Detailed information for compound 29079

Basic information

Technical information
  • TDR Targets ID: 29079
  • Name: 5-ethyl-1-[4-fluoro-5-(hydroxymethyl)oxolan-2 -yl]pyrimidine-2,4-dione
  • MW: 258.246 | Formula: C11H15FN2O4
  • H donors: 2 H acceptors: 3 LogP: -0.04 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: OCC1OC(CC1F)n1cc(CC)c(=O)[nH]c1=O
  • InChi: 1S/C11H15FN2O4/c1-2-6-4-14(11(17)13-10(6)16)9-3-7(12)8(5-15)18-9/h4,7-9,15H,2-3,5H2,1H3,(H,13,16,17)
  • InChiKey: SSFQGWVTTOGGKN-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 5-ethyl-1-[4-fluoro-5-(hydroxymethyl)tetrahydrofuran-2-yl]pyrimidine-2,4-dione
  • 5-ethyl-1-[4-fluoro-5-(hydroxymethyl)-2-tetrahydrofuranyl]pyrimidine-2,4-dione
  • 5-ethyl-1-(4-fluoro-5-methylol-tetrahydrofuran-2-yl)pyrimidine-2,4-quinone

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0884 0.0854 1
Trypanosoma brucei pyruvate kinase 1, putative 0.0039 0.0005 0.0012
Trichomonas vaginalis sucrase-isomaltase, putative 0.0042 0.0008 0.0069
Loa Loa (eye worm) peptidase family M13 containing protein 0.0135 0.0101 0.1141
Schistosoma mansoni endothelin-converting enzyme-related 0.0045 0.001 0.0264
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.006 0.0026 0.0026
Trichomonas vaginalis alpha-glucosidase, putative 0.0042 0.0008 0.0069
Toxoplasma gondii pyruvate kinase PyK1 0.0039 0.0005 0.0005
Trypanosoma brucei Polypeptide deformylase 1 0.3809 0.3794 1
Brugia malayi Matrixin family protein 0.0449 0.0417 1
Giardia lamblia Pyruvate kinase 0.0039 0.0005 1
Echinococcus multilocularis adam 0.0073 0.0039 0.0424
Echinococcus granulosus pyruvate kinase 0.0039 0.0005 0.007
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.006 0.0026 0.0026
Loa Loa (eye worm) hypothetical protein 0.0183 0.015 0.1707
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0043 0.0009 0.0023
Plasmodium vivax glutathione reductase, putative 0.0099 0.0065 0.0065
Loa Loa (eye worm) hypothetical protein 0.0139 0.0105 0.1179
Echinococcus granulosus neuropeptide receptor A26 0.0542 0.051 0.7916
Schistosoma mansoni neprilysin-2 (M13 family) 0.0092 0.0058 0.1501
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0091 0.0057 0.0057
Onchocerca volvulus 0.0097 0.0063 0.1558
Echinococcus multilocularis a disintegrin and metalloproteinase with 0.0199 0.0165 0.1801
Brugia malayi Inositol-1 0.0043 0.0009 0.021
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0227 0.0193 0.0193
Trypanosoma cruzi polypeptide deformylase-like protein, putative 0.3809 0.3794 1
Loa Loa (eye worm) thioredoxin reductase 0.0099 0.0065 0.0715
Echinococcus granulosus adam 17 protease 0.0463 0.043 0.6684
Brugia malayi glutathione reductase 0.0099 0.0065 0.1566
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0227 0.0193 0.0193
Schistosoma mansoni ADAM17 peptidase (M12 family) 0.0421 0.0388 1
Schistosoma mansoni inositol monophosphatase 0.0043 0.0009 0.0225
Echinococcus granulosus endothelin converting enzyme 1 0.0183 0.015 0.2322
Loa Loa (eye worm) hypothetical protein 0.0183 0.015 0.1707
Schistosoma mansoni pyruvate kinase 0.0039 0.0005 0.0117
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0227 0.0193 0.0193
Treponema pallidum polypeptide deformylase (def) 0.9982 1 1
Brugia malayi Disintegrin family protein 0.0042 0.0008 0.0181
Trypanosoma brucei pyruvate kinase 1 0.0039 0.0005 0.0012
Trypanosoma cruzi hypothetical protein, conserved 0.0042 0.0008 0.0021
