TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 390.47 | Formula: C22H30O6
H donors: 0 H acceptors: 2 LogP: 2.16 Rotable bonds: 7
Rule of 5 violations (Lipinski): 1
SMILES: CC(CC(=O)O[C@H]1C[C@@]2(COC(=O)C)[C@@H](C=C1C)O[C@H]1[C@]3([C@]2(C)C=C1)CO3)C
InChi: 1S/C22H30O6/c1-13(2)8-19(24)27-16-10-21(11-25-15(4)23)18(9-14(16)3)28-17-6-7-20(21,5)22(17)12-26-22/h6-7,9,13,16-18H,8,10-12H2,1-5H3/t16-,17+,18+,20+,21+,22-/m0/s1
InChiKey: LKJIOQBUMROOLO-RLFCDOPRSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus granulosus	ephrin type A receptor 4 A	0.0038	0.095	0.095
Trichomonas vaginalis	AGC family protein kinase	0.0038	0.095	0.1085
Trichomonas vaginalis	conserved hypothetical protein	0.0038	0.095	0.1085
Trichomonas vaginalis	TKL family protein kinase	0.0038	0.095	0.1085
Echinococcus multilocularis	cyclin dependent kinase 1	0.0177	0.5861	1
Onchocerca volvulus		0.0038	0.095	0.4614
Loa Loa (eye worm)	sex muscle abnormal protein 5	0.0021	0.0327	0.0263
Echinococcus multilocularis	tyrosine protein kinase Srms	0.0059	0.1678	0.2863
Entamoeba histolytica	protein kinase, putative	0.0038	0.095	0.1092
Entamoeba histolytica	protein kinase, putative	0.0038	0.095	0.1092
Echinococcus granulosus	N chimaerin	0.0021	0.0327	0.0327
Leishmania major	protein kinase, putative	0.004	0.1024	0.1489
Echinococcus granulosus	tyrosine protein kinase Src42A	0.0059	0.1678	0.1678
Loa Loa (eye worm)	TK/FER protein kinase	0.0059	0.1678	0.264
Loa Loa (eye worm)	TK protein kinase	0.0038	0.095	0.1359
Loa Loa (eye worm)	TK/FER protein kinase	0.0059	0.1678	0.264
Trichomonas vaginalis	TKL family protein kinase	0.0038	0.095	0.1085
Entamoeba histolytica	protein kinase with ankyrin repeats, putative	0.0038	0.095	0.1092
Entamoeba histolytica	tyrosine kinase, putative	0.0038	0.095	0.1092
Loa Loa (eye worm)	cytokine inducible SH2-containing protein 5	0.0021	0.0327	0.0263
Trypanosoma brucei	AGC/RSK family serine/threonine kinase, putative	0.0038	0.095	0.1359
Brugia malayi	Protein kinase domain containing protein	0.0038	0.095	0.1359
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase src	0.0059	0.1678	0.2441
Schistosoma mansoni	tyrosine-protein kinase fps85d	0.0038	0.095	0.1126
Echinococcus multilocularis	basement membrane specific heparan sulfate	0.0071	0.2102	0.3586
Entamoeba histolytica	protein kinase domain containing protein	0.0038	0.095	0.1092
Loa Loa (eye worm)	TK/CSK protein kinase	0.0038	0.095	0.1359
Entamoeba histolytica	protein kinase, putative	0.0038	0.095	0.1092
Plasmodium vivax	protein kinase Crk2	0.0177	0.5861	1
Trichomonas vaginalis	TKL family protein kinase	0.0038	0.095	0.1085
Entamoeba histolytica	protein kinase, putative	0.0023	0.0401	0.0129
Trichomonas vaginalis	TKL family protein kinase	0.0038	0.095	0.1085
Entamoeba histolytica	hypothetical protein	0.0038	0.095	0.1092
Schistosoma mansoni	voltage-gated potassium channel	0.0025	0.048	0.0276
Schistosoma mansoni	protein kinase	0.004	0.1024	0.1259
Echinococcus multilocularis	growth factor receptor bound protein 2	0.0021	0.0327	0.0558
Entamoeba histolytica	tyrosine kinase, putative	0.0038	0.095	0.1092
Echinococcus granulosus	tyrosine kinase	0.0042	0.1086	0.1086
Echinococcus multilocularis	neuroglian	0.0071	0.2102	0.3586
Echinococcus multilocularis	macrophage colony stimulating factor 1 receptor	0.0038	0.095	0.1621
Echinococcus granulosus	tyrosine protein kinase shark	0.0059	0.1678	0.1678
Onchocerca volvulus		0.0059	0.1678	1
Echinococcus multilocularis	tyrosine protein kinase HCK	0.0038	0.095	0.1621
Trichomonas vaginalis	TKL family protein kinase	0.0038	0.095	0.1085
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0038	0.095	0.1092
Schistosoma mansoni	tyrosine kinase	0.0038	0.095	0.1126
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0038	0.095	0.1092
Entamoeba histolytica	tyrosine kinase, putative	0.0038	0.095	0.1092
Trichomonas vaginalis	CMGC family protein kinase	0.0177	0.5861	1
Schistosoma mansoni	defective proboscis extension response (dpr)-related	0.0071	0.2102	0.3207
Entamoeba histolytica	protein kinase domain containing protein	0.0038	0.095	0.1092
Onchocerca volvulus	Atrial natriuretic peptide receptor 3 homolog	0.0042	0.1086	0.5619
Entamoeba histolytica	protein kinase, putative	0.0038	0.095	0.1092
Trichomonas vaginalis	TKL family protein kinase	0.0038	0.095	0.1085
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0059	0.1678	0.2863
Echinococcus multilocularis	Immunoglobulin	0.0071	0.2102	0.3586
Schistosoma mansoni	tyrosine kinase	0.0038	0.095	0.1126
Echinococcus granulosus	cyclin dependent kinase	0.0177	0.5861	0.5861
Entamoeba histolytica	tyrosine kinase, putative	0.0038	0.095	0.1092
Echinococcus granulosus	retinal guanylyl cyclase 2	0.0038	0.095	0.095
Entamoeba histolytica	tyrosine kinase, putative	0.0038	0.095	0.1092
Trypanosoma cruzi	cdc2-related kinase 3	0.0177	0.5861	1
Brugia malayi	Raf kinase	0.0038	0.095	0.1359
Echinococcus multilocularis	tyrosine protein kinase csk	0.0038	0.095	0.1621
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0112	0.3535	0.5908
Loa Loa (eye worm)	hypothetical protein	0.0059	0.1678	0.264
Trichomonas vaginalis	conserved hypothetical protein	0.0038	0.095	0.1085
Entamoeba histolytica	protein kinase, putative	0.0038	0.095	0.1092
Echinococcus granulosus	neurotracting:lsamp:neurotrimin:obcam	0.0073	0.2185	0.2185
Brugia malayi	Protein kinase domain containing protein	0.0038	0.095	0.1359
Entamoeba histolytica	protein kinase domain containing protein	0.004	0.1024	0.1221
Loa Loa (eye worm)	TK/FER protein kinase	0.0059	0.1678	0.264
Brugia malayi	Fibronectin type III domain containing protein	0.0071	0.2102	0.3385
Trichomonas vaginalis	TKL family protein kinase	0.0038	0.095	0.1085
Echinococcus multilocularis	tyrosine protein kinase ABL1	0.0059	0.1678	0.2863
Echinococcus granulosus	roundabout 2	0.0073	0.2185	0.2185
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0038	0.095	0.1092
Echinococcus multilocularis	tyrosine protein kinase Fgr	0.0059	0.1678	0.2863
Trichomonas vaginalis	protein kinase atn1, putative	0.0038	0.095	0.1085
Giardia lamblia	Kinase, CMGC CDK	0.0177	0.5861	1
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0059	0.1678	0.1678
