001	0.0047	0.0047
Onchocerca volvulus		0.0013	0.0123	0.0369
Schistosoma mansoni	serine/threonine protein kinase	0.0123	0.2514	0.2514
Trypanosoma brucei	DNA polymerase kappa, putative	0.0013	0.0116	0.0355
Echinococcus multilocularis	importin subunit beta 1	0.002	0.0257	0.0257
Trypanosoma cruzi	cAMP-dependent protein kinase catalytic subunit 3	0.0123	0.2514	1
Echinococcus multilocularis	tyrosine protein kinase ABL1	0.001	0.0047	0.0047
Schistosoma mansoni	nck2/grb4	0.0015	0.0164	0.0164
Loa Loa (eye worm)	TK/FER protein kinase	0.001	0.0047	0.0108
Trypanosoma cruzi	dihydrolipoyl dehydrogenase, putative	0.002	0.0267	0.0627
Plasmodium falciparum	glutathione reductase	0.0058	0.1086	0.4029
Echinococcus granulosus	growth factor receptor bound protein 2	0.0015	0.0164	0.0164
Brugia malayi	Pre-SET motif family protein	0.002	0.0272	0.0938
Trypanosoma cruzi	importin beta-1 subunit, putative	0.0016	0.0177	0.0251
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase src	0.0017	0.0211	0.0211
Echinococcus multilocularis	terminal deoxycytidyl transferase rev1	0.0013	0.0116	0.0116
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.002	0.0267	0.0627
Brugia malayi	SH2 domain containing protein	0.001	0.0047	0.0163
Trypanosoma cruzi	GTP-binding nuclear protein rtb2, putative	0.0014	0.0145	0.0118
Leishmania major	aldehyde dehydrogenase, mitochondrial precursor	0.0041	0.0727	0.2545
Echinococcus multilocularis	cAMP dependent protein kinase catalytic subunit	0.0123	0.2514	0.2514
Brugia malayi	Tyrosine-protein kinase abl-1	0.0017	0.0211	0.0728
Mycobacterium tuberculosis	Probable NADH dehydrogenase Ndh	0.0132	0.2693	0.8898
Onchocerca volvulus		0.0013	0.0123	0.0369
Echinococcus granulosus	tyrosine protein kinase shark	0.001	0.0047	0.0047
Schistosoma mansoni	histone-lysine n-methyltransferase suv9	0.002	0.0272	0.0272
Echinococcus multilocularis	arachidonate 5 lipoxygenase	0.008	0.157	0.157
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0123	0.2514	1
Schistosoma mansoni	tyrosine kinase	0.0077	0.1512	0.1512
Echinococcus granulosus	Polycystic kidney disease protein	0.0013	0.0123	0.0123
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.0068	0.1301	0.1301
Loa Loa (eye worm)	hypothetical protein	0.0123	0.2514	0.5756
Echinococcus multilocularis	NCK adaptor protein	0.0015	0.0164	0.0164
Entamoeba histolytica	Ran family GTPase	0.0014	0.0145	0.0576
Echinococcus granulosus	tyrosine protein kinase Btk29A	0.0017	0.0211	0.0211
Schistosoma mansoni	polycystin 1-related	0.0013	0.0123	0.0123
Trichomonas vaginalis	glutathione reductase, putative	0.002	0.0267	0.0469
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase abl1	0.0015	0.0164	0.0164
Plasmodium falciparum	dihydrolipoyl dehydrogenase, apicoplast	0.002	0.0267	0.0602
Mycobacterium tuberculosis	Putative ferredoxin reductase	0.0132	0.2693	0.8898
Mycobacterium tuberculosis	Probable membrane NADH dehydrogenase NdhA	0.0132	0.2693	0.8898
Brugia malayi	Thioredoxin reductase	0.0058	0.1086	0.3747
Echinococcus granulosus	tyrosine protein kinase ABL1	0.001	0.0047	0.0047
Trypanosoma brucei	cAMP-dependent protein kinase catalytic subunit 1	0.0123	0.2514	1
Trypanosoma cruzi	cAMP-dependent protein kinase catalytic subunit 1	0.0123	0.2514	1
Loa Loa (eye worm)	doublecortin family protein	0.0013	0.0123	0.028
Mycobacterium tuberculosis	NADPH-dependent mycothiol reductase Mtr	0.0058	0.1086	0.3349
