Detailed information for compound 286302

Basic information

Technical information
  • TDR Targets ID: 286302
  • Name: 2,7-dinitro-9H-fluorene
  • MW: 256.214 | Formula: C13H8N2O4
  • H donors: 0 H acceptors: 4 LogP: 3.21 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: [O-][N+](=O)c1ccc2c(c1)Cc1c2ccc(c1)[N+](=O)[O-]
  • InChi: 1S/C13H8N2O4/c16-14(17)10-1-3-12-8(6-10)5-9-7-11(15(18)19)2-4-13(9)12/h1-4,6-7H,5H2
  • InChiKey: IHZCVUBSTYOFSJ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 2,7-dinitrofluorene
  • 5405-53-8
  • ZINC01680753
  • 4-05-00-02153 (Beilstein Handbook Reference)
  • 9H-Fluorene, 2,7-dinitro- (9CI)
  • BRN 2057852
  • CCRIS 2909
  • EINECS 226-457-8
  • NSC 5180
  • Oprea1_216229
  • 9H-Fluorene, 2,7-dinitro-
  • Fluorene, 2,7-dinitro-
  • NSC5180
  • WLN: L B656 HHJ ENW KNW
  • A1355/0061133
  • D196401_ALDRICH

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0026 0.0171 0.0221
Echinococcus granulosus geminin 0.0205 0.2016 0.2373
Echinococcus multilocularis microtubule associated protein 2 0.0833 0.8496 0.8496
Loa Loa (eye worm) hypothetical protein 0.018 0.1766 0.2278
Trypanosoma cruzi 3-Beta-hydroxysteroid-delta(8), delta(7)-isomerase, putative 0.0284 0.2838 0.366
Brugia malayi RNA, U transporter 1 0.0099 0.0927 0.1196
Trypanosoma brucei beta lactamase 0.0077 0.07 0.0902
Loa Loa (eye worm) hypothetical protein 0.0761 0.7754 1
Loa Loa (eye worm) hypothetical protein 0.018 0.1766 0.2278
Schistosoma mansoni hypothetical protein 0.0041 0.0331 0.039
Trypanosoma brucei BRCA1 C Terminus (BRCT) domain containing protein, putative 0.0012 0.0029 0.0038
Echinococcus granulosus metabotropic glutamate receptor 5 0.0011 0.0018 0.0022
Loa Loa (eye worm) hypothetical protein 0.0011 0.0018 0.0024
Loa Loa (eye worm) hypothetical protein 0.0033 0.0242 0.0313
Brugia malayi ATP dependent DNA ligase C terminal region family protein 0.0012 0.0029 0.0038
Schistosoma mansoni topbp1 0.0012 0.0029 0.0035
Echinococcus granulosus cpg binding protein 0.0037 0.0285 0.0335
Echinococcus granulosus dnaJ subfamily B 0.0494 0.4998 0.5883
Schistosoma mansoni hypothetical protein 0.0372 0.3738 0.44
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0026 0.0171 0.5991
Trypanosoma brucei C-8 sterol isomerase, putative 0.0761 0.7754 1
Schistosoma mansoni topbp1 0.0012 0.0029 0.0035
Schistosoma mansoni microtubule-associated protein tau 0.0833 0.8496 1
Echinococcus granulosus tyrosine kinase 0.0011 0.0018 0.0022
Leishmania major C-8 sterol isomerase-like protein 0.0761 0.7754 1
Echinococcus granulosus nmda type glutamate receptor 0.0075 0.0683 0.0804
Brugia malayi cytoplasmic intermediate filament protein 0.0017 0.0087 0.0112
Loa Loa (eye worm) hypothetical protein 0.0011 0.0018 0.0024
Echinococcus multilocularis metabotropic glutamate receptor 2 0.0011 0.0018 0.0018
Echinococcus granulosus glutamate receptor 2 0.0011 0.0018 0.0022
Echinococcus multilocularis atrial natriuretic peptide receptor 0.0011 0.0018 0.0018
Schistosoma mansoni cpg binding protein 0.0035 0.0264 0.0311
Echinococcus multilocularis glutamate receptor subunit protein glur 0.0021 0.0125 0.0125
Onchocerca volvulus 0.0033 0.0242 0.0661
Brugia malayi hypothetical protein 0.0011 0.0018 0.0024
Echinococcus multilocularis receptor type guanylyl cyclase 0.0011 0.0018 0.0018
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.0029 0.0911
Trichomonas vaginalis replication factor C large subunit, putative 0.0012 0.0029 0.0911
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.0029 0.0911
Schistosoma mansoni hypothetical protein 0.0019 0.0103 0.0121
Schistosoma mansoni hypothetical protein 0.0019 0.0103 0.0121
Onchocerca volvulus 0.0012 0.0034 0.0093
Echinococcus granulosus receptor type guanylyl cyclase 0.0011 0.0018 0.0022