Echinococcus multilocularis pyruvate kinase 0.0039 0.0005 0.0049
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0091 0.0057 0.0057
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0138 0.0104 0.1132
Echinococcus granulosus adam 0.0073 0.0039 0.0604
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0043 0.0009 0.0008
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0227 0.0193 0.0189
Brugia malayi Thioredoxin reductase 0.0099 0.0065 0.1566
Mycobacterium ulcerans zinc metalloprotease 0.0183 0.015 0.015
Echinococcus granulosus subfamily M12B unassigned peptidase 0.0042 0.0008 0.0117
Mycobacterium leprae PROBABLE POLYPEPTIDE DEFORMYLASE DEF (PDF) (FORMYLMETHIONINE DEFORMYLASE) 0.9982 1 1
Onchocerca volvulus 0.0186 0.0152 0.3935
Loa Loa (eye worm) matrix metalloproteinase 0.0186 0.0152 0.1736
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0273 0.024 0.2771
Echinococcus multilocularis lysosomal alpha glucosidase 0.019 0.0157 0.1708
Echinococcus multilocularis inositol monophosphatase 1 0.0043 0.0009 0.0095
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0042 0.0008 0.0069
Schistosoma mansoni adam (A disintegrin and metalloprotease 0.0073 0.0039 0.1002
Mycobacterium tuberculosis Probable reductase 0.0227 0.0193 0.0193
Toxoplasma gondii hypothetical protein 0.9982 1 1
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.019 0.0157 0.1789
Mycobacterium tuberculosis Probable polypeptide deformylase Def (PDF) (formylmethionine deformylase) 0.9982 1 1
Wolbachia endosymbiont of Brugia malayi peptide deformylase 0.9982 1 1
Schistosoma mansoni hypothetical protein 0.0048 0.0013 0.0346
Mycobacterium ulcerans hydrolase 0.0226 0.0193 0.0193
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0091 0.0057 0.0057
Brugia malayi Pyruvate kinase, muscle isozyme 0.0039 0.0005 0.0109
Loa Loa (eye worm) hypothetical protein 0.0135 0.0101 0.1141
Loa Loa (eye worm) hypothetical protein 0.0186 0.0152 0.1736
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0091 0.0057 0.0057
Mycobacterium leprae probable zinc metalloprotease 0.0183 0.015 0.0145
Loa Loa (eye worm) glutathione reductase 0.0099 0.0065 0.0715
Trypanosoma cruzi Peptide deformylase 2, putative 0.3809 0.3794 1
Echinococcus granulosus L aminoadipate semialdehyde 0.0097 0.0063 0.0977
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0043 0.0009 0.0077
Loa Loa (eye worm) peptidase family M13 containing protein 0.0135 0.0101 0.1141
Schistosoma mansoni hypothetical protein 0.0048 0.0013 0.0346
Brugia malayi Glycosyl hydrolases family 31 protein 0.0042 0.0008 0.0187
Schistosoma mansoni hypothetical protein 0.0048 0.0013 0.0346
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0091 0.0057 0.0887
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0043 0.0009 0.0009
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0043 0.0009 0.0023
Echinococcus multilocularis thioredoxin glutathione reductase 0.01 0.0066 0.0718
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0091 0.0057 0.0057
Loa Loa (eye worm) hypothetical protein 0.0135 0.0101 0.1141
Schistosoma mansoni hypothetical protein 0.0048 0.0013 0.0346
Plasmodium vivax peptide deformylase, putative 0.9982 1 1
Schistosoma mansoni matrix metallopeptidase-7 (M10 family) 0.0186 0.0152 0.3916
Trichomonas vaginalis maltase-glucoamylase, putative 0.0042 0.0008 0.0069
Echinococcus multilocularis endothelin converting enzyme 1 0.0183 0.015 0.1631
