Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | cannabinoid receptor 1 (brain) | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium ulcerans | protoporphyrinogen oxidase | 0.0132 | 0.0325 | 0.0066 |
Giardia lamblia | Kinase, CMGC GSK | 0.0073 | 0 | 0.5 |
Mycobacterium leprae | probable 3-phosphoshikimate 1-carboxyvinyl transferase AroA (5-ENOLPYRUVYLSHIKIMATE-3-PHOSPHATE SYNTHASE) (EPSP SYNTHASE) (EPSPS | 0.0309 | 0.131 | 0.798 |
Plasmodium falciparum | conserved Plasmodium protein, unknown function | 0.0132 | 0.0325 | 0.09 |
Brugia malayi | Uncharacterized hematopoietic stem/progenitor cells protein MDS029 | 0.0122 | 0.0273 | 0.84 |
Schistosoma mansoni | Protoporphyrinogen oxidase chloroplast/mitochondrial precursor | 0.0132 | 0.0325 | 0.252 |
Chlamydia trachomatis | UDP-N-acetylglucosamine 1-carboxyvinyltransferase | 0.0189 | 0.0641 | 0.1135 |
Mycobacterium ulcerans | monoamine oxidase | 0.0132 | 0.0325 | 0.0066 |
Mycobacterium tuberculosis | Probable chorismate synthase AroF (5-enolpyruvylshikimate-3-phosphate phospholyase) | 0.0357 | 0.1575 | 0.146 |
Plasmodium vivax | chorismate synthase | 0.0723 | 0.3614 | 1 |
Chlamydia trachomatis | chorismate synthase | 0.0723 | 0.3614 | 1 |
Toxoplasma gondii | chorismate synthase, putative | 0.0723 | 0.3614 | 1 |
Mycobacterium leprae | Chorismate synthase AroF (5-enolpyruvylshikimate-3-phosphate phospholyase). | 0.0357 | 0.1575 | 1 |
Schistosoma mansoni | amine oxidase | 0.0132 | 0.0325 | 0.252 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0073 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0132 | 0.0325 | 1 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0132 | 0.0325 | 0.0072 |
Giardia lamblia | Kinase, CMGC GSK | 0.0073 | 0 | 0.5 |
Chlamydia trachomatis | protoporphyrinogen oxidase | 0.0132 | 0.0325 | 0.0192 |
Treponema pallidum | UDP-N-acetylglucosamine 1-carboxyvinyltransferase | 0.0189 | 0.0641 | 0.5 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0073 | 0 | 0.5 |
Echinococcus granulosus | cdgsh iron sulfur domain containing protein | 0.0288 | 0.1194 | 1 |
Onchocerca volvulus | 0.0122 | 0.0273 | 0.84 | |
Mycobacterium ulcerans | flavin-containing monoamine oxidase AofH | 0.1871 | 1 | 1 |
Plasmodium falciparum | protoporphyrinogen oxidase | 0.0132 | 0.0325 | 0.09 |
Wolbachia endosymbiont of Brugia malayi | UDP-N-acetylglucosamine 1-carboxyvinyltransferase | 0.0189 | 0.0641 | 0.5 |
Brugia malayi | SWIRM domain containing protein | 0.0132 | 0.0325 | 1 |
Mycobacterium ulcerans | oxidoreductase | 0.0132 | 0.0325 | 0.0066 |
Trypanosoma brucei | protein kinase, putative | 0.0073 | 0 | 0.5 |
Echinococcus multilocularis | cdgsh iron sulfur domain containing protein | 0.0288 | 0.1194 | 1 |
Mycobacterium ulcerans | 3-phosphoshikimate 1-carboxyvinyltransferase | 0.0309 | 0.131 | 0.1077 |
Echinococcus multilocularis | lysine specific histone demethylase 1A | 0.0132 | 0.0325 | 0.2724 |
Schistosoma mansoni | hypothetical protein | 0.0305 | 0.129 | 1 |
Toxoplasma gondii | shikimate dehydrogenase substrate binding domain-containing protein | 0.0309 | 0.131 | 0.3624 |
