TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 243.123 | Formula: C7H8NaO8
H donors: 2 H acceptors: 6 LogP: -0.78 Rotable bonds: 4
Rule of 5 violations (Lipinski): 1
SMILES: O=C1OC(C(C1O)O)COC(=O)C(=O)[O-].[NaH+]
InChi: 1S/C7H8O8.Na/c8-3-2(15-6(12)4(3)9)1-14-7(13)5(10)11;/h2-4,8-9H,1H2,(H,10,11);/q;+1/p-1
InChiKey: MDMBDSDIXGKBNS-UHFFFAOYSA-M

Network

Hover on a compound node to display the structore

Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

This is a work in progress. Come back soon to try this features!

Clustering layers

This is a work in progress. Come back soon to try this features!

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Schistosoma mansoni	receptor protein tyrosine phosphatase r (pcptp1)	0.0124	0.0176	0.0176
Entamoeba histolytica	protein tyrosine phosphatase, putative	0.0124	0.0176	0.0749
Loa Loa (eye worm)	hypothetical protein	0.0124	0.0176	0.0061
Echinococcus multilocularis	Receptor type tyrosine protein phosphatase O	0.0124	0.0176	0.0176
Schistosoma mansoni	receptor tyrosine phosphatase type r2a	0.0124	0.0176	0.0176
Brugia malayi	hypothetical protein	0.0132	0.0198	0.0198
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0124	0.0176	0.0176
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0124	0.0176	0.0061
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0124	0.0176	0.0176
Echinococcus multilocularis		0.0124	0.0176	0.0176
Loa Loa (eye worm)	hypothetical protein	0.0124	0.0176	0.0061
Onchocerca volvulus		0.0124	0.0176	0.0104
Schistosoma mansoni	rgs-gaip interacting protein gipc	0.0124	0.0176	0.0176
Onchocerca volvulus		0.0124	0.0176	0.0104
Loa Loa (eye worm)	dual specificity protein phosphatase CDC14B	0.0124	0.0176	0.0061
Loa Loa (eye worm)	hypothetical protein	0.0124	0.0176	0.0061
Brugia malayi	ERG2 and Sigma1 receptor like protein	0.0417	0.0985	0.0985
Mycobacterium tuberculosis	Probable pyruvate kinase PykA	0.0564	0.139	1
Loa Loa (eye worm)	pyruvate kinase-PB	0.0393	0.092	0.0813
Onchocerca volvulus	Huntingtin homolog	0.0132	0.0198	0.0142
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0124	0.0176	0.0176
Schistosoma mansoni	pyruvate kinase	0.0564	0.139	0.139
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0124	0.0176	0.0176
Schistosoma mansoni	receptor tyrosine phosphatase type r2a	0.0124	0.0176	0.0176
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.3686	1	1
Echinococcus multilocularis	aldehyde dehydrogenase, mitochondrial	0.0066	0.0016	0.0016
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0124	0.0176	0.0176
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0124	0.0176	0.0176
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.0124	0.0176	0.0176
Echinococcus multilocularis	receptor type tyrosine protein phosphatase H	0.0124	0.0176	0.0176
Loa Loa (eye worm)	protein-tyrosine-phosphatase	0.0124	0.0176	0.0061
Loa Loa (eye worm)	hypothetical protein	0.0132	0.0198	0.0083
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0124	0.0176	0.0061
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0124	0.0176	0.0176
Echinococcus granulosus	pyruvate kinase	0.0564	0.139	0.139
Loa Loa (eye worm)	hypothetical protein	0.0124	0.0176	0.0061
Echinococcus multilocularis	pyruvate kinase	0.029	0.0633	0.0633
Schistosoma mansoni	protein tyrosine phosphatase	0.0124	0.0176	0.0176
Schistosoma mansoni	pcd6 interacting protein-related	0.0124	0.0176	0.0176
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0124	0.0176	0.0176
Entamoeba histolytica	protein tyrosine phosphatase, putative	0.0124	0.0176	0.0749
Loa Loa (eye worm)	hypothetical protein	0.0124	0.0176	0.0061
Echinococcus multilocularis	pyruvate kinase	0.029	0.0633	0.0633
