Detailed information for compound 287497

Basic information

Technical information
  • TDR Targets ID: 287497
  • Name: 3-[(E)-2-pyridin-4-ylethenyl]-1H-indole
  • MW: 220.269 | Formula: C15H12N2
  • H donors: 1 H acceptors: 1 LogP: 3.25 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: n1ccc(cc1)/C=C/c1c[nH]c2c1cccc2
  • InChi: 1S/C15H12N2/c1-2-4-15-14(3-1)13(11-17-15)6-5-12-7-9-16-10-8-12/h1-11,17H/b6-5+
  • InChiKey: GWFLOYNQTNXGOJ-AATRIKPKSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 3-[(E)-2-(4-pyridyl)vinyl]-1H-indole

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Rattus norvegicus Tryptophan 2,3-dioxygenase Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Onchocerca volvulus 0.015 0.129 0.2699
Loa Loa (eye worm) hypothetical protein 0.0073 0.0438 0.0568
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.004 0.0063 0.0132
Schistosoma mansoni nAChR subunit 0.0073 0.0438 0.0917
Echinococcus multilocularis mitogen activated protein kinase 14 0.0139 0.1165 0.2437
Loa Loa (eye worm) hypothetical protein 0.0073 0.0438 0.0568
Loa Loa (eye worm) CMGC/MAPK/P38 protein kinase 0.0139 0.1165 0.151
Loa Loa (eye worm) hypothetical protein 0.0387 0.3915 0.5075
Echinococcus granulosus nAChR subunit 0.004 0.0063 0.0132
Onchocerca volvulus 0.0067 0.0367 0.0767
Onchocerca volvulus Chorion peroxidase homolog 0.0465 0.478 1
Onchocerca volvulus Slit protein homolog 0.015 0.129 0.2699
Brugia malayi Peroxidasin 0.0465 0.478 1
Echinococcus multilocularis neurogenic locus protein delta 0.015 0.129 0.2699
Loa Loa (eye worm) hypothetical protein 0.0465 0.478 0.6196
Loa Loa (eye worm) hypothetical protein 0.004 0.0063 0.0082
Schistosoma mansoni neurotransmitter gated ion channel 0.004 0.0063 0.0132
Echinococcus multilocularis protein jagged 1 0.015 0.129 0.2699
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0073 0.0438 0.0917
Brugia malayi EGF-like domain containing protein 0.015 0.129 0.2699
Leishmania major mitochondrial DNA topoisomerase II 0.0541 0.5621 1
Entamoeba histolytica DNA topoisomerase II, putative 0.0219 0.2049 1
Loa Loa (eye worm) hypothetical protein 0.0073 0.0438 0.0568
Onchocerca volvulus 0.015 0.129 0.2699
Schistosoma mansoni nAChR subunit (ShAR1-beta2-like) 0.0073 0.0438 0.0917
Trypanosoma cruzi mitogen-activated protein kinase 3, putative 0.0139 0.1165 0.1519
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.004 0.0063 0.0132
Leishmania major mitogen-activated protein kinase 3, putative,map kinase 3, putative 0.0139 0.1165 0.1519
Trypanosoma brucei DNA topoisomerase ii 0.0541 0.5621 1
Loa Loa (eye worm) hypothetical protein 0.015 0.129 0.1673
Echinococcus granulosus neurogenic locus notch protein 0.015 0.129 0.2699
Loa Loa (eye worm) animal heme peroxidase 0.0465 0.478 0.6196
Echinococcus multilocularis protein jagged 1 0.015 0.129 0.2699
Trypanosoma cruzi mitogen-activated protein kinase 3, putative 0.0139 0.1165 0.1519
Schistosoma mansoni nAChR subunit 0.0073 0.0438 0.0917
Echinococcus multilocularis slit 2 protein 0.015 0.129 0.2699
Trypanosoma cruzi mitochondrial DNA topoisomerase II, putative 0.0541 0.5621 1
Schistosoma mansoni notch 0.015 0.129 0.2699