Echinococcus multilocularis geminin 0.0205 0.2016 0.2016
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0026 0.0171 0.5991
Echinococcus granulosus nibrin 0.0012 0.0029 0.0035
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0026 0.0171 1
Trichomonas vaginalis rotamase, putative 0.004 0.0323 1
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.0029 0.0911
Entamoeba histolytica hypothetical protein 0.0043 0.0355 1
Echinococcus multilocularis tar DNA binding protein 0.0076 0.0695 0.0695
Onchocerca volvulus Atrial natriuretic peptide receptor 3 homolog 0.0011 0.0018 0.005
Mycobacterium tuberculosis Class a beta-lactamase BlaC 0.016 0.1559 1
Loa Loa (eye worm) pigment dispersing factor receptor c 0.006 0.0527 0.068
Brugia malayi Receptor family ligand binding region containing protein 0.0011 0.0018 0.0024
Schistosoma mansoni chromosome transmission fidelity factor 0.0012 0.0029 0.0035
Echinococcus multilocularis sodium channel protein 0.014 0.1347 0.1347
Leishmania major hypothetical protein, conserved 0.0284 0.2838 0.366
Echinococcus granulosus glutamate receptor ionotrophic AMPA 3 0.0032 0.0236 0.0278
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0074 0.0665 0.0783
Mycobacterium leprae PROBABLE CONSERVED LIPOPROTEIN LPQF 0.0077 0.07 1
Schistosoma mansoni ran 0.0026 0.0171 0.0201
Echinococcus granulosus metabotropic glutamate receptor 2 0.0011 0.0018 0.0022
Loa Loa (eye worm) hypothetical protein 0.0365 0.3668 0.4731
Echinococcus multilocularis nibrin 0.0012 0.0029 0.0029
Trypanosoma cruzi importin beta-1 subunit, putative 0.0028 0.0198 0.0255
Onchocerca volvulus 0.0033 0.0242 0.0661
Loa Loa (eye worm) TAR-binding protein 0.0076 0.0695 0.0897
Echinococcus multilocularis nmda type glutamate receptor 0.0075 0.0683 0.0683
Brugia malayi RNA binding protein 0.0076 0.0695 0.0897
Loa Loa (eye worm) hypothetical protein 0.0011 0.0018 0.0024
Trypanosoma cruzi hypothetical protein, conserved 0.0012 0.0029 0.0038
Brugia malayi ERG2 and Sigma1 receptor like protein 0.0761 0.7754 1
Entamoeba histolytica hypothetical protein 0.0012 0.0029 0.0324
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0032 0.0236 0.0278
Echinococcus multilocularis cpg binding protein 0.0037 0.0285 0.0285
Echinococcus granulosus atrial natriuretic peptide receptor 0.0011 0.0018 0.0022
Echinococcus granulosus muscleblind protein 0.018 0.1766 0.2079
Schistosoma mansoni DNA ligase IV 0.0012 0.0029 0.0035
Brugia malayi hypothetical protein 0.0012 0.0029 0.0038
Toxoplasma gondii PPIC-type PPIASE domain-containing protein 0.0012 0.0033 0.0569
Toxoplasma gondii peptidylprolyl isomerase 0.0039 0.0313 0.5355
Echinococcus granulosus glutamate receptor ionotropic kainate 0.0021 0.0125 0.0147
Loa Loa (eye worm) hypothetical protein 0.0012 0.0029 0.0038
Schistosoma mansoni hypothetical protein 0.0205 0.2016 0.2373
Schistosoma mansoni glutamate receptor AMPA 0.0021 0.0125 0.0147
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.006 0.0527 0.068
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0033 0.0242 0.0313
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.0029 0.0911
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0032 0.0236 0.0278
Echinococcus granulosus glutamate NMDA receptor subunit 0.0021 0.0125 0.0147
Echinococcus multilocularis expressed protein 0.004 0.0323 0.0323
Echinococcus multilocularis muscleblind protein 1 0.018 0.1766 0.1766
Schistosoma mansoni tyrosine kinase 0.0011 0.0018 0.0022
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0372 0.3738 0.4821
Schistosoma mansoni lamin 0.0033 0.0242 0.0285
Schistosoma mansoni glutamate receptor kainate 0.0021 0.0125 0.0147
Echinococcus granulosus glutamate receptor 2 0.0032 0.0236 0.0278
Entamoeba histolytica Activator 1 140 kDa subunit, putative 0.0012 0.0029 0.0324