Brugia malayi	cAMP-dependent protein kinase catalytic subunit, putative	0.0123	0.2514	0.8673
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0041	0.0727	1
Echinococcus granulosus	5'partial\|histone lysine N methyltransferase SETDB2	0.0019	0.0256	0.0256
Loa Loa (eye worm)	TK/FER protein kinase	0.001	0.0047	0.0108
Brugia malayi	hypothetical protein	0.001	0.0047	0.0163
Schistosoma mansoni	hypothetical protein	0.0209	0.4368	0.4368
Echinococcus multilocularis	snurportin 1	0.0209	0.4368	0.4368
Trypanosoma cruzi	dihydrolipoyl dehydrogenase, putative	0.002	0.0267	0.0627
Trypanosoma brucei	DNA polymerase kappa, putative	0.0013	0.0116	0.0355
Trypanosoma brucei	importin beta-1 subunit, putative	0.002	0.0257	0.092
Echinococcus granulosus	tyrosine protein kinase Fps85D	0.001	0.0047	0.0047
Echinococcus multilocularis	tyrosine kinase	0.001	0.0047	0.0047
Brugia malayi	protein-tyrosine kinase	0.007	0.1349	0.4653
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.002	0.0267	0.0627
Echinococcus multilocularis	tyrosine protein kinase Btk29A	0.0017	0.0211	0.0211
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0077	0.1512	0.1512
Echinococcus multilocularis	tyrosine protein kinase Abl	0.0017	0.0211	0.0211
Trypanosoma brucei	unspecified product	0.0013	0.0116	0.0355
Loa Loa (eye worm)	TK protein kinase	0.0062	0.1181	0.2703
Echinococcus multilocularis	cAMP dependent protein kinase catalytic subunit	0.0123	0.2514	0.2514
Echinococcus granulosus	cAMP dependent protein kinase catalytic subunit	0.0123	0.2514	0.2514
Brugia malayi	ImpB/MucB/SamB family protein	0.0013	0.0116	0.0401
Toxoplasma gondii	NADPH-glutathione reductase	0.002	0.0267	0.0514
Brugia malayi	Protein kinase domain containing protein	0.001	0.0047	0.0163
Plasmodium falciparum	importin beta, putative	0.002	0.0257	0.0562
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.002	0.0272	0.0272
Onchocerca volvulus		0.001	0.0047	0.0142
Brugia malayi	hypothetical protein	0.0013	0.0123	0.0423
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.007	0.1349	0.1349
Brugia malayi	RNA, U transporter 1	0.0056	0.104	0.3589
Echinococcus granulosus	terminal deoxycytidyl transferase rev1	0.0013	0.0116	0.0116
Trichomonas vaginalis	Importin beta-1 subunit, putative	0.0016	0.0177	0.0188
Schistosoma mansoni	tyrosine kinase	0.0017	0.0211	0.0211
Mycobacterium ulcerans	dihydrolipoamide dehydrogenase	0.002	0.0267	0.2461
Toxoplasma gondii	aldehyde dehydrogenase	0.0041	0.0727	0.2456
Toxoplasma gondii	histone lysine methyltransferase SET/SUV39	0.002	0.0272	0.0537
Onchocerca volvulus		0.002	0.0272	0.0818
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.002	0.0267	0.0627
Brugia malayi	SH2 domain containing protein	0.001	0.0047	0.0163
Entamoeba histolytica	SH2-protein kinase domain containing protein	0.001	0.0047	0.0188
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0041	0.0727	1
Echinococcus multilocularis	tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase	0.0077	0.1512	0.1512
Trypanosoma brucei	dihydrolipoamide dehydrogenase	0.002	0.0267	0.0959
Schistosoma mansoni	ran	0.0014	0.0145	0.0145
Echinococcus granulosus	dihydrolipoamide dehydrogenase	0.002	0.0267	0.0267
Brugia malayi	Pre-SET motif family protein	0.0141	0.2899	1
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.002	0.0267	0.0627
Brugia malayi	Protein kinase domain containing protein	0.001	0.0047	0.0163
Schistosoma mansoni	hypothetical protein	0.0013	0.0123	0.0123