Echinococcus granulosus acetylcholine receptor subunit beta 1 0.0073 0.0438 0.0917
Onchocerca volvulus 0.015 0.129 0.2699
Echinococcus granulosus peroxidasin 0.0465 0.478 1
Loa Loa (eye worm) hypothetical protein 0.015 0.129 0.1673
Schistosoma mansoni hypothetical protein 0.015 0.129 0.2699
Schistosoma mansoni hypothetical protein 0.015 0.129 0.2699
Echinococcus multilocularis DNA topoisomerase 3 beta 1 0.0067 0.0367 0.0767
Brugia malayi nicotinic acetylcholine receptor alpha subunit, putative 0.0073 0.0438 0.0917
Giardia lamblia DNA topoisomerase II 0.0189 0.1724 1
Schistosoma mansoni Pro-neuregulin-4 membrane-bound isoform (Pro-NRG4) [Contains: Neuregulin-4 (NRG-4)] 0.015 0.129 0.2699
Echinococcus granulosus delta-like protein 1 0.015 0.129 0.2699
Echinococcus multilocularis nicotinic acetylcholine receptor subunit alpha 8 0.0073 0.0438 0.0917
Echinococcus multilocularis neural cadherin 0.015 0.129 0.2699
Loa Loa (eye worm) nicotinic acetylcholine receptor alpha subunit 0.0073 0.0438 0.0568
Echinococcus multilocularis fibropellin Ia 0.015 0.129 0.2699
Schistosoma mansoni hypothetical protein 0.015 0.129 0.2699
Brugia malayi acetylcholine receptor protein, alpha-like chain, putative 0.0073 0.0438 0.0917
Echinococcus granulosus neurogenic locus notch protein 4 0.015 0.129 0.2699
Echinococcus multilocularis nicotinic acetylcholine receptor a11 subunit 0.0073 0.0438 0.0917
Schistosoma mansoni laminin gamma-3 chain 0.015 0.129 0.2699
Loa Loa (eye worm) hypothetical protein 0.0073 0.0438 0.0568
Brugia malayi hypothetical protein 0.0465 0.478 1
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0073 0.0438 0.0917
Loa Loa (eye worm) hypothetical protein 0.0421 0.429 0.5561
Echinococcus granulosus protein jagged 1 0.015 0.129 0.2699
Echinococcus granulosus nicotinic acetylcholine receptor alpha subunit 0.0073 0.0438 0.0917
Brugia malayi Probable DNA topoisomerase II 0.0219 0.2049 0.4288
Schistosoma mansoni peroxidasin 0.0465 0.478 1
Echinococcus multilocularis protein jagged 2 0.015 0.129 0.2699
Onchocerca volvulus 0.015 0.129 0.2699
Toxoplasma gondii EGF family domain-containing protein 0.015 0.129 0.1758
Loa Loa (eye worm) hypothetical protein 0.0465 0.478 0.6196
Loa Loa (eye worm) hypothetical protein 0.004 0.0063 0.0082
Brugia malayi acetylcholine receptor alpha subunit precursor, putative 0.0073 0.0438 0.0917
Brugia malayi Muscle positioning protein 4 0.015 0.129 0.2699
Echinococcus granulosus nAChR subunit 0.0073 0.0438 0.0917
Echinococcus granulosus slit 2 protein 0.015 0.129 0.2699
Brugia malayi Calcium binding EGF domain containing protein 0.015 0.129 0.2699
Echinococcus multilocularis acetylcholine receptor subunit beta 1 0.0073 0.0438 0.0917
Onchocerca volvulus Neurogenic locus notch protein homolog 0.015 0.129 0.2699
Leishmania major DNA topoisomerase ii 0.0152 0.1308 0.1791
Loa Loa (eye worm) acetylcholine receptor alpha subunit 0.0073 0.0438 0.0568
Loa Loa (eye worm) Notch2 0.015 0.129 0.1673
Echinococcus multilocularis glycine receptor subunit beta 0.0073 0.0438 0.0917
Loa Loa (eye worm) hypothetical protein 0.015 0.129 0.1673
Echinococcus granulosus fibropellin Ia 0.015 0.129 0.2699
Loa Loa (eye worm) animal heme peroxidase 0.0465 0.478 0.6196