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0124	0.0176	0.0061
Trichomonas vaginalis	pyruvate kinase, putative	0.0564	0.139	1
Plasmodium vivax	pyruvate kinase, putative	0.0564	0.139	1
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0124	0.0176	0.0176
Loa Loa (eye worm)	pyruvate kinase	0.0564	0.139	0.129
Echinococcus multilocularis	protein tyrosine phosphatase n9	0.0124	0.0176	0.0176
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0124	0.0176	0.0176
Onchocerca volvulus		0.0124	0.0176	0.0104
Loa Loa (eye worm)	glutaminase	0.0286	0.0622	0.0512
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0124	0.0176	0.0176
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0066	0.0016	0.0116
Loa Loa (eye worm)	protein tyrosine phosphatase	0.0124	0.0176	0.0061
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0124	0.0176	0.0176
Loa Loa (eye worm)	hypothetical protein	0.0124	0.0176	0.0061
Brugia malayi	glutaminase DH11.1	0.0286	0.0622	0.0622
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0124	0.0176	0.0176
Onchocerca volvulus		0.0124	0.0176	0.0104
Loa Loa (eye worm)	hypothetical protein	0.0124	0.0176	0.0061
Schistosoma mansoni	receptor tyrosine phosphatase type r2a	0.0124	0.0176	0.0176
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0124	0.0176	0.0176
Onchocerca volvulus		0.0124	0.0176	0.0104
Onchocerca volvulus		0.0124	0.0176	0.0104
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0124	0.0176	0.0061
Brugia malayi	Pyruvate kinase, muscle isozyme	0.0564	0.139	0.139
Chlamydia trachomatis	pyruvate kinase	0.0564	0.139	0.5
Leishmania major	pyruvate kinase	0.0564	0.139	1
Onchocerca volvulus		0.0124	0.0176	0.0104
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0066	0.0016	0.0116
Schistosoma mansoni	glutaminase	0.0286	0.0622	0.0622
Brugia malayi	Pyruvate kinase, M2 isozyme	0.0564	0.139	0.139
Brugia malayi	hypothetical protein	0.0124	0.0176	0.0176
Loa Loa (eye worm)	hypothetical protein	0.0124	0.0176	0.0061
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0124	0.0176	0.0176
Onchocerca volvulus		0.0124	0.0176	0.0104
Schistosoma mansoni	pyruvate kinase	0.029	0.0633	0.0633
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0124	0.0176	0.0176
Brugia malayi	hypothetical protein	0.0124	0.0176	0.0176
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0124	0.0176	0.0176
Echinococcus multilocularis	serine:threonine protein kinase PLK1	0.0102	0.0116	0.0116
Brugia malayi	pyruvate kinase	0.0119	0.0162	0.0162
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0124	0.0176	0.0176
Onchocerca volvulus	Pyruvate kinase homolog	0.0564	0.139	0.2208
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0124	0.0176	0.0061
Brugia malayi	protein-tyrosine phosphatase Lar-like precursor, putative	0.0124	0.0176	0.0176
Onchocerca volvulus		0.0124	0.0176	0.0104
Schistosoma mansoni	receptor protein tyrosine phosphatase n (ia2)	0.0124	0.0176	0.0176
Trypanosoma cruzi	tyrosine specific protein phosphatase, putative	0.0124	0.0176	0.0473
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.0124	0.0176	0.0176
Onchocerca volvulus		0.0124	0.0176	0.0104
Echinococcus granulosus	pyruvate kinase	0.0564	0.139	0.139
Onchocerca volvulus		0.0124	0.0176	0.0104
Trypanosoma cruzi	C-8 sterol isomerase, putative	0.0417	0.0985	0.6822
Brugia malayi	Protein-tyrosine phosphatase	0.0124	0.0176	0.0176
Echinococcus multilocularis	pyruvate kinase	0.0564	0.139	0.139
Echinococcus multilocularis	hypothetical protein	0.0124	0.0176	0.0176
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0124	0.0176	0.0176
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0124	0.0176	0.0176
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0124	0.0176	0.0061
Onchocerca volvulus		0.0124	0.0176	0.0104