Echinococcus multilocularis muscleblind protein 0.018 0.1766 0.1766
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0032 0.0236 0.0278
Echinococcus multilocularis tyrosine kinase 0.0011 0.0018 0.0018
Echinococcus granulosus importin subunit beta 1 0.0035 0.0266 0.0313
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0695 0.0818
Mycobacterium ulcerans glutamine-binding lipoprotein GlnH 0.0054 0.0465 0.2849
Trypanosoma cruzi hypothetical protein, conserved 0.0012 0.0029 0.0038
Brugia malayi hypothetical protein 0.0365 0.3668 0.4731
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0019 0.0103 0.0103
Loa Loa (eye worm) hypothetical protein 0.0016 0.0069 0.0089
Trypanosoma cruzi C-8 sterol isomerase, putative 0.0761 0.7754 1
Loa Loa (eye worm) hypothetical protein 0.0012 0.0029 0.0038
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0695 0.0818
Loa Loa (eye worm) glutamate receptor 1 0.0021 0.0125 0.0161
Loa Loa (eye worm) hypothetical protein 0.0012 0.0029 0.0038
Schistosoma mansoni transcription factor LCR-F1 0.0043 0.0355 0.0417
Schistosoma mansoni cpg binding protein 0.0037 0.0285 0.0335
Loa Loa (eye worm) RGC/RGC protein kinase 0.0011 0.0018 0.0024
Brugia malayi Pin1-type peptidyl-prolyl cis-trans isomerase, BmPin1 0.004 0.0323 0.0416
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0028 0.0198 0.6134
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0011 0.0017 0.0021
Leishmania major calcium channel protein, putative,ion transporter, putative 0.014 0.1347 0.1737
Loa Loa (eye worm) hypothetical protein 0.0011 0.0018 0.0024
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0028 0.0198 0.6134
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0032 0.0236 0.0236
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0695 0.0818
Loa Loa (eye worm) hypothetical protein 0.0015 0.0063 0.0081
Brugia malayi latrophilin 2 splice variant baaae 0.0041 0.0331 0.0427
Trypanosoma cruzi Emopamil binding protein, putative 0.0284 0.2838 0.366
Schistosoma mansoni hypothetical protein 0.0043 0.0355 0.0417
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0019 0.0103 0.0133
Brugia malayi metabotropic glutamate receptor type 2 0.0011 0.0018 0.0024
Schistosoma mansoni cpg binding protein 0.0037 0.0285 0.0335
Echinococcus multilocularis lamin dm0 0.0033 0.0242 0.0242
Leishmania major peptidyl-prolyl cis-trans isomerase, putative 0.0012 0.0033 0.0043
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, putative 0.0039 0.0313 0.8755
Entamoeba histolytica hypothetical protein 0.0043 0.0355 1
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0043 0.0355 0.0417
Brugia malayi Guanylyl cyclase protein 23 0.0011 0.0018 0.0024
Trichomonas vaginalis RNA polymerase II ctd phosphatase, putative 0.0012 0.0029 0.0911
Loa Loa (eye worm) Pin1-type peptidyl-prolyl cis-trans isomerase 0.004 0.0323 0.0416
Echinococcus granulosus expressed protein 0.004 0.0323 0.038
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0017 0.0087 0.0112
Echinococcus granulosus intermediate filament protein 0.0033 0.0242 0.0285
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0011 0.0017 0.0017
Treponema pallidum amino acid ABC transporter, periplasmic binding protein 0.0054 0.0465 1
Entamoeba histolytica hypothetical protein 0.0028 0.0198 0.5336
Loa Loa (eye worm) hypothetical protein 0.0032 0.0236 0.0305
Brugia malayi Latrophilin receptor protein 2 0.0019 0.0103 0.0133
Wolbachia endosymbiont of Brugia malayi parvulin-like peptidyl-prolyl isomerase, PPID 0.0012 0.0033 1
Loa Loa (eye worm) hypothetical protein 0.0012 0.0029 0.0038
Schistosoma mansoni ATP-binding cassette transporter 0.0021 0.0125 0.0147
Echinococcus granulosus tar DNA binding protein 0.0076 0.0695 0.0818
