TDR Targets

Basic information

Technical information

TDR Targets ID: 281362
Name: 2-(hydroxymethyl)-5-(3-methyl-5-methylsulfany limidazo[4,5-d][1,2]thiazol-6-yl)oxolane-3,4- diol
MW: 317.385 | Formula: C11H15N3O4S2
H donors: 3 H acceptors: 5 LogP: 0.47 Rotable bonds: 3
Rule of 5 violations (Lipinski): 1
SMILES: OCC1OC(C(C1O)O)n1c(SC)nc2c1snc2C
InChi: 1S/C11H15N3O4S2/c1-4-6-10(20-13-4)14(11(12-6)19-2)9-8(17)7(16)5(3-15)18-9/h5,7-9,15-17H,3H2,1-2H3
InChiKey: PAGGYHJQVZRZGF-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

2-(hydroxymethyl)-5-(3-methyl-5-methylsulfanyl-imidazo[4,5-d]isothiazol-6-yl)tetrahydrofuran-3,4-diol
2-(hydroxymethyl)-5-[3-methyl-5-(methylthio)-6-imidazo[4,5-d]isothiazolyl]tetrahydrofuran-3,4-diol
2-(hydroxymethyl)-5-(3-methyl-5-methylsulfanyl-imidazo[4,5-d][1,2]thiazol-6-yl)oxolane-3,4-diol
2-[3-methyl-5-(methylthio)imidazo[4,5-d]isothiazol-6-yl]-5-methylol-tetrahydrofuran-3,4-diol

