Detailed information for compound 269265

Basic information

Technical information
  • TDR Targets ID: 269265
  • Name: (E)-but-2-enamide
  • MW: 85.1045 | Formula: C4H7NO
  • H donors: 1 H acceptors: 1 LogP: -0.04 Rotable bonds: 1
    Rule of 5 violations (Lipinski): 1
  • SMILES: C/C=C/C(=O)N
  • InChi: 1S/C4H7NO/c1-2-3-4(5)6/h2-3H,1H3,(H2,5,6)/b3-2+
  • InChiKey: NQQRXZOPZBKCNF-NSCUHMNNSA-N  


Substructure search Similarity search

Network

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Synonyms

  • (E)-2-butenamide
  • but-2-enamide
  • 23350-58-5
  • 625-37-6
  • AIDS-018362
  • 2-Butenamide, (E)-
  • AIDS018362
  • 2-02-00-00394 (Beilstein Handbook Reference)
  • 2-Butenamide (9CI)
  • AI3-16505
  • BRN 0506110
  • CROTONAMIDE
  • trans-2-Butenoic acid amide
  • 2-Butenamide
  • NSC11802
  • trans-Crotonamide

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0014 0.0041 0.0177
Loa Loa (eye worm) hypothetical protein 0.0014 0.0041 0.0177
Schistosoma mansoni roundabout 0.0015 0.0066 0.0295
Toxoplasma gondii facilitative glucose transporter GT1 0.0111 0.216 0.3201
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0111 0.216 1
Echinococcus multilocularis nicotinic acetylcholine receptor a11 subunit 0.0014 0.0041 0.0177
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0039 0.0589 1
Loa Loa (eye worm) hypothetical protein 0.006 0.1044 0.4827
Echinococcus multilocularis hemicentin 1 0.0015 0.0066 0.0295
Echinococcus multilocularis roundabout 2 0.0062 0.1108 0.5122
Brugia malayi major facilitator superfamily protein 0.0016 0.0084 0.0377
Echinococcus multilocularis nAChR subunit 0.0014 0.0041 0.0177
Onchocerca volvulus 0.0016 0.0084 1
Brugia malayi Cation transporter family protein 0.0014 0.0041 0.0177
Echinococcus multilocularis solute carrier family 22 0.0016 0.0084 0.0377
Loa Loa (eye worm) hypothetical protein 0.0048 0.0786 0.3629
Toxoplasma gondii protein kinase, putative 0.0313 0.6571 1
Trichomonas vaginalis conserved hypothetical protein 0.0111 0.216 1
Loa Loa (eye worm) hypothetical protein 0.0014 0.0041 0.0177
Echinococcus multilocularis neuroglian 0.0051 0.0849 0.3924
Echinococcus multilocularis Immunoglobulin 0.0048 0.0786 0.3629
Loa Loa (eye worm) hypothetical protein 0.0015 0.0066 0.0295
Plasmodium vivax proline--tRNA ligase, putative 0.0039 0.0589 0.051
Brugia malayi Cation transporter family protein 0.0014 0.0041 0.0177
Leishmania major glucose transporter, lmgt2 0.0034 0.0493 0.8107
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0111 0.216 1
Onchocerca volvulus 0.0016 0.0084 1
Schistosoma mansoni cell adhesion molecule 0.0015 0.0066 0.0295
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0014 0.0041 0.0177
Echinococcus granulosus nicotinic acetylcholine receptor alpha subunit 0.0014 0.0041 0.0177
Brugia malayi Immunoglobulin I-set domain containing protein 0.0064 0.1139 0.5266
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0033 0.0469 0.2162
Echinococcus multilocularis roundabout 2 0.0015 0.0066 0.0295
Brugia malayi Major Facilitator Superfamily protein 0.0016 0.0084 0.0377
Brugia malayi Sugar transporter family protein 0.0111 0.216 1
Echinococcus multilocularis glutamyl tRNA synthetase cytoplasmic 0.0033 0.0469 0.2162
Toxoplasma gondii prolyl-tRNA synthetase (ProRS) 0.0039 0.0589 0.0779
Loa Loa (eye worm) hypothetical protein 0.0016 0.0084 0.0377
Schistosoma mansoni glucose transporter 0.0016 0.0084 0.0377
Trypanosoma cruzi hexose transporter, putative 0.0034 0.0493 0.8107