Schistosoma mansoni alpha-glucosidase 0.0164 0.013 0.3346
Brugia malayi Matrixin family protein 0.0186 0.0152 0.3649
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0043 0.0009 0.0023
Schistosoma mansoni Nep2 peptidase (M13 family) 0.0092 0.0058 0.1501
Brugia malayi Matrixin family protein 0.0186 0.0152 0.3649
Echinococcus granulosus Blood coagulation inhibitor Disintegrin 0.0264 0.0231 0.3583
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0252 0.0219 0.0219
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.006 0.0026 0.0021
Loa Loa (eye worm) zinc metallopeptidase 4 0.0045 0.001 0.0067
Schistosoma mansoni subfamily M12B unassigned peptidase (M12 family) 0.0042 0.0008 0.0195
Mycobacterium tuberculosis Probable zinc metalloprotease Zmp1 0.0183 0.015 0.015
Echinococcus multilocularis adam 17 protease 0.0421 0.0388 0.4235
Trypanosoma cruzi Peptide deformylase 2, putative 0.3809 0.3794 1
Mycobacterium tuberculosis Probable peptidoglycan hydrolase 0.0226 0.0193 0.0193
Echinococcus multilocularis subfamily M12B unassigned peptidase 0.0042 0.0008 0.0082
Brugia malayi Hypothetical zinc metalloproteinase T16A9.4 0.0183 0.015 0.3588
Trichomonas vaginalis pyruvate kinase, putative 0.0039 0.0005 0.004
Echinococcus multilocularis matrix metallopeptidase 7 (M10 family) 0.0675 0.0644 0.7025
Trichomonas vaginalis alpha-glucosidase, putative 0.0042 0.0008 0.0069
Mycobacterium ulcerans peptide deformylase 0.9982 1 1
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0091 0.0057 0.0057
Schistosoma mansoni neprilysin 0.0048 0.0013 0.0346
Loa Loa (eye worm) matrixin family protein 0.0412 0.0379 0.4412
Echinococcus granulosus disintegrin and metalloproteinase 0.0042 0.0008 0.0117
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0091 0.0057 0.0623
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0252 0.0219 0.0219
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0138 0.0104 0.1611
Schistosoma mansoni hypothetical protein 0.0263 0.023 0.5924
Brugia malayi follicle stimulating hormone receptor 0.0273 0.024 0.5758
Schistosoma mansoni family M13 unassigned peptidase (M13 family) 0.0048 0.0013 0.0346
Chlamydia trachomatis pyruvate kinase 0.0039 0.0005 0.0005
Onchocerca volvulus Matrilysin homolog 0.0412 0.0379 1
Schistosoma mansoni family M13 unassigned peptidase (M13 family) 0.0183 0.015 0.3851
Brugia malayi hypothetical protein 0.0073 0.0039 0.0934
Echinococcus multilocularis disintegrin and metalloproteinase 0.0042 0.0008 0.0082
Plasmodium falciparum pyruvate kinase 0.0039 0.0005 0.0005
Schistosoma mansoni ADAMTS5 peptidase (M12 family) 0.0199 0.0165 0.4252
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0043 0.0009 0.0023
Loa Loa (eye worm) hypothetical protein 0.0139 0.0105 0.1179
Trypanosoma cruzi hypothetical protein, conserved 0.0042 0.0008 0.0021
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0091 0.0057 0.0057
Schistosoma mansoni lipoxygenase 0.0138 0.0104 0.2672
Trichomonas vaginalis inositol monophosphatase, putative 0.0043 0.0009 0.0077
Mycobacterium tuberculosis Probable dehydrogenase 0.0227 0.0193 0.0193
Schistosoma mansoni dihydroceramide desaturase 0.0042 0.0008 0.0195
Toxoplasma gondii thioredoxin reductase 0.0099 0.0065 0.0065
Plasmodium falciparum glutathione reductase 0.0099 0.0065 0.0065
Echinococcus granulosus thioredoxin glutathione reductase 0.01 0.0066 0.1022
Loa Loa (eye worm) hypothetical protein 0.0091 0.0057 0.0613
