Detailed information for compound 272431

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 452.93 | Formula: C25H25ClN2O4
  • H donors: 2 H acceptors: 2 LogP: 5.67 Rotable bonds: 9
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1cc(/C=N/NC(=O)c2ccc(c(c2)Cl)O)ccc1OCc1ccc(cc1)C(C)C
  • InChi: 1S/C25H25ClN2O4/c1-16(2)19-7-4-17(5-8-19)15-32-23-11-6-18(12-24(23)31-3)14-27-28-25(30)20-9-10-22(29)21(26)13-20/h4-14,16,29H,15H2,1-3H3,(H,28,30)/b27-14+
  • InChiKey: POMDFIAGRWBFAV-MZJWZYIUSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens glucagon receptor Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Loa Loa (eye worm) pigment dispersing factor receptor c glucagon receptor 477 aa 457 aa 25.4 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi Muscleblind-like protein 0.0145 0.1513 0.1498
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0911 1 1
Echinococcus granulosus cpg binding protein 0.0029 0.0237 0.0237
Schistosoma mansoni hypothetical protein 0.0034 0.0292 0.0292
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0029 0.0238 0.0238
Brugia malayi nuclear receptor NHR-67 0.043 0.4671 0.4661
Loa Loa (eye worm) hypothetical protein 0.0145 0.1513 0.1497
Echinococcus granulosus geminin 0.0164 0.1728 0.1728
Schistosoma mansoni hypothetical protein 0.0034 0.0292 0.0292
Toxoplasma gondii histone lysine methyltransferase SET1 0.0054 0.0507 0.0802
Brugia malayi nuclear hormone receptor 0.0911 1 1
Loa Loa (eye worm) hypothetical protein 0.043 0.4671 0.4661
Schistosoma mansoni hypothetical protein 0.0034 0.0292 0.0292
Echinococcus granulosus Nuclear hormone receptor HR96 0.043 0.4671 0.4671
Brugia malayi nuclear receptor NHR-88 0.043 0.4671 0.4661
Loa Loa (eye worm) hypothetical protein 0.0481 0.5241 0.5232
Echinococcus multilocularis FTZ F1 alpha 0.0911 1 1
Schistosoma mansoni nuclear receptor 0.043 0.4671 0.4671
Echinococcus granulosus Nuclear hormone receptor HR96 0.043 0.4671 0.4671
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0911 1 1
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0911 1 1
Schistosoma mansoni retinoic acid receptor RXR 0.0911 1 1
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0911 1 1
Toxoplasma gondii glutamine synthetase, type I, putative 0.0494 0.5389 1
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0481 0.5241 0.5241
Brugia malayi Nuclear hormone receptor E75 0.043 0.4671 0.4661
Loa Loa (eye worm) hypothetical protein 0.0911 1 1
Loa Loa (eye worm) hypothetical protein 0.0911 1 1
Schistosoma mansoni nuclear receptor 0.043 0.4671 0.4671
Echinococcus multilocularis ecdysone induced protein 78C 0.0911 1 1
Echinococcus multilocularis GPCR, family 2 0.0034 0.0292 0.0292
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0481 0.5241 0.5241
Entamoeba histolytica glutamine synthetase, putative 0.0194 0.2061 1
Brugia malayi Pre-SET motif family protein 0.0202 0.2149 0.2135
Echinococcus granulosus glutamine synthetase 0.0769 0.8428 0.8428
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.022 0.0201
Echinococcus multilocularis glutamine synthetase 0.0769 0.8428 0.8428
Schistosoma mansoni coup transcription factor 0.0911 1 1
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0028 0.022 0.022
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0911 1 1
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0911 1 1
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0911 1 1
Schistosoma mansoni nuclear receptor nhr-48 0.043 0.4671 0.4671
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0784 0.8602 0.8602
Loa Loa (eye worm) hypothetical protein 0.0145 0.1513 0.1497
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0015 0.0081 0.0081
Schistosoma mansoni hypothetical protein 0.0034 0.0292 0.0292
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0911 1 1
Trichomonas vaginalis glutamine synthetase, putative 0.0194 0.2061 0.8175
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0911 1 1
Brugia malayi nuclear hormone receptor 0.043 0.4671 0.4661
Brugia malayi conserved hypotetical protein 0.043 0.4671 0.4661
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0481 0.5241 0.5241
Brugia malayi hypothetical protein 0.043 0.4671 0.4661
Echinococcus multilocularis isocitrate dehydrogenase 0.0015 0.0081 0.0081
Echinococcus granulosus histone lysine methyltransferase setb 0.0029 0.0238 0.0238
Schistosoma mansoni transcription factor btf3 0.0034 0.0286 0.0286
Onchocerca volvulus Protein ultraspiracle homolog 0.0911 1 1