Echinococcus granulosus	SH2 motif	0.0021	0.0327	0.0327
Echinococcus multilocularis	suppressor of cytokine signaling 6	0.0021	0.0327	0.0558
Trichomonas vaginalis	TKL family protein kinase	0.0038	0.095	0.1085
Onchocerca volvulus		0.0038	0.095	0.4614
Loa Loa (eye worm)	TK/FER protein kinase	0.0038	0.095	0.1359
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0327	0.0263
Trichomonas vaginalis	TK family protein kinase	0.0038	0.095	0.1085
Schistosoma mansoni	Neurotrimin precursor (hNT)	0.0071	0.2102	0.3207
Schistosoma mansoni	tyrosine kinase	0.0059	0.1678	0.2441
Brugia malayi	SH2 domain containing protein	0.0021	0.0327	0.0263
Entamoeba histolytica	protein kinase domain containing protein	0.0038	0.095	0.1092
Brugia malayi	Protein kinase domain containing protein	0.0059	0.1678	0.264
Schistosoma mansoni	tyrosine kinase	0.0038	0.095	0.1126
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0327	0.0263
Treponema pallidum	amino acid ABC transporter, periplasmic binding protein (hisJ)	0.0019	0.0278	0.5
Brugia malayi	Protein kinase domain containing protein	0.0038	0.095	0.1359
Schistosoma mansoni	tyrosine kinase	0.0038	0.095	0.1126
Schistosoma mansoni	ephrin receptor	0.0038	0.095	0.1126
Loa Loa (eye worm)	voltage and ligand gated potassium channel	0.0023	0.0406	0.0401
Trichomonas vaginalis	serine-threonine protein kinase, putative	0.0038	0.095	0.1085
Brugia malayi	Protein kinase domain containing protein	0.0059	0.1678	0.264
Schistosoma mansoni	serine/threonine RGC	0.0038	0.095	0.1126
Entamoeba histolytica	protein kinase, putative	0.0038	0.095	0.1092
Entamoeba histolytica	tyrosine kinase, putative	0.0038	0.095	0.1092
Schistosoma mansoni	nephrin	0.0071	0.2102	0.3207
Echinococcus granulosus	protein kinase	0.0038	0.095	0.095
Loa Loa (eye worm)	TK/FER protein kinase	0.0059	0.1678	0.264
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0038	0.095	0.1092
Echinococcus multilocularis	retinal guanylyl cyclase 2	0.0038	0.095	0.1621
Trichomonas vaginalis	TKL family protein kinase	0.0038	0.095	0.1085
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0327	0.0263
Schistosoma mansoni	tyrosine kinase	0.0038	0.095	0.1126
Echinococcus multilocularis	tensin	0.0021	0.0327	0.0558
Schistosoma mansoni	tyrosine kinase	0.0038	0.095	0.1126
Brugia malayi	Variant SH3 domain containing protein	0.0021	0.0327	0.0263
Echinococcus granulosus	mitogen-activated protein kinase kinase kinase 9	0.0038	0.095	0.095
Echinococcus granulosus	tyrosine protein kinase ABL1	0.0059	0.1678	0.1678
Loa Loa (eye worm)	cytochrome P450 family protein	0.0035	0.082	0.1131
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0059	0.1678	0.1678
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0038	0.095	0.1092
Leishmania major	protein kinase, putative	0.0038	0.095	0.1359
Trypanosoma brucei	protein kinase, putative	0.004	0.1024	0.1489
Schistosoma mansoni	serine/threonine protein kinase	0.0038	0.095	0.1126
Brugia malayi	Protein kinase domain containing protein	0.0038	0.095	0.1359
Echinococcus multilocularis	raf serine:threonine protein kinase	0.0038	0.095	0.1621
Echinococcus granulosus	tyrosine protein kinase csk	0.0038	0.095	0.095
Entamoeba histolytica	protein kinase domain containing protein	0.0038	0.095	0.1092
Echinococcus multilocularis	atrial natriuretic peptide receptor 1	0.0038	0.095	0.1621
Brugia malayi	Protein kinase domain containing protein	0.0059	0.1678	0.264
Brugia malayi	Tyrosine-protein kinase abl-1	0.0059	0.1678	0.264
Brugia malayi	cyclin-dependent kinase 9	0.003	0.0654	0.0838
Brugia malayi	Protein kinase domain containing protein	0.0038	0.095	0.1359
Trypanosoma cruzi	STE/STE11 serine/threonine-protein kinase, putative	0.004	0.1024	0.1489
Schistosoma mansoni	protein kinase	0.0038	0.095	0.1126
Trichomonas vaginalis	TKL family protein kinase	0.0038	0.095	0.1085
Loa Loa (eye worm)	TK protein kinase	0.0038	0.095	0.1359
Schistosoma mansoni	tyrosine kinase	0.0038	0.095	0.1126
Brugia malayi	hypothetical protein	0.0071	0.2102	0.3385
Echinococcus multilocularis	Immunoglobulin	0.0071	0.2102	0.3586
Entamoeba histolytica	protein kinase, putative	0.0038	0.095	0.1092
Echinococcus granulosus	SHC transforming protein 3	0.0021	0.0327	0.0327
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0038	0.095	0.1092
Echinococcus multilocularis	protein tyrosine kinase	0.0038	0.095	0.1621
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0038	0.095	0.1092
Trichomonas vaginalis	TKL family protein kinase	0.0038	0.095	0.1085
Entamoeba histolytica	protein kinase, putative	0.0038	0.095	0.1092
Entamoeba histolytica	SH2-protein kinase domain containing protein	0.0059	0.1678	0.2367
Echinococcus granulosus	nmda type glutamate receptor	0.0084	0.2547	0.2547
Schistosoma mansoni	tyrosine kinase	0.0038	0.095	0.1126
Trichomonas vaginalis	TKL family protein kinase	0.0038	0.095	0.1085
Entamoeba histolytica	protein kinase domain containing protein	0.0038	0.095	0.1092
Echinococcus granulosus	hypothetical protein	0.0021	0.0327	0.0327
Entamoeba histolytica	hypothetical protein	0.0038	0.095	0.1092
Onchocerca volvulus		0.0038	0.095	0.4614
Entamoeba histolytica	leucine-rich repeat domain-containing protein	0.0038	0.095	0.1092
Leishmania major	cell division protein kinase 2,cdc2-related kinase	0.0177	0.5861	1
Brugia malayi	Protein kinase domain containing protein	0.0038	0.095	0.1359
Loa Loa (eye worm)	TK/RYK protein kinase	0.0038	0.095	0.1359
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0038	0.095	0.1092
Echinococcus multilocularis	tyrosine protein kinase lyn tyrosine protein kinase blk	0.0059	0.1678	0.2863
Entamoeba histolytica	receptor protein kinase, putative	0.0038	0.095	0.1092
Echinococcus multilocularis	basic fibroblast growth factor receptor 1 A	0.0038	0.095	0.1621
Echinococcus granulosus	tyrosine protein kinase transmembrane receptor	0.0038	0.095	0.095
Schistosoma mansoni	tyrosine kinase	0.0059	0.1678	0.2441
Trichomonas vaginalis	TKL family protein kinase	0.0038	0.095	0.1085
Loa Loa (eye worm)	TK/FER protein kinase	0.0038	0.095	0.1359
Trichomonas vaginalis	TKL family protein kinase	0.0038	0.095	0.1085
Loa Loa (eye worm)	TK/FER protein kinase	0.0059	0.1678	0.264