Brugia malayi DNA topoisomerase III 0.0067 0.0367 0.0767
Loa Loa (eye worm) hypothetical protein 0.0073 0.0438 0.0568
Trypanosoma cruzi DNA topoisomerase II, putative 0.0152 0.1308 0.1791
Brugia malayi glutamate-gated chloride channel alpha3A subunit, putative 0.004 0.0063 0.0132
Loa Loa (eye worm) excitatory GABA receptor EXP-1A 0.0073 0.0438 0.0568
Brugia malayi DNA topoisomerase II, alpha isozyme 0.0219 0.2049 0.4288
Loa Loa (eye worm) hypothetical protein 0.0073 0.0438 0.0568
Loa Loa (eye worm) hypothetical protein 0.0152 0.1308 0.1695
Brugia malayi EGF-like domain containing protein 0.015 0.129 0.2699
Loa Loa (eye worm) hypothetical protein 0.015 0.129 0.1673
Loa Loa (eye worm) hypothetical protein 0.015 0.129 0.1673
Echinococcus multilocularis nicotinic acetylcholine receptor alpha subunit 0.0073 0.0438 0.0917
Brugia malayi Cation transporter family protein 0.0073 0.0438 0.0917
Brugia malayi DNA topoisomerase III beta-1 0.0067 0.0367 0.0767
Loa Loa (eye worm) hypothetical protein 0.015 0.129 0.1673
Onchocerca volvulus Putative cubilin 0.015 0.129 0.2699
Brugia malayi notch-like transmembrane receptor 0.015 0.129 0.2699
Brugia malayi EGF-like domain containing protein 0.015 0.129 0.2699
Entamoeba histolytica DNA topoisomerase III, putative 0.0067 0.0367 0.1528
Echinococcus granulosus mitogen activated protein kinase 11 0.0139 0.1165 0.2437
Echinococcus granulosus DNA topoisomerase 3 alpha 0.0067 0.0367 0.0767
Schistosoma mansoni nicotinic acetylcholine receptor alpha 0.004 0.0063 0.0132
Schistosoma mansoni DNA topoisomerase II 0.0219 0.2049 0.4288
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0073 0.0438 0.0917
Brugia malayi Cation transporter family protein 0.0073 0.0438 0.0917
Echinococcus granulosus glycine receptor subunit beta 0.0073 0.0438 0.0917
Brugia malayi Animal haem peroxidase family protein 0.0465 0.478 1
Loa Loa (eye worm) animal heme peroxidase 0.0465 0.478 0.6196
Brugia malayi DNA gyrase/topoisomerase IV, A subunit family protein 0.0219 0.2049 0.4288
Echinococcus granulosus nicotinic acetylcholine receptor subunit type 0.0073 0.0438 0.0917
Mycobacterium ulcerans DNA gyrase subunit B 0.0936 1 1
Schistosoma mansoni cell polarity protein 0.015 0.129 0.2699
Echinococcus granulosus neuronal acetylcholine receptor subunit alpha 4 0.0073 0.0438 0.0917
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0073 0.0438 0.0917
Loa Loa (eye worm) GABA receptor subunit 0.004 0.0063 0.0082
Loa Loa (eye worm) animal heme peroxidase 0.0465 0.478 0.6196
Echinococcus multilocularis peroxidasin 0.0465 0.478 1
Schistosoma mansoni nAChR subunit 0.0073 0.0438 0.0917
Onchocerca volvulus 0.015 0.129 0.2699
Loa Loa (eye worm) blistered cuticle protein 3 0.0465 0.478 0.6196
Onchocerca volvulus 0.0073 0.0438 0.0917
Schistosoma mansoni notch 0.015 0.129 0.2699
Toxoplasma gondii ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein 0.0541 0.5621 1
Schistosoma mansoni nAChR subunit (ShAR1-alpha-like) 0.0073 0.0438 0.0917
Onchocerca volvulus Dual oxidase homolog 0.0465 0.478 1
Brugia malayi Calcium binding EGF domain containing protein 0.015 0.129 0.2699
Echinococcus granulosus neurogenic locus protein delta 0.015 0.129 0.2699
