Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | neuropeptide s receptor | 0.0542 | 0.051 | 0.7916 |
Onchocerca volvulus | 0.0186 | 0.0152 | 0.3935 | |
Schistosoma mansoni | peptidase Clp (S14 family) | 0.0091 | 0.0057 | 0.1472 |
Schistosoma mansoni | hypothetical protein | 0.0048 | 0.0013 | 0.0346 |
Schistosoma mansoni | family M13 non-peptidase homologue (M13 family) | 0.0045 | 0.001 | 0.0264 |
Echinococcus multilocularis | lysosomal alpha glucosidase | 0.019 | 0.0157 | 0.1708 |
Echinococcus granulosus | Blood coagulation inhibitor Disintegrin | 0.0264 | 0.0231 | 0.3583 |
Schistosoma mansoni | pyruvate kinase | 0.0039 | 0.0005 | 0.0117 |
Trichomonas vaginalis | myo inositol monophosphatase, putative | 0.0043 | 0.0009 | 0.0077 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0042 | 0.0008 | 0.0069 |
Trichomonas vaginalis | pyruvate kinase, putative | 0.0039 | 0.0005 | 0.004 |
Schistosoma mansoni | family M13 unassigned peptidase (M13 family) | 0.0045 | 0.001 | 0.0264 |
Mycobacterium tuberculosis | Probable zinc metalloprotease Zmp1 | 0.0183 | 0.015 | 0.015 |
Echinococcus granulosus | matrix metallopeptidase 7 M10 family | 0.0675 | 0.0644 | 1 |
Plasmodium vivax | thioredoxin reductase, putative | 0.0099 | 0.0065 | 0.0065 |
Mycobacterium leprae | PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) | 0.006 | 0.0026 | 0.0021 |
Schistosoma mansoni | alpha-glucosidase | 0.0164 | 0.013 | 0.3346 |
Echinococcus granulosus | adam 17 protease | 0.0463 | 0.043 | 0.6684 |
Trypanosoma brucei | pyruvate kinase 1 | 0.0039 | 0.0005 | 0.0012 |
Echinococcus granulosus | L aminoadipate semialdehyde | 0.0097 | 0.0063 | 0.0977 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0042 | 0.0008 | 0.0069 |
Loa Loa (eye worm) | hypothetical protein | 0.0135 | 0.0101 | 0.1141 |
Toxoplasma gondii | pyruvate kinase PyK1 | 0.0039 | 0.0005 | 0.0005 |
Echinococcus multilocularis | peptidase Clp (S14 family) | 0.006 | 0.0026 | 0.0279 |
Trichomonas vaginalis | inositol monophosphatase, putative | 0.0043 | 0.0009 | 0.0077 |
Wolbachia endosymbiont of Brugia malayi | ATP-dependent Clp protease proteolytic subunit | 0.0091 | 0.0057 | 0.0057 |
Plasmodium falciparum | peptide deformylase | 0.9982 | 1 | 1 |
Brugia malayi | follicle stimulating hormone receptor | 0.0273 | 0.024 | 0.5758 |
Leishmania major | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0043 | 0.0009 | 0.0023 |
Schistosoma mansoni | neprilysin | 0.0048 | 0.0013 | 0.0346 |
Schistosoma mansoni | ADAMTS5 peptidase (M12 family) | 0.0199 | 0.0165 | 0.4252 |
Brugia malayi | metalloprotease disintegrin 16 with thrombospondin type I motif | 0.0199 | 0.0165 | 0.3962 |
Onchocerca volvulus | Matrilysin homolog | 0.0186 | 0.0152 | 0.3935 |
Mycobacterium ulcerans | ATP-dependent Clp protease proteolytic subunit | 0.0091 | 0.0057 | 0.0057 |
Schistosoma mansoni | alpha-glucosidase | 0.0164 | 0.013 | 0.3346 |
Brugia malayi | Glycosyl hydrolases family 31 protein | 0.0042 | 0.0008 | 0.0187 |
Schistosoma mansoni | hypothetical protein | 0.0048 | 0.0013 | 0.0346 |
Mycobacterium ulcerans | extragenic suppressor protein SuhB | 0.0043 | 0.0009 | 0.0009 |
Trichomonas vaginalis | neutral alpha-glucosidase ab precursor, putative | 0.0042 | 0.0008 | 0.0069 |
Mycobacterium tuberculosis | Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras | 0.0252 | 0.0219 | 0.0219 |
Brugia malayi | Pyruvate kinase, M2 isozyme | 0.0039 | 0.0005 | 0.0109 |
Echinococcus granulosus | subfamily M12B unassigned peptidase | 0.0042 | 0.0008 | 0.0117 |