Brugia malayi	Variant SH3 domain containing protein	0.0021	0.0327	0.0263
Echinococcus multilocularis	signal transduction protein lnk realted	0.0021	0.0327	0.0558
Loa Loa (eye worm)	TK/FER protein kinase	0.0059	0.1678	0.264
Echinococcus multilocularis	activated cdc42 kinase 1	0.0038	0.095	0.1621
Trichomonas vaginalis	TKL family protein kinase	0.0038	0.095	0.1085
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.0059	0.1678	0.2863
Trichomonas vaginalis	TKL family protein kinase	0.0038	0.095	0.1085
Loa Loa (eye worm)	hypothetical protein	0.0071	0.2102	0.3385
Entamoeba histolytica	protein kinase domain containing protein	0.003	0.0654	0.0573
Echinococcus multilocularis	nmda type glutamate receptor	0.0084	0.2547	0.4346
Entamoeba histolytica	tyrosin kinase, putative	0.0038	0.095	0.1092
Echinococcus multilocularis	glutamate receptor NMDA	0.008	0.2411	0.4114
Onchocerca volvulus		0.0059	0.1678	1
Echinococcus granulosus	tyrosine protein kinase Src42A	0.0021	0.0327	0.0327
Loa Loa (eye worm)	hypothetical protein	0.0038	0.095	0.1359
Echinococcus granulosus	tyrosine protein kinase Btk29A	0.0059	0.1678	0.1678
Onchocerca volvulus		0.0038	0.095	0.4614
Schistosoma mansoni	tyrosine protein kinase	0.0038	0.095	0.1126
Trichomonas vaginalis	TKL family protein kinase	0.0038	0.095	0.1085
Loa Loa (eye worm)	hypothetical protein	0.0071	0.2102	0.3385
Schistosoma mansoni	protein kinase	0.0038	0.095	0.1126
Echinococcus granulosus	epidermal growth factor receptor	0.0038	0.095	0.095
Echinococcus multilocularis	SH2 motif	0.0021	0.0327	0.0558
Trichomonas vaginalis	TKL family protein kinase	0.0038	0.095	0.1085
Schistosoma mansoni	protein kinase	0.0038	0.095	0.1126
Echinococcus multilocularis	mitogen activated protein kinase kinase kinase	0.0038	0.095	0.1621
Entamoeba histolytica	protein kinase, putative	0.0038	0.095	0.1092
Onchocerca volvulus	Tyrosine kinase homolog	0.0038	0.095	0.4614
Echinococcus multilocularis	tensin	0.0021	0.0327	0.0558
Trichomonas vaginalis	TKL family protein kinase	0.0038	0.095	0.1085
Entamoeba histolytica	hypothetical protein	0.0038	0.095	0.1092
Entamoeba histolytica	tyrosine kinase, putative	0.0038	0.095	0.1092
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0038	0.095	0.1092
Trichomonas vaginalis	TKL family protein kinase	0.0038	0.095	0.1085
Echinococcus multilocularis	insulin receptor	0.0038	0.095	0.1621
Entamoeba histolytica	tyrosin kinase, putative	0.0038	0.095	0.1092
Schistosoma mansoni	tyrosine kinase	0.0038	0.095	0.1126
Echinococcus multilocularis	NCK adaptor protein	0.0021	0.0327	0.0558
Trichomonas vaginalis	conserved hypothetical protein	0.0038	0.095	0.1085
Entamoeba histolytica	hypothetical protein	0.0038	0.095	0.1092
Loa Loa (eye worm)	hypothetical protein	0.0038	0.095	0.1359
Giardia lamblia	Kinase, CMGC CDK	0.0177	0.5861	1
Echinococcus granulosus	suppressor of cytokine signaling 6	0.0021	0.0327	0.0327
Loa Loa (eye worm)	TK/FER protein kinase	0.0059	0.1678	0.264
Echinococcus granulosus	tyrosine protein kinase HCK	0.0038	0.095	0.095
Echinococcus granulosus	twitchin	0.0073	0.2175	0.2175
Echinococcus granulosus	tyrosine protein kinase csk	0.0038	0.095	0.095
Leishmania major	cell division related protein kinase 2,cdc2-related kinase	0.0177	0.5861	1
Schistosoma mansoni	tyrosine protein kinase fes (fps) (ptk group IV)	0.0038	0.095	0.1126
Echinococcus granulosus	tyrosine protein kinase transmembrane receptor	0.0038	0.095	0.095
Brugia malayi	Adenylate and Guanylate cyclase catalytic domain containing protein	0.0038	0.095	0.1359
Loa Loa (eye worm)	serine/threonine protein kinase	0.0038	0.095	0.1359
Trichomonas vaginalis	TKL family protein kinase	0.0038	0.095	0.1085
Loa Loa (eye worm)	hypothetical protein	0.0042	0.1086	0.1598
Loa Loa (eye worm)	SH2 domain-containing protein	0.0021	0.0327	0.0263
Onchocerca volvulus		0.0038	0.095	0.4614
Schistosoma mansoni	tyrosine protein kinase fes (fps) (ptk group IV)	0.0038	0.095	0.1126
Schistosoma mansoni	protein kinase	0.0038	0.095	0.1126
Loa Loa (eye worm)	TK protein kinase	0.0038	0.095	0.1359
Onchocerca volvulus		0.0042	0.1086	0.5619
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0327	0.0263
Schistosoma mansoni	tyrosine kinase	0.0038	0.095	0.1126
Echinococcus multilocularis	cyclin dependent kinase 9	0.0035	0.0826	0.1409
Entamoeba histolytica	tyrosine kinase, putative	0.0038	0.095	0.1092
Echinococcus granulosus	raf serine:threonine protein kinase	0.0038	0.095	0.095
Entamoeba histolytica	cysteine surface protein, putative	0.0038	0.095	0.1092
Echinococcus granulosus	tyrosine protein kinase Fps85D	0.0059	0.1678	0.1678
Echinococcus multilocularis	tyrosine protein kinase Abl	0.0059	0.1678	0.2863
Loa Loa (eye worm)	TK/FER protein kinase	0.0038	0.095	0.1359
Trichomonas vaginalis	TKL family protein kinase	0.0038	0.095	0.1085
Brugia malayi	hypothetical protein	0.0038	0.095	0.1359
Echinococcus granulosus	expressed conserved protein	0.0021	0.0327	0.0327
Echinococcus granulosus	activin receptor type	0.004	0.1024	0.1024
Schistosoma mansoni	tyrosine kinase	0.0038	0.095	0.1126
Entamoeba histolytica	protein kinase domain containing protein	0.0038	0.095	0.1092
Brugia malayi	Protein kinase domain containing protein	0.0038	0.095	0.1359
Entamoeba histolytica	serine/threonine kinase, putative	0.0038	0.095	0.1092
Echinococcus granulosus	fibroblast growth factor receptor 4	0.0038	0.095	0.095
Echinococcus granulosus	tyrosine kinase\|tyrosine protein kinase Fyn	0.0059	0.1678	0.1678
Echinococcus granulosus	tyrosine protein kinase Blk	0.0059	0.1678	0.1678
Loa Loa (eye worm)	TK protein kinase	0.0038	0.095	0.1359
Echinococcus multilocularis	cyclin dependent kinase 5	0.0177	0.5861	1
Loa Loa (eye worm)	hypothetical protein	0.0071	0.2102	0.3385
Brugia malayi	Protein kinase domain containing protein	0.0038	0.095	0.1359
Entamoeba histolytica	hypothetical protein	0.0038	0.095	0.1092
Echinococcus granulosus	SH2 domain containing protein 7	0.0021	0.0327	0.0327
Echinococcus multilocularis	tyrosine protein kinase csk	0.0038	0.095	0.1621
Entamoeba histolytica	tyrosine- protein kinase 2, putative	0.0038	0.095	0.1092
Onchocerca volvulus		0.0038	0.095	0.4614
Echinococcus granulosus	tyrosine kinase	0.0059	0.1678	0.1678
