Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | choline O-acetyltransferase | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Trypanosoma brucei | carnitine O-acetyltransferase, putative | choline O-acetyltransferase | 630 aa | 632 aa | 31.6 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0198 | 1 | 1 |
Leishmania major | choline/Carnitine o-acyltransferase-like protein | 0.003 | 0 | 0.5 |
Trypanosoma cruzi | choline/carnitine O-acyltransferase, putative | 0.003 | 0 | 0.5 |
Leishmania major | carnitine palmitoyltransferase-like protein | 0.003 | 0 | 0.5 |
Trypanosoma brucei | carnitine O-palmitoyltransferase II, putative | 0.003 | 0 | 0.5 |
Onchocerca volvulus | 0.003 | 0 | 0.5 | |
Onchocerca volvulus | 0.003 | 0 | 0.5 | |
Echinococcus granulosus | choline O acetyltransferase | 0.0198 | 1 | 1 |
Onchocerca volvulus | 0.003 | 0 | 0.5 | |
Trypanosoma brucei | carnitine O-acetyltransferase, putative | 0.003 | 0 | 0.5 |
Leishmania major | carnitine/choline acetyltransferase, putative | 0.003 | 0 | 0.5 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.003 | 0 | 0.5 |
Trypanosoma brucei | carnitine O-palmitoyltransferase II, putative | 0.003 | 0 | 0.5 |
Trypanosoma cruzi | choline/carnitine O-acyltransferase, putative | 0.003 | 0 | 0.5 |
Echinococcus multilocularis | choline O acetyltransferase | 0.0198 | 1 | 1 |
Trypanosoma cruzi | carnitine/choline acetyltransferase, putative | 0.003 | 0 | 0.5 |
Trypanosoma cruzi | choline/carnitine O-acetyltransferase, putative | 0.003 | 0 | 0.5 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.003 | 0 | 0.5 |
Trypanosoma brucei | hypothetical protein, conserved | 0.003 | 0 | 0.5 |
Trypanosoma cruzi | carnitine/choline acetyltransferase, putative | 0.003 | 0 | 0.5 |
Trypanosoma cruzi | carnitine O-palmitoyltransferase II, putative | 0.003 | 0 | 0.5 |
Trypanosoma cruzi | choline/carnitine O-acyltransferase, putative | 0.003 | 0 | 0.5 |
Onchocerca volvulus | 0.003 | 0 | 0.5 | |
Trypanosoma cruzi | hypothetical protein, conserved | 0.003 | 0 | 0.5 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.003 | 0 | 0.5 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.003 | 0 | 0.5 |
Trypanosoma cruzi | carnitine O-acetyltransferase, putative | 0.003 | 0 | 0.5 |
Trypanosoma brucei | carnitine O-palmitoyltransferase, putative | 0.003 | 0 | 0.5 |
Schistosoma mansoni | choline o-acyltransferase | 0.0198 | 1 | 1 |
Loa Loa (eye worm) | choline O-acetyltransferase | 0.0198 | 1 | 1 |
Brugia malayi | Choline O-acetyltransferase | 0.0198 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
I50 (binding) | = 12 uM | Inhibition of choline acetyltransferase (CAT) enzyme | ChEMBL. | 3351860 |
I50 (binding) | = 1200 uM | Inhibitory activity against acetylcholinetransferase (AChE) enzyme | ChEMBL. | 3351860 |
IC50 (binding) | = 12 uM | Inhibition of choline acetyltransferase (CAT) enzyme | ChEMBL. | 3351860 |
IC50 (binding) | = 1200 uM | Inhibitory activity against acetylcholinetransferase (AChE) enzyme | ChEMBL. | 3351860 |
Ratio (functional) | = 2.6 | Effect on rate of aging of soman-inhibited acetylcholinetransferase (AChE) in rat erythrocyte lysate at 1mM, ratio of control/treated | ChEMBL. | 3351860 |
Ratio (binding) | = 100 | Selectivity ratio of I50 of AChE to I50 of CAT | ChEMBL. | 3351860 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.