Leishmania major	acetoin dehydrogenase e3 component-like protein	0.002	0.0267	0.0627
Loa Loa (eye worm)	sex muscle abnormal protein 5	0.0015	0.0164	0.0375
Loa Loa (eye worm)	AGC/PKA protein kinase	0.0123	0.2514	0.5756
Entamoeba histolytica	protein kinase, putative	0.0009	0.0031	0.0122
Loa Loa (eye worm)	TK/FER protein kinase	0.001	0.0047	0.0108
Plasmodium vivax	cAMP-dependent protein kinase catalytic subunit, putative	0.0123	0.2514	1
Echinococcus multilocularis	aldehyde dehydrogenase, mitochondrial	0.0041	0.0727	0.0727
Echinococcus multilocularis	cAMP dependent protein kinase catalytic subunit	0.0123	0.2514	0.2514
Echinococcus granulosus	tyrosine protein kinase Src42A	0.0068	0.1301	0.1301
Mycobacterium tuberculosis	NAD(P)H quinone reductase LpdA	0.0146	0.3012	1
Brugia malayi	ImpB/MucB/SamB family protein	0.0013	0.0116	0.0401
Trypanosoma cruzi	trypanothione reductase, putative	0.002	0.0267	0.0627
Trypanosoma brucei	DNA polymerase kappa, putative	0.0013	0.0116	0.0355
Loa Loa (eye worm)	AGC/PKA protein kinase	0.0123	0.2514	0.5756
Loa Loa (eye worm)	variant SH3 domain-containing protein	0.0015	0.0164	0.0375
Echinococcus granulosus	tyrosine protein kinase Src64B	0.0077	0.1512	0.1512
Echinococcus granulosus	tyrosine kinase\|tyrosine protein kinase Fyn	0.007	0.1349	0.1349
Trichomonas vaginalis	mercuric reductase, putative	0.002	0.0267	0.0469
Echinococcus multilocularis	histone lysine methyltransferase setb histone lysine methyltransferase eggless	0.002	0.0272	0.0272
Trypanosoma brucei	DNA polymerase kappa, putative	0.0013	0.0116	0.0355
Toxoplasma gondii	AGC kinase	0.0123	0.2514	1
Echinococcus granulosus	tyrosine kinase	0.001	0.0047	0.0047
Loa Loa (eye worm)	thioredoxin reductase	0.0058	0.1086	0.2487
Treponema pallidum	NADH oxidase	0.002	0.0267	0.5
Loa Loa (eye worm)	nucleolar RNA-associated protein alpha	0.0209	0.4368	1
Brugia malayi	hypothetical protein	0.0013	0.0123	0.0423
Leishmania major	importin beta-1 subunit, putative	0.0016	0.0177	0.0251
Echinococcus multilocularis	dna polymerase eta	0.0013	0.0116	0.0116
Schistosoma mansoni	serine/threonine protein kinase	0.001	0.0043	0.0043
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0123	0.028
Loa Loa (eye worm)	hypothetical protein	0.001	0.0047	0.0108
Echinococcus multilocularis	cAMP dependent protein kinase catalytic subunit	0.0123	0.2514	0.2514
Onchocerca volvulus		0.0009	0.0027	0.008
Leishmania major	protein kinase A catalytic subunit	0.0123	0.2514	1
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.002	0.0267	0.0627
Trichomonas vaginalis	importin beta-1, putative	0.0016	0.0177	0.0188
Schistosoma mansoni	aldehyde dehydrogenase	0.0041	0.0727	0.0727
Brugia malayi	SRC-1	0.0077	0.1512	0.5218
Trypanosoma cruzi	trypanothione reductase, putative	0.0058	0.1086	0.4044
Loa Loa (eye worm)	TK/FER protein kinase	0.001	0.0047	0.0108
Trypanosoma brucei	DNA polymerase kappa, putative	0.0013	0.0116	0.0355
Schistosoma mansoni	growth factor receptor-bound protein	0.0015	0.0164	0.0164
Echinococcus granulosus	RUN	0.0013	0.0123	0.0123
Loa Loa (eye worm)	TK/ABL protein kinase	0.001	0.0047	0.0108
Trichomonas vaginalis	Importin beta-1 subunit, putative	0.0016	0.0177	0.0188
Echinococcus granulosus	dna polymerase eta	0.0013	0.0116	0.0116
Mycobacterium tuberculosis	Probable aldehyde dehydrogenase	0.0041	0.0727	0.2108
Echinococcus multilocularis	tyrosine protein kinase shark	0.001	0.0047	0.0047