Onchocerca volvulus Peroxidasin homolog 0.0465 0.478 1
Onchocerca volvulus 0.0073 0.0438 0.0917
Loa Loa (eye worm) hypothetical protein 0.0465 0.478 0.6196
Echinococcus multilocularis nicotinic acetylcholine receptor beta 1 subunit 0.0073 0.0438 0.0917
Loa Loa (eye worm) hypothetical protein 0.015 0.129 0.1673
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0073 0.0438 0.0917
Onchocerca volvulus 0.0073 0.0438 0.0917
Brugia malayi Cation transporter family protein 0.0073 0.0438 0.0917
Trypanosoma brucei mitogen-activated protein kinase 3, putative 0.0139 0.1165 0.1519
Brugia malayi Transmembrane cell adhesion receptor mua-3 precursor, putative 0.015 0.129 0.2699
Onchocerca volvulus 0.0073 0.0438 0.0917
Onchocerca volvulus 0.004 0.0063 0.0132
Schistosoma mansoni prokaryotic DNA topoisomerase 0.0067 0.0367 0.0767
Loa Loa (eye worm) hypothetical protein 0.015 0.129 0.1673
Brugia malayi Cadherin domain containing protein 0.015 0.129 0.2699
Loa Loa (eye worm) hypothetical protein 0.015 0.129 0.1673
Loa Loa (eye worm) hypothetical protein 0.0073 0.0438 0.0568
Schistosoma mansoni nAChR subunit 0.0073 0.0438 0.0917
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0073 0.0438 0.0917
Brugia malayi GRF zinc finger family protein 0.0067 0.0367 0.0767
Echinococcus multilocularis mitogen activated protein kinase 11 0.0139 0.1165 0.2437
Plasmodium vivax DNA topoisomerase II, putative 0.0219 0.2049 0.1747
Echinococcus multilocularis fat cadherin tumor suppressor 0.015 0.129 0.2699
Plasmodium falciparum DNA topoisomerase 2 0.0219 0.2049 0.1747
Echinococcus granulosus neural cadherin 0.015 0.129 0.2699
Brugia malayi EGF-like domain containing protein 0.015 0.129 0.2699
Loa Loa (eye worm) hypothetical protein 0.015 0.129 0.1673
Loa Loa (eye worm) hypothetical protein 0.0073 0.0438 0.0568
Schistosoma mansoni septate junction protein 0.015 0.129 0.2699
Onchocerca volvulus 0.0073 0.0438 0.0917
Echinococcus granulosus mitogen activated protein kinase 14 0.0139 0.1165 0.2437
Echinococcus granulosus nicotinic acetylcholine receptor beta 1 subunit 0.0073 0.0438 0.0917
Schistosoma mansoni nAChR subunit 0.0073 0.0438 0.0917
Loa Loa (eye worm) hypothetical protein 0.004 0.0063 0.0082
Trypanosoma brucei DNA topoisomerase II alpha, putative 0.0152 0.1308 0.1791
Echinococcus multilocularis nAChR subunit 0.004 0.0063 0.0132
Schistosoma mansoni notch 0.015 0.129 0.2699
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0073 0.0438 0.0917
Loa Loa (eye worm) hypothetical protein 0.015 0.129 0.1673
Loa Loa (eye worm) hypothetical protein 0.015 0.129 0.1673
Loa Loa (eye worm) hypothetical protein 0.004 0.0063 0.0082
Loa Loa (eye worm) hypothetical protein 0.015 0.129 0.1673
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0073 0.0438 0.0917
Loa Loa (eye worm) hypothetical protein 0.015 0.129 0.1673
Loa Loa (eye worm) hypothetical protein 0.015 0.129 0.1673
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0073 0.0438 0.0917
Loa Loa (eye worm) hypothetical protein 0.015 0.129 0.1673
Loa Loa (eye worm) hypothetical protein 0.0073 0.0438 0.0568
Echinococcus multilocularis neurogenic locus notch protein 0.015 0.129 0.2699