Onchocerca volvulus		0.0124	0.0176	0.0104
Echinococcus granulosus	protein tyrosine phosphatase n9	0.0124	0.0176	0.0176
Loa Loa (eye worm)	hypothetical protein	0.0124	0.0176	0.0061
Loa Loa (eye worm)	hypothetical protein	0.0393	0.092	0.0813
Giardia lamblia	Protein tyrosine phosphatase	0.0124	0.0176	0.0473
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0124	0.0176	0.0176
Loa Loa (eye worm)	protein-tyrosine phosphatase 1	0.0124	0.0176	0.0061
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0124	0.0176	0.0176
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0124	0.0176	0.0061
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0124	0.0176	0.0176
Loa Loa (eye worm)	hypothetical protein	0.0124	0.0176	0.0061
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0124	0.0176	0.0176
Schistosoma mansoni	receptor tyrosine phosphatase type r2a	0.0124	0.0176	0.0176
Brugia malayi	Dual specificity protein phosphatase CDC14B	0.0124	0.0176	0.0176
Schistosoma mansoni	non-receptor protein-tyrosine phosphatase	0.0124	0.0176	0.0176
Mycobacterium tuberculosis	Probable aldehyde dehydrogenase	0.0066	0.0016	0.0116
Loa Loa (eye worm)	hypothetical protein	0.0124	0.0176	0.0061
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.0124	0.0176	0.0176
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0124	0.0176	0.0176
Echinococcus multilocularis	receptor type tyrosine protein phosphatase F	0.0124	0.0176	0.0176
Loa Loa (eye worm)	fibronectin type III domain-containing protein	0.0124	0.0176	0.0061
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0124	0.0176	0.0176
Echinococcus granulosus	aldehyde dehydrogenase mitochondrial	0.0066	0.0016	0.0016
Echinococcus multilocularis	pyruvate kinase	0.029	0.0633	0.0633
Brugia malayi	hypothetical protein	0.0124	0.0176	0.0176
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0124	0.0176	0.0176
Loa Loa (eye worm)	pyruvate kinase	0.0564	0.139	0.129
Onchocerca volvulus	4.1 G protein, putative homolog	0.0124	0.0176	0.0104
Onchocerca volvulus		0.0124	0.0176	0.0104
Toxoplasma gondii	pyruvate kinase PyKII	0.029	0.0633	0.449
Schistosoma mansoni	lipoxygenase	0.0086	0.0072	0.0072
Schistosoma mansoni	receptor protein tyrosine phosphatase	0.0124	0.0176	0.0176
Mycobacterium ulcerans	pyruvate kinase	0.0564	0.139	1
Onchocerca volvulus		0.0124	0.0176	0.0104
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0124	0.0176	0.0176
Loa Loa (eye worm)	pyruvate kinase	0.0564	0.139	0.129
Brugia malayi	hypothetical protein	0.0124	0.0176	0.0176
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0124	0.0176	0.0176
Onchocerca volvulus		0.0124	0.0176	0.0104
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0124	0.0176	0.0176
Entamoeba histolytica	pyruvate kinase, putative	0.0393	0.092	1
Giardia lamblia	Pyruvate kinase	0.0564	0.139	1
Echinococcus granulosus	receptor type tyrosine protein phosphatase zeta	0.0124	0.0176	0.0176
Schistosoma mansoni	protein tyrosine phosphatase	0.0124	0.0176	0.0176
Brugia malayi	Pyruvate kinase, alpha/beta domain containing protein	0.0171	0.0305	0.0305
Loa Loa (eye worm)	hypothetical protein	0.0417	0.0985	0.088
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0124	0.0176	0.0061
Trypanosoma brucei	pyruvate kinase 1, putative	0.0564	0.139	1
Echinococcus multilocularis	Receptor type tyrosine protein phosphatase O	0.0124	0.0176	0.0176
Echinococcus multilocularis	pyruvate kinase	0.0564	0.139	0.139
Loa Loa (eye worm)	hypothetical protein	0.0132	0.0198	0.0083
Mycobacterium ulcerans	glutaminase	0.0286	0.0622	0.4476
Echinococcus multilocularis	Receptor type tyrosine protein phosphatase O	0.0124	0.0176	0.0176
Loa Loa (eye worm)	pyruvate kinase	0.0119	0.0162	0.0047