Brugia malayi Glutamate receptor 2 precursor 0.0021 0.0125 0.0161
Loa Loa (eye worm) hypothetical protein 0.0041 0.0331 0.0427
Schistosoma mansoni rotamase 0.004 0.0323 0.038
Loa Loa (eye worm) hypothetical protein 0.0012 0.0029 0.0038
Echinococcus multilocularis glutamate (NMDA) receptor subunit 0.0021 0.0125 0.0125
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0039 0.0313 0.0403
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 3 0.0075 0.0683 0.0683
Brugia malayi CXXC zinc finger family protein 0.0035 0.0264 0.0341
Onchocerca volvulus 0.0011 0.0018 0.005
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.0012 0.0029 0.0911
Loa Loa (eye worm) RGC/RGC protein kinase 0.0011 0.0018 0.0024
Brugia malayi Receptor family ligand binding region containing protein 0.0011 0.0018 0.0024
Brugia malayi Metabotropic glutamate receptor precursor. 0.0011 0.0018 0.0024
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0016 0.0069 0.0081
Loa Loa (eye worm) receptor family ligand binding region containing protein 0.0011 0.0018 0.0024
Leishmania major GTP-binding protein, putative 0.0026 0.0171 0.0221
Loa Loa (eye worm) CXXC zinc finger family protein 0.0035 0.0264 0.0341
Trichomonas vaginalis importin beta-1, putative 0.0028 0.0198 0.6134
Loa Loa (eye worm) hypothetical protein 0.0015 0.0063 0.0081
Schistosoma mansoni hypothetical protein 0.0019 0.0103 0.0121
Echinococcus granulosus glutamate receptor ionotropic kainate 3 0.0021 0.0125 0.0147
Brugia malayi TAR-binding protein 0.0076 0.0695 0.0897
Echinococcus multilocularis replication factor c subunit 1 0.0012 0.0029 0.0029
Echinococcus granulosus GTP binding nuclear protein Ran 0.0026 0.0171 0.0201
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0026 0.0171 0.0221
Onchocerca volvulus 0.0284 0.2838 0.7737
Echinococcus multilocularis glutamate receptor ionotropic kainate 0.0021 0.0125 0.0125
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0323 1
Loa Loa (eye worm) hypothetical protein 0.0011 0.0018 0.0024
Schistosoma mansoni glutamate receptor NMDA 0.0032 0.0236 0.0278
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0019 0.0103 0.0103
Schistosoma mansoni hypothetical protein 0.0494 0.4998 0.5883
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase, putative 0.0012 0.0033 0.0043
Onchocerca volvulus 0.0365 0.3668 1
Loa Loa (eye worm) metabotropic glutamate receptor 8 0.0011 0.0018 0.0024
Leishmania major 3-Beta-hydroxysteroid-delta(8), delta(7)-isomerase, putative 0.0284 0.2838 0.366
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0695 0.0818
Schistosoma mansoni intermediate filament proteins 0.0033 0.0242 0.0285
Loa Loa (eye worm) hypothetical protein 0.0012 0.0029 0.0038
Trichomonas vaginalis ran, putative 0.0026 0.0171 0.53
Echinococcus granulosus microtubule associated protein 2 0.0833 0.8496 1
Brugia malayi DKFZp564C0469 protein 0.0012 0.0029 0.0038
Trypanosoma cruzi extracellular receptor, putative 0.0011 0.0018 0.0024
Trypanosoma cruzi Emopamil binding protein, putative 0.0284 0.2838 0.366
Brugia malayi metabotropic GABA-B receptor subtype 2 0.0011 0.0018 0.0024
Brugia malayi hypothetical protein 0.0012 0.0029 0.0038
Leishmania major extracellular receptor, putative 0.0011 0.0018 0.0024
Trypanosoma cruzi 3-Beta-hydroxysteroid-delta(8), delta(7)-isomerase, putative 0.0284 0.2838 0.366
Mycobacterium ulcerans lipoprotein LpqF 0.0077 0.07 0.4383
Loa Loa (eye worm) hypothetical protein 0.006 0.0527 0.068
Toxoplasma gondii histone lysine methyltransferase SET1 0.0066 0.0584 1
Brugia malayi F/Y-rich N-terminus family protein 0.0011 0.0016 0.0021
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0016 0.0069 0.0069
Schistosoma mansoni lamin 0.0033 0.0242 0.0285
Echinococcus granulosus lamin dm0 0.0033 0.0242 0.0285
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0026 0.0171 0.0171