Schistosoma mansoni | inositol monophosphatase | 0.0043 | 0.0009 | 0.0225 |
Loa Loa (eye worm) | hypothetical protein | 0.0135 | 0.0101 | 0.1141 |
Schistosoma mansoni | matrix metallopeptidase-9 (M10 family) | 0.0144 | 0.011 | 0.2825 |
Trypanosoma cruzi | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0043 | 0.0009 | 0.0023 |
Leishmania major | pyruvate kinase | 0.0039 | 0.0005 | 0.0012 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0042 | 0.0008 | 0.0069 |
Leishmania major | alpha glucosidase II subunit, putative | 0.0042 | 0.0008 | 0.0021 |
Brugia malayi | Matrixin family protein | 0.0186 | 0.0152 | 0.3649 |
Toxoplasma gondii | inositol(myo)-1(or 4)-monophosphatase 2, putative | 0.0043 | 0.0009 | 0.0009 |
Toxoplasma gondii | hypothetical protein | 0.9982 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0091 | 0.0057 | 0.0619 |
Echinococcus multilocularis | pyruvate kinase | 0.0039 | 0.0005 | 0.0049 |
Entamoeba histolytica | dual specificity protein phosphatase, putative | 0.1161 | 0.1133 | 1 |
Trichomonas vaginalis | pps1 dual specificty phosphatase, putative | 0.1161 | 0.1133 | 1 |
Trichomonas vaginalis | pyruvate kinase, putative | 0.0039 | 0.0005 | 0.004 |
Loa Loa (eye worm) | hypothetical protein | 0.0135 | 0.0101 | 0.1141 |
Brugia malayi | Hypothetical zinc metalloproteinase T16A9.4 | 0.0183 | 0.015 | 0.3588 |
Mycobacterium tuberculosis | NAD(P)H quinone reductase LpdA | 0.0252 | 0.0219 | 0.0219 |
Mycobacterium leprae | DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE | 0.0252 | 0.0219 | 0.0214 |
Brugia malayi | glutathione reductase | 0.0099 | 0.0065 | 0.1566 |
Brugia malayi | Matrixin family protein | 0.0186 | 0.0152 | 0.3649 |
Trypanosoma brucei | trypanothione reductase | 0.0099 | 0.0065 | 0.0172 |
Schistosoma mansoni | hypothetical protein | 0.0048 | 0.0013 | 0.0346 |
Schistosoma mansoni | inositol monophosphatase | 0.0043 | 0.0009 | 0.0225 |
Loa Loa (eye worm) | glycosyl hydrolase family 31 protein | 0.019 | 0.0157 | 0.1789 |
Toxoplasma gondii | ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein | 0.0091 | 0.0057 | 0.0057 |
Mycobacterium tuberculosis | Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) | 0.006 | 0.0026 | 0.0026 |
Trypanosoma cruzi | pyruvate kinase 2, putative | 0.0039 | 0.0005 | 0.0012 |
Trypanosoma brucei | Polypeptide deformylase 1 | 0.3809 | 0.3794 | 1 |
Onchocerca volvulus | 0.0091 | 0.0057 | 0.139 | |
Mycobacterium tuberculosis | Probable peptidoglycan hydrolase | 0.0226 | 0.0193 | 0.0193 |
Loa Loa (eye worm) | glutathione reductase | 0.0099 | 0.0065 | 0.0715 |
Loa Loa (eye worm) | hypothetical protein | 0.0183 | 0.015 | 0.1707 |
Loa Loa (eye worm) | hypothetical protein | 0.0183 | 0.015 | 0.1707 |
Plasmodium vivax | ATP-dependent Clp protease proteolytic subunit, putative | 0.0091 | 0.0057 | 0.0057 |
Schistosoma mansoni | lipoxygenase | 0.0138 | 0.0104 | 0.2672 |
Brugia malayi | Matrix metalloprotease, N-terminal domain containing protein | 0.0226 | 0.0193 | 0.4625 |
Echinococcus granulosus | inositol monophosphatase 1 | 0.0043 | 0.0009 | 0.0136 |
Mycobacterium leprae | PROBABLE HYDROLASE | 0.0226 | 0.0193 | 0.0189 |
Echinococcus multilocularis | inositol monophosphatase 1 | 0.0043 | 0.0009 | 0.0095 |
Loa Loa (eye worm) | peptidase family M13 containing protein | 0.0135 | 0.0101 | 0.1141 |
Trypanosoma cruzi | pyruvate kinase 2, putative | 0.0039 | 0.0005 | 0.0012 |
Plasmodium falciparum | glutathione reductase | 0.0099 | 0.0065 | 0.0065 |