Echinococcus granulosus	Receptor type tyrosine protein phosphatase O	0.0124	0.0176	0.0176
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.2195	0.5888	0.584
Giardia lamblia	Pyruvate kinase	0.029	0.0633	0.4059
Loa Loa (eye worm)	hypothetical protein	0.0213	0.0423	0.0311
Trichomonas vaginalis	glutaminase, putative	0.0286	0.0622	0.3974
Echinococcus multilocularis	Receptor type tyrosine protein phosphatase O	0.0124	0.0176	0.0176
Schistosoma mansoni	aldehyde dehydrogenase	0.0066	0.0016	0.0016
Entamoeba histolytica	Pten 3-phosphoinositide phosphatase, putative	0.0124	0.0176	0.0749
Leishmania major	tyrosine specific protein phosphatase, putative	0.0124	0.0176	0.1266
Leishmania major	protein-tyrosine phosphatase 1-like protein	0.0124	0.0176	0.1266
Brugia malayi	serine/threonine-protein kinase plk-2	0.0102	0.0116	0.0116
Echinococcus granulosus	Receptor type tyrosine protein phosphatase O	0.0124	0.0176	0.0176
Onchocerca volvulus		0.0124	0.0176	0.0104
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0124	0.0176	0.0176
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0124	0.0176	0.0176
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0124	0.0176	0.0061
Schistosoma mansoni	aldehyde dehydrogenase	0.0066	0.0016	0.0016
Trypanosoma cruzi	tyrosine specific protein phosphatase, putative	0.0124	0.0176	0.0473
Loa Loa (eye worm)	hypothetical protein	0.0124	0.0176	0.0061
Echinococcus multilocularis	arachidonate 5 lipoxygenase	0.0123	0.0175	0.0175
Schistosoma mansoni	protein tyrosine phosphatase n11 (shp2)	0.0124	0.0176	0.0176
Leishmania major	pyruvate kinase	0.0564	0.139	1
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0124	0.0176	0.0176
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0124	0.0176	0.0061
Trypanosoma cruzi	pyruvate kinase 2, putative	0.0564	0.139	1
Onchocerca volvulus		0.2195	0.5888	1
Leishmania major	C-8 sterol isomerase-like protein	0.0417	0.0985	0.7086
Trypanosoma brucei	C-8 sterol isomerase, putative	0.0417	0.0985	0.6822
Schistosoma mansoni	protein tyrosine phosphatase non-receptor type nt1	0.3686	1	1
Trichomonas vaginalis	pyruvate kinase, putative	0.0564	0.139	1
Plasmodium falciparum	pyruvate kinase	0.0564	0.139	1
Loa Loa (eye worm)	hypothetical protein	0.0564	0.139	0.129
Schistosoma mansoni	protein-tyrosine phosphatase non-receptor type nt5	0.0124	0.0176	0.0176
Loa Loa (eye worm)	hypothetical protein	0.0124	0.0176	0.0061
Loa Loa (eye worm)	glutaminase 2	0.0286	0.0622	0.0512
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.3686	1	1
Onchocerca volvulus		0.2195	0.5888	1
Leishmania major	aldehyde dehydrogenase, mitochondrial precursor	0.0066	0.0016	0.0116
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.3686	1	1
Mycobacterium leprae	Probable pyruvate kinase PykA	0.0564	0.139	0.5
Trypanosoma cruzi	tyrosine specific protein phosphatase, putative	0.0124	0.0176	0.0473
Leishmania major	protein kinase, putative,polo-like protein kinase, putative	0.0102	0.0116	0.0833
Echinococcus granulosus	serine:threonine protein kinase PLK1	0.0102	0.0116	0.0116
Onchocerca volvulus		0.0124	0.0176	0.0104
Toxoplasma gondii	pyruvate kinase PyK1	0.0564	0.139	1
Echinococcus multilocularis	receptor type tyrosine protein phosphatase zeta	0.0124	0.0176	0.0176
Echinococcus multilocularis	receptor type tyrosine protein phosphatase zeta	0.0124	0.0176	0.0176
Loa Loa (eye worm)	hypothetical protein	0.0124	0.0176	0.0061
Schistosoma mansoni	serine/threonine protein kinase	0.0102	0.0116	0.0116
Loa Loa (eye worm)	hypothetical protein	0.0124	0.0176	0.0061
Loa Loa (eye worm)	hypothetical protein	0.0124	0.0176	0.0061
Onchocerca volvulus		0.0124	0.0176	0.0104
Echinococcus granulosus	arachidonate 5 lipoxygenase	0.0123	0.0175	0.0175