Brugia malayi Immunoglobulin I-set domain containing protein 0.0048 0.0786 0.3629
Echinococcus granulosus glycine receptor subunit beta 0.0014 0.0041 0.0177
Trichomonas vaginalis glucose transporter, putative 0.0034 0.0493 0.1973
Loa Loa (eye worm) hypothetical protein 0.0015 0.0066 0.0295
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0025 0.0283 0.0961
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0039 0.0589 1
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0111 0.216 1
Schistosoma mansoni protein kinase 0.0034 0.0484 0.2231
Schistosoma mansoni nAChR subunit (ShAR1-alpha-like) 0.0014 0.0041 0.0177
Loa Loa (eye worm) CAMK/CAMK2 protein kinase 0.0034 0.0484 0.2231
Schistosoma mansoni neuroglian 0.0015 0.0066 0.0295
Giardia lamblia Lysyl-tRNA synthetase 0.0025 0.0283 0.5182
Onchocerca volvulus 0.0016 0.0084 1
Echinococcus granulosus Sugar transporter ERD6 protein 0.0016 0.0084 0.0377
Schistosoma mansoni sugar transporter 0.0016 0.0084 0.0377
Chlamydia trachomatis lysine--tRNA ligase 0.0025 0.0283 1
Trypanosoma brucei glucose transporter, putative 0.0034 0.0493 0.8107
Loa Loa (eye worm) hypothetical protein 0.0015 0.0066 0.0295
Loa Loa (eye worm) major facilitator superfamily transporter 0.0016 0.0084 0.0377
Loa Loa (eye worm) hypothetical protein 0.0015 0.0066 0.0295
Echinococcus granulosus neuroglian 0.0051 0.0849 0.3924
Schistosoma mansoni hypothetical protein 0.0111 0.216 1
Trypanosoma brucei glucose transporter 1E 0.0034 0.0493 0.8107
Loa Loa (eye worm) hypothetical protein 0.0014 0.0041 0.0177
Brugia malayi acetylcholine receptor, alpha-type subunit unc-38 precursor 0.0014 0.0041 0.0177
Echinococcus multilocularis hemicentin 1 0.0015 0.0066 0.0295
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0111 0.216 1
Schistosoma mansoni nAChR subunit 0.0014 0.0041 0.0177
Echinococcus granulosus glycine receptor subunit beta 0.0014 0.0041 0.0177
Echinococcus multilocularis solute carrier family 2, facilitated glucose 0.0111 0.216 1
Echinococcus granulosus neuroglian 0.0015 0.0066 0.0295
Loa Loa (eye worm) bifunctional aminoacyl-tRNA synthetase 0.0014 0.0042 0.0181
Schistosoma mansoni nAChR subunit 0.0014 0.0041 0.0177
Plasmodium falciparum calcium-dependent protein kinase 5 0.0034 0.0484 0.0404
Leishmania major lysyl-tRNA synthetase, putative 0.0025 0.0283 0.395
Loa Loa (eye worm) hypothetical protein 0.0048 0.0786 0.3629
Leishmania major glucose transporter/membrane transporter D2, putative 0.0034 0.0493 0.8107
Plasmodium falciparum calcium-dependent protein kinase 1 0.0034 0.0484 0.0404
Echinococcus granulosus glycine receptor subunit alpha 1 0.0014 0.0041 0.0177
Echinococcus granulosus nicotinic acetylcholine receptor a11 subunit 0.0014 0.0041 0.0177
Loa Loa (eye worm) hypothetical protein 0.0016 0.0084 0.0377
Echinococcus multilocularis neurotracting:lsamp:neurotrimin:obcam 0.0015 0.0066 0.0295
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0014 0.0041 0.0177
Loa Loa (eye worm) hypothetical protein 0.0015 0.0066 0.0295
Echinococcus multilocularis General substrate transporter 0.0095 0.1821 0.8426
Onchocerca volvulus 0.0016 0.0084 1
Loa Loa (eye worm) hypothetical protein 0.0014 0.0041 0.0177
Brugia malayi Immunoglobulin I-set domain containing protein 0.0015 0.0066 0.0295
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0014 0.0041 0.0177
Loa Loa (eye worm) hypothetical protein 0.0033 0.0469 0.2162
Loa Loa (eye worm) hypothetical protein 0.0016 0.0084 0.0377