Loa Loa (eye worm) | hypothetical protein | 0.0132 | 0.0325 | 1 |
Mycobacterium ulcerans | chorismate synthase | 0.0723 | 0.3614 | 0.3443 |
Mycobacterium leprae | PROBABLE PROTOPORPHYRINOGEN OXIDASE HEMY (PROTOPORPHYRINOGEN-IX OXIDASE) (PROTOPORPHYRINOGENASE) (PPO) | 0.0132 | 0.0325 | 0.049 |
Brugia malayi | hypothetical protein | 0.0132 | 0.0325 | 1 |
Schistosoma mansoni | Lysine-specific histone demethylase 1 | 0.0132 | 0.0325 | 0.252 |
Loa Loa (eye worm) | hypothetical protein | 0.0132 | 0.0325 | 1 |
Plasmodium falciparum | chorismate synthase | 0.0723 | 0.3614 | 1 |
Entamoeba histolytica | protein kinase, putative | 0.0073 | 0 | 0.5 |
Plasmodium falciparum | lysine-specific histone demethylase 1, putative | 0.0132 | 0.0325 | 0.09 |
Plasmodium vivax | lysine-specific histone demethylase 1, putative | 0.0132 | 0.0325 | 0.09 |
Plasmodium vivax | hypothetical protein, conserved | 0.0132 | 0.0325 | 0.09 |
Schistosoma mansoni | amine oxidase | 0.0132 | 0.0325 | 0.252 |
Mycobacterium tuberculosis | Probable flavin-containing monoamine oxidase AofH (amine oxidase) (MAO) | 0.1739 | 0.9267 | 1 |
Plasmodium vivax | hypothetical protein, conserved | 0.0132 | 0.0325 | 0.09 |
Loa Loa (eye worm) | hypothetical protein | 0.0122 | 0.0273 | 0.84 |
Brugia malayi | amine oxidase, flavin-containing family protein | 0.0132 | 0.0325 | 1 |
Leishmania major | UDP-galactopyranose mutase | 0.0132 | 0.0325 | 1 |
Toxoplasma gondii | histone lysine-specific demethylase LSD1/BHC110/KDMA1A | 0.0132 | 0.0325 | 0.09 |
Echinococcus multilocularis | 0.0132 | 0.0325 | 0.2724 | |
Chlamydia trachomatis | phosphoshikimate 1-carboxyl vinyltransferase | 0.0309 | 0.131 | 0.3128 |
Mycobacterium ulcerans | dehydrogenase | 0.0132 | 0.0325 | 0.0066 |
Trypanosoma cruzi | UDP-galactopyranose mutase | 0.0132 | 0.0325 | 1 |
Onchocerca volvulus | 0.0132 | 0.0325 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0132 | 0.0325 | 1 |
Echinococcus granulosus | lysine specific histone demethylase 1A | 0.0132 | 0.0325 | 0.2724 |
Loa Loa (eye worm) | hypothetical protein | 0.0132 | 0.0325 | 1 |
Mycobacterium ulcerans | UDP-N-acetylglucosamine 1-carboxyvinyltransferase | 0.0189 | 0.0641 | 0.0391 |
Mycobacterium tuberculosis | Possible oxidoreductase | 0.0132 | 0.0325 | 0.0072 |
Echinococcus granulosus | lysine specific histone demethylase 1A | 0.0132 | 0.0325 | 0.2724 |
Trypanosoma cruzi | UDP-galactopyranose mutase | 0.0132 | 0.0325 | 1 |
Entamoeba histolytica | protein kinase domain containing protein | 0.0073 | 0 | 0.5 |
Echinococcus multilocularis | protoporphyrinogen oxidase | 0.0132 | 0.0325 | 0.2724 |
Entamoeba histolytica | protein kinase domain containing protein | 0.0073 | 0 | 0.5 |
Schistosoma mansoni | CDGSH-type Zn finger-containing protein-like protein | 0.0305 | 0.129 | 1 |
Schistosoma mansoni | 3-dehydroquinate synthase | 0.012 | 0.0261 | 0.202 |
Toxoplasma gondii | histone lysine-specific demethylase | 0.0132 | 0.0325 | 0.09 |
Plasmodium vivax | protoporphyrinogen oxidase, putative | 0.0132 | 0.0325 | 0.09 |
Loa Loa (eye worm) | hypothetical protein | 0.0132 | 0.0325 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.