Brugia malayi	cytokine inducible SH2-containing protein 5	0.0021	0.0327	0.0263
Trichomonas vaginalis	TKL family protein kinase	0.0038	0.095	0.1085
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0059	0.1678	0.2863
Brugia malayi	C-terminal src kinase protein 1	0.0038	0.095	0.1359
Brugia malayi	RhoGAP domain containing protein	0.0021	0.0327	0.0263
Schistosoma mansoni	tyrosine-protein kinase fps85d	0.0038	0.095	0.1126
Echinococcus multilocularis	retinal guanylyl cyclase 2	0.0038	0.095	0.1621
Entamoeba histolytica	protein kinase, putative	0.0038	0.095	0.1092
Echinococcus multilocularis	nmda type glutamate receptor	0.0106	0.3355	0.5724
Trichomonas vaginalis	TKL family protein kinase	0.0038	0.095	0.1085
Echinococcus multilocularis	dual specificity testis specific protein kinase	0.004	0.1024	0.1747
Entamoeba histolytica	protein kinase domain containing protein	0.0038	0.095	0.1092
Brugia malayi	Receptor family ligand binding region containing protein	0.0042	0.1086	0.1598
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0038	0.095	0.1359
Trichomonas vaginalis	TKL family protein kinase	0.0038	0.095	0.1085
Brugia malayi	SRC-1	0.0059	0.1678	0.264
Brugia malayi	cell division control protein 2 homolog	0.0177	0.5861	1
Brugia malayi	Adenylate and Guanylate cyclase catalytic domain containing protein	0.0038	0.095	0.1359
Echinococcus multilocularis	phosphatidylinositol 3 kinase regulatory subunit	0.0021	0.0327	0.0558
Entamoeba histolytica	tyrosin kinase, putative	0.0038	0.095	0.1092
Echinococcus multilocularis	cyclin dependent kinase 1	0.0177	0.5861	1
Echinococcus granulosus	cyclin dependent kinase 5	0.0177	0.5861	0.5861
Entamoeba histolytica	protein kinase, putative	0.0038	0.095	0.1092
Echinococcus granulosus	activated cdc42 kinase 1	0.0038	0.095	0.095
Brugia malayi	SH2 domain containing protein	0.0021	0.0327	0.0263
Treponema pallidum	amino acid ABC transporter, periplasmic binding protein	0.0019	0.0278	0.5
Echinococcus multilocularis	tyrosine protein kinase Fes:Fps	0.0038	0.095	0.1621
Trichomonas vaginalis	TKL family protein kinase	0.0038	0.095	0.1085
Echinococcus multilocularis	tyrosine protein kinase Src64B	0.0059	0.1678	0.2863
Schistosoma mansoni	tyrosine kinase	0.0038	0.095	0.1126
Trypanosoma cruzi	protein kinase, putative	0.0038	0.095	0.1359
Echinococcus multilocularis	FL cytokine receptor	0.0038	0.095	0.1621
Loa Loa (eye worm)	CMGC/CDK/CDK5 protein kinase	0.0177	0.5861	1
Echinococcus multilocularis	tyrosine protein kinase Fps85D	0.0059	0.1678	0.2863
Trichomonas vaginalis	TKL family protein kinase	0.0038	0.095	0.1085
Echinococcus multilocularis	tyrosine protein kinase transmembrane receptor	0.0038	0.095	0.1621
Echinococcus granulosus	nmda type glutamate receptor	0.0106	0.3355	0.3355
Echinococcus granulosus	NCK adaptor protein	0.0021	0.0327	0.0327
Schistosoma mansoni	vesicular amine transporter	0.0072	0.2155	0.3303
Entamoeba histolytica	serine/threonine kinase, putative	0.0038	0.095	0.1092
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0059	0.1678	0.2863
Trichomonas vaginalis	conserved hypothetical protein	0.0038	0.095	0.1085
Brugia malayi	Tensin	0.0021	0.0327	0.0263
Echinococcus multilocularis	SH2 domain containing protein 7	0.0021	0.0327	0.0558
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0327	0.0263
Brugia malayi	Protein kinase domain containing protein	0.0038	0.095	0.1359
Brugia malayi	integrin-linked kinase	0.0038	0.095	0.1359
Brugia malayi	SH2 domain containing protein	0.0021	0.0327	0.0263
Loa Loa (eye worm)	TK/ALK protein kinase	0.0038	0.095	0.1359
Entamoeba histolytica	hypothetical protein	0.0038	0.095	0.1092
Schistosoma mansoni	protein kinase	0.0038	0.095	0.1126
Loa Loa (eye worm)	TK/Met protein kinase	0.0038	0.095	0.1359
Trichomonas vaginalis	TKL family protein kinase	0.0038	0.095	0.1085
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0071	0.2102	0.3385
Plasmodium falciparum	protein kinase 5	0.0177	0.5861	1
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0327	0.0263
Trypanosoma brucei	Flagellum attachment zone protein 20	0.0038	0.095	0.1359
Echinococcus multilocularis	c src tyrosine kinase	0.0059	0.1678	0.2863
Echinococcus granulosus	tyrosine protein kinase csk	0.0038	0.095	0.095
Brugia malayi	SH2 domain containing protein	0.0021	0.0327	0.0263
Trypanosoma cruzi	protein kinase, putative	0.0038	0.095	0.1359
Loa Loa (eye worm)	hypothetical protein	0.0071	0.2102	0.3385
Echinococcus multilocularis	tyrosine protein kinase	0.0038	0.095	0.1621
Brugia malayi	hypothetical protein	0.0059	0.1678	0.264
Echinococcus multilocularis	cyclin dependent kinase	0.0177	0.5861	1
Trichomonas vaginalis	TKL family protein kinase	0.0038	0.095	0.1085
Schistosoma mansoni	tyrosine kinase	0.0038	0.095	0.1126
Trichomonas vaginalis	TKL family protein kinase	0.0038	0.095	0.1085
Loa Loa (eye worm)	STAT protein	0.0021	0.0327	0.0263
Echinococcus granulosus	tyrosine protein kinase pr2	0.0038	0.095	0.095
Schistosoma mansoni	serine/threonine protein kinase	0.0038	0.095	0.1126
Trypanosoma cruzi	cdc2-related kinase 1	0.0177	0.5861	1
Echinococcus multilocularis	tyrosine kinase	0.0042	0.1086	0.1853
Loa Loa (eye worm)	TK/FER protein kinase	0.0059	0.1678	0.264
Trichomonas vaginalis	TKL family protein kinase	0.0038	0.095	0.1085
Chlamydia trachomatis	arginine ABC transporter substrate-binding protein ArtJ	0.0019	0.0278	0.5
Schistosoma mansoni	tyrosine kinase	0.0038	0.095	0.1126
Echinococcus multilocularis		0.0021	0.0327	0.0558
Echinococcus granulosus	neuroglian	0.0071	0.2102	0.2102
Entamoeba histolytica	protein kinase domain containing protein	0.0038	0.095	0.1092
Trichomonas vaginalis	TKL family protein kinase	0.0038	0.095	0.1085
Loa Loa (eye worm)	TK protein kinase	0.0038	0.095	0.1359
Trichomonas vaginalis	TKL family protein kinase	0.0038	0.095	0.1085
Loa Loa (eye worm)	hypothetical protein	0.0073	0.2185	0.3531
Brugia malayi	hypothetical protein	0.0038	0.095	0.1359
Schistosoma mansoni	src-type protein tyrosine kinase-related	0.0038	0.095	0.1126
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0327	0.0263
Trichomonas vaginalis	TKL family protein kinase	0.0038	0.095	0.1085
Schistosoma mansoni	serine/threonine protein kinase	0.0038	0.095	0.1126