Leishmania major	dihydrolipoamide dehydrogenase, putative	0.002	0.0267	0.0627
Leishmania major	GTP-binding protein, putative	0.0014	0.0145	0.0118
Echinococcus multilocularis	dna polymerase kappa	0.0013	0.0116	0.0116
Echinococcus granulosus	thioredoxin glutathione reductase	0.0058	0.1094	0.1094
Echinococcus multilocularis	proto oncogene tyrosine protein kinase LCK	0.0077	0.1512	0.1512
Trypanosoma brucei	DNA polymerase IV, putative	0.0013	0.0116	0.0355
Echinococcus granulosus	tyrosine protein kinase Src42A	0.0077	0.1512	0.1512
Trypanosoma brucei	DNA polymerase kappa, putative	0.0013	0.0116	0.0355
Loa Loa (eye worm)	TK/FER protein kinase	0.001	0.0047	0.0108
Trypanosoma cruzi	GTP-binding nuclear protein rtb2, putative	0.0014	0.0145	0.0118
Echinococcus granulosus	lipoxygenase domain containing protein	0.0013	0.0123	0.0123
Loa Loa (eye worm)	TK/FER protein kinase	0.001	0.0047	0.0108
Schistosoma mansoni	terminal deoxycytidyl transferase	0.0013	0.0116	0.0116
Giardia lamblia	Kinase, AGC PKA	0.0123	0.2514	1
Trypanosoma brucei	dihydrolipoamide dehydrogenase	0.002	0.0267	0.0959
Entamoeba histolytica	protein kinase, putative	0.0062	0.1181	0.4696
Brugia malayi	alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase	0.0015	0.0151	0.0522
Echinococcus granulosus	cAMP dependent protein kinase catalytic subunit	0.0123	0.2514	0.2514
Plasmodium falciparum	cAMP-dependent protein kinase catalytic subunit	0.0123	0.2514	1
Echinococcus granulosus	cAMP dependent protein kinase catalytic subunit	0.0123	0.2514	0.2514
Entamoeba histolytica	deoxycytidyl transferase, putative	0.0013	0.0116	0.0463
Echinococcus granulosus	c src tyrosine kinase	0.0017	0.0211	0.0211
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0077	0.1512	0.1512
Trypanosoma brucei	trypanothione reductase	0.0058	0.1086	0.4256
Leishmania major	protein kinase A catalytic subunit isoform 2	0.0123	0.2514	1
Echinococcus multilocularis	tyrosine protein kinase lyn tyrosine protein kinase blk	0.0077	0.1512	0.1512
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0123	0.028
Echinococcus multilocularis	growth factor receptor bound protein 2	0.0015	0.0164	0.0164
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.0077	0.1512	0.1512
Loa Loa (eye worm)	glutathione reductase	0.0058	0.1086	0.2487
Echinococcus multilocularis	tyrosine protein kinase HCK	0.0062	0.1181	0.1181
Plasmodium vivax	importin-beta 2, putative	0.002	0.0257	0.0562
Toxoplasma gondii	HEAT repeat-containing protein	0.002	0.0257	0.0473
Echinococcus granulosus	dna polymerase kappa	0.0013	0.0116	0.0116
Echinococcus multilocularis	GTP binding nuclear protein Ran	0.0014	0.0145	0.0145
Trypanosoma brucei	GTP-binding nuclear protein rtb2, putative	0.0014	0.0145	0.0469
Toxoplasma gondii	pyruvate dehydrogenase complex subunit PDH-E3II	0.002	0.0267	0.0514
Loa Loa (eye worm)	GTP-binding nuclear protein RAN/TC4	0.0014	0.0145	0.0331
Brugia malayi	Protein kinase domain containing protein	0.001	0.0047	0.0163
Echinococcus granulosus	importin subunit beta 1	0.002	0.0257	0.0257
Loa Loa (eye worm)	hypothetical protein	0.002	0.0257	0.0588
Echinococcus granulosus	lipoxygenase domain containing protein	0.0013	0.0123	0.0123
Schistosoma mansoni	growth factor receptor-bound protein	0.0015	0.0164	0.0164
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0041	0.0727	1
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0123	0.2514	1
Schistosoma mansoni	tyrosine kinase	0.0077	0.1512	0.1512