Entamoeba histolytica glutamine synthetase, putative 0.0194 0.2061 1
Plasmodium falciparum glutamine synthetase, putative 0.0494 0.5389 1
Schistosoma mansoni cpg binding protein 0.0029 0.0237 0.0237
Echinococcus multilocularis dnaJ subfamily B 0.0396 0.4295 0.4295
Schistosoma mansoni cpg binding protein 0.0029 0.0237 0.0237
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0911 1 1
Schistosoma mansoni nuclear hormone receptor 0.043 0.4671 0.4671
Trichomonas vaginalis glutamine synthetase-bacteria, putative 0.0194 0.2061 0.8175
Plasmodium vivax basic transcription factor 3b, putative 0.0034 0.0286 0.0387
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0015 0.0081 0.0081
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.043 0.4671 0.4671
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.001 0.0019 0.0019
Loa Loa (eye worm) latrophilin receptor protein 2 0.0034 0.0292 0.0274
Mycobacterium leprae PROBABLE GLUTAMINE SYNTHETASE GLNA2 (GLUTAMINE SYNTHASE) (GS-II) 0.0494 0.5389 0.5
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0911 1 1
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0911 1 1
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.043 0.4671 0.4551
Echinococcus multilocularis geminin 0.0164 0.1728 0.1728
Schistosoma mansoni nuclear hormone receptor 0.043 0.4671 0.4671
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0911 1 1
Loa Loa (eye worm) hypothetical protein 0.0911 1 1
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0481 0.5241 0.5241
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0911 1 1
Loa Loa (eye worm) ICD-1 protein 0.0034 0.0286 0.0268
Loa Loa (eye worm) hypothetical protein 0.043 0.4671 0.4661
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0911 1 1
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0015 0.0081 0.0081
Loa Loa (eye worm) hypothetical protein 0.0074 0.0733 0.0715
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.043 0.4671 0.4551
Wolbachia endosymbiont of Brugia malayi glutamine synthetase 0.0194 0.2061 0.5
Schistosoma mansoni steroid hormone receptor ad4bp 0.0911 1 1
Echinococcus multilocularis neuropeptide s receptor 0.0447 0.4867 0.4867
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0034 0.0292 0.0292
Loa Loa (eye worm) hypothetical protein 0.043 0.4671 0.4661
Loa Loa (eye worm) hypothetical protein 0.043 0.4671 0.4661
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0911 1 1
Schistosoma mansoni hypothetical protein 0.0074 0.0733 0.0733
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0238 0.0238
Toxoplasma gondii NAC domain-containing protein 0.0034 0.0286 0.0387
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0911 1 1
Schistosoma mansoni nuclear hormone receptor 0.0911 1 1
Onchocerca volvulus 0.043 0.4671 0.4551
Echinococcus granulosus neuropeptide s receptor 0.0447 0.4867 0.4867
Loa Loa (eye worm) DR-78 0.043 0.4671 0.4661
Brugia malayi isocitrate dehydrogenase 0.0015 0.0081 0.0064
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0911 1 1
Echinococcus multilocularis transcription factor btf3 0.0034 0.0286 0.0286
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.043 0.4671 0.4671
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.043 0.4671 0.4671
Loa Loa (eye worm) hypothetical protein 0.043 0.4671 0.4661
Plasmodium vivax SET domain protein, putative 0.0029 0.0238 0.0296
Brugia malayi Isocitrate dehydrogenase 0.0015 0.0081 0.0064
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0238 0.0238
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0911 1 1
Brugia malayi ecdysone receptor 0.043 0.4671 0.4661
Loa Loa (eye worm) hypothetical protein 0.043 0.4671 0.4661
Brugia malayi Calcitonin receptor-like protein seb-1 0.0108 0.1113 0.1097
Echinococcus granulosus muscleblind protein 0.0145 0.1513 0.1513
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0911 1 1
Echinococcus multilocularis nuclear receptor nhr 48 0.043 0.4671 0.4671
Brugia malayi Nuclear hormone receptor E75 0.043 0.4671 0.4661
Loa Loa (eye worm) hypothetical protein 0.043 0.4671 0.4661
Schistosoma mansoni glutamine synthetase 1 2 (glutamate-amonia ligase) (gs) 0.0769 0.8428 0.8428
Brugia malayi tailless protein 0.043 0.4671 0.4661
Trypanosoma cruzi transcription factor btf3, putative 0.0034 0.0286 0.0246
Brugia malayi Nuclear hormone receptor-like 1 0.0911 1 1
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0911 1 1
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0911 1 1
Brugia malayi Latrophilin receptor protein 2 0.0034 0.0292 0.0275