Brugia malayi Sugar transporter family protein 0.0016 0.0084 0.0377
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0111 0.216 1
Loa Loa (eye worm) hypothetical protein 0.0014 0.0041 0.0177
Trypanosoma brucei bifunctional aminoacyl-tRNA synthetase, putative 0.0039 0.0589 1
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0014 0.0041 0.0177
Loa Loa (eye worm) ligand-Gated ion Channel family member 0.0014 0.0041 0.0177
Schistosoma mansoni protein kinase 0.0034 0.0484 0.2231
Loa Loa (eye worm) ACC-1 protein 0.0014 0.0041 0.0177
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0034 0.0484 0.2231
Leishmania major glucose transporter, lmgt3 0.0034 0.0493 0.8107
Loa Loa (eye worm) nicotinic acetylcholine receptor non-alpha subunit 0.0014 0.0041 0.0177
Trichomonas vaginalis glucose transporter, putative 0.0034 0.0493 0.1973
Trypanosoma brucei THT1 - hexose transporter, putative 0.0034 0.0493 0.8107
Trypanosoma brucei glucose transporter, putative 0.0034 0.0493 0.8107
Trichomonas vaginalis CAMK family protein kinase 0.0034 0.0484 0.1927
Toxoplasma gondii calcium-dependent protein kinase CDPK2A 0.0034 0.0484 0.0617
Echinococcus granulosus basic fibroblast growth factor receptor 1 A 0.0101 0.1948 0.9017
Echinococcus multilocularis Immunoglobulin 0.0048 0.0786 0.3629
Schistosoma mansoni nAChR subunit 0.0014 0.0041 0.0177
Loa Loa (eye worm) acetylcholine receptor alpha subunit 0.0014 0.0041 0.0177
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0014 0.0041 0.0177
Plasmodium vivax calcium-dependent protein kinase, putative 0.0034 0.0484 0.0404
Echinococcus multilocularis neuroglian 0.0015 0.0066 0.0295
Plasmodium vivax calcium-dependent protein kinase 4, putative 0.0034 0.0484 0.0404
Brugia malayi acetylcholine receptor alpha subunit precursor, putative 0.0014 0.0041 0.0177
Brugia malayi Immunoglobulin I-set domain containing protein 0.0015 0.0066 0.0295
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0015 0.0066 0.0295
Echinococcus granulosus solute carrier family 22 0.0016 0.0084 0.0377
Loa Loa (eye worm) TK/KIN16 protein kinase 0.0064 0.1139 0.5266
Loa Loa (eye worm) hypothetical protein 0.0015 0.0066 0.0295
Echinococcus multilocularis glycine receptor subunit beta 0.0014 0.0041 0.0177
Echinococcus multilocularis Sugar transporter ERD6 protein 0.0016 0.0084 0.0377
Loa Loa (eye worm) hypothetical protein 0.0016 0.0084 0.0377
Schistosoma mansoni cell adhesion molecule 0.006 0.1044 0.4827
Plasmodium falciparum calcium-dependent protein kinase 3 0.0034 0.0484 0.0404
Schistosoma mansoni neurotracting/lsamp/neurotrimin/obcam related cell adhesion molecule 0.0015 0.0066 0.0295
Schistosoma mansoni sugar transporter 0.0016 0.0084 0.0377
Trypanosoma brucei glucose transporter, putative 0.0034 0.0493 0.8107
Brugia malayi Fibronectin type III domain containing protein 0.0048 0.0786 0.3629
Plasmodium falciparum proline--tRNA ligase 0.0039 0.0589 0.051
Onchocerca volvulus 0.0016 0.0084 1
Onchocerca volvulus 0.0016 0.0084 1
Onchocerca volvulus Basement membrane proteoglycan homolog 0.0015 0.0066 0.5889
Trypanosoma brucei lysyl-tRNA synthetase, putative 0.0025 0.0283 0.395
Plasmodium falciparum lysine--tRNA ligase 0.0025 0.0283 0.0201
Echinococcus granulosus acetylcholine receptor subunit beta 1 0.0014 0.0041 0.0177
Entamoeba histolytica protein kinase, putative 0.0034 0.0484 1
Schistosoma mansoni sugar transporter 0.0016 0.0084 0.0377
Mycobacterium leprae Probable prolyl tRNA synthetase ProS 0.0033 0.0469 1