Brugia malayi	Protein kinase domain containing protein	0.0038	0.095	0.1359
Loa Loa (eye worm)	TK/KIN6 protein kinase	0.0038	0.095	0.1359
Entamoeba histolytica	protein kinase, putative	0.0038	0.095	0.1092
Brugia malayi	SH2 domain containing protein	0.0021	0.0327	0.0263
Echinococcus granulosus	tyrosine protein kinase	0.0038	0.095	0.095
Echinococcus granulosus	basic fibroblast growth factor receptor 1 A	0.0038	0.095	0.095
Schistosoma mansoni	serine/threonine protein kinase	0.0177	0.5861	1
Echinococcus multilocularis	suppressor of cytokine signaling 7	0.0021	0.0327	0.0558
Schistosoma mansoni	protein kinase	0.0042	0.1086	0.1372
Brugia malayi	Variant SH3 domain containing protein	0.0021	0.0327	0.0263
Trichomonas vaginalis	TKL family protein kinase	0.0038	0.095	0.1085
Echinococcus granulosus	tensin C1 domain containing phosphatase	0.0021	0.0327	0.0327
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0059	0.1678	0.2863
Schistosoma mansoni	protein kinase	0.0038	0.095	0.1126
Echinococcus multilocularis	natriuretic peptide receptor 1	0.0038	0.095	0.1621
Schistosoma mansoni	serine/threonine protein kinase	0.0177	0.5861	1
Loa Loa (eye worm)	hypothetical protein	0.0038	0.095	0.1359
Entamoeba histolytica	SH2-protein kinase domain containing protein	0.0023	0.0401	0.0129
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0327	0.0263
Schistosoma mansoni	tyrosine kinase	0.0038	0.095	0.1126
Echinococcus granulosus	defective proboscis extension response	0.0071	0.2102	0.2102
Schistosoma mansoni	tyrosine kinase	0.0059	0.1678	0.2441
Echinococcus granulosus	SH2 domain containing adapter protein F	0.0021	0.0327	0.0327
Loa Loa (eye worm)	TK/EGFR protein kinase	0.0038	0.095	0.1359
Echinococcus multilocularis	tyrosine protein kinase shark	0.0059	0.1678	0.2863
Echinococcus multilocularis	kinase suppressor of Ras 1	0.0038	0.095	0.1621
Echinococcus multilocularis	N chimaerin	0.0021	0.0327	0.0558
Trichomonas vaginalis	TKL family protein kinase	0.0038	0.095	0.1085
Trichomonas vaginalis	CMGC family protein kinase	0.0177	0.5861	1
Brugia malayi	SH2 domain containing protein	0.0059	0.1678	0.264
Loa Loa (eye worm)	TK/INSR protein kinase	0.0038	0.095	0.1359
Onchocerca volvulus		0.0038	0.095	0.4614
Brugia malayi	Guanylyl cyclase protein 23	0.0042	0.1086	0.1598
Brugia malayi	Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog	0.0023	0.0406	0.0401
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0038	0.095	0.1092
Echinococcus granulosus	tyrosine protein kinase Fes:Fps	0.0038	0.095	0.095
Trypanosoma cruzi	cdc2-related kinase 1	0.0177	0.5861	1
Entamoeba histolytica	protein kinase, putative	0.0038	0.095	0.1092
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0021	0.0327	0.0327
Schistosoma mansoni	protein kinase	0.004	0.1024	0.1259
Trichomonas vaginalis	TKL family protein kinase	0.0038	0.095	0.1085
Loa Loa (eye worm)	TK/ACK protein kinase	0.0038	0.095	0.1359
Trichomonas vaginalis	TKL family protein kinase	0.0038	0.095	0.1085
Echinococcus granulosus	dual specificity testis-specific protein kinase	0.004	0.1024	0.1024
Trichomonas vaginalis	TKL family protein kinase	0.0038	0.095	0.1085
Loa Loa (eye worm)	hypothetical protein	0.0038	0.095	0.1359
Brugia malayi	SH2 domain containing protein	0.0021	0.0327	0.0263
Trichomonas vaginalis	TKL family protein kinase	0.0038	0.095	0.1085
Echinococcus multilocularis	protein kinase	0.0038	0.095	0.1621
Echinococcus granulosus	tyrosine kinase	0.0059	0.1678	0.1678
Chlamydia trachomatis	glutamine binding protein	0.0019	0.0278	0.5
Brugia malayi	Tyrosine-protein kinase F09A5.2 in chromosome X, putative	0.0038	0.095	0.1359
Brugia malayi	STAT protein, DNA binding domain containing protein	0.0021	0.0327	0.0263
Entamoeba histolytica	protein kinase domain containing protein	0.0038	0.095	0.1092
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0042	0.1086	0.1598
Echinococcus granulosus	atrial natriuretic peptide receptor 1	0.0038	0.095	0.095
Echinococcus multilocularis	tyrosine protein kinase transmembrane receptor	0.0038	0.095	0.1621
Entamoeba histolytica	protein kinase domain containing protein	0.0038	0.095	0.1092
Loa Loa (eye worm)	TK/KIN16 protein kinase	0.0112	0.3535	0.5908
Brugia malayi	proto-oncogene tyrosine-protein kinase FER	0.0038	0.095	0.1359
Echinococcus granulosus	tyrosine protein kinase Btk29A	0.0038	0.095	0.095
Loa Loa (eye worm)	TK protein kinase	0.0038	0.095	0.1359
Trichomonas vaginalis	TKL family protein kinase	0.0038	0.095	0.1085
Trichomonas vaginalis	TKL family protein kinase	0.0038	0.095	0.1085
Toxoplasma gondii	calcium dependent protein kinase CDPK8	0.004	0.1024	0.015
Echinococcus multilocularis	tyrosine protein kinase csk	0.0038	0.095	0.1621
Brugia malayi	Protein kinase domain containing protein	0.0038	0.095	0.1359
Entamoeba histolytica	hypothetical protein	0.0038	0.095	0.1092
Loa Loa (eye worm)	CMGC/CDK/CDC2 protein kinase	0.0177	0.5861	1
Trypanosoma cruzi	STE/STE11 serine/threonine-protein kinase, putative	0.004	0.1024	0.1489
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase src	0.0038	0.095	0.1126
Schistosoma mansoni	tyrosine kinase	0.0059	0.1678	0.2441
Schistosoma mansoni	protein kinase	0.004	0.1024	0.1259
Trichomonas vaginalis	TKL family protein kinase	0.0038	0.095	0.1085
Echinococcus multilocularis	epidermal growth factor receptor	0.0038	0.095	0.1621
Entamoeba histolytica	hypothetical protein	0.0038	0.095	0.1092
Trichomonas vaginalis	TKL family protein kinase	0.0038	0.095	0.1085
Brugia malayi	Protein kinase domain containing protein	0.0038	0.095	0.1359
Schistosoma mansoni	serine/threonine protein kinase	0.0038	0.095	0.1126
Echinococcus multilocularis	ephrin type A receptor 4 A	0.0038	0.095	0.1621
Echinococcus granulosus	proto oncogene tyrosine protein kinase LCK	0.0059	0.1678	0.1678
Entamoeba histolytica	tyrosine kinase, putative	0.0038	0.095	0.1092
Brugia malayi	SH2 domain containing protein	0.0059	0.1678	0.264
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0327	0.0263
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0327	0.0263
Echinococcus multilocularis	cyclin dependent kinase 9	0.003	0.0654	0.1115
Echinococcus multilocularis	SH2 domain containing adapter protein F	0.0021	0.0327	0.0558