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0034 0.0292 0.0292
Echinococcus granulosus GPCR family 2 0.0034 0.0292 0.0292
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0911 1 1
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0911 1 1
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.043 0.4671 0.4671
Loa Loa (eye worm) nuclear hormone receptor 0.043 0.4671 0.4661
Loa Loa (eye worm) hypothetical protein 0.0034 0.0292 0.0274
Brugia malayi hypothetical protein 0.0481 0.5241 0.5233
Brugia malayi Nuclear hormone receptor-like 1 0.0481 0.5241 0.5233
Schistosoma mansoni mixed-lineage leukemia protein mll 0.006 0.0576 0.0576
Loa Loa (eye worm) hypothetical protein 0.0911 1 1
Brugia malayi nuclear hormone receptor family member odr-7 0.043 0.4671 0.4661
Onchocerca volvulus 0.023 0.2457 0.2288
Trichomonas vaginalis set domain proteins, putative 0.023 0.2457 1
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0911 1 1
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0481 0.5241 0.5232
Loa Loa (eye worm) nuclear receptor nhr-7B 0.043 0.4671 0.4661
Brugia malayi nuclear hormone receptor family member nhr-6 0.043 0.4671 0.4661
Loa Loa (eye worm) hypothetical protein 0.0481 0.5241 0.5232
Echinococcus multilocularis Nuclear hormone receptor HR96 0.043 0.4671 0.4671
Brugia malayi glutamine synthetase 0.0274 0.2951 0.2938
Brugia malayi Nuclear hormone receptor-like 1 0.0481 0.5241 0.5233
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0911 1 1
Leishmania major basic transcription factor 3a, putative 0.0034 0.0286 0.0246
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0911 1 1
Echinococcus multilocularis Nuclear hormone receptor HR96 0.043 0.4671 0.4671
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0911 1 1
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0911 1 1
Loa Loa (eye worm) steroid hormone receptor 0.0911 1 1
Schistosoma mansoni thyroid hormone receptor 0.0911 1 1
Schistosoma mansoni cpg binding protein 0.0028 0.022 0.022
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0911 1 1
Loa Loa (eye worm) hypothetical protein 0.0911 1 1
Echinococcus granulosus transcription factor btf3 0.0034 0.0286 0.0286
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0029 0.0238 0.0238
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0911 1 1
Trypanosoma brucei transcription factor BTF3, putative 0.0034 0.0286 0.0246
Schistosoma mansoni RAR-like nuclear receptor 0.0911 1 1
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0911 1 1
Schistosoma mansoni zinc finger protein 0.043 0.4671 0.4671
Brugia malayi nuclear receptor NHR-88 0.0911 1 1
Echinococcus granulosus dnaJ subfamily B 0.0396 0.4295 0.4295
Brugia malayi orphan nuclear receptor NR2E1 0.043 0.4671 0.4661
Brugia malayi Pre-SET motif family protein 0.0029 0.0238 0.0221
Loa Loa (eye worm) hypothetical protein 0.0481 0.5241 0.5232
Loa Loa (eye worm) hypothetical protein 0.0911 1 1
Echinococcus granulosus nuclear receptor nhr 48 0.043 0.4671 0.4671
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0034 0.0292 0.0292
Schistosoma mansoni glutamine synthetase bacteria 0.0194 0.2061 0.2061
Mycobacterium ulcerans glutamine synthetase GlnA1 0.0494 0.5389 1
Schistosoma mansoni thyroid hormone receptor 0.0911 1 1
Trypanosoma cruzi transcription factor btf3, putative 0.0034 0.0286 0.0246
Loa Loa (eye worm) hypothetical protein 0.0481 0.5241 0.5232
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0108 0.1113 0.1096
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0034 0.0292 0.0275
Loa Loa (eye worm) hypothetical protein 0.043 0.4671 0.4661
Loa Loa (eye worm) hypothetical protein 0.043 0.4671 0.4661
Loa Loa (eye worm) hypothetical protein 0.043 0.4671 0.4661
Echinococcus granulosus neuropeptide receptor A26 0.0447 0.4867 0.4867
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.043 0.4671 0.4671
Onchocerca volvulus Bile acid receptor homolog 0.0911 1 1
Schistosoma mansoni hypothetical protein 0.0396 0.4295 0.4295
Loa Loa (eye worm) isocitrate dehydrogenase 0.0015 0.0081 0.0062
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0202 0.2149 0.2134
Mycobacterium ulcerans glutamine synthetase 0.0494 0.5389 1
Echinococcus multilocularis muscleblind protein 0.0145 0.1513 0.1513
Echinococcus multilocularis neuropeptide receptor A26 0.0447 0.4867 0.4867
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0034 0.0292 0.0292
Brugia malayi hypothetical protein 0.043 0.4671 0.4661
Brugia malayi CXXC zinc finger family protein 0.0028 0.022 0.0202