Loa Loa (eye worm) hypothetical protein 0.0135 0.0101 0.1141
Loa Loa (eye worm) hypothetical protein 0.0139 0.0105 0.1179
Leishmania major pyruvate kinase 0.0039 0.0005 0.0012
Leishmania major trypanothione reductase 0.0099 0.0065 0.0172
Leishmania major pyruvate kinase 0.0039 0.0005 0.0012
Echinococcus multilocularis neutral alpha glucosidase AB 0.0042 0.0008 0.0085
Mycobacterium ulcerans pyruvate kinase 0.0039 0.0005 0.0005
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0099 0.0065 0.0065
Loa Loa (eye worm) hypothetical protein 0.0139 0.0105 0.1179
Trypanosoma cruzi polypeptide deformylase-like protein, putative 0.3809 0.3794 1
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0091 0.0057 0.0057
Loa Loa (eye worm) inositol-1 0.0043 0.0009 0.0049
Schistosoma mansoni hypothetical protein 0.0048 0.0013 0.0346
Brugia malayi Probable ClpP-like protease 0.0091 0.0057 0.1371
Schistosoma mansoni alpha glucosidase 0.0042 0.0008 0.0201
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0091 0.0057 0.0053
Loa Loa (eye worm) hypothetical protein 0.0139 0.0105 0.1179
Loa Loa (eye worm) matrixin family protein 0.0449 0.0417 0.4852
Schistosoma mansoni alpha-glucosidase 0.0164 0.013 0.3346
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0097 0.0063 0.1511
Echinococcus granulosus neuropeptide s receptor 0.0542 0.051 0.7916
Schistosoma mansoni matrix metallopeptidase-9 (M10 family) 0.0144 0.011 0.2825
Loa Loa (eye worm) hypothetical protein 0.0139 0.0105 0.1179
Brugia malayi Matrixin family protein 0.0186 0.0152 0.3649
Onchocerca volvulus 0.011 0.0076 0.1905
Brugia malayi Peptidase family M13 containing protein 0.0183 0.015 0.3588
Schistosoma mansoni family M13 unassigned peptidase (M13 family) 0.0045 0.001 0.0264
Trichomonas vaginalis alpha-glucosidase, putative 0.0042 0.0008 0.0069
Trichomonas vaginalis pps1 dual specificty phosphatase, putative 0.1161 0.1133 1
Leishmania major alpha glucosidase II subunit, putative 0.0042 0.0008 0.0021
Trichomonas vaginalis alpha-glucosidase, putative 0.0042 0.0008 0.0069
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0042 0.0008 0.0069
Schistosoma mansoni pyruvate kinase 0.0039 0.0005 0.0117
Trypanosoma brucei glucosidase, putative 0.0042 0.0008 0.0021
Brugia malayi Matrixin family protein 0.0186 0.0152 0.3649
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0252 0.0219 0.0214
Mycobacterium tuberculosis Possible exported protein 0.1491 0.1464 0.1464
Onchocerca volvulus Matrix metalloproteinase homolog 0.0412 0.0379 1
Echinococcus granulosus lysosomal alpha glucosidase 0.019 0.0157 0.2431
Schistosoma mansoni lipoxygenase 0.0096 0.0062 0.16
Trichomonas vaginalis pyruvate kinase, putative 0.0039 0.0005 0.004
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0091 0.0057 0.0057
Schistosoma mansoni subfamily M12B unassigned peptidase (M12 family) 0.0042 0.0008 0.0195
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0946 0.0917 1
Schistosoma mansoni family M13 non-peptidase homologue (M13 family) 0.0092 0.0058 0.1501
Mycobacterium leprae PROBABLE HYDROLASE 0.0226 0.0193 0.0189
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0227 0.0193 0.0193
Trichomonas vaginalis alpha-glucosidase, putative 0.0042 0.0008 0.0069
Echinococcus granulosus neutral alpha glucosidase AB 0.0042 0.0008 0.0121
Echinococcus multilocularis neuropeptide s receptor 0.0542 0.051 0.5561
Loa Loa (eye worm) hypothetical protein 0.0183 0.015 0.1707