Echinococcus granulosus	suppressor of cytokine signaling 7	0.0021	0.0327	0.0327
Echinococcus granulosus	cyclin dependent kinase 1	0.0177	0.5861	0.5861
Echinococcus granulosus	retinal guanylyl cyclase 2	0.0038	0.095	0.095
Brugia malayi	Protein kinase domain containing protein	0.0059	0.1678	0.264
Trichomonas vaginalis	TKL family protein kinase	0.0038	0.095	0.1085
Loa Loa (eye worm)	hypothetical protein	0.0038	0.095	0.1359
Brugia malayi	Protein kinase domain containing protein	0.0038	0.095	0.1359
Trypanosoma brucei	cdc2-related kinase 1	0.0177	0.5861	1
Brugia malayi	hypothetical protein	0.0021	0.0327	0.0263
Echinococcus granulosus	SH2 motif	0.0021	0.0327	0.0327
Echinococcus granulosus	melanoma receptor tyrosine protein kinase	0.0038	0.095	0.095
Plasmodium falciparum	protein kinase, putative	0.004	0.1024	0.015
Entamoeba histolytica	hypothetical protein, conserved	0.0038	0.095	0.1092
Trichomonas vaginalis	TKL family protein kinase	0.0038	0.095	0.1085
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0327	0.0263
Echinococcus granulosus	cyclin dependent kinase 9	0.0035	0.0826	0.0826
Echinococcus multilocularis	tyrosine protein kinase csk	0.0038	0.095	0.1621
Loa Loa (eye worm)	CMGC/CDK/CDC2 protein kinase	0.0177	0.5861	1
Trichomonas vaginalis	CAMK family protein kinase	0.0038	0.095	0.1085
Entamoeba histolytica	protein kinase domain containing protein	0.0038	0.095	0.1092
Entamoeba histolytica	cell division protein kinase 2, putative	0.0182	0.6033	1
Schistosoma mansoni	voltage-gated potassium channel	0.0025	0.048	0.0276
Trichomonas vaginalis	TKL family protein kinase	0.0038	0.095	0.1085
Trichomonas vaginalis	TKL family protein kinase	0.0038	0.095	0.1085
Onchocerca volvulus		0.0059	0.1678	1
Loa Loa (eye worm)	TKL/RAF/RAF protein kinase	0.0038	0.095	0.1359
Onchocerca volvulus		0.0059	0.1678	1
Trichomonas vaginalis	TKL family protein kinase	0.0038	0.095	0.1085
Brugia malayi	Furin-like cysteine rich region family protein	0.0038	0.095	0.1359
Schistosoma mansoni	tyrosine kinase	0.0038	0.095	0.1126
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0327	0.0263
Echinococcus granulosus	integrin linked protein kinase	0.0038	0.095	0.095
Trichomonas vaginalis	TKL family protein kinase	0.0038	0.095	0.1085
Trichomonas vaginalis	TKL family protein kinase	0.0038	0.095	0.1085
Echinococcus granulosus	signal transduction protein lnk realted	0.0021	0.0327	0.0327
Trichomonas vaginalis	conserved hypothetical protein	0.0038	0.095	0.1085
Echinococcus multilocularis	receptor type guanylyl cyclase	0.0042	0.1086	0.1853
Schistosoma mansoni	tyrosine kinase	0.0059	0.1678	0.2441
Echinococcus multilocularis	Glutamate receptor, ionotropic kainate 3	0.0027	0.0543	0.0926
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0038	0.095	0.1092
Brugia malayi	Tyrosine-protein kinase PR2	0.0038	0.095	0.1359
Loa Loa (eye worm)	TK/FER protein kinase	0.0059	0.1678	0.264
Trypanosoma cruzi	cdc2-related kinase 3	0.0177	0.5861	1
Trichomonas vaginalis	CMGC family protein kinase	0.0177	0.5861	1
Brugia malayi	Protein kinase domain containing protein	0.0038	0.095	0.1359
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0327	0.0263
Brugia malayi	Protein kinase domain containing protein	0.0059	0.1678	0.264
Echinococcus multilocularis	tyrosine kinase	0.0059	0.1678	0.2863
Echinococcus granulosus	guanine nucleotide exchange factor VAV2	0.0021	0.0327	0.0327
Entamoeba histolytica	serine/threonine kinase, putative	0.0038	0.095	0.1092
Echinococcus granulosus	insulin growth factor 1 receptor beta	0.0038	0.095	0.095
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0327	0.0263
Loa Loa (eye worm)	TKL/MLK/TAK1 protein kinase	0.0038	0.095	0.1359
Trichomonas vaginalis	serine/threonine-protein kinase wnk, putative	0.0038	0.095	0.1085
Echinococcus granulosus	Immunoglobulin	0.0071	0.2102	0.2102
Entamoeba histolytica	protein kinase domain containing protein	0.0038	0.095	0.1092
Onchocerca volvulus		0.0038	0.095	0.4614
Loa Loa (eye worm)	TK/ROR protein kinase	0.0038	0.095	0.1359
Echinococcus multilocularis	insulin growth factor 1 receptor beta	0.0038	0.095	0.1621
Loa Loa (eye worm)	TKL/RAF/KSR protein kinase	0.0038	0.095	0.1359
Trichomonas vaginalis	TKL family protein kinase	0.0038	0.095	0.1085
Trichomonas vaginalis	TKL family protein kinase	0.0038	0.095	0.1085
Entamoeba histolytica	hypothetical protein	0.0038	0.095	0.1092
Entamoeba histolytica	protein kinase domain containing protein	0.0038	0.095	0.1092
Entamoeba histolytica	receptor protein kinase, putative	0.0038	0.095	0.1092
Echinococcus multilocularis	tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase	0.0059	0.1678	0.2863
Schistosoma mansoni	protein kinase	0.0038	0.095	0.1126
Schistosoma mansoni	tyrosine kinase	0.0038	0.095	0.1126
Echinococcus multilocularis	SH2 motif	0.0021	0.0327	0.0558
Echinococcus granulosus	tyrosine protein kinase Lyn	0.0061	0.1751	0.1751
Echinococcus multilocularis	suppressor of cytokine signaling 7	0.0021	0.0327	0.0558
Loa Loa (eye worm)	hypothetical protein	0.0073	0.2185	0.3531
Echinococcus granulosus	tyrosine protein kinase Srms	0.0059	0.1678	0.1678
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0059	0.1678	0.1678
Loa Loa (eye worm)	hypothetical protein	0.0071	0.2102	0.3385
Mycobacterium tuberculosis	Probable glutamine-binding lipoprotein GlnH (GLNBP)	0.0019	0.0278	0.5
Schistosoma mansoni	glutamate receptor NMDA	0.0091	0.2812	0.449
Trichomonas vaginalis	TKL family protein kinase	0.0038	0.095	0.1085
Trichomonas vaginalis	TKL family protein kinase	0.0038	0.095	0.1085
Entamoeba histolytica	tyrosine kinase, putative	0.0038	0.095	0.1092
Mycobacterium ulcerans	glutamine-binding lipoprotein GlnH	0.0019	0.0278	1
Echinococcus granulosus	phosphatidylinositol 3 kinase regulatory subunit	0.0021	0.0327	0.0327
Loa Loa (eye worm)	SRC-1	0.0059	0.1678	0.264
Brugia malayi	ephrin receptor 1 precursor	0.0038	0.095	0.1359
Echinococcus granulosus	retinal guanylyl cyclase 2	0.0038	0.095	0.095
Echinococcus multilocularis	heat shock protein 70	0.0038	0.095	0.1621
Loa Loa (eye worm)	variant SH3 domain-containing protein	0.0021	0.0327	0.0263
Loa Loa (eye worm)	hypothetical protein	0.0073	0.2185	0.3531
