Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0243 | 0.3092 | 0.3092 |
Onchocerca volvulus | 0.0243 | 0.3092 | 0.3092 | |
Echinococcus granulosus | neurogenic locus protein delta | 0.0243 | 0.3092 | 0.3092 |
Onchocerca volvulus | 0.0243 | 0.3092 | 0.3092 | |
Echinococcus granulosus | neurogenic locus notch protein | 0.0243 | 0.3092 | 0.3092 |
Echinococcus granulosus | protein jagged 2 | 0.0243 | 0.3092 | 0.3092 |
Loa Loa (eye worm) | hypothetical protein | 0.0243 | 0.3092 | 0.3092 |
Echinococcus granulosus | delta-like protein 1 | 0.0243 | 0.3092 | 0.3092 |
Loa Loa (eye worm) | notch protein | 0.0243 | 0.3092 | 0.3092 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0752 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0243 | 0.3092 | 0.3092 |
Loa Loa (eye worm) | hypothetical protein | 0.0752 | 1 | 1 |
Brugia malayi | Delta serrate ligand family protein | 0.0243 | 0.3092 | 0.3092 |
Schistosoma mansoni | notch | 0.0243 | 0.3092 | 0.3092 |
Brugia malayi | Calcium binding EGF domain containing protein | 0.0243 | 0.3092 | 0.3092 |
Loa Loa (eye worm) | hypothetical protein | 0.0243 | 0.3092 | 0.3092 |
Loa Loa (eye worm) | hypothetical protein | 0.0752 | 1 | 1 |
Schistosoma mansoni | notch | 0.0243 | 0.3092 | 0.3092 |
Onchocerca volvulus | Peroxidase homolog | 0.0752 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0243 | 0.3092 | 0.3092 |
Brugia malayi | Calcium binding EGF domain containing protein | 0.0243 | 0.3092 | 0.3092 |
Echinococcus multilocularis | protein jagged 1 | 0.0243 | 0.3092 | 0.3092 |
Loa Loa (eye worm) | hypothetical protein | 0.0752 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0752 | 1 | 1 |
Brugia malayi | Animal haem peroxidase family protein | 0.0752 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0243 | 0.3092 | 0.3092 |
Loa Loa (eye worm) | hypothetical protein | 0.0243 | 0.3092 | 0.3092 |
Schistosoma mansoni | laminin gamma-3 chain | 0.0243 | 0.3092 | 0.3092 |
Brugia malayi | Animal haem peroxidase family protein | 0.0752 | 1 | 1 |
Brugia malayi | EGF-like domain containing protein | 0.0243 | 0.3092 | 0.3092 |
Echinococcus multilocularis | neurogenic locus notch protein | 0.0243 | 0.3092 | 0.3092 |
Toxoplasma gondii | EGF family domain-containing protein | 0.0243 | 0.3092 | 0.5 |
Onchocerca volvulus | 0.0752 | 1 | 1 | |
Echinococcus granulosus | protein jagged 1 | 0.0243 | 0.3092 | 0.3092 |
Echinococcus granulosus | notch | 0.0243 | 0.3092 | 0.3092 |
Echinococcus granulosus | fibropellin Ia | 0.0243 | 0.3092 | 0.3092 |
Echinococcus multilocularis | neurogenic locus notch protein 4 | 0.0243 | 0.3092 | 0.3092 |
Echinococcus granulosus | protein jagged 2 | 0.0243 | 0.3092 | 0.3092 |
Onchocerca volvulus | Neurogenic locus notch protein homolog | 0.0243 | 0.3092 | 0.3092 |
Schistosoma mansoni | notch | 0.0243 | 0.3092 | 0.3092 |
Onchocerca volvulus | 0.0752 | 1 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0752 | 1 | 1 |
Onchocerca volvulus | Chorion peroxidase homolog | 0.0752 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0752 | 1 | 1 |
Brugia malayi | GCC2 and GCC3 family protein | 0.0243 | 0.3092 | 0.3092 |
Loa Loa (eye worm) | hypothetical protein | 0.0243 | 0.3092 | 0.3092 |
Onchocerca volvulus | Slit protein homolog | 0.0243 | 0.3092 | 0.3092 |