Loa Loa (eye worm) hypothetical protein 0.0097 0.0063 0.0688
Mycobacterium tuberculosis Probable oxidoreductase 0.0252 0.0219 0.0219
Echinococcus granulosus peptidase Clp S14 family 0.006 0.0026 0.0397
Loa Loa (eye worm) hypothetical protein 0.0042 0.0008 0.0036
Trypanosoma cruzi pyruvate kinase 2, putative 0.0039 0.0005 0.0012
Brugia malayi peptidase family M13 containing protein 0.0045 0.001 0.0246
Schistosoma mansoni family M13 unassigned peptidase (M13 family) 0.0092 0.0058 0.1501
Trypanosoma cruzi pyruvate kinase 2, putative 0.0039 0.0005 0.0012
Echinococcus multilocularis neuropeptide receptor A26 0.0542 0.051 0.5561
Echinococcus multilocularis peptidase Clp (S14 family) 0.006 0.0026 0.0279
Brugia malayi metalloprotease disintegrin 16 with thrombospondin type I motif 0.0199 0.0165 0.3962
Schistosoma mansoni endothelin-converting enzyme-like 1 (damage-induced neuronal endopeptidase) 0.0045 0.001 0.0264
Echinococcus granulosus inositol monophosphatase 1 0.0043 0.0009 0.0136
Schistosoma mansoni inositol monophosphatase 0.0043 0.0009 0.0225
Echinococcus multilocularis Blood coagulation inhibitor, Disintegrin 0.0264 0.0231 0.2517
Trypanosoma brucei trypanothione reductase 0.0099 0.0065 0.0172
Echinococcus multilocularis lysosomal alpha glucosidase 0.019 0.0157 0.1708
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0097 0.0063 0.1621
Entamoeba histolytica dual specificity protein phosphatase, putative 0.1161 0.1133 1
Brugia malayi Pyruvate kinase, M2 isozyme 0.0039 0.0005 0.0109
Plasmodium vivax pyruvate kinase, putative 0.0039 0.0005 0.0005
Loa Loa (eye worm) hypothetical protein 0.0186 0.0152 0.1736
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0039 0.0004 0.0004
Trypanosoma cruzi trypanothione reductase, putative 0.0099 0.0065 0.0172
Loa Loa (eye worm) hypothetical protein 0.0226 0.0193 0.2215
Schistosoma mansoni family M13 unassigned peptidase (M13 family) 0.0045 0.001 0.0264
Loa Loa (eye worm) hypothetical protein 0.0091 0.0057 0.0619
Mycobacterium tuberculosis Probable pyruvate kinase PykA 0.0039 0.0005 0.0005
Schistosoma mansoni hypothetical protein 0.0048 0.0013 0.0346
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0042 0.0008 0.0039
Echinococcus granulosus a disintegrin and metalloproteinase with 0.0199 0.0165 0.2564
Leishmania major polypeptide deformylase-like protein, putative 0.3809 0.3794 1
Loa Loa (eye worm) hypothetical protein 0.0186 0.0152 0.1736
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0091 0.0057 0.0057
Toxoplasma gondii peptidase family M13 protein 0.0183 0.015 0.015
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0043 0.0009 0.0009
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0042 0.0008 0.0008
Echinococcus granulosus pyruvate kinase 0.0039 0.0005 0.007
Loa Loa (eye worm) hypothetical protein 0.0135 0.0101 0.1141
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0043 0.0009 0.0009
Loa Loa (eye worm) reprolysin 0.0042 0.0008 0.0036
Plasmodium falciparum peptide deformylase 0.9982 1 1
Schistosoma mansoni family M13 unassigned peptidase (M13 family) 0.0092 0.0058 0.1501
Trypanosoma brucei Peptide deformylase 2 0.3809 0.3794 1
Brugia malayi Matrix metalloprotease, N-terminal domain containing protein 0.0226 0.0193 0.4625
Schistosoma mansoni peptidase Clp (S14 family) 0.0091 0.0057 0.1472
Onchocerca volvulus 0.0091 0.0057 0.139
Plasmodium falciparum thioredoxin reductase 0.0099 0.0065 0.0065
