Detailed information for compound 28901

Basic information

Technical information
  • TDR Targets ID: 28901
  • Name: 2,3-dihydro-1H-indole-2-carboxylic acid
  • MW: 163.173 | Formula: C9H9NO2
  • H donors: 2 H acceptors: 2 LogP: 1.57 Rotable bonds: 1
    Rule of 5 violations (Lipinski): 1
  • SMILES: OC(=O)C1Cc2c(N1)cccc2
  • InChi: 1S/C9H9NO2/c11-9(12)8-5-6-3-1-2-4-7(6)10-8/h1-4,8,10H,5H2,(H,11,12)
  • InChiKey: QNRXNRGSOJZINA-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • indoline-2-carboxylic acid
  • 2-indolinecarboxylic acid
  • 16851-56-2
  • (-)-Indoline-2-carboxylic acid
  • ()-2,3-Dihydroindole-2-carboxylic acid
  • ()-Indoline-2-carboxylic acid
  • 57245_FLUKA
  • 1H-Indole-2-carboxylic acid, 2,3-dihydro-, (.+/-.)-
  • SDCCGMLS-0065896.P001
  • L-Indoline-2-carboxylic acid
  • STK260845
  • 302244_ALDRICH
  • EINECS 278-899-6
  • (1)-Indoline-2-carboxylic acid
  • EINECS 240-875-8

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Entamoeba histolytica Rab geranylgeranyltransferase beta subunit, putative 0.0151 0.1357 0.2202
Onchocerca volvulus 0.0431 0.4905 1
Trypanosoma brucei hypothetical protein, conserved 0.0291 0.3126 0.3588
Trypanosoma brucei lanosterol synthase 0.061 0.7171 0.823
Trypanosoma cruzi squalene synthase, putative 0.0732 0.8713 1
Onchocerca volvulus 0.0291 0.3126 0.5571
Echinococcus multilocularis protein prenyltransferase alpha subunit 0.0291 0.3126 0.3126
Trichomonas vaginalis geranylgeranyl transferase type I beta subunit, putative 0.0435 0.4957 0.8045
Toxoplasma gondii prenyltransferase and squalene oxidase repeat-containing protein 0.0151 0.1357 0.2737
Trypanosoma brucei Protein prenyltransferase alpha subunit repeat, putative 0.0291 0.3126 0.3588
Toxoplasma gondii prenyltransferase and squalene oxidase repeat-containing protein 0.0435 0.4957 1
Brugia malayi Protein prenyltransferase alpha subunit repeat containing protein 0.0291 0.3126 0.3814
Echinococcus multilocularis Squalene phytoene synthase 0.0228 0.2335 0.2335
Trypanosoma cruzi protein farnesyltransferase alpha subunit, putative 0.0291 0.3126 0.3588
Schistosoma mansoni alpha-glucosidase 0.0169 0.1592 0.1592
Echinococcus granulosus protein farnesyltransferase subunit beta 0.0435 0.4957 0.4957
Echinococcus multilocularis microtubule associated protein 2 0.0833 1 1
Echinococcus granulosus geranylgeranyl transferase type 2 subunit alpha 0.0291 0.3126 0.3126
Entamoeba histolytica protein farnesyltransferase alpha subunit, putative 0.053 0.6162 1
Trypanosoma cruzi hypothetical protein, conserved 0.0151 0.1357 0.1557
Loa Loa (eye worm) hypothetical protein 0.0691 0.8197 1
Loa Loa (eye worm) hypothetical protein 0.0431 0.4905 0.5984
Leishmania major farnesyltransferase beta subunit 0.0435 0.4957 0.569
Brugia malayi Probable protein farnesyltransferase beta subunit, putative 0.0151 0.1357 0.1655
Trypanosoma brucei Protein prenyltransferase alpha subunit repeat, putative 0.0291 0.3126 0.3588
Trypanosoma cruzi hypothetical protein, conserved 0.0291 0.3126 0.3588
Loa Loa (eye worm) prenyltransferase alpha subunit repeat containing protein 0.0291 0.3126 0.3814
Leishmania major protein farnesyltransferase alpha subunit, putative 0.0291 0.3126 0.3588
Schistosoma mansoni geranylgeranyl transferase type I beta subunit 0.0402 0.4536 0.4536