Toxoplasma gondii lysine-tRNA ligase 0.0025 0.0283 0.0308
Echinococcus granulosus twitchin 0.0053 0.0895 0.4138
Schistosoma mansoni glucose transport protein 0.0111 0.216 1
Echinococcus granulosus nicotinic acetylcholine receptor subunit alpha 8 0.0014 0.0041 0.0177
Echinococcus granulosus defective proboscis extension response 0.0048 0.0786 0.3629
Onchocerca volvulus 0.0016 0.0084 1
Loa Loa (eye worm) hypothetical protein 0.0048 0.0786 0.3629
Toxoplasma gondii calcium-dependent protein kinase CDPK3 0.0034 0.0484 0.0617
Loa Loa (eye worm) ACC-1 protein 0.0014 0.0041 0.0177
Brugia malayi hypothetical protein 0.0016 0.0084 0.0377
Loa Loa (eye worm) hypothetical protein 0.0016 0.0084 0.0377
Brugia malayi hypothetical protein 0.0048 0.0786 0.3629
Echinococcus multilocularis tyrosine protein kinase otk 0.0015 0.0066 0.0295
Echinococcus granulosus roundabout 2 0.0015 0.0066 0.0295
Brugia malayi Cation transporter family protein 0.0014 0.0041 0.0177
Onchocerca volvulus 0.0016 0.0084 1
Toxoplasma gondii calcium-dependent protein kinase CDPK2B 0.0034 0.0484 0.0617
Brugia malayi Immunoglobulin I-set domain containing protein 0.0015 0.0066 0.0295
Echinococcus multilocularis lachesin 0.0015 0.0066 0.0295
Loa Loa (eye worm) hypothetical protein 0.0016 0.0084 0.0377
Brugia malayi Immunoglobulin I-set domain containing protein 0.0015 0.0066 0.0295
Schistosoma mansoni septate junction protein 0.0015 0.0066 0.0295
Loa Loa (eye worm) hypothetical protein 0.0048 0.0786 0.3629
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0014 0.0041 0.0177
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0014 0.0041 0.0177
Echinococcus granulosus glutamyl tRNA synthetase cytoplasmic 0.0033 0.0469 0.2162
Trypanosoma brucei THT1 - hexose transporter, putative 0.0034 0.0493 0.8107
Trichomonas vaginalis prolyl-tRNA synthetase, putative 0.0033 0.0469 0.1855
Echinococcus multilocularis nicotinic acetylcholine receptor alpha subunit 0.0014 0.0041 0.0177
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0014 0.0041 0.0177
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0015 0.0066 0.0295
Echinococcus granulosus solute carrier family 22 0.0016 0.0084 0.0377
Trypanosoma brucei glucose transporter, putative 0.0034 0.0493 0.8107
Entamoeba histolytica prolyl-tRNA synthetase, putative 0.0033 0.0469 0.9253
Leishmania major protein kinase, putative 0.0034 0.0484 0.7919
Trypanosoma brucei glucose transporter, putative 0.0034 0.0493 0.8107
Loa Loa (eye worm) hypothetical protein 0.0016 0.0084 0.0377
Plasmodium falciparum calcium-dependent protein kinase 4 0.0034 0.0484 0.0404
Echinococcus multilocularis contactin neuroglian septate junction protein 0.0015 0.0066 0.0295
Brugia malayi acetylcholine receptor protein, alpha-like chain, putative 0.0014 0.0041 0.0177
Plasmodium falciparum calcium-dependent protein kinase 2 0.0034 0.0484 0.0404
Echinococcus multilocularis glycine receptor subunit beta 0.0014 0.0041 0.0177
Loa Loa (eye worm) major facilitator superfamily transporter 0.0016 0.0084 0.0377
Onchocerca volvulus Putative transporter 0.0016 0.0084 1
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0025 0.0283 1
Schistosoma mansoni sugar transporter 0.0016 0.0084 0.0377
Loa Loa (eye worm) hypothetical protein 0.0027 0.0333 0.1532
Mycobacterium leprae Possible lysyl-tRNA synthetase 2 LysX 0.0025 0.0283 0.3046
Loa Loa (eye worm) hypothetical protein 0.0016 0.0084 0.0377
Schistosoma mansoni protein kinase 0.0034 0.0484 0.2231