Echinococcus multilocularis	mitogen activated protein kinase kinase kinase	0.0038	0.095	0.1621
Entamoeba histolytica	hypothetical protein	0.0038	0.095	0.1092
Echinococcus multilocularis	integrin linked protein kinase	0.0038	0.095	0.1621
Trichomonas vaginalis	TKL family protein kinase	0.0038	0.095	0.1085
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.0038	0.095	0.1085
Echinococcus multilocularis	guanine nucleotide exchange factor VAV2	0.0021	0.0327	0.0558
Loa Loa (eye worm)	TKL/STKR/TYPE1 protein kinase	0.0038	0.095	0.1359
Brugia malayi	Protein kinase domain containing protein	0.0038	0.095	0.1359
Trichomonas vaginalis	conserved hypothetical protein	0.0038	0.095	0.1085
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0021	0.0327	0.0327
Trichomonas vaginalis	TKL family protein kinase	0.0038	0.095	0.1085
Schistosoma mansoni	tyrosine kinase	0.0038	0.095	0.1126
Loa Loa (eye worm)	hypothetical protein	0.0175	0.5787	0.9871
Brugia malayi	Protein kinase domain containing protein	0.0038	0.095	0.1359
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0021	0.0327	0.0558
Schistosoma mansoni	serine/threonine protein kinase	0.003	0.0654	0.059
Entamoeba histolytica	protein kinase, putative	0.0038	0.095	0.1092
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0038	0.095	0.1092
Loa Loa (eye worm)	TK/EPH protein kinase	0.0038	0.095	0.1359
Schistosoma mansoni	tyrosine kinase	0.0038	0.095	0.1126
Echinococcus multilocularis	potassium voltage gated channel subfamily H	0.0023	0.0406	0.0692
Entamoeba histolytica	tyrosine kinase, putative	0.0038	0.095	0.1092
Entamoeba histolytica	protein kinase, putative	0.0038	0.095	0.1092
Loa Loa (eye worm)	TK/DDR protein kinase	0.0038	0.095	0.1359
Loa Loa (eye worm)	TK/FER protein kinase	0.0038	0.095	0.1359
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0021	0.0327	0.0558
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0042	0.1086	0.1598
Echinococcus granulosus	kinase suppressor of Ras 1	0.0038	0.095	0.095
Loa Loa (eye worm)	TK protein kinase	0.0059	0.1678	0.264
Echinococcus granulosus	glutamate receptor NMDA	0.008	0.2411	0.2411
Entamoeba histolytica	protein kinase domain containing protein	0.0038	0.095	0.1092
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0021	0.0327	0.0263
Loa Loa (eye worm)	hypothetical protein	0.0038	0.095	0.1359
Echinococcus multilocularis	tyrosine protein kinase Btk29A	0.0059	0.1678	0.2863
Entamoeba histolytica	tyrosine kinase, putative	0.0038	0.095	0.1092
Echinococcus granulosus	c src tyrosine kinase	0.0059	0.1678	0.1678
Entamoeba histolytica	cell division protein kinase 2, putative	0.0177	0.5861	0.9699
Brugia malayi	Protein kinase domain containing protein	0.0038	0.095	0.1359
Entamoeba histolytica	protein kinase domain containing protein	0.0038	0.095	0.1092
Toxoplasma gondii	cell-cycle-associated protein kinase CDK, putative	0.0177	0.5861	1
Loa Loa (eye worm)	hypothetical protein	0.0038	0.095	0.1359
Loa Loa (eye worm)	TK/FER protein kinase	0.0038	0.095	0.1359
Entamoeba histolytica	serine/threonine kinase, putative	0.0038	0.095	0.1092
Schistosoma mansoni	tyrosine kinase	0.0038	0.095	0.1126
Onchocerca volvulus		0.0059	0.1678	1
Schistosoma mansoni	ephrin receptor	0.0038	0.095	0.1126
Loa Loa (eye worm)	hypothetical protein	0.0071	0.2102	0.3385
Entamoeba histolytica	protein kinase, putative	0.0038	0.095	0.1092
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.0021	0.0327	0.0558
Trichomonas vaginalis	TKL family protein kinase	0.0038	0.095	0.1085
Loa Loa (eye worm)	TKL/MLK/ILK protein kinase	0.0038	0.095	0.1359
Loa Loa (eye worm)	TK/FER protein kinase	0.0038	0.095	0.1359
Trichomonas vaginalis	TKL family protein kinase	0.0038	0.095	0.1085
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0038	0.095	0.1092
Echinococcus granulosus	epidermal growth factor receptor	0.0038	0.095	0.095
Entamoeba histolytica	serine/threonine kinase, putative	0.0038	0.095	0.1092
Schistosoma mansoni	tyrosine kinase	0.0042	0.1086	0.1372
Loa Loa (eye worm)	hypothetical protein	0.0038	0.095	0.1359
Echinococcus multilocularis	activin receptor type	0.004	0.1024	0.1747
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0042	0.1086	0.1598
Trichomonas vaginalis	protein tyrosine kinase, putative	0.0038	0.095	0.1085
Trichomonas vaginalis	conserved hypothetical protein	0.0038	0.095	0.1085
Echinococcus granulosus	mitogen activated protein kinase kinase kinase	0.0038	0.095	0.095
Trichomonas vaginalis	TKL family protein kinase	0.0038	0.095	0.1085
Entamoeba histolytica	protein kinase domain containing protein	0.0038	0.095	0.1092
Schistosoma mansoni	tyrosine kinase	0.0038	0.095	0.1126
Echinococcus granulosus	natriuretic peptide receptor 1	0.0038	0.095	0.095
Brugia malayi	Protein kinase domain containing protein	0.0038	0.095	0.1359
Echinococcus multilocularis	epidermal growth factor receptor	0.0038	0.095	0.1621
Schistosoma mansoni	protein tyrosine kinase	0.0038	0.095	0.1126
Brugia malayi	Protein kinase domain containing protein	0.0038	0.095	0.1359
Brugia malayi	Protein kinase domain containing protein	0.0038	0.095	0.1359
Trichomonas vaginalis	TKL family protein kinase	0.0038	0.095	0.1085
Echinococcus multilocularis	proto oncogene tyrosine protein kinase LCK	0.0059	0.1678	0.2863
Onchocerca volvulus		0.0059	0.1678	1
Brugia malayi	Protein kinase domain containing protein	0.0038	0.095	0.1359
Trichomonas vaginalis	STE family protein kinase	0.0038	0.095	0.1085
Entamoeba histolytica	protein kinase, putative	0.0038	0.095	0.1092
Schistosoma mansoni	cell adhesion molecule	0.0073	0.2185	0.3357
Entamoeba histolytica	protein kinase domain containing protein	0.0038	0.095	0.1092
Entamoeba histolytica	protein kinase, putative	0.0038	0.095	0.1092
Loa Loa (eye worm)	hypothetical protein	0.0038	0.095	0.1359
Echinococcus multilocularis	transfer RNA-Thr	0.0038	0.095	0.1621
Loa Loa (eye worm)	TK/ABL protein kinase	0.0059	0.1678	0.264
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0021	0.0327	0.0263
Echinococcus multilocularis	tyrosine protein kinase Blk	0.0059	0.1678	0.2863
Echinococcus granulosus	receptor type guanylyl cyclase	0.0042	0.1086	0.1086
Entamoeba histolytica	ankyrin repeat protein	0.0038	0.095	0.1092