Trypanosoma cruzi phytoene synthase, putative 0.0228 0.2335 0.268
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0064 0.0261 0.0261
Trypanosoma brucei geranylgeranyl transferase type II beta subunit, putative 0.0151 0.1357 0.1557
Brugia malayi Copper type II ascorbate-dependent monooxygenase, N-terminal domain containing protein 0.0186 0.1805 0.2203
Leishmania major geranylgeranyltransferase, putative 0.0151 0.1357 0.1557
Onchocerca volvulus NADH dehydrogenase (ubiquinone) complex I, assembly factor 6 homolog 0.0228 0.2335 0.3602
Mycobacterium tuberculosis Halimadienyl diphosphate synthase 0.061 0.7171 1
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0064 0.0261 0.0318
Mycobacterium ulcerans phytoene synthase, CrtB 0.0228 0.2335 0.5
Trichomonas vaginalis geranylgeranyl transferase type II beta subunit, putative 0.0435 0.4957 0.8045
Brugia malayi Copper type II ascorbate-dependent monooxygenase, C-terminal domain containing protein 0.0181 0.1736 0.2118
Echinococcus multilocularis lysosomal alpha glucosidase 0.0197 0.1939 0.1939
Brugia malayi Protein prenyltransferase alpha subunit repeat containing protein 0.053 0.6162 0.7517
Loa Loa (eye worm) hypothetical protein 0.0431 0.4905 0.5984
Echinococcus granulosus geranylgeranyl transferase type I beta subunit 0.0402 0.4536 0.4536
Giardia lamblia Prenyltransferase 0.0435 0.4957 0.7493
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0824 0.9881 0.9881
Trichomonas vaginalis geranylgeranyl transferase type I beta subunit, putative 0.0402 0.4536 0.7361
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0064 0.0261 0.0318
Brugia malayi Copper type II ascorbate-dependent monooxygenase, C-terminal domain containing protein 0.0691 0.8197 1
Trichomonas vaginalis geranylgeranyl transferase type beta subunit, putative 0.0435 0.4957 0.8045
Entamoeba histolytica protein farnesyltransferase beta subunit, putative 0.0435 0.4957 0.8045
Trichomonas vaginalis protein farnesyltransferase alpha subunit, putative 0.0291 0.3126 0.5073
Trypanosoma brucei squalene synthase, putative 0.0732 0.8713 1
Schistosoma mansoni geranylgeranyl transferase type II beta subunit 0.0151 0.1357 0.1357
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0291 0.3126 0.3126
Trichomonas vaginalis protein farnesyltransferase alpha subunit/RAB geranylgeranyl transferase alpha subunit, putative 0.024 0.2483 0.403
Leishmania major lanosterol synthase, putative 0.0459 0.5261 0.6038
Echinococcus multilocularis protein farnesyltransferase alpha subunit 0.053 0.6162 0.6162
Schistosoma mansoni peptidylglycine monooxygenase 0.0367 0.4094 0.4094
Trichomonas vaginalis protein farnesyltransferase beta subunit, putative 0.0151 0.1357 0.2202
Toxoplasma gondii hypothetical protein 0.024 0.2483 0.5009
Trichomonas vaginalis set domain proteins, putative 0.0231 0.2366 0.384
Brugia malayi Copper type II ascorbate-dependent monooxygenase, C-terminal domain containing protein 0.0367 0.4094 0.4995
Entamoeba histolytica geranylgeranyl transferase beta subunit 0.0402 0.4536 0.7361
Loa Loa (eye worm) hypothetical protein 0.0228 0.2335 0.2849
Trichomonas vaginalis type I geranylgeranyltransferase beta subunit, putative 0.0435 0.4957 0.8045
Schistosoma mansoni peptidyl-glycine monooxygenase 0.0691 0.8197 0.8197
Loa Loa (eye worm) prenyltransferase and squalene oxidase repeat family protein 0.0402 0.4536 0.5533