Loa Loa (eye worm) hypothetical protein 0.004 0.0063 0.0082
Loa Loa (eye worm) hypothetical protein 0.015 0.129 0.1673
Brugia malayi EGF-like domain containing protein 0.015 0.129 0.2699
Brugia malayi EGF-like domain containing protein 0.015 0.129 0.2699
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0073 0.0438 0.0917
Loa Loa (eye worm) hypothetical protein 0.0465 0.478 0.6196
Echinococcus granulosus protein jagged 2 0.015 0.129 0.2699
Loa Loa (eye worm) hypothetical protein 0.0465 0.478 0.6196
Trypanosoma cruzi DNA topoisomerase II, putative 0.0152 0.1308 0.1791
Echinococcus granulosus glycine receptor subunit alpha 1 0.0073 0.0438 0.0917
Loa Loa (eye worm) hypothetical protein 0.0465 0.478 0.6196
Echinococcus multilocularis rho GTPase activating protein 20 0.0067 0.0367 0.0767
Loa Loa (eye worm) hypothetical protein 0.0152 0.1308 0.1695
Echinococcus multilocularis neurogenic locus notch protein 4 0.015 0.129 0.2699
Onchocerca volvulus 0.004 0.0063 0.0132
Schistosoma mansoni slit 0.015 0.129 0.2699
Loa Loa (eye worm) hypothetical protein 0.015 0.129 0.1673
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0073 0.0438 0.0917
Loa Loa (eye worm) hypothetical protein 0.0465 0.478 0.6196
Loa Loa (eye worm) hypothetical protein 0.073 0.7714 1
Onchocerca volvulus 0.0073 0.0438 0.0917
Echinococcus multilocularis nAChR subunit 0.0073 0.0438 0.0917
Brugia malayi nicotinic acetylcholine receptor beta-1 chain precursor 0.0073 0.0438 0.0917
Loa Loa (eye worm) hypothetical protein 0.0465 0.478 0.6196
Echinococcus multilocularis mitogen activated protein kinase 11 0.0139 0.1165 0.2437
Echinococcus granulosus glycine receptor subunit alpha 1 0.0073 0.0438 0.0917
Loa Loa (eye worm) hypothetical protein 0.0465 0.478 0.6196
Onchocerca volvulus Neurogenic locus notch homolog 0.015 0.129 0.2699
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0073 0.0438 0.0917
Brugia malayi Calcium binding EGF domain containing protein 0.015 0.129 0.2699
Brugia malayi gamma-aminobutyric-acid receptor beta subunit precursor 0.0421 0.429 0.8975
Trichomonas vaginalis DNA topoisomerase II, putative 0.0219 0.2049 1
Loa Loa (eye worm) nicotinic acetylcholine receptor non-alpha subunit 0.0073 0.0438 0.0568
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.004 0.0063 0.0132
Schistosoma mansoni notch 0.015 0.129 0.2699
Echinococcus granulosus glycine receptor subunit alpha 1 0.0073 0.0438 0.0917
Brugia malayi Animal haem peroxidase family protein 0.0465 0.478 1
Schistosoma mansoni hypothetical protein 0.015 0.129 0.2699
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0073 0.0438 0.0917
Echinococcus granulosus protein jagged 2 0.015 0.129 0.2699
Brugia malayi Animal haem peroxidase family protein 0.0465 0.478 1
Echinococcus granulosus DNA topoisomerase 2 alpha 0.0219 0.2049 0.4288
Loa Loa (eye worm) hypothetical protein 0.015 0.129 0.1673
Schistosoma mansoni nAChR subunit 0.0073 0.0438 0.0917
Brugia malayi P38 map kinase family protein 2 0.0139 0.1165 0.2437
Brugia malayi GCC2 and GCC3 family protein 0.015 0.129 0.2699
Echinococcus multilocularis glycine receptor subunit beta 0.0073 0.0438 0.0917
Brugia malayi Animal haem peroxidase family protein 0.0465 0.478 1