Brugia malayi	hypothetical protein	0.0124	0.0176	0.0176
Loa Loa (eye worm)	hypothetical protein	0.0124	0.0176	0.0061
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.0124	0.0176	0.0176
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0124	0.0176	0.0176
Loa Loa (eye worm)	hypothetical protein	0.0124	0.0176	0.0061
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.0124	0.0176	0.0176
Onchocerca volvulus		0.0124	0.0176	0.0104
Trichomonas vaginalis	pten, drome, putative	0.0124	0.0176	0.0473
Trypanosoma brucei	pyruvate kinase 1	0.0564	0.139	1
Loa Loa (eye worm)	hypothetical protein	0.0124	0.0176	0.0061
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0124	0.0176	0.0061
Echinococcus granulosus	pyruvate kinase	0.029	0.0633	0.0633
Loa Loa (eye worm)	hypothetical protein	0.0124	0.0176	0.0061
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0124	0.0176	0.0176
Schistosoma mansoni	receptor tyrosine phosphatase type r2a	0.0124	0.0176	0.0176
Loa Loa (eye worm)	hypothetical protein	0.0124	0.0176	0.0061
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0124	0.0176	0.0061
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0124	0.0176	0.0176
Echinococcus granulosus	pyruvate kinase	0.029	0.0633	0.0633
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0124	0.0176	0.0176
Echinococcus granulosus	receptor type tyrosine protein phosphatase zeta	0.0124	0.0176	0.0176
Schistosoma mansoni	protein tyrosine phosphatase	0.0124	0.0176	0.0176
Loa Loa (eye worm)	hypothetical protein	0.0124	0.0176	0.0061
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.2195	0.5888	0.5888
Onchocerca volvulus	Pyruvate kinase homolog	0.0564	0.139	0.2208
Trypanosoma brucei	protein tyrosine phosphatase 1	0.0124	0.0176	0.0473
Schistosoma mansoni	lipoxygenase	0.0123	0.0175	0.0175
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0124	0.0176	0.0061
Echinococcus granulosus	pyruvate kinase	0.029	0.0633	0.0633
Echinococcus multilocularis	receptor type tyrosine protein phosphatase protein tyrosine phosphatase receptor type	0.0124	0.0176	0.0176
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.0124	0.0176	0.0176
Schistosoma mansoni	pyruvate kinase	0.0564	0.139	0.139
Brugia malayi	pyruvate kinase, muscle isozyme	0.0119	0.0162	0.0162
Echinococcus multilocularis	pyruvate kinase	0.0445	0.1063	0.1063
Loa Loa (eye worm)	hypothetical protein	0.0124	0.0176	0.0061
Schistosoma mansoni	protein-tyrosine phosphatase n9	0.0124	0.0176	0.0176
Onchocerca volvulus		0.0124	0.0176	0.0104
Loa Loa (eye worm)	hypothetical protein	0.0124	0.0176	0.0061
Trypanosoma cruzi	pyruvate kinase 2, putative	0.0564	0.139	1
Loa Loa (eye worm)	hypothetical protein	0.0124	0.0176	0.0061
Brugia malayi	Protein-tyrosine phosphatase	0.0124	0.0176	0.0176
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0124	0.0176	0.0176
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0066	0.0016	0.0116
Loa Loa (eye worm)	hypothetical protein	0.0124	0.0176	0.0061
Onchocerca volvulus	Huntingtin homolog	0.0132	0.0198	0.0142
Schistosoma mansoni	receptor protein tyrosine phosphatase n (ia2)	0.0124	0.0176	0.0176
Brugia malayi	Protein-tyrosine phosphatase 1	0.0124	0.0176	0.0176
Onchocerca volvulus	Pyruvate kinase homolog	0.0564	0.139	0.2208
Echinococcus multilocularis	receptor type tyrosine protein phosphatase protein tyrosine phosphatase receptor type	0.0124	0.0176	0.0176

Activities

Activity type	Activity value	Assay description	Source	Reference
Inhibition (binding)	NA 0 %	Inhibitory activity against Arabinose-5-phosphate isomerase; Not active.	ChEMBL.	6429331

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: 370335

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 278816