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0111 0.216 1
Schistosoma mansoni serine/threonine protein kinase 0.0034 0.0484 0.2231
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0014 0.0041 0.0177
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0039 0.0589 1
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0015 0.0066 0.0295
Loa Loa (eye worm) hypothetical protein 0.0025 0.0283 0.1302
Schistosoma mansoni nAChR subunit 0.0014 0.0041 0.0177
Brugia malayi gamma-aminobutyric-acid receptor beta subunit precursor 0.0014 0.0041 0.0177
Brugia malayi Peroxidasin 0.0015 0.0066 0.0295
Schistosoma mansoni nephrin 0.0051 0.0849 0.3924
Mycobacterium tuberculosis Lysyl-tRNA synthetase 2 LysX 0.0021 0.0202 1
Echinococcus multilocularis solute carrier family 22 0.0016 0.0084 0.0377
Mycobacterium ulcerans sugar transporter 0.0016 0.0084 0.2954
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0014 0.0041 0.0177
Trichomonas vaginalis sugar transporter, putative 0.0034 0.0493 0.1973
Schistosoma mansoni titin 0.0015 0.0066 0.0295
Plasmodium vivax lysine--tRNA ligase, putative 0.0025 0.0283 0.0201
Schistosoma mansoni lysyl-tRNA synthetase 0.0025 0.0283 0.1302
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0014 0.0041 0.0177
Loa Loa (eye worm) TK protein kinase 0.0104 0.2012 0.9312
Onchocerca volvulus 0.0016 0.0084 1
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0111 0.216 1
Echinococcus granulosus fibroblast growth factor receptor 4 0.0101 0.1948 0.9017
Toxoplasma gondii cell-cycle-associated protein kinase MAPK, putative 0.0179 0.3649 0.5495
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0493 0.1973
Schistosoma mansoni nAChR subunit (ShAR1-beta-like) 0.0014 0.0041 0.0177
Trypanosoma brucei glucose transporter, putative 0.0034 0.0493 0.8107
Schistosoma mansoni cell adhesion molecule 0.0015 0.0066 0.0295
Echinococcus multilocularis synaptic vesicle 2 protein 0.0016 0.0084 0.0377
Echinococcus multilocularis neuronal acetylcholine receptor subunit alpha 4 0.0014 0.0041 0.0177
Echinococcus multilocularis calcium dependent protein kinase 0.0032 0.0438 0.2019
Echinococcus multilocularis nicotinic acetylcholine receptor beta 1 subunit 0.0014 0.0041 0.0177
Plasmodium vivax hexose transporter 0.0111 0.216 0.2094
Loa Loa (eye worm) hypothetical protein 0.0016 0.0084 0.0377
Echinococcus multilocularis acetylcholine receptor subunit beta 1 0.0014 0.0041 0.0177
Brugia malayi excitatory GABA receptor EXP-1A 0.0014 0.0041 0.0177
Loa Loa (eye worm) hypothetical protein 0.0014 0.0041 0.0177
Brugia malayi hypothetical protein 0.0016 0.0084 0.0377
Trypanosoma cruzi hexose transporter, putative 0.0034 0.0493 0.8107
Trypanosoma cruzi lysyl-tRNA synthetase, putative 0.0025 0.0283 0.395
Schistosoma mansoni nAChR subunit 0.0014 0.0041 0.0177
Loa Loa (eye worm) hypothetical protein 0.0016 0.0084 0.0377
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0034 0.0484 0.0404
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0014 0.0041 0.0177
Echinococcus multilocularis receptor type tyrosine protein phosphatase F 0.0015 0.0066 0.0295
Brugia malayi hypothetical protein 0.0016 0.0084 0.0377
Echinococcus granulosus nicotinic acetylcholine receptor subunit type 0.0014 0.0041 0.0177
Entamoeba histolytica protein kinase, putative 0.0034 0.0484 1
Schistosoma mansoni nAChR subunit (ShAR1-beta2-like) 0.0014 0.0041 0.0177
Echinococcus granulosus nicotinic acetylcholine receptor beta 1 subunit 0.0014 0.0041 0.0177