Giardia lamblia | High cysteine protein | 0.0243 | 0.3092 | 0.5 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0752 | 1 | 1 |
Onchocerca volvulus | Neurogenic locus notch homolog | 0.0243 | 0.3092 | 0.3092 |
Echinococcus multilocularis | neural cadherin | 0.0243 | 0.3092 | 0.3092 |
Loa Loa (eye worm) | hypothetical protein | 0.0243 | 0.3092 | 0.3092 |
Loa Loa (eye worm) | hypothetical protein | 0.0243 | 0.3092 | 0.3092 |
Brugia malayi | EGF-like domain containing protein | 0.0243 | 0.3092 | 0.3092 |
Schistosoma mansoni | hypothetical protein | 0.0243 | 0.3092 | 0.3092 |
Loa Loa (eye worm) | hypothetical protein | 0.0752 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0243 | 0.3092 | 0.3092 |
Echinococcus granulosus | neural cadherin | 0.0243 | 0.3092 | 0.3092 |
Schistosoma mansoni | cell polarity protein | 0.0243 | 0.3092 | 0.3092 |
Echinococcus multilocularis | slit 2 protein | 0.0243 | 0.3092 | 0.3092 |
Brugia malayi | EGF-like domain containing protein | 0.0243 | 0.3092 | 0.3092 |
Schistosoma mansoni | Pro-neuregulin-4 membrane-bound isoform (Pro-NRG4) [Contains: Neuregulin-4 (NRG-4)] | 0.0243 | 0.3092 | 0.3092 |
Echinococcus granulosus | protein jagged 1 | 0.0243 | 0.3092 | 0.3092 |
Onchocerca volvulus | Putative cubilin | 0.0243 | 0.3092 | 0.3092 |
Schistosoma mansoni | hypothetical protein | 0.0243 | 0.3092 | 0.3092 |
Loa Loa (eye worm) | hypothetical protein | 0.0243 | 0.3092 | 0.3092 |
Brugia malayi | Peroxidasin | 0.0752 | 1 | 1 |
Onchocerca volvulus | Dual oxidase homolog | 0.0752 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0243 | 0.3092 | 0.3092 |
Echinococcus granulosus | slit 2 protein | 0.0243 | 0.3092 | 0.3092 |
Loa Loa (eye worm) | hypothetical protein | 0.0243 | 0.3092 | 0.3092 |
Loa Loa (eye worm) | hypothetical protein | 0.0752 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0243 | 0.3092 | 0.3092 |
Echinococcus multilocularis | fat cadherin tumor suppressor | 0.0243 | 0.3092 | 0.3092 |
Brugia malayi | Blistered cuticle protein 3 | 0.0752 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0243 | 0.3092 | 0.3092 |
Brugia malayi | EGF-like domain containing protein | 0.0243 | 0.3092 | 0.3092 |
Onchocerca volvulus | 0.0243 | 0.3092 | 0.3092 | |
Loa Loa (eye worm) | hypothetical protein | 0.0752 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0243 | 0.3092 | 0.3092 |
Echinococcus granulosus | neurogenic locus notch protein | 0.0243 | 0.3092 | 0.3092 |
Echinococcus multilocularis | peroxidasin | 0.0752 | 1 | 1 |
Echinococcus multilocularis | neurogenic locus protein delta | 0.0243 | 0.3092 | 0.3092 |
Onchocerca volvulus | Peroxidase homolog | 0.0752 | 1 | 1 |
Echinococcus granulosus | neurogenic locus notch protein 4 | 0.0243 | 0.3092 | 0.3092 |
Brugia malayi | EGF-like domain containing protein | 0.0243 | 0.3092 | 0.3092 |
Echinococcus multilocularis | protein jagged 2 | 0.0243 | 0.3092 | 0.3092 |
Schistosoma mansoni | hypothetical protein | 0.0243 | 0.3092 | 0.3092 |
Loa Loa (eye worm) | hypothetical protein | 0.0752 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0243 | 0.3092 | 0.3092 |
Loa Loa (eye worm) | hypothetical protein | 0.0243 | 0.3092 | 0.3092 |
Loa Loa (eye worm) | hypothetical protein | 0.0243 | 0.3092 | 0.3092 |
Loa Loa (eye worm) | hypothetical protein | 0.0752 | 1 | 1 |