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0315	0.2959	0.2959
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.0326	0.3093	0.3093
Brugia malayi	Cathepsin L-like precursor	0.0315	0.2959	0.2959
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0315	0.2959	0.9567
Plasmodium vivax	vivapain-2	0.0315	0.2959	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0315	0.2959	0.9567
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0315	0.2959	0.9567
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0315	0.2959	0.9567
Trypanosoma cruzi	Eukaryotic initiation factor 4A-1	0.0098	0.0246	0.0246
Entamoeba histolytica	cysteine proteinase, putative	0.0174	0.12	0.4054
Onchocerca volvulus	Cathepsin L homolog	0.0315	0.2959	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0315	0.2959	0.953
Loa Loa (eye worm)	hypothetical protein	0.0315	0.2959	0.2959
Loa Loa (eye worm)	DEAH box polypeptide 35	0.0095	0.0205	0.0205
Loa Loa (eye worm)	hypothetical protein	0.0137	0.0735	0.0735
Brugia malayi	Cathepsin L-like cysteine proteinase	0.0219	0.1759	0.1759
Schistosoma mansoni	cathepsin F (C01 family)	0.0219	0.1759	0.1759
Loa Loa (eye worm)	hypothetical protein	0.0232	0.1923	0.1923
Giardia lamblia	Cathepsin B precursor	0.0326	0.3093	1
Toxoplasma gondii	eukaryotic initiation factor-4A, putative	0.0098	0.0246	0.0794
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0315	0.2959	0.9567
Entamoeba histolytica	cysteine protease, putative	0.0174	0.12	0.4054
Trypanosoma cruzi	cruzipain precursor, putative	0.0315	0.2959	0.2959
Entamoeba histolytica	cysteine protease, putative	0.0174	0.12	0.4054
Entamoeba histolytica	cysteine proteinase, putative	0.0174	0.12	0.4054
Plasmodium vivax	RNA helicase-1, putative	0.0098	0.0246	0.083
Trichomonas vaginalis	DEAD box ATP-dependent RNA helicase, putative	0.0098	0.0246	0.0794
Loa Loa (eye worm)	hypothetical protein	0.0098	0.0246	0.0246
Plasmodium vivax	unspecified product	0.0096	0.0221	0.0746
Echinococcus multilocularis	cysteine protease	0.0315	0.2959	0.2959
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0315	0.2959	0.953
Onchocerca volvulus		0.0315	0.2959	1
Loa Loa (eye worm)	hypothetical protein	0.0219	0.1759	0.1759
Trypanosoma cruzi	cysteine protease, putative	0.0174	0.12	0.12
Brugia malayi	Cathepsin L-like precursor	0.0315	0.2959	0.2959
Onchocerca volvulus		0.0315	0.2959	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0315	0.2959	0.9567
Plasmodium falciparum	cysteine proteinase falcipain 3	0.0315	0.2959	1
Onchocerca volvulus		0.0315	0.2959	1
Plasmodium falciparum	eukaryotic initiation factor 4A	0.0098	0.0246	0.083
Schistosoma mansoni	cathepsin F (C01 family)	0.0315	0.2959	0.2959
Echinococcus multilocularis	cathepsin L cysteine protease	0.0315	0.2959	0.2959
Trichomonas vaginalis	DEAD box ATP-dependent RNA helicase, putative	0.0098	0.0246	0.0794
Trypanosoma cruzi	cysteine peptidase, putative	0.0315	0.2959	0.2959
Loa Loa (eye worm)	hypothetical protein	0.0095	0.0205	0.0205
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.0137	0.0735	0.0735
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0315	0.2959	0.9567
Treponema pallidum	ATP-dependent RNA helicase	0.0098	0.0246	0.5
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0315	0.2959	0.9567
Loa Loa (eye worm)	hypothetical protein	0.0219	0.1759	0.1759
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0315	0.2959	0.9567
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0315	0.2959	0.953
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0315	0.2959	0.9567
Leishmania major	cathepsin L-like protease	0.0315	0.2959	0.953
Brugia malayi	hypothetical protein	0.0232	0.1923	0.1923
Brugia malayi	cathepsin L-like precursor	0.0219	0.1759	0.1759
Onchocerca volvulus		0.0089	0.0129	0.0437
Brugia malayi	Papain family cysteine protease containing protein	0.0315	0.2959	0.2959
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.0315	0.2959	0.2959
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0315	0.2959	0.953
Brugia malayi	Cathepsin L-like precursor	0.0315	0.2959	0.2959
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0315	0.2959	0.9567
Entamoeba histolytica	cysteine proteinase, putative	0.0174	0.12	0.4054
Entamoeba histolytica	cysteine protease, putative	0.0174	0.12	0.4054
Loa Loa (eye worm)	hypothetical protein	0.0096	0.0221	0.0221
Onchocerca volvulus	Cathepsin L homolog	0.0315	0.2959	1
Entamoeba histolytica	cysteine protease, putative	0.0174	0.12	0.4054
Trypanosoma cruzi	cysteine peptidase, putative	0.0315	0.2959	0.2959
Echinococcus granulosus	cathepsin L cysteine proteinase	0.0315	0.2959	0.2959
Echinococcus granulosus	eukaryotic initiation factor 4A	0.0098	0.0246	0.0246
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0315	0.2959	0.9567
Schistosoma mansoni	DEAD box ATP-dependent RNA helicase	0.0098	0.0246	0.0246
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0219	0.1759	0.5688
Entamoeba histolytica	cysteine proteinase, putative	0.0174	0.12	0.4054
Plasmodium falciparum	cysteine proteinase falcipain 2b	0.0315	0.2959	1
Entamoeba histolytica	cysteine protease, putative	0.0174	0.12	0.4054