Mycobacterium tuberculosis | Probable reductase | 0.0227 | 0.0193 | 0.0193 |
Onchocerca volvulus | 0.0263 | 0.023 | 0.6016 | |
Trypanosoma brucei | Peptide deformylase 2 | 0.3809 | 0.3794 | 1 |
Schistosoma mansoni | family M13 unassigned peptidase (M13 family) | 0.0045 | 0.001 | 0.0264 |
Schistosoma mansoni | alpha glucosidase | 0.0042 | 0.0008 | 0.0201 |
Brugia malayi | Disintegrin family protein | 0.0042 | 0.0008 | 0.0181 |
Loa Loa (eye worm) | hypothetical protein | 0.0139 | 0.0105 | 0.1179 |
Echinococcus granulosus | pyruvate kinase | 0.0039 | 0.0005 | 0.007 |
Schistosoma mansoni | adam (A disintegrin and metalloprotease | 0.0073 | 0.0039 | 0.1002 |
Trypanosoma brucei | pyruvate kinase 1, putative | 0.0039 | 0.0005 | 0.0012 |
Loa Loa (eye worm) | hypothetical protein | 0.0139 | 0.0105 | 0.1179 |
Mycobacterium tuberculosis | Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB | 0.0227 | 0.0193 | 0.0193 |
Trypanosoma cruzi | polypeptide deformylase-like protein, putative | 0.3809 | 0.3794 | 1 |
Treponema pallidum | polypeptide deformylase (def) | 0.9982 | 1 | 1 |
Schistosoma mansoni | family M13 unassigned peptidase (M13 family) | 0.0045 | 0.001 | 0.0264 |
Leishmania major | polypeptide deformylase-like protein, putative | 0.3809 | 0.3794 | 1 |
Leishmania major | trypanothione reductase | 0.0099 | 0.0065 | 0.0172 |
Plasmodium vivax | peptide deformylase, putative | 0.9982 | 1 | 1 |
Plasmodium falciparum | ATP-dependent Clp protease proteolytic subunit | 0.0091 | 0.0057 | 0.0057 |
Schistosoma mansoni | hypothetical protein | 0.0048 | 0.0013 | 0.0346 |
Loa Loa (eye worm) | inositol-1 | 0.0043 | 0.0009 | 0.0049 |
Loa Loa (eye worm) | matrixin family protein | 0.0449 | 0.0417 | 0.4852 |
Echinococcus multilocularis | pyruvate kinase | 0.0039 | 0.0005 | 0.0049 |
Echinococcus multilocularis | L aminoadipate semialdehyde | 0.0097 | 0.0063 | 0.0687 |
Brugia malayi | aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase | 0.0097 | 0.0063 | 0.1511 |
Wolbachia endosymbiont of Brugia malayi | fructose-1,6-bisphosphatase | 0.0043 | 0.0009 | 0.0009 |
Trichomonas vaginalis | neutral alpha-glucosidase ab precursor, putative | 0.0042 | 0.0008 | 0.0069 |
Echinococcus multilocularis | a disintegrin and metalloproteinase with | 0.0199 | 0.0165 | 0.1801 |
Echinococcus multilocularis | adam | 0.0073 | 0.0039 | 0.0424 |
Schistosoma mansoni | Nep2 peptidase (M13 family) | 0.0092 | 0.0058 | 0.1501 |
Schistosoma mansoni | neprilysin-2 (M13 family) | 0.0092 | 0.0058 | 0.1501 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0042 | 0.0008 | 0.0069 |
Loa Loa (eye worm) | hypothetical protein | 0.0139 | 0.0105 | 0.1179 |
Giardia lamblia | Pyruvate kinase | 0.0039 | 0.0005 | 1 |
Mycobacterium leprae | PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) | 0.0091 | 0.0057 | 0.0053 |
Echinococcus granulosus | a disintegrin and metalloproteinase with | 0.0199 | 0.0165 | 0.2564 |
Toxoplasma gondii | glycosyl hydrolase, family 31 protein | 0.0042 | 0.0008 | 0.0008 |
Mycobacterium tuberculosis | Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) | 0.006 | 0.0026 | 0.0026 |
Echinococcus multilocularis | matrix metallopeptidase 7 (M10 family) | 0.0675 | 0.0644 | 0.7025 |
Mycobacterium tuberculosis | Probable polypeptide deformylase Def (PDF) (formylmethionine deformylase) | 0.9982 | 1 | 1 |
Echinococcus multilocularis | ATP dependent Clp protease proteolytic subunit | 0.0091 | 0.0057 | 0.0623 |