Loa Loa (eye worm) hypothetical protein 0.0014 0.0041 0.0177
Plasmodium falciparum protein kinase 7 0.0313 0.6571 0.6542
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0034 0.0484 0.2231
Loa Loa (eye worm) hypothetical protein 0.0014 0.0041 0.0177
Echinococcus granulosus roundabout 2 0.0062 0.1108 0.5122
Brugia malayi Bifunctional aminoacyl-tRNA synthetase 0.0033 0.0469 0.2162
Brugia malayi Immunoglobulin I-set domain containing protein 0.0015 0.0066 0.0295
Onchocerca volvulus 0.0016 0.0084 1
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0015 0.0066 0.0295
Echinococcus multilocularis nicotinic acetylcholine receptor subunit alpha 8 0.0014 0.0041 0.0177
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0015 0.0066 0.0295
Brugia malayi Major Facilitator Superfamily protein 0.0016 0.0084 0.0377
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0493 0.1973
Plasmodium falciparum hexose transporter 0.0111 0.216 0.2094
Loa Loa (eye worm) hypothetical protein 0.0014 0.0041 0.0177
Echinococcus granulosus contactin 0.0015 0.0066 0.0295
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0025 0.0283 1
Loa Loa (eye worm) hypothetical protein 0.0014 0.0041 0.0177
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0014 0.0041 0.0177
Plasmodium falciparum mitogen-activated protein kinase 2 0.0179 0.3649 0.3595
Onchocerca volvulus 0.0016 0.0084 1
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0034 0.0484 0.2231
Echinococcus granulosus Immunoglobulin 0.0048 0.0786 0.3629
Echinococcus granulosus neurotracting:lsamp:neurotrimin:obcam 0.006 0.1044 0.4827
Brugia malayi bifunctional aminoacyl-tRNA synthetase 0.0033 0.0469 0.2162
Brugia malayi Immunoglobulin I-set domain containing protein 0.0015 0.0066 0.0295
Trichomonas vaginalis sugar transporter, putative 0.0034 0.0493 0.1973
Loa Loa (eye worm) excitatory GABA receptor EXP-1A 0.0014 0.0041 0.0177
Schistosoma mansoni tyrosine kinase 0.0019 0.0161 0.0733
Loa Loa (eye worm) hypothetical protein 0.0034 0.0484 0.2231
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0014 0.0041 0.0177
Echinococcus multilocularis peroxidasin 0.0015 0.0066 0.0295
Echinococcus granulosus hemicentin 1 0.0015 0.0066 0.0295
Echinococcus granulosus General substrate transporter 0.0095 0.1821 0.8426
Brugia malayi nicotinic acetylcholine receptor alpha subunit, putative 0.0014 0.0041 0.0177
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0022 0.0217 0.0641
Loa Loa (eye worm) hypothetical protein 0.0016 0.0084 0.0377
Echinococcus granulosus lysyl tRNA synthetase 0.0025 0.0283 0.1302
Schistosoma mansoni defective proboscis extension response (dpr)-related 0.0048 0.0786 0.3629
Loa Loa (eye worm) hypothetical protein 0.0062 0.1108 0.5122
Loa Loa (eye worm) hypothetical protein 0.0015 0.0066 0.0295
Loa Loa (eye worm) hypothetical protein 0.0062 0.1108 0.5122
Leishmania major glucose transporter, lmgt1 0.0034 0.0493 0.8107
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0014 0.0041 0.0177
Trypanosoma brucei calcium/calmodulin-dependent protein kinase, putative 0.0034 0.0484 0.7919
Trypanosoma cruzi hexose transporter, putative 0.0034 0.0493 0.8107
Loa Loa (eye worm) LGC-31 protein 0.0014 0.0041 0.0177
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0034 0.0484 0.2231
Trypanosoma cruzi hexose transporter 0.0034 0.0493 0.8107
Treponema pallidum prolyl-tRNA synthetase 0.0012 0 0.5
Schistosoma mansoni cell adhesion molecule 0.0015 0.0066 0.0295
Echinococcus granulosus tyrosine protein kinase otk 0.0015 0.0066 0.0295