Schistosoma mansoni lozenge 0.0054 0.0132 0.0132
Trypanosoma cruzi protein farnesyltransferase, putative 0.0435 0.4957 0.569
Plasmodium falciparum geranylgeranyl transferase type-2 subunit alpha, putative 0.0291 0.3126 0.3682
Trypanosoma brucei protein farnesyltransferase alpha subunit, putative 0.0291 0.3126 0.3588
Echinococcus multilocularis lysosomal alpha glucosidase 0.0197 0.1939 0.1939
Trypanosoma cruzi hypothetical protein, conserved 0.0151 0.1357 0.1557
Brugia malayi Prenyltransferase and squalene oxidase repeat family protein 0.0402 0.4536 0.5533
Schistosoma mansoni alpha-glucosidase 0.0169 0.1592 0.1592
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0064 0.0261 0.0299
Schistosoma mansoni hypothetical protein 0.0228 0.2335 0.2335
Trichomonas vaginalis protein farnesyltransferase alpha subunit/RAB geranylgeranyl transferase alpha subunit, putative 0.053 0.6162 1
Loa Loa (eye worm) hypothetical protein 0.0151 0.1357 0.1655
Plasmodium falciparum protein farnesyltransferase subunit beta 0.0435 0.4957 0.7493
Brugia malayi Glycosyl hydrolases family 31 protein 0.0197 0.1939 0.2365
Echinococcus granulosus tm gpcr rhodopsin 0.0824 0.9881 0.9881
Trypanosoma cruzi protein farnesyltransferase, putative 0.0435 0.4957 0.569
Trypanosoma cruzi squalene synthase, putative 0.0732 0.8713 1
Loa Loa (eye worm) hypothetical protein 0.0151 0.1357 0.1655
Trypanosoma cruzi protein farnesyltransferase alpha subunit, putative 0.0291 0.3126 0.3588
Toxoplasma gondii Rab geranylgeranyl transferase type II beta subunit, putative 0.0151 0.1357 0.2737
Echinococcus multilocularis peptidyl glycine alpha amidating monooxygenase 0.0691 0.8197 0.8197
Trichomonas vaginalis protein farnesyltransferase beta subunit, putative 0.0151 0.1357 0.2202
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0064 0.0261 0.0299
Trichomonas vaginalis geranylgeranyl transferase type II beta subunit, putative 0.0435 0.4957 0.8045
Schistosoma mansoni microtubule-associated protein tau 0.0833 1 1
Trypanosoma brucei protein farnesyltransferase beta subunit 0.0435 0.4957 0.569
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0064 0.0261 0.0299
Loa Loa (eye worm) prenyltransferase alpha subunit repeat containing protein 0.053 0.6162 0.7517
Plasmodium vivax farnesyltransferase beta subunit, putative 0.0435 0.4957 0.7493
Leishmania major squalene synthase, putative 0.0732 0.8713 1
Plasmodium vivax protein prenyltransferase alpha subunit, putative 0.0291 0.3126 0.3682
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0064 0.0261 0.0261
Echinococcus granulosus Squalene phytoene synthase 0.0228 0.2335 0.2335
Schistosoma mansoni protein farnesyltransferase alpha subunit 0.053 0.6162 0.6162
Loa Loa (eye worm) hypothetical protein 0.0367 0.4094 0.4995
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0197 0.1939 0.2365
Giardia lamblia Rab geranylgeranyltransferase 0.053 0.6162 1
Brugia malayi Pre-SET motif family protein 0.0203 0.2012 0.2454
Leishmania major hypothetical protein, conserved 0.0228 0.2335 0.268
Trichomonas vaginalis protein farnesyltransferase alpha subunit, putative 0.053 0.6162 1
Echinococcus multilocularis geranylgeranyl transferase type I beta subunit 0.0402 0.4536 0.4536
Trypanosoma cruzi geranylgeranyl transferase type II beta subunit, putative 0.0151 0.1357 0.1557