Toxoplasma gondii	thioredoxin reductase	0.0058	0.1086	0.3973
Echinococcus multilocularis	enhancer of mRNA decapping protein 4	0.0122	0.2483	0.2483
Toxoplasma gondii	AGC kinase	0.0123	0.2514	1
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.0141	0.2899	0.6637
Echinococcus granulosus	tyrosine protein kinase Srms	0.001	0.0047	0.0047
Schistosoma mansoni	microtubule-associated protein tau	0.0468	1	1
Trichomonas vaginalis	ran, putative	0.0014	0.0145	0.0088
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0077	0.1512	0.1512
Echinococcus multilocularis	microtubule associated protein 2	0.0468	1	1
Echinococcus granulosus	tyrosine protein kinase Blk	0.007	0.1349	0.1349
Plasmodium vivax	SET domain protein, putative	0.002	0.0272	0.0624
Trypanosoma brucei	dihydrolipoyl dehydrogenase	0.002	0.0267	0.0959
Echinococcus multilocularis	lipoxygenase domain containing protein	0.0013	0.0123	0.0123
Schistosoma mansoni	rab6-interacting	0.0013	0.0123	0.0123
Echinococcus multilocularis	Polycystic kidney disease protein	0.0013	0.0123	0.0123
Schistosoma mansoni	importin beta-1	0.002	0.0257	0.0257
Giardia lamblia	NADH oxidase lateral transfer candidate	0.002	0.0267	0.0627
Plasmodium falciparum	glutathione reductase	0.002	0.0267	0.0602
Trypanosoma brucei	importin beta-1 subunit, putative	0.002	0.0257	0.092
Schistosoma mansoni	tyrosine kinase	0.001	0.0047	0.0047
Wolbachia endosymbiont of Brugia malayi	dihydrolipoamide dehydrogenase E3 component	0.002	0.0267	0.5
Schistosoma mansoni	rab6-interacting	0.0013	0.0123	0.0123
Mycobacterium tuberculosis	Probable reductase	0.0132	0.2693	0.8898
Plasmodium falciparum	thioredoxin reductase	0.002	0.0267	0.0602
Chlamydia trachomatis	dihydrolipoyl dehydrogenase	0.002	0.0267	0.5
Entamoeba histolytica	hypothetical protein	0.0016	0.0177	0.0702
Brugia malayi	Importin beta-1 subunit	0.002	0.0257	0.0886
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0164	0.0375
Echinococcus multilocularis	tyrosine protein kinase Fps85D	0.001	0.0047	0.0047
Toxoplasma gondii	protein kinase, cAMP-dependent, catalytic chain	0.0123	0.2514	1
Echinococcus granulosus	GTP binding nuclear protein Ran	0.0014	0.0145	0.0145
Loa Loa (eye worm)	TK protein kinase	0.007	0.1349	0.3088
Schistosoma mansoni	lipoxygenase	0.008	0.157	0.157
Echinococcus multilocularis	tyrosine protein kinase Srms	0.007	0.1349	0.1349
Echinococcus granulosus	NCK adaptor protein	0.0015	0.0164	0.0164
Trypanosoma cruzi	cAMP-dependent protein kinase catalytic subunit 3	0.0123	0.2514	1
Onchocerca volvulus		0.001	0.0047	0.0142
Loa Loa (eye worm)	hypothetical protein	0.002	0.0272	0.0622
Mycobacterium tuberculosis	Probable oxidoreductase	0.0146	0.3012	1
Echinococcus granulosus	tyrosine protein kinase HCK	0.0062	0.1181	0.1181
Schistosoma mansoni	dihydrolipoamide dehydrogenase	0.002	0.0267	0.0267
Schistosoma mansoni	loxhd1	0.0013	0.0123	0.0123
Trypanosoma brucei	protein kinase A catalytic subunit, putative	0.0123	0.2514	1
Onchocerca volvulus		0.001	0.0047	0.0142
Loa Loa (eye worm)	SRC-1	0.0077	0.1512	0.3463
Brugia malayi	Variant SH3 domain containing protein	0.0015	0.0164	0.0565
Leishmania major	trypanothione reductase	0.0058	0.1086	0.4044
Schistosoma mansoni	DNA polymerase eta	0.0013	0.0116	0.0116
Mycobacterium ulcerans	dihydrolipoamide dehydrogenase, LpdB	0.002	0.0267	0.2461
Loa Loa (eye worm)	TK/FER protein kinase	0.001	0.0047	0.0108