Entamoeba histolytica	cysteine protease, putative	0.0174	0.12	0.4054
Echinococcus granulosus	eukaryotic initiation factor 4A III	0.0098	0.0246	0.0246
Echinococcus granulosus	survival motor neuron protein 1	0.0232	0.1923	0.1923
Leishmania major	cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like	0.0326	0.3093	1
Echinococcus multilocularis	cathepsin b	0.0878	1	1
Entamoeba histolytica	cysteine proteinase 2	0.0174	0.12	0.4054
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0174	0.12	0.3878
Echinococcus granulosus	cathepsin b	0.0878	1	1
Schistosoma mansoni	cathepsin F (C01 family)	0.0315	0.2959	0.2959
Loa Loa (eye worm)	hypothetical protein	0.0219	0.1759	0.1759
Echinococcus granulosus	cathepsin l cysteine peptidase	0.0315	0.2959	0.2959
Trypanosoma cruzi	cysteine peptidase, putative	0.0315	0.2959	0.2959
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0315	0.2959	0.2959
Trypanosoma cruzi	cysteine proteinase, putative	0.0174	0.12	0.12
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.024	0.2016	0.2016
Echinococcus multilocularis	eukaryotic initiation factor 4A III	0.0098	0.0246	0.0246
Plasmodium falciparum	cysteine proteinase falcipain 2a	0.0315	0.2959	1
Trypanosoma brucei	cysteine peptidase C (CPC)	0.0326	0.3093	1
Plasmodium falciparum	cysteine proteinase falcipain 1	0.0174	0.12	0.4054
Echinococcus granulosus	cathepsin L	0.0174	0.12	0.12
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0326	0.3093	1
Entamoeba histolytica	cysteine protease, putative	0.0174	0.12	0.4054
Loa Loa (eye worm)	hypothetical protein	0.0096	0.0221	0.0221
Brugia malayi	Cathepsin L-like precursor	0.0219	0.1759	0.1759
Loa Loa (eye worm)	hypothetical protein	0.0137	0.0735	0.0735
Echinococcus multilocularis	cathepsin b	0.0878	1	1
Leishmania major	cathepsin L-like protease	0.0315	0.2959	0.953
Mycobacterium tuberculosis	Probable cold-shock DeaD-box protein A homolog DeaD (ATP-dependent RNA helicase dead homolog)	0.0098	0.0246	0.5
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0174	0.12	0.12
Brugia malayi	Cathepsin L-like precursor	0.0315	0.2959	0.2959
Onchocerca volvulus		0.0315	0.2959	1
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.0878	1	1
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0096	0.0221	0.0221
Onchocerca volvulus	Cathepsin F homolog	0.0315	0.2959	1
Onchocerca volvulus		0.0315	0.2959	1
Trypanosoma cruzi	cysteine proteinase, putative	0.0174	0.12	0.12
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0878	1	1
Echinococcus multilocularis	cathepsin L	0.0174	0.12	0.12
Leishmania major	cathepsin L-like protease	0.0315	0.2959	0.953
Leishmania major	cysteine peptidase A (CPA)	0.0315	0.2959	0.953
Entamoeba histolytica	cysteine protease, putative	0.0174	0.12	0.4054
Trypanosoma cruzi	cysteine peptidase, putative	0.0315	0.2959	0.2959
Onchocerca volvulus		0.0315	0.2959	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0315	0.2959	0.9567
Trypanosoma cruzi	cysteine peptidase, putative	0.0096	0.0221	0.0221
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0315	0.2959	0.953
Brugia malayi	Cathepsin L-like precursor	0.0096	0.0221	0.0221
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0315	0.2959	0.9567
Brugia malayi	Cathepsin L-like precursor	0.0315	0.2959	0.2959
Toxoplasma gondii	cathepsin B	0.0326	0.3093	1
Onchocerca volvulus		0.0273	0.243	0.8213
Echinococcus multilocularis	cathepsin L cysteine protease	0.0315	0.2959	0.2959
Onchocerca volvulus		0.0219	0.1759	0.5946
Onchocerca volvulus		0.0315	0.2959	1
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0315	0.2959	0.2959
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0315	0.2959	0.953
Trypanosoma cruzi	cysteine peptidase, putative	0.0174	0.12	0.12
Giardia lamblia	Cathepsin B precursor	0.0326	0.3093	1
Brugia malayi	Papain family cysteine protease containing protein	0.0174	0.12	0.12
Entamoeba histolytica	cysteine proteinase, putative	0.0315	0.2959	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0315	0.2959	0.9567
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.0219	0.1759	0.1759
Echinococcus granulosus	cathepsin L cysteine protease	0.0174	0.12	0.12
Loa Loa (eye worm)	hypothetical protein	0.0096	0.0221	0.0221
Brugia malayi	Probable ATP-dependent helicase DHX35	0.0095	0.0205	0.0205
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0315	0.2959	0.9567
Plasmodium vivax	vivapain-1	0.0174	0.12	0.4054
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0315	0.2959	0.953
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.0137	0.0735	0.0735
Leishmania major	cathepsin L-like protease	0.0315	0.2959	0.953
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0174	0.12	0.335
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0326	0.3093	0.3093
Brugia malayi	Cathepsin L-like precursor	0.0219	0.1759	0.1759
Leishmania major	cathepsin L-like protease	0.0315	0.2959	0.953
Trichomonas vaginalis	set domain proteins, putative	0.0273	0.243	0.7858
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0219	0.1759	0.5688
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0315	0.2959	0.9567