Plasmodium vivax thioredoxin reductase, putative 0.0099 0.0065 0.0065
Schistosoma mansoni family M13 non-peptidase homologue (M13 family) 0.0045 0.001 0.0264
Echinococcus multilocularis L aminoadipate semialdehyde 0.0097 0.0063 0.0687
Schistosoma mansoni family M13 unassigned peptidase (M13 family) 0.0045 0.001 0.0264
Onchocerca volvulus 0.0263 0.023 0.6016
Echinococcus multilocularis pyruvate kinase 0.0039 0.0005 0.0049
Echinococcus granulosus matrix metallopeptidase 7 M10 family 0.0675 0.0644 1
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0043 0.0009 0.0077
Brugia malayi Glycosyl hydrolases family 31 protein 0.019 0.0157 0.3757
Brugia malayi Hemopexin family protein 0.0263 0.023 0.5521
Onchocerca volvulus Matrilysin homolog 0.0186 0.0152 0.3935

Activities

Activity type Activity value Assay description Source Reference
ED50 (functional) > 500 uM Protection of ATH8 cells against the cytopathic effect of HIV. ChEMBL. 3497272
ID50 (functional) > 500 uM Required dose to reduce viability of normal uninfected ATH8 cells. ChEMBL. 3497272
Protection (functional) = 10 % Protection was determined by evaluation of cluster morphology and reclustering properties in mock infected MT-4 cells at 125 uM concentration; Range is 10-40 ChEMBL. 3497272
Protection (functional) < 10 % Protection was determined by evaluation of cluster morphology and reclustering properties in mock infected MT-4 cells at 5 uM concentration. ChEMBL. 3497272
Protection (functional) < 10 % Protection was determined by evaluation of cluster morphology and reclustering properties in mock infected MT-4 cells at 0.2 uM concentration ChEMBL. 3497272
Protection (functional) = 10 % Protection was determined by evaluation of cluster morphology and reclustering properties in mock infected MT-4 cells at 125 uM concentration; Range is 10-40 ChEMBL. 3497272
Protection (functional) < 10 % Protection was determined by evaluation of cluster morphology and reclustering properties in mock infected MT-4 cells at 5 uM concentration. ChEMBL. 3497272
Protection (functional) < 10 % Protection was determined by evaluation of cluster morphology and reclustering properties in mock infected MT-4 cells at 0.2 uM concentration ChEMBL. 3497272
Toxicity (ADMET) < 10 % Toxicity was determined by evaluation of cluster morphology and reclustering properties in mock infected MT-4 cells at 125 uM concentration ChEMBL. 3497272
Toxicity (ADMET) < 10 % Toxicity was determined by evaluation of cluster morphology and reclustering properties in mock infected MT-4 cells at 5 uM concentration ChEMBL. 3497272
Toxicity (ADMET) < 10 % Toxicity was determined by evaluation of cluster morphology and reclustering properties in mock infected MT-4 cells at 0.2 uM concentration ChEMBL. 3497272
Toxicity (ADMET) < 10 % Toxicity was determined by evaluation of cluster morphology and reclustering properties in mock infected MT-4 cells at 125 uM concentration ChEMBL. 3497272
Toxicity (ADMET) < 10 % Toxicity was determined by evaluation of cluster morphology and reclustering properties in mock infected MT-4 cells at 5 uM concentration ChEMBL. 3497272
Toxicity (ADMET) < 10 % Toxicity was determined by evaluation of cluster morphology and reclustering properties in mock infected MT-4 cells at 0.2 uM concentration ChEMBL. 3497272

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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