Trypanosoma brucei	DNA polymerase kappa, putative	0.0013	0.0116	0.0355
Schistosoma mansoni	ran	0.0014	0.0145	0.0145
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0077	0.1512	0.1512
Trypanosoma brucei	DNA polymerase IV, putative	0.0013	0.0116	0.0355
Entamoeba histolytica	SH2-protein kinase domain containing protein	0.0009	0.0031	0.0122
Schistosoma mansoni	lipoxygenase	0.0056	0.1047	0.1047
Echinococcus multilocularis	histone lysine N methyltransferase SETMAR	0.002	0.0272	0.0272
Brugia malayi	Variant SH3 domain containing protein	0.0015	0.0164	0.0565
Trypanosoma brucei	dihydrolipoamide dehydrogenase, point mutation	0.002	0.0267	0.0959
Mycobacterium tuberculosis	Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB	0.0132	0.2693	0.8898
Brugia malayi	dihydrolipoyl dehydrogenase, mitochondrial precursor, putative	0.002	0.0267	0.092
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0077	0.1512	0.1512
Onchocerca volvulus		0.001	0.0047	0.0142
Leishmania major	dihydrolipoamide dehydrogenase, putative	0.002	0.0267	0.0627
Echinococcus multilocularis	lipoxygenase domain containing protein	0.0013	0.0123	0.0123
Schistosoma mansoni	aldehyde dehydrogenase	0.0041	0.0727	0.0727
Schistosoma mansoni	adapter molecule crk	0.0015	0.0164	0.0164
Brugia malayi	glutathione reductase	0.0058	0.1086	0.3747
Echinococcus granulosus	tyrosine kinase	0.007	0.1349	0.1349
Trypanosoma brucei	cAMP-dependent protein kinase catalytic subunit 2	0.0123	0.2514	1
Echinococcus granulosus	proto oncogene tyrosine protein kinase LCK	0.0077	0.1512	0.1512
Trypanosoma brucei	DNA polymerase kappa, putative	0.0013	0.0116	0.0355
Plasmodium vivax	dihydrolipoyl dehydrogenase, mitochondrial, putative	0.002	0.0267	0.0602
Plasmodium falciparum	thioredoxin reductase	0.0058	0.1086	0.4029
Brugia malayi	Doublecortin family protein	0.0013	0.0123	0.0423
Mycobacterium tuberculosis	Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras	0.0146	0.3012	1
Trypanosoma brucei	DNA polymerase IV, putative	0.0013	0.0116	0.0355
Schistosoma mansoni	serine/threonine protein kinase	0.0123	0.2514	0.2514
Schistosoma mansoni	serine/threonine protein kinase	0.0123	0.2514	0.2514
Onchocerca volvulus		0.001	0.0047	0.0142
Trichomonas vaginalis	set domain proteins, putative	0.0161	0.3322	1
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.002	0.0272	0.0272
Giardia lamblia	GTP-binding nuclear protein RAN/TC4	0.0014	0.0145	0.0118
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.002	0.0267	0.0627
Echinococcus granulosus	tyrosine protein kinase Lyn	0.0079	0.1543	0.1543
Echinococcus multilocularis	dihydrolipoamide dehydrogenase	0.002	0.0267	0.0267
Echinococcus granulosus	3'partial\|tyrosine protein kinase Fgr	0.0077	0.1512	0.1512
Mycobacterium ulcerans	flavoprotein disulfide reductase	0.002	0.0267	0.2461
Trypanosoma brucei	DNA polymerase eta, putative	0.0013	0.0116	0.0355
Trichomonas vaginalis	AGC family protein kinase	0.0123	0.2514	0.7479
Brugia malayi	GTP-binding nuclear protein RAN/TC4	0.0014	0.0145	0.0499
Echinococcus granulosus	aldehyde dehydrogenase mitochondrial	0.0041	0.0727	0.0727
Brugia malayi	Protein kinase domain containing protein	0.001	0.0047	0.0163
Plasmodium vivax	GTP-binding nuclear protein RAN/TC4, putative	0.0014	0.0145	0.0093
Plasmodium falciparum	dihydrolipoyl dehydrogenase, mitochondrial	0.002	0.0267	0.0602
Mycobacterium leprae	DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE	0.0146	0.3012	1