Trypanosoma cruzi	cruzipain precursor, putative	0.0096	0.0221	0.0221
Entamoeba histolytica	cysteine protease, putative	0.0174	0.12	0.4054
Entamoeba histolytica	cysteine protease, putative	0.0174	0.12	0.4054
Entamoeba histolytica	cysteine protease, putative	0.0174	0.12	0.4054
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0315	0.2959	0.9567
Entamoeba histolytica	cysteine proteinase 1, putative	0.0174	0.12	0.4054
Echinococcus multilocularis	survival motor neuron protein 1	0.0232	0.1923	0.1923
Entamoeba histolytica	cysteine protease, putative	0.0174	0.12	0.4054
Loa Loa (eye worm)	cathepsin B	0.0326	0.3093	0.3093
Brugia malayi	Cathepsin L-like precursor	0.0315	0.2959	0.2959
Onchocerca volvulus		0.0137	0.0735	0.2486
Echinococcus granulosus	cathepsin l1	0.0315	0.2959	0.2959
Brugia malayi	cathepsin F-like cysteine proteinase	0.0096	0.0221	0.0221
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0315	0.2959	0.953
Echinococcus multilocularis	eukaryotic initiation factor 4A	0.0098	0.0246	0.0246
Entamoeba histolytica	DEAD/DEAH box helicase, putative	0.0098	0.0246	0.083
Echinococcus granulosus	cysteine protease	0.0174	0.12	0.12
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0315	0.2959	0.9567
Trichomonas vaginalis	DEAD box ATP-dependent RNA helicase, putative	0.0098	0.0246	0.0794
Schistosoma mansoni	cathepsin s	0.0096	0.0221	0.0221
Leishmania major	cathepsin L-like protease	0.0315	0.2959	0.953
Loa Loa (eye worm)	cysteine protease	0.0315	0.2959	0.2959
Brugia malayi	eukaryotic initiation factor 4A	0.0098	0.0246	0.0246
Echinococcus granulosus	cathepsin b	0.0878	1	1
Toxoplasma gondii	cathepsin CPL	0.0315	0.2959	0.9567
Leishmania major	cathepsin L-like protease	0.0315	0.2959	0.953
Echinococcus multilocularis	cysteine protease	0.0315	0.2959	0.2959
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0315	0.2959	0.953
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0174	0.12	0.3878
Trypanosoma cruzi	Eukaryotic initiation factor 4A-1	0.0098	0.0246	0.0246
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0315	0.2959	0.9567
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0315	0.2959	0.953
Giardia lamblia	Cathepsin B precursor	0.0326	0.3093	1
Brugia malayi	cathepsin L-like cysteine proteinase, identical	0.0096	0.0221	0.0221
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0315	0.2959	0.9567
Schistosoma mansoni	DEAD box ATP-dependent RNA helicase	0.0098	0.0246	0.0246
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0174	0.12	0.12
Leishmania major	cathepsin L-like protease	0.0315	0.2959	0.953
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0315	0.2959	0.9567
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0315	0.2959	0.9567
Entamoeba histolytica	cysteine protease, putative	0.0174	0.12	0.4054
Giardia lamblia	Translation initiation factor eIF-4A, putative	0.0098	0.0246	0.0794
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0315	0.2959	0.9567
Loa Loa (eye worm)	hypothetical protein	0.0878	1	1
Schistosoma mansoni	SmCB2 peptidase (C01 family)	0.0878	1	1
Entamoeba histolytica	cysteine proteinase, putative	0.0219	0.1759	0.5946
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0315	0.2959	0.953
Brugia malayi	Papain family cysteine protease containing protein	0.0174	0.12	0.12
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0174	0.12	0.12
Loa Loa (eye worm)	fibroinase	0.0315	0.2959	0.2959
Brugia malayi	Trypsin family protein	0.0137	0.0735	0.0735
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0878	1	1
Plasmodium vivax	vivapain-2	0.0315	0.2959	1
Onchocerca volvulus	Eukaryotic initiation factor 4A homolog	0.0098	0.0246	0.083
Plasmodium vivax	vivapain-3	0.0174	0.12	0.4054
Brugia malayi	Pre-SET motif family protein	0.024	0.2016	0.2016
Trypanosoma cruzi	cysteine peptidase (N-terminal), putative	0.0174	0.12	0.12
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0315	0.2959	0.9567
Entamoeba histolytica	cysteine proteinase, putative	0.0315	0.2959	1
Entamoeba histolytica	cysteine protease, putative	0.0315	0.2959	1
Loa Loa (eye worm)	ctsf protein	0.0315	0.2959	0.2959
Echinococcus granulosus	cathepsin l1	0.0219	0.1759	0.1759
Plasmodium vivax	unspecified product	0.0174	0.12	0.4054
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0878	1	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0174	0.12	0.335

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (functional)	> 100 uM	Antiproliferative activity against murine L1210 cells	ChEMBL.	9057864
IC50 (functional)	> 100 uM	Antiproliferative activity against KB cell	ChEMBL.	9057864
IC50 (functional)	> 100 uM	Inhibition against human foreskin fibroblast (HFF) in a visual assay at time of plaque enumeration	ChEMBL.	9057864
IC50 (functional)	> 100 uM	Antiviral activity against human cytomegalovirus (HCMV) in plaque reduction assay	ChEMBL.	9057864
IC50 (functional)	> 100 uM	Antiviral activity against herpes simplex virus type 1 (HSV-1) by ELISA test	ChEMBL.	9057864

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: 375109
PubChem: 22211495

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 281362