Echinococcus granulosus neurogenic locus notch protein 0.015 0.129 0.2699
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.004 0.0063 0.0132
Echinococcus multilocularis notch 0.015 0.129 0.2699
Echinococcus multilocularis mitogen activated protein kinase 14 0.0139 0.1165 0.2437
Brugia malayi acetylcholine receptor, alpha-type subunit unc-38 precursor 0.0073 0.0438 0.0917
Loa Loa (eye worm) ACC-1 protein 0.0073 0.0438 0.0568
Echinococcus multilocularis neurogenic locus protein delta 0.015 0.129 0.2699
Entamoeba histolytica DNA topoisomerase III, putative 0.0067 0.0367 0.1528
Brugia malayi Blistered cuticle protein 3 0.0465 0.478 1
Echinococcus granulosus nicotinic acetylcholine receptor subunit alpha 8 0.0073 0.0438 0.0917
Loa Loa (eye worm) DNA topoisomerase III beta-1 0.0067 0.0367 0.0475
Treponema pallidum DNA gyrase, subunit B (gyrB) 0.0936 1 1
Loa Loa (eye worm) ligand-Gated ion Channel family member 0.0073 0.0438 0.0568
Loa Loa (eye worm) hypothetical protein 0.0073 0.0438 0.0568
Schistosoma mansoni hypothetical protein 0.015 0.129 0.2699
Loa Loa (eye worm) hypothetical protein 0.015 0.129 0.1673
Loa Loa (eye worm) TOPoisomerase family member 0.0219 0.2049 0.2657
Toxoplasma gondii DNA topoisomerase 2, putative 0.0219 0.2049 0.3202
Mycobacterium leprae Probable DNA gyrase (subunit B) GyrB (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (Type II DNA topoisomerase) 0.0322 0.3197 1
Onchocerca volvulus DNA topoisomerase 2 homolog 0.0219 0.2049 0.4288
Schistosoma mansoni hypothetical protein 0.015 0.129 0.2699
Echinococcus multilocularis neuronal acetylcholine receptor subunit alpha 4 0.0073 0.0438 0.0917
Onchocerca volvulus 0.0465 0.478 1
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0073 0.0438 0.0568
Onchocerca volvulus Peroxidase homolog 0.0465 0.478 1
Schistosoma mansoni notch 0.015 0.129 0.2699
Echinococcus multilocularis DNA topoisomerase 2 alpha 0.0219 0.2049 0.4288
Loa Loa (eye worm) hypothetical protein 0.0073 0.0438 0.0568
Onchocerca volvulus DNA topoisomerase 2 homolog 0.0219 0.2049 0.4288
Loa Loa (eye worm) hypothetical protein 0.004 0.0063 0.0082
Loa Loa (eye worm) hypothetical protein 0.0465 0.478 0.6196
Schistosoma mansoni hypothetical protein 0.015 0.129 0.2699
Onchocerca volvulus Peroxidasin homolog 0.0465 0.478 1
Onchocerca volvulus Putative nachr subunit 0.0073 0.0438 0.0917
Brugia malayi Animal haem peroxidase family protein 0.0465 0.478 1
Brugia malayi Delta serrate ligand family protein 0.015 0.129 0.2699
Giardia lamblia High cysteine protein 0.015 0.129 0.6806
Loa Loa (eye worm) hypothetical protein 0.0073 0.0438 0.0568
Trypanosoma brucei DNA topoisomerase II beta, putative 0.0152 0.1308 0.1791
Schistosoma mansoni nAChR subunit (ShAR1-beta-like) 0.0073 0.0438 0.0917
Loa Loa (eye worm) hypothetical protein 0.0465 0.478 0.6196
Brugia malayi EGF-like domain containing protein 0.015 0.129 0.2699
Loa Loa (eye worm) ACC-1 protein 0.0073 0.0438 0.0568
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0073 0.0438 0.0917
Loa Loa (eye worm) LGC-31 protein 0.0073 0.0438 0.0568
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0073 0.0438 0.0917
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0073 0.0438 0.0917