Brugia malayi nicotinic acetylcholine receptor beta-1 chain precursor 0.0014 0.0041 0.0177
Echinococcus granulosus lachesin 0.0015 0.0066 0.0295
Onchocerca volvulus 0.0016 0.0084 1
Schistosoma mansoni septate junction protein 0.0015 0.0066 0.0295
Loa Loa (eye worm) hypothetical protein 0.0014 0.0041 0.0177
Loa Loa (eye worm) hypothetical protein 0.0014 0.0041 0.0177
Schistosoma mansoni glucose transport protein 0.0111 0.216 1
Brugia malayi Immunoglobulin I-set domain containing protein 0.0104 0.2012 0.9312
Loa Loa (eye worm) hypothetical protein 0.0048 0.0786 0.3629
Onchocerca volvulus 0.0016 0.0084 1
Brugia malayi major facilitator superfamily protein 0.0016 0.0084 0.0377
Mycobacterium ulcerans sugar-transport integral membrane protein SugI 0.0016 0.0084 0.2954
Echinococcus multilocularis fibroblast growth factor receptor 4 0.0101 0.1948 0.9017
Plasmodium vivax CDK-related protein kinase 6, putative 0.047 1 1
Loa Loa (eye worm) hypothetical protein 0.0016 0.0084 0.0377
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0015 0.0066 0.0295
Loa Loa (eye worm) sugar transporter 0.0111 0.216 1
Echinococcus multilocularis roundabout 2 0.0015 0.0066 0.0295
Echinococcus granulosus solute carrier family 22 0.0016 0.0084 0.0377
Schistosoma mansoni nuclear transcription factor X-box binding 1 (nfx1) 0.0016 0.0084 0.0377
Schistosoma mansoni nAChR subunit 0.0014 0.0041 0.0177
Loa Loa (eye worm) hypothetical protein 0.0016 0.0084 0.0377
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0014 0.0041 0.0177
Schistosoma mansoni glucose transport protein 0.0111 0.216 1
Echinococcus granulosus neuronal acetylcholine receptor subunit alpha 4 0.0014 0.0041 0.0177
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0034 0.0484 0.2231
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0015 0.0066 0.0295
Trichomonas vaginalis sugar transporter, putative 0.0034 0.0493 0.1973
Echinococcus multilocularis basement membrane specific heparan sulfate 0.0048 0.0786 0.3629
Echinococcus granulosus glycine receptor subunit alpha 1 0.0014 0.0041 0.0177
Brugia malayi Prion-like- 0.0015 0.0066 0.0295
Echinococcus multilocularis lysyl tRNA synthetase 0.0025 0.0283 0.1302
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0014 0.0041 0.0177
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID 0.0034 0.0484 0.2231
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0014 0.0041 0.0177
Loa Loa (eye worm) hypothetical protein 0.0033 0.0469 0.2162
Loa Loa (eye worm) hypothetical protein 0.0014 0.0041 0.0177
Plasmodium vivax mitogen-activated protein kinase 2, putative 0.0179 0.3649 0.3595
Echinococcus granulosus solute carrier family 22 0.0016 0.0084 0.0377
Schistosoma mansoni lysyl-tRNA synthetase 0.0025 0.0283 0.1302
Brugia malayi lysyl-tRNA synthetase 0.0025 0.0283 0.1302
Schistosoma mansoni nAChR subunit 0.0014 0.0041 0.0177
Onchocerca volvulus 0.0016 0.0084 1
Brugia malayi Major Facilitator Superfamily protein 0.0016 0.0084 0.0377
Loa Loa (eye worm) nicotinic acetylcholine receptor alpha subunit 0.0014 0.0041 0.0177
Loa Loa (eye worm) hypothetical protein 0.0014 0.0041 0.0177
Echinococcus granulosus nAChR subunit 0.0014 0.0041 0.0177
Echinococcus multilocularis solute carrier family 22 0.0016 0.0084 0.0377
Schistosoma mansoni tyrosine kinase 0.0101 0.1948 0.9017
Giardia lamblia Prolyl-tRNA synthetase 0.0033 0.0469 1
Echinococcus granulosus peroxidasin 0.0015 0.0066 0.0295
