Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Staphylococcus aureus subsp. aureus MW2 | Methionyl-tRNA synthetase | Starlite/ChEMBL | References |
Escherichia coli | methionyl-tRNA synthetase | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Dictyostelium discoideum | methionine-tRNA ligase | Methionyl-tRNA synthetase | 657 aa | 698 aa | 25.6 % |
Onchocerca volvulus | Methionyl-tRNA synthetase | 657 aa | 662 aa | 23.4 % | |
Echinococcus granulosus | methionyl tRNA synthetase cytoplasmic | Methionyl-tRNA synthetase | 657 aa | 560 aa | 25.2 % |
Echinococcus multilocularis | methionyl tRNA synthetase, cytoplasmic | Methionyl-tRNA synthetase | 657 aa | 561 aa | 25.1 % |
Entamoeba histolytica | methionyl-tRNA synthetase, putative | Methionyl-tRNA synthetase | 657 aa | 699 aa | 26.5 % |
Brugia malayi | methionyl-tRNA synthetase | Methionyl-tRNA synthetase | 657 aa | 665 aa | 22.6 % |
Treponema pallidum | methionyl-tRNA synthetase | Methionyl-tRNA synthetase | 657 aa | 755 aa | 25.4 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | methionine tRNA synthetase | 0.005 | 0.1633 | 0.2045 |
Treponema pallidum | methionyl-tRNA synthetase | 0.0149 | 1 | 1 |
Schistosoma mansoni | leucyl-tRNA synthetase | 0.0036 | 0.0475 | 0.0595 |
Schistosoma mansoni | methionine-tRNA synthetase | 0.005 | 0.1633 | 0.2045 |
Wolbachia endosymbiont of Brugia malayi | methionyl-tRNA synthetase | 0.005 | 0.1633 | 1 |
Mycobacterium ulcerans | leucyl-tRNA synthetase | 0.0036 | 0.0475 | 0.2911 |
Plasmodium vivax | methionine--tRNA ligase, putative | 0.005 | 0.1633 | 1 |
Echinococcus granulosus | methionyl tRNA synthetase cytoplasmic | 0.0126 | 0.7986 | 1 |
Loa Loa (eye worm) | multisynthetase complex auxiliary component p43 | 0.012 | 0.7511 | 1 |
Wolbachia endosymbiont of Brugia malayi | leucyl-tRNA synthetase | 0.0036 | 0.0475 | 0.2911 |
Chlamydia trachomatis | methionine--tRNA ligase | 0.0126 | 0.7986 | 1 |
Mycobacterium tuberculosis | Methionyl-tRNA synthetase MetS (MetRS) (methionine--tRNA ligase) | 0.005 | 0.1633 | 1 |
Leishmania major | methionyl-tRNA synthetase, putative | 0.005 | 0.1633 | 1 |
Echinococcus multilocularis | leucyl tRNA synthetase | 0.0036 | 0.0475 | 0.0595 |
Mycobacterium leprae | Probable methionyl-tRNA synthase MetS | 0.005 | 0.1633 | 0.5 |
Giardia lamblia | Methionyl-tRNA synthetase | 0.005 | 0.1633 | 1 |
Plasmodium falciparum | methionine--tRNA ligase | 0.005 | 0.1633 | 1 |
Trichomonas vaginalis | methionine-tRNA synthetase, putative | 0.005 | 0.1633 | 1 |
Toxoplasma gondii | methionyl-tRNA synthetase | 0.0081 | 0.4217 | 1 |
Mycobacterium ulcerans | methionyl-tRNA synthetase | 0.005 | 0.1633 | 1 |
Loa Loa (eye worm) | methionyl-tRNA synthetase | 0.005 | 0.1633 | 0.1645 |
Plasmodium vivax | hypothetical protein, conserved | 0.0036 | 0.0475 | 0.2911 |
Leishmania major | leucyl-tRNA synthetase, putative | 0.0036 | 0.0475 | 0.2911 |
Echinococcus multilocularis | methionine tRNA synthetase | 0.005 | 0.1633 | 0.2045 |
Trypanosoma brucei | methionyl-tRNA synthetase, putative | 0.005 | 0.1633 | 1 |
Schistosoma mansoni | methionine-tRNA synthetase | 0.0126 | 0.7986 | 1 |
Echinococcus multilocularis | methionyl tRNA synthetase, cytoplasmic | 0.0126 | 0.7986 | 1 |
Trypanosoma cruzi | methionyl-tRNA synthetase, putative | 0.005 | 0.1633 | 1 |
Entamoeba histolytica | methionyl-tRNA synthetase, putative | 0.0149 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0119 | 0.7415 | 0.9865 |
Chlamydia trachomatis | leucine--tRNA ligase | 0.0036 | 0.0475 | 0.0595 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | < 3 nM | Compound tested for inhibition of Staphylococcus aureus MRS(methionyl tRNA synthetase) in aminoacylation assay | ChEMBL. | 12639554 |
IC50 (binding) | < 3 nM | Inhibitory concentration against Staphylococcus aureus methionyl tRNA synthetase | ChEMBL. | 15225702 |
IC50 (binding) | < 3 nM | Compound tested for inhibition of Staphylococcus aureus MRS(methionyl tRNA synthetase) in aminoacylation assay | ChEMBL. | 12639554 |
IC50 (binding) | < 3 nM | Inhibitory concentration against Staphylococcus aureus methionyl tRNA synthetase | ChEMBL. | 15225702 |
MIC (functional) | < 0.06 ug ml-1 | In vitro Antibacterial activity of compound against Enterococcus faecalis 1 | ChEMBL. | 12639554 |
MIC (functional) | <= 0.06 ug ml-1 | Antibacterial activity against Enterococcus faecalis 1 | ChEMBL. | 15225702 |
MIC (functional) | = 0.25 ug ml-1 | In vitro Antibacterial activity of compound against Staphylococcus aureus Oxford | ChEMBL. | 12639554 |
MIC (functional) | = 0.25 ug ml-1 | Antibacterial activity against Staphylococcus aureus Oxford | ChEMBL. | 15225702 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
2 literature references were collected for this gene.