Plasmodium vivax prenyltransferase alpha subunit, putative 0.053 0.6162 1
Schistosoma mansoni geranylgeranyl transferase type I beta subunit 0.0402 0.4536 0.4536
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0064 0.0261 0.0261
Schistosoma mansoni dopamine-beta-monooxygenase 0.0367 0.4094 0.4094
Plasmodium vivax conserved Plasmodium protein, unknown function 0.0284 0.3048 0.3519
Trichomonas vaginalis protein farnesyltransferase alpha subunit, putative 0.053 0.6162 1
Toxoplasma gondii hypothetical protein 0.0291 0.3126 0.6306
Giardia lamblia Rab geranylgeranyltransferase 0.0291 0.3126 0.3682
Schistosoma mansoni protein farnesyltransferase subunit beta 0.0435 0.4957 0.4957
Echinococcus multilocularis expressed protein 0.0363 0.4047 0.4047
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0064 0.0261 0.0423
Plasmodium falciparum protein farnesyltransferase subunit alpha 0.053 0.6162 1
Trypanosoma cruzi lanosterol synthase, putative 0.061 0.7171 0.823
Echinococcus granulosus lysosomal alpha glucosidase 0.0197 0.1939 0.1939
Trypanosoma cruzi hypothetical protein, conserved 0.0291 0.3126 0.3588
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0203 0.2012 0.2454
Echinococcus granulosus protein farnesyltransferase alpha subunit 0.053 0.6162 0.6162
Echinococcus multilocularis protein farnesyltransferase subunit beta 0.0435 0.4957 0.4957
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0064 0.0261 0.0299
Echinococcus granulosus protein prenyltransferase alpha subunit 0.0291 0.3126 0.3126
Echinococcus multilocularis Protein lozenge 0.0054 0.0132 0.0132
Trichomonas vaginalis geranylgeranyl transferase type II beta subunit, putative 0.0435 0.4957 0.8045
Echinococcus multilocularis Rab geranylgeranyltransferase, beta subunit 0.0151 0.1357 0.1357
Echinococcus granulosus expressed protein 0.0363 0.4047 0.4047
Trypanosoma cruzi Protein prenyltransferase alpha subunit repeat, putative 0.0291 0.3126 0.3588
Echinococcus multilocularis geranylgeranyl transferase type 2 subunit alpha 0.0291 0.3126 0.3126
Brugia malayi Prenyltransferase and squalene oxidase repeat family protein 0.0435 0.4957 0.6048
Echinococcus granulosus peptidyl glycine alpha amidating monooxygenase 0.0691 0.8197 0.8197
Trypanosoma cruzi lanosterol synthase, putative 0.061 0.7171 0.823
Brugia malayi hypothetical protein 0.0431 0.4905 0.5984
Entamoeba histolytica Rab geranylgeranyltransferase alpha subunit, putative 0.0291 0.3126 0.5073
Loa Loa (eye worm) prenyltransferase and squalene oxidase repeat family protein 0.0435 0.4957 0.6048
Onchocerca volvulus 0.0231 0.2366 0.3679
Loa Loa (eye worm) runx1 0.0054 0.0132 0.0161
Loa Loa (eye worm) hypothetical protein 0.053 0.6162 0.7517

Activities

Activity type Activity value Assay description Source Reference
Ki (binding) > 30 uM Inhibition of strychnine-insensitive [3H]-glycine binding to the N-methyl-D-aspartate glutamate receptor of synaptic plasma membranes(SPM) prepared from rat forebrain ChEMBL. 1849994
Ki (binding) > 30 uM Inhibition of strychnine-insensitive [3H]-glycine binding to the N-methyl-D-aspartate glutamate receptor of synaptic plasma membranes(SPM) prepared from rat forebrain ChEMBL. 1849994

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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