Echinococcus multilocularis basic fibroblast growth factor receptor 1 A 0.0101 0.1948 0.9017
Loa Loa (eye worm) sugar transporter 0.0016 0.0084 0.0377
Wolbachia endosymbiont of Brugia malayi major facilitator superfamily permease 0.0016 0.0084 0.5
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0034 0.0484 0.2231
Loa Loa (eye worm) hypothetical protein 0.0014 0.0041 0.0177
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0034 0.0484 0.2231
Mycobacterium tuberculosis Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.0021 0.0202 1
Onchocerca volvulus 0.0016 0.0084 1
Schistosoma mansoni nephrin 0.0015 0.0066 0.0295
Brugia malayi Immunoglobulin I-set domain containing protein 0.0015 0.0066 0.0295
Brugia malayi Immunoglobulin I-set domain containing protein 0.0015 0.0066 0.0295
Echinococcus multilocularis solute carrier family 22 0.0016 0.0084 0.0377
Brugia malayi Cam kinase protein 1 0.0034 0.0484 0.2231
Trypanosoma brucei glucose transporter, putative 0.0034 0.0493 0.8107
Trypanosoma brucei glucose transporter, putative 0.0034 0.0493 0.8107
Loa Loa (eye worm) hypothetical protein 0.0016 0.0084 0.0377
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 0.0034 0.0484 0.2231
Loa Loa (eye worm) CAMK/MLCK protein kinase 0.0017 0.0112 0.0509
Onchocerca volvulus 0.0016 0.0084 1
Echinococcus granulosus synaptic vesicle 2 protein 0.0016 0.0084 0.0377
Plasmodium vivax calcium-dependent protein kinase 1, putative 0.0034 0.0484 0.0404
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0039 0.0589 1
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0034 0.0484 0.2231
Trypanosoma brucei glucose transporter 2A 0.0034 0.0493 0.8107
Loa Loa (eye worm) hypothetical protein 0.0015 0.0066 0.0295
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0033 0.0469 0.2162
Loa Loa (eye worm) hypothetical protein 0.0014 0.0041 0.0177
Loa Loa (eye worm) hypothetical protein 0.0014 0.0041 0.0177
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0014 0.0041 0.0177
Loa Loa (eye worm) hypothetical protein 0.0014 0.0041 0.0177
Brugia malayi Sugar transporter family protein 0.0016 0.0084 0.0377
Mycobacterium ulcerans fusion protein of transposase for IS2606 and sialic acid-transport integral membrane protein NanT 0.0016 0.0084 0.2954
Trypanosoma brucei THT1 - hexose transporter, putative 0.0034 0.0493 0.8107
Echinococcus granulosus calcium dependent protein kinase 0.0032 0.0438 0.2019
Loa Loa (eye worm) hypothetical protein 0.0048 0.0786 0.3629
Loa Loa (eye worm) hypothetical protein 0.0016 0.0084 0.0377
Echinococcus granulosus glycine receptor subunit alpha 1 0.0014 0.0041 0.0177
Mycobacterium ulcerans integral membrane transport protein 0.0016 0.0084 0.2954
Echinococcus granulosus roundabout 2 0.0015 0.0066 0.0295
Brugia malayi Immunoglobulin I-set domain containing protein 0.0015 0.0066 0.0295
Schistosoma mansoni Neurotrimin precursor (hNT) 0.0048 0.0786 0.3629
Trypanosoma cruzi hexose transporter, putative 0.0019 0.0154 0.1383
Schistosoma mansoni vesicular amine transporter 0.0048 0.0786 0.3629

Activities

Activity type Activity value Assay description Source Reference
Ki (binding) = 2.89 Inhibitory activity against horse liver alcohol dehydrogenase (ADH) ChEMBL. 2939242
Log 1/Ki (binding) = 2.89 Inhibitory activity against horse liver alcohol dehydrogenase (ADH) ChEMBL. 2939242
logP (ADMET) = -0.51 Partition coefficient (logP) ChEMBL. 2939242

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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