Echinococcus multilocularis	c src tyrosine kinase	0.0017	0.0211	0.0211
Trypanosoma brucei	DNA polymerase kappa, putative	0.0013	0.0116	0.0355
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.002	0.0272	0.0272
Echinococcus granulosus	arachidonate 5 lipoxygenase	0.008	0.157	0.157
Echinococcus multilocularis	RUN	0.0013	0.0123	0.0123
Mycobacterium tuberculosis	Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot	0.002	0.0267	0.0519
Loa Loa (eye worm)	ImpB/MucB/SamB family protein	0.0013	0.0116	0.0266
Loa Loa (eye worm)	TK/FER protein kinase	0.001	0.0047	0.0108
Loa Loa (eye worm)	TK/FER protein kinase	0.001	0.0047	0.0108
Plasmodium vivax	thioredoxin reductase, putative	0.0058	0.1086	0.4029
Onchocerca volvulus		0.0161	0.3322	1
Echinococcus granulosus	histone lysine methyltransferase setb	0.002	0.0272	0.0272
Leishmania major	protein kinase A catalytic subunit isoform 1	0.0123	0.2514	1
Plasmodium vivax	dihydrolipoyl dehydrogenase, apicoplast, putative	0.002	0.0267	0.0602
Echinococcus multilocularis	tyrosine protein kinase Blk	0.007	0.1349	0.1349
Echinococcus multilocularis	tyrosine protein kinase Src64B	0.0077	0.1512	0.1512
Trypanosoma brucei	DNA polymerase kappa, putative	0.0013	0.0116	0.0355
Brugia malayi	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein	0.0015	0.0151	0.0522
Mycobacterium tuberculosis	Probable dehydrogenase	0.0132	0.2693	0.8898
Schistosoma mansoni	tyrosine kinase	0.0017	0.0211	0.0211
Plasmodium falciparum	GTP-binding nuclear protein RAN/TC4	0.0014	0.0145	0.0093
Schistosoma mansoni	rab geranylgeranyl transferase alpha subunit	0.0013	0.0116	0.0116
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0116	0.0266
Wolbachia endosymbiont of Brugia malayi	dihydrolipoamide dehydrogenase E3 component	0.002	0.0267	0.5
Loa Loa (eye worm)	TK/FER protein kinase	0.001	0.0047	0.0108
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0077	0.1512	0.1512
Onchocerca volvulus		0.001	0.0047	0.0142
Echinococcus granulosus	snurportin 1	0.0209	0.4368	0.4368
Brugia malayi	Protein kinase domain containing protein	0.001	0.0047	0.0163
Echinococcus multilocularis	thioredoxin glutathione reductase	0.0058	0.1094	0.1094
Echinococcus multilocularis	tyrosine protein kinase Fgr	0.0077	0.1512	0.1512
Echinococcus granulosus	enhancer of mRNA decapping protein 4	0.0122	0.2483	0.2483
Brugia malayi	Sex muscle abnormal protein 5	0.0015	0.0164	0.0565
Plasmodium vivax	glutathione reductase, putative	0.0058	0.1086	0.4029
Trypanosoma cruzi	cAMP-dependent protein kinase catalytic subunit 2	0.0123	0.2514	1
Leishmania major	2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein	0.002	0.0267	0.0627

Activities

Activity type	Activity value	Assay description	Source	Reference
Log IC50 (functional)	= 7.7	Concentration of the compound required to inhibit calcium-induced constriction of potassium-depolarised rat aorta by 50%	ChEMBL.	2918502
pIC25 (functional)	= 6.2	In vitro assessment of negative inotropy in the isolated Langendorff perfused guinea pig heart	ChEMBL.	2918502
Selectivity (functional)	= 32	Selectivity between calcium antagonist activity vs negative inotropy in guinea pig	ChEMBL.	2918502
Selectivity (functional)	= 32	Selectivity between calcium antagonist activity vs negative inotropy in guinea pig	ChEMBL.	2918502

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

ChEMBL: CHEMBL152146

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 263130