Echinococcus granulosus nmda type glutamate receptor 0.0011 0.0018 0.0022
Schistosoma mansoni glutamate receptor NMDA 0.0021 0.0125 0.0147
Loa Loa (eye worm) RGC/RGC protein kinase 0.0011 0.0018 0.0024
Schistosoma mansoni tyrosine kinase 0.0011 0.0018 0.0022
Echinococcus multilocularis lamin 0.0033 0.0242 0.0242
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0043 0.0355 0.0355
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0012 0.0033 0.0043
Brugia malayi Calcitonin receptor-like protein seb-1 0.006 0.0527 0.068
Trypanosoma cruzi BRCA1 C Terminus (BRCT) domain containing protein, putative 0.0012 0.0029 0.0038
Echinococcus multilocularis musashi 0.0033 0.0242 0.0242
Entamoeba histolytica Ran family GTPase 0.0026 0.0171 0.4536
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0019 0.0103 0.0121
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.0029 0.0911
Brugia malayi Intermediate filament tail domain containing protein 0.0033 0.0242 0.0313
Loa Loa (eye worm) hypothetical protein 0.0011 0.0018 0.0024
Echinococcus granulosus sodium channel protein 0.014 0.1347 0.1585
Treponema pallidum amino acid ABC transporter, periplasmic binding protein (hisJ) 0.0054 0.0465 1
Loa Loa (eye worm) glutamate receptor 0.0011 0.0018 0.0024
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0019 0.0103 0.0121
Onchocerca volvulus 0.0035 0.0264 0.072
Echinococcus granulosus replication factor c subunit 1 0.0012 0.0029 0.0035
Echinococcus multilocularis importin subunit beta 1 0.0035 0.0266 0.0266
Brugia malayi hypothetical protein 0.0043 0.0355 0.0457
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0032 0.0236 0.0236
Brugia malayi Pax transcription activation domain interacting protein 0.0012 0.0029 0.0038
Toxoplasma gondii poly(ADP-ribose) polymerase catalytic domain-containing protein 0.0012 0.0029 0.0503
Entamoeba histolytica hypothetical protein 0.0043 0.0355 1
Trypanosoma brucei importin beta-1 subunit, putative 0.0035 0.0266 0.0343
Loa Loa (eye worm) histone methyltransferase 0.0011 0.0017 0.0022
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0026 0.0171 0.2927
Schistosoma mansoni glutamate receptor AMPA 0.0021 0.0125 0.0147
Loa Loa (eye worm) hypothetical protein 0.0035 0.0266 0.0343
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0695 0.0818
Schistosoma mansoni importin beta-1 0.0035 0.0266 0.0313
Schistosoma mansoni hypothetical protein 0.0205 0.2016 0.2373
Loa Loa (eye worm) hypothetical protein 0.0019 0.0103 0.0133
Loa Loa (eye worm) hypothetical protein 0.0011 0.0018 0.0024
Schistosoma mansoni glutamate receptor kainate 0.0021 0.0125 0.0147
Loa Loa (eye worm) RNA binding protein 0.0076 0.0695 0.0897
Toxoplasma gondii ATPase, AAA family protein 0.0012 0.0029 0.0503
Echinococcus multilocularis Ribosomal protein S1, RNA binding domain 0.0021 0.0125 0.0125
Chlamydia trachomatis arginine ABC transporter substrate-binding protein ArtJ 0.0054 0.0465 1
Leishmania major importin beta-1 subunit, putative 0.0028 0.0198 0.0255
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase, putative 0.0012 0.0033 0.0043
Trichomonas vaginalis RNA polymerase II ctd phosphatase, putative 0.0012 0.0029 0.0911
Entamoeba histolytica hypothetical protein 0.0043 0.0355 1
Mycobacterium tuberculosis Probable conserved lipoprotein LpqF 0.0077 0.07 0.2145
Echinococcus granulosus GPCR family 2 0.0019 0.0103 0.0121
Loa Loa (eye worm) latrophilin receptor protein 2 0.0019 0.0103 0.0133
Onchocerca volvulus 0.0012 0.0029 0.008
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0039 0.0313 0.0403
Leishmania major peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative 0.0039 0.0313 0.0403
Onchocerca volvulus 0.0011 0.0018 0.005