Brugia malayi | Cadherin domain containing protein | 0.0243 | 0.3092 | 0.3092 |
Schistosoma mansoni | slit | 0.0243 | 0.3092 | 0.3092 |
Loa Loa (eye worm) | hypothetical protein | 0.0243 | 0.3092 | 0.3092 |
Brugia malayi | Animal haem peroxidase family protein | 0.0752 | 1 | 1 |
Schistosoma mansoni | notch | 0.0243 | 0.3092 | 0.3092 |
Echinococcus multilocularis | neurogenic locus protein delta | 0.0243 | 0.3092 | 0.3092 |
Schistosoma mansoni | notch | 0.0243 | 0.3092 | 0.3092 |
Loa Loa (eye worm) | blistered cuticle protein 3 | 0.0752 | 1 | 1 |
Brugia malayi | Muscle positioning protein 4 | 0.0243 | 0.3092 | 0.3092 |
Onchocerca volvulus | Peroxidasin homolog | 0.0752 | 1 | 1 |
Onchocerca volvulus | 0.0243 | 0.3092 | 0.3092 | |
Echinococcus multilocularis | neurogenic locus notch protein | 0.0243 | 0.3092 | 0.3092 |
Echinococcus multilocularis | notch | 0.0243 | 0.3092 | 0.3092 |
Echinococcus multilocularis | protein jagged 1 | 0.0243 | 0.3092 | 0.3092 |
Brugia malayi | EGF-like domain containing protein | 0.0243 | 0.3092 | 0.3092 |
Schistosoma mansoni | peroxidasin | 0.0752 | 1 | 1 |
Onchocerca volvulus | 0.0752 | 1 | 1 | |
Brugia malayi | notch-like transmembrane receptor | 0.0243 | 0.3092 | 0.3092 |
Brugia malayi | Animal haem peroxidase family protein | 0.0752 | 1 | 1 |
Brugia malayi | EGF-like domain containing protein | 0.0243 | 0.3092 | 0.3092 |
Loa Loa (eye worm) | hypothetical protein | 0.0752 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0243 | 0.3092 | 0.3092 |
Loa Loa (eye worm) | hypothetical protein | 0.0752 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0752 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0243 | 0.3092 | 0.3092 |
Loa Loa (eye worm) | hypothetical protein | 0.0243 | 0.3092 | 0.3092 |
Brugia malayi | Cadherin domain containing protein | 0.0243 | 0.3092 | 0.3092 |
Loa Loa (eye worm) | Notch2 | 0.0243 | 0.3092 | 0.3092 |
Brugia malayi | Calcium binding EGF domain containing protein | 0.0243 | 0.3092 | 0.3092 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0752 | 1 | 1 |
Echinococcus granulosus | peroxidasin | 0.0752 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0243 | 0.3092 | 0.3092 |
Schistosoma mansoni | peroxidasin | 0.0752 | 1 | 1 |
Onchocerca volvulus | Peroxidasin homolog | 0.0752 | 1 | 1 |
Echinococcus multilocularis | fibropellin Ia | 0.0243 | 0.3092 | 0.3092 |
Brugia malayi | Transmembrane cell adhesion receptor mua-3 precursor, putative | 0.0243 | 0.3092 | 0.3092 |
Schistosoma mansoni | notch | 0.0243 | 0.3092 | 0.3092 |
Brugia malayi | Animal haem peroxidase family protein | 0.0752 | 1 | 1 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0752 | 1 | 1 |
Onchocerca volvulus | 0.0243 | 0.3092 | 0.3092 | |
Schistosoma mansoni | hypothetical protein | 0.0243 | 0.3092 | 0.3092 |
Schistosoma mansoni | septate junction protein | 0.0243 | 0.3092 | 0.3092 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | > 100 nM | Concentration required to inhibit the binding of radioligand [3H]-GR-65,630 to serotonin 5-hydroxytryptamine-3 receptor (5-HT 3 receptor)in rat brain cortical membrane | ChEMBL. | 12593651 |
IC50 (binding) | > 1000 nM | Inhibition of the binding of radioligand [3H]-spiperone to dopamine receptor D2 in rat brain synaptic membrane | ChEMBL. | 12593651 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.