Echinococcus granulosus thyroid hormone receptor alpha 0.043 0.4671 0.4671
Schistosoma mansoni hypothetical protein 0.0164 0.1728 0.1728
Brugia malayi Steroid receptor seven-up type 2 0.0911 1 1
Echinococcus multilocularis muscleblind protein 1 0.0145 0.1513 0.1513
Onchocerca volvulus 0.043 0.4671 0.4551
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.043 0.4671 0.4661
Loa Loa (eye worm) hypothetical protein 0.0108 0.1113 0.1096
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0911 1 1
Onchocerca volvulus 0.0911 1 1
Brugia malayi nuclear receptor RXR 0.043 0.4671 0.4661
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0911 1 1
Brugia malayi hypothetical protein 0.0481 0.5241 0.5233
Echinococcus granulosus ecdysone induced protein 78C 0.0911 1 1
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.001 0.0019 0.0019
Loa Loa (eye worm) hypothetical protein 0.0029 0.0238 0.022
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0238 0.0238
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0029 0.0238 0.0238
Mycobacterium tuberculosis Probable glutamine synthetase GlnA2 (glutamine synthase) (GS-II) 0.0494 0.5389 1
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0911 1 1
Echinococcus granulosus FTZ F1 alpha 0.0911 1 1
Onchocerca volvulus Glutamine synthetase homolog 0.0494 0.5389 0.5286
Brugia malayi latrophilin 2 splice variant baaae 0.0074 0.0733 0.0717
Loa Loa (eye worm) hypothetical protein 0.043 0.4671 0.4661
Brugia malayi nuclear receptor RXR 0.0481 0.5241 0.5233
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0029 0.0238 0.0296
Loa Loa (eye worm) hypothetical protein 0.0911 1 1
Loa Loa (eye worm) nuclear receptor NHR-67 0.043 0.4671 0.4661
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0015 0.0081 0.0081
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0911 1 1
Mycobacterium tuberculosis Probable glutamine synthetase GlnA3 (glutamine synthase) (GS-I) 0.0194 0.2061 0.373
Echinococcus multilocularis cpg binding protein 0.0029 0.0237 0.0237
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0015 0.0081 0.0081
Schistosoma mansoni glutamine synthetase bacteria 0.0194 0.2061 0.2061
Schistosoma mansoni hypothetical protein 0.0164 0.1728 0.1728
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.043 0.4671 0.4671
Plasmodium vivax glutamine synthetase, putative 0.0494 0.5389 1
Brugia malayi beta-NAC-like protein 0.0034 0.0286 0.0269
Brugia malayi steroid hormone receptor 0.0911 1 1
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0911 1 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0911 1 1
Loa Loa (eye worm) hypothetical protein 0.043 0.4671 0.4661
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0015 0.0081 0.0081
Leishmania major glutamine synthetase, putative 0.0769 0.8428 1
Brugia malayi photoreceptor-specific nuclear receptor 0.0911 1 1
Trypanosoma brucei glutamine synthetase, putative 0.0769 0.8428 1
Plasmodium falciparum basic transcription factor 3b, putative 0.0034 0.0286 0.0387
Onchocerca volvulus 0.0029 0.0238 0.0019
Echinococcus granulosus nuclear receptor 2DBD gamma 0.043 0.4671 0.4671
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0108 0.1113 0.1097
Loa Loa (eye worm) hypothetical protein 0.0911 1 1
Trypanosoma cruzi glutamine synthetase, putative 0.0769 0.8428 1
Trypanosoma cruzi glutamine synthetase, putative 0.0769 0.8428 1
Loa Loa (eye worm) hypothetical protein 0.0481 0.5241 0.5232
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0911 1 1
Loa Loa (eye worm) Gln-2 protein 0.0494 0.5389 0.538
Loa Loa (eye worm) hypothetical protein 0.043 0.4671 0.4661
Echinococcus multilocularis thyroid hormone receptor alpha 0.0911 1 1
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0911 1 1

Activities

Activity type Activity value Assay description Source Reference
Activity (binding) Displacement of [125I]PACAP27 from PAC1R (unknown origin) expressed in HEK293f cells ChEMBL. 18272364
Activity (binding) 0 Displacement of [125I]PACAP27 from PAC1R (unknown origin) expressed in HEK293f cells ChEMBL. 18272364
IC50 (binding) = 1.3 uM In vitro inhibitory activity against human glucagon receptor using [127I]-labeled glucagon ChEMBL. 11844695
IC50 (binding) = 1.3 uM In vitro inhibitory activity against human glucagon receptor using [127I]-labeled glucagon ChEMBL. 11844695

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

2 literature references were collected for this gene.

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