Echinococcus granulosus nicotinic acetylcholine receptor a11 subunit 0.0073 0.0438 0.0917
Loa Loa (eye worm) hypothetical protein 0.0073 0.0438 0.0568
Loa Loa (eye worm) hypothetical protein 0.0073 0.0438 0.0568
Echinococcus granulosus DNA topoisomerase 3 beta 1 0.0067 0.0367 0.0767
Loa Loa (eye worm) hypothetical protein 0.015 0.129 0.1673
Brugia malayi Cadherin domain containing protein 0.015 0.129 0.2699
Loa Loa (eye worm) notch protein 0.015 0.129 0.1673
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0073 0.0438 0.0917
Loa Loa (eye worm) hypothetical protein 0.004 0.0063 0.0082
Loa Loa (eye worm) DNA topoisomerase III 0.0067 0.0367 0.0475
Wolbachia endosymbiont of Brugia malayi DNA gyrase, topoisomerase II, B subunit, GyrB 0.0936 1 1
Chlamydia trachomatis DNA gyrase subunit B 0.0614 0.6428 0.6292
Loa Loa (eye worm) hypothetical protein 0.0073 0.0438 0.0568
Onchocerca volvulus Putative DNA topoisomerase 2, mitochondrial 0.0219 0.2049 0.4288
Loa Loa (eye worm) hypothetical protein 0.0073 0.0438 0.0568
Mycobacterium tuberculosis DNA gyrase (subunit B) GyrB (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (type II DNA topoisomerase) 0.0936 1 0.5
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0073 0.0438 0.0917
Schistosoma mansoni nAChR subunit 0.0073 0.0438 0.0917
Echinococcus granulosus protein jagged 1 0.015 0.129 0.2699
Schistosoma mansoni prokaryotic DNA topoisomerase 0.0067 0.0367 0.0767
Loa Loa (eye worm) hypothetical protein 0.004 0.0063 0.0082
Echinococcus multilocularis neurogenic locus notch protein 0.015 0.129 0.2699
Trypanosoma cruzi mitochondrial DNA topoisomerase II, putative 0.0541 0.5621 1
Loa Loa (eye worm) hypothetical protein 0.0073 0.0438 0.0568
Echinococcus granulosus glycine receptor subunit beta 0.0073 0.0438 0.0917
Loa Loa (eye worm) hypothetical protein 0.0465 0.478 0.6196
Echinococcus granulosus notch 0.015 0.129 0.2699
Onchocerca volvulus Peroxidase homolog 0.0465 0.478 1
Plasmodium falciparum DNA gyrase subunit B 0.0936 1 1
Onchocerca volvulus 0.0465 0.478 1
Loa Loa (eye worm) hypothetical protein 0.015 0.129 0.1673
Brugia malayi excitatory GABA receptor EXP-1A 0.0073 0.0438 0.0917
Schistosoma mansoni notch 0.015 0.129 0.2699
Loa Loa (eye worm) hypothetical protein 0.0465 0.478 0.6196
Onchocerca volvulus 0.0465 0.478 1
Loa Loa (eye worm) hypothetical protein 0.0465 0.478 0.6196
Plasmodium vivax DNA gyrase subunit B, putative 0.0936 1 1
Schistosoma mansoni peroxidasin 0.0465 0.478 1

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) = 1.5 uM Inhibition of 5-HT reuptake in rat cerebrospinal fluid (CSF) was measured ChEMBL. No reference
IC50 (binding) = 20 uM Inhibition of mouse TDO expressed in mouse P815B cells assessed as inhibition of tryptophan catabolism by measuring kynurenine production after 8 hrs by HPLC analysis ChEMBL. 21726069
Ki (binding) = 30 nM Compound was tested for inhibition of Tryptophan dioxygenase (TDO) from rat liver ChEMBL. No reference
Ki (binding) = 30 nM Compound was tested for inhibition of Tryptophan dioxygenase (TDO) from rat liver ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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