Echinococcus multilocularis glutamate receptor, ionotrophic, AMPA 3 0.0032 0.0236 0.0236
Schistosoma mansoni ran 0.0026 0.0171 0.0201
Chlamydia trachomatis glutamine binding protein 0.0054 0.0465 1
Brugia malayi Glutamate receptor 1 precursor 0.0021 0.0125 0.0161
Echinococcus multilocularis glutamate receptor 2 0.0032 0.0236 0.0236
Echinococcus granulosus lamin 0.0033 0.0242 0.0285
Mycobacterium ulcerans class a beta-lactamase, BlaC 0.016 0.1559 1
Plasmodium vivax importin-beta 2, putative 0.0035 0.0266 1
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0026 0.0171 0.0221
Loa Loa (eye worm) hypothetical protein 0.0011 0.0018 0.0024
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0032 0.0236 0.0236
Plasmodium falciparum importin beta, putative 0.0035 0.0266 1
Echinococcus multilocularis NMDA receptor 0.0021 0.0125 0.0125
Loa Loa (eye worm) intermediate filament protein 0.0033 0.0242 0.0313
Echinococcus multilocularis dnaJ subfamily B 0.0494 0.4998 0.4998
Echinococcus multilocularis nmda type glutamate receptor 0.0011 0.0018 0.0018
Brugia malayi topoisomerase 0.0012 0.0029 0.0038
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0026 0.0171 0.0221
Echinococcus granulosus Ribosomal protein S1 RNA binding domain 0.0021 0.0125 0.0147
Echinococcus multilocularis snurportin 1 0.0372 0.3738 0.3738
Brugia malayi intermediate filament protein 0.0033 0.0242 0.0313
Echinococcus multilocularis metabotropic glutamate receptor 5 0.0011 0.0018 0.0018
Loa Loa (eye worm) glutamate receptor 2 0.0021 0.0125 0.0161
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0026 0.0171 0.0221
Echinococcus granulosus voltage gated sodium channel Nav1 alpha subunit 0.014 0.1347 0.1585
Trypanosoma brucei importin beta-1 subunit, putative 0.0035 0.0266 0.0343
Schistosoma mansoni metabotropic glutamate receptor 0.0011 0.0018 0.0022
Schistosoma mansoni hypothetical protein 0.0021 0.0125 0.0147
Schistosoma mansoni hypothetical protein 0.0019 0.0103 0.0121
Loa Loa (eye worm) hypothetical protein 0.0389 0.3918 0.5052
Brugia malayi RNA recognition motif domain containing protein 0.0076 0.0695 0.0897
Trypanosoma cruzi FHA domain containing protein, putative 0.0012 0.0029 0.0038
Brugia malayi Muscleblind-like protein 0.018 0.1766 0.2278
Brugia malayi Importin beta-1 subunit 0.0035 0.0266 0.0343
Echinococcus granulosus snurportin 1 0.0372 0.3738 0.44
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase/rotamase, putative 0.0039 0.0313 0.0403
Loa Loa (eye worm) hypothetical protein 0.0011 0.0018 0.0024
Trypanosoma brucei Emopamil binding protein, putative 0.0284 0.2838 0.366
Trichomonas vaginalis rotamase, putative 0.0039 0.0313 0.9696
Echinococcus multilocularis glutamate receptor 2 0.0011 0.0018 0.0018
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.0012 0.0029 0.0911
Echinococcus multilocularis GPCR, family 2 0.0019 0.0103 0.0103
Echinococcus multilocularis glutamate receptor 2 0.0021 0.0125 0.0125
Schistosoma mansoni glutamate receptor kainate 0.0021 0.0125 0.0147
Loa Loa (eye worm) metabotropic GABA-B receptor subtype 2 0.0011 0.0018 0.0024
Schistosoma mansoni metabotropic glutamate receptor 0.0011 0.0018 0.0022
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0076 0.0695 0.0897
Toxoplasma gondii HEAT repeat-containing protein 0.0035 0.0266 0.455
Echinococcus granulosus glutamate receptor subunit protein glur 0.0021 0.0125 0.0147
Schistosoma mansoni protein kinase 0.0011 0.0018 0.0022

Activities

Activity type Activity value Assay description Source Reference
Activity (functional) = 3.22 Mutagenic activity of the compound was tested in an Ames test on S. typhimurium TA98; Activity is log of revertants/nmol ChEMBL. 1995902
logP (ADMET) = 3.35 Partition coefficient (logP) ChEMBL. 1995902

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.