Leishmania major	hypothetical protein, conserved	0.0038	0.095	0.1359
Echinococcus multilocularis	protein kinase	0.0038	0.095	0.1621
Echinococcus multilocularis	SH2 motif	0.0021	0.0327	0.0558
Schistosoma mansoni	tyrosine kinase	0.0059	0.1678	0.2441
Loa Loa (eye worm)	hypothetical protein	0.002	0.0299	0.0214
Brugia malayi	bone morphogenetic protein type 1 receptor	0.0038	0.095	0.1359
Schistosoma mansoni	tyrosine kinase	0.0041	0.1033	0.1276
Loa Loa (eye worm)	TK/FER protein kinase	0.0038	0.095	0.1359
Brugia malayi	Cytochrome P450 family protein	0.0035	0.082	0.1131
Schistosoma mansoni	kinase	0.003	0.0654	0.059
Echinococcus granulosus	growth factor receptor bound protein 2	0.0021	0.0327	0.0327
Brugia malayi	SH2 domain containing protein	0.0021	0.0327	0.0263
Loa Loa (eye worm)	hypothetical protein	0.0038	0.095	0.1359
Trypanosoma brucei	Pseudokinase, putative	0.0038	0.095	0.1359
Brugia malayi	tRNA modification GTPase TrmE family protein	0.0021	0.0327	0.0263
Entamoeba histolytica	protein kinase domain containing protein	0.0038	0.095	0.1092
Entamoeba histolytica	tyrosine kinase, putative	0.0038	0.095	0.1092
Echinococcus multilocularis	tyrosine protein kinase pr2	0.0038	0.095	0.1621
Brugia malayi	protein-tyrosine kinase	0.0059	0.1678	0.264
Trichomonas vaginalis	TKL family protein kinase	0.0038	0.095	0.1085
Brugia malayi	Sex muscle abnormal protein 5	0.0021	0.0327	0.0263
Echinococcus granulosus	insulin receptor	0.0038	0.095	0.095
Brugia malayi	Protein kinase domain containing protein	0.0177	0.5861	1
Brugia malayi	Probable tyrosine-protein kinase kin-31	0.0038	0.095	0.1359
Echinococcus granulosus	tensin	0.0021	0.0327	0.0327
Loa Loa (eye worm)	TK/FER protein kinase	0.0059	0.1678	0.264
Schistosoma mansoni	tyrosine kinase	0.0038	0.095	0.1126
Entamoeba histolytica	tyrosine kinase, putative	0.0038	0.095	0.1092
Onchocerca volvulus	Tyrosine kinase receptor Cad96Ca homolog	0.0038	0.095	0.4614
Echinococcus multilocularis	roundabout 2	0.0073	0.2185	0.3727
Trypanosoma brucei	cdc2-related kinase 3	0.0177	0.5861	1
Echinococcus granulosus	tyrosine protein kinase Src64B	0.0059	0.1678	0.1678
Entamoeba histolytica	protein kinase, putative	0.0038	0.095	0.1092
Echinococcus granulosus	5'partial\|cyclin dependent kinase 1	0.0177	0.5861	0.5861
Echinococcus multilocularis	retinal guanylyl cyclase 2	0.0038	0.095	0.1621
Echinococcus granulosus	potassium voltage gated channel subfamily H	0.0023	0.0406	0.0406
Loa Loa (eye worm)	RhoGAP domain-containing protein	0.0021	0.0327	0.0263
Loa Loa (eye worm)	SH2 domain-containing protein	0.0021	0.0327	0.0263
Trichomonas vaginalis	TKL family protein kinase	0.0038	0.095	0.1085
Entamoeba histolytica	protein kinase domain containing protein	0.0038	0.095	0.1092
Trichomonas vaginalis	TKL family protein kinase	0.0038	0.095	0.1085
Schistosoma mansoni	tyrosine kinase	0.0042	0.1086	0.1372
Loa Loa (eye worm)	CMGC/CDK/CDK9 protein kinase	0.003	0.0654	0.0838
Entamoeba histolytica	tyrosin kinase, putative	0.0038	0.095	0.1092
Entamoeba histolytica	ankyrin repeat protein	0.0038	0.095	0.1092
Brugia malayi	Probable tyrosine-protein kinase kin-31	0.0038	0.095	0.1359
Echinococcus granulosus	3'partial\|retinal guanylyl cyclase 2	0.0038	0.095	0.095
Trichomonas vaginalis	br serine/threonine-protein kinase, putative	0.0038	0.095	0.1085
Loa Loa (eye worm)	TK protein kinase	0.0038	0.095	0.1359
Loa Loa (eye worm)	TK protein kinase	0.0038	0.095	0.1359
Echinococcus multilocularis	SHC transforming protein 3	0.0021	0.0327	0.0558
Entamoeba histolytica	tyrosine kinase, putative	0.0038	0.095	0.1092
Loa Loa (eye worm)	variant SH3 domain-containing protein	0.0021	0.0327	0.0263
Trichomonas vaginalis	TKL family protein kinase	0.0038	0.095	0.1085
Trypanosoma brucei	STE/STE11 serine/threonine-protein kinase, putative	0.004	0.1024	0.1489
Loa Loa (eye worm)	SH2 domain-containing protein	0.0021	0.0327	0.0263
Brugia malayi	Variant SH3 domain containing protein	0.0021	0.0327	0.0263
Brugia malayi	Protein kinase domain containing protein	0.0038	0.095	0.1359
Entamoeba histolytica	hypothetical protein	0.0038	0.095	0.1092
Echinococcus multilocularis	fibroblast growth factor receptor 4	0.0038	0.095	0.1621
Echinococcus granulosus	cyclin dependent kinase 9	0.003	0.0654	0.0654
Loa Loa (eye worm)	TKL/MLK/HH498 protein kinase	0.0038	0.095	0.1359
Entamoeba histolytica	tyrosine kinase, putative	0.0038	0.095	0.1092
Schistosoma mansoni	hypothetical protein	0.0038	0.095	0.1126
Entamoeba histolytica	protein kinase domain containing protein	0.0038	0.095	0.1092
Loa Loa (eye worm)	protein kinase domain-containing protein	0.0038	0.095	0.1359
Entamoeba histolytica	serine/threonine kinase, putative	0.0038	0.095	0.1092
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0038	0.095	0.1359
Trichomonas vaginalis	TKL family protein kinase	0.0038	0.095	0.1085
Entamoeba histolytica	protein kinase domain containing protein	0.0038	0.095	0.1092
Loa Loa (eye worm)	TK/FAK protein kinase	0.0038	0.095	0.1359
Echinococcus granulosus	3'partial\|tyrosine protein kinase Fgr	0.0059	0.1678	0.1678
Loa Loa (eye worm)	TK protein kinase	0.0038	0.095	0.1359
Echinococcus granulosus	activated cdc42 kinase 1	0.0038	0.095	0.095
Brugia malayi	Protein kinase domain containing protein	0.0038	0.095	0.1359
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0327	0.0263
Loa Loa (eye worm)	hypothetical protein	0.0038	0.095	0.1359
Echinococcus multilocularis	protein KINase family member (kin 25)	0.0038	0.095	0.1621
Brugia malayi	Protein kinase domain containing protein	0.0038	0.095	0.1359
Brugia malayi	Protein kinase domain containing protein	0.0038	0.095	0.1359
Echinococcus granulosus	protein tyrosine kinase	0.0038	0.095	0.095
Entamoeba histolytica	tyrosine kinase, putative	0.0038	0.095	0.1092

Activities

Activity type	Activity value	Assay description	Source	Reference
LC50 (ADMET)	= 2000 ng ml-1	Cytotoxicity, assayed on L5178Y mouse lymphoma cells	ChEMBL.	2918501
LC50 (ADMET)	= 2000 ng ml-1	Cytotoxicity, assayed on L5178Y mouse lymphoma cells	ChEMBL.	2918501

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

No external resources registered for this compound

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 264174