Schistosoma mansoni | hypothetical protein | 0.0048 | 0.0013 | 0.0346 |
Echinococcus multilocularis | Blood coagulation inhibitor, Disintegrin | 0.0264 | 0.0231 | 0.2517 |
Schistosoma mansoni | family M13 unassigned peptidase (M13 family) | 0.0092 | 0.0058 | 0.1501 |
Loa Loa (eye worm) | hypothetical protein | 0.0097 | 0.0063 | 0.0688 |
Loa Loa (eye worm) | hypothetical protein | 0.0139 | 0.0105 | 0.1179 |
Schistosoma mansoni | family M13 unassigned peptidase (M13 family) | 0.0048 | 0.0013 | 0.0346 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0042 | 0.0008 | 0.0069 |
Brugia malayi | Pyruvate kinase, muscle isozyme | 0.0039 | 0.0005 | 0.0109 |
Toxoplasma gondii | peptidase family M13 protein | 0.0183 | 0.015 | 0.015 |
Brugia malayi | Inositol-1 | 0.0043 | 0.0009 | 0.021 |
Mycobacterium ulcerans | ATP-dependent Clp protease proteolytic subunit | 0.0091 | 0.0057 | 0.0057 |
Mycobacterium ulcerans | hydrolase | 0.0226 | 0.0193 | 0.0193 |
Onchocerca volvulus | 0.011 | 0.0076 | 0.1905 | |
Brugia malayi | Probable ClpP-like protease | 0.0091 | 0.0057 | 0.1371 |
Echinococcus granulosus | pyruvate kinase | 0.0039 | 0.0005 | 0.007 |
Mycobacterium tuberculosis | Probable membrane NADH dehydrogenase NdhA | 0.0227 | 0.0193 | 0.0193 |
Echinococcus multilocularis | neuropeptide receptor A26 | 0.0542 | 0.051 | 0.5561 |
Loa Loa (eye worm) | hypothetical protein | 0.0183 | 0.015 | 0.1707 |
Plasmodium falciparum | thioredoxin reductase | 0.0099 | 0.0065 | 0.0065 |
Echinococcus multilocularis | neutral alpha glucosidase AB | 0.0042 | 0.0008 | 0.0085 |
Mycobacterium ulcerans | pyruvate kinase | 0.0039 | 0.0005 | 0.0005 |
Trypanosoma brucei | inositol-1(or 4)-monophosphatase 1, putative | 0.0043 | 0.0009 | 0.0023 |
Echinococcus multilocularis | lysosomal alpha glucosidase | 0.019 | 0.0157 | 0.1708 |
Echinococcus multilocularis | subfamily M12B unassigned peptidase | 0.0042 | 0.0008 | 0.0082 |
Echinococcus granulosus | peptidase Clp S14 family | 0.006 | 0.0026 | 0.0397 |
Treponema pallidum | ATP-dependent Clp protease proteolytic subunit | 0.0091 | 0.0057 | 0.0057 |
Loa Loa (eye worm) | follicle stimulating hormone receptor | 0.0273 | 0.024 | 0.2771 |
Mycobacterium ulcerans | peptide deformylase | 0.9982 | 1 | 1 |
Schistosoma mansoni | family M13 unassigned peptidase (M13 family) | 0.0183 | 0.015 | 0.3851 |
Loa Loa (eye worm) | hypothetical protein | 0.0139 | 0.0105 | 0.1179 |
Loa Loa (eye worm) | peptidase family M13 containing protein | 0.0135 | 0.0101 | 0.1141 |
Loa Loa (eye worm) | hypothetical protein | 0.0135 | 0.0101 | 0.1141 |
Onchocerca volvulus | 0.0097 | 0.0063 | 0.1558 | |
Echinococcus granulosus | lysosomal alpha glucosidase | 0.019 | 0.0157 | 0.2431 |
Chlamydia trachomatis | ATP-dependent Clp protease proteolytic subunit | 0.0091 | 0.0057 | 0.0057 |
Loa Loa (eye worm) | hypothetical protein | 0.0139 | 0.0105 | 0.1179 |
Schistosoma mansoni | pyruvate kinase | 0.0039 | 0.0005 | 0.0117 |
Mycobacterium tuberculosis | Probable NADH dehydrogenase Ndh | 0.0227 | 0.0193 | 0.0193 |
Echinococcus granulosus | endothelin converting enzyme 1 | 0.0183 | 0.015 | 0.2322 |
Echinococcus multilocularis | endothelin converting enzyme 1 | 0.0183 | 0.015 | 0.1631 |
Schistosoma mansoni | dihydroceramide desaturase | 0.0042 | 0.0008 | 0.0195 |
Toxoplasma gondii | thioredoxin reductase | 0.0099 | 0.0065 | 0.0065 |
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0.0008 | 0.0036 |
Loa Loa (eye worm) | hypothetical protein | 0.0186 | 0.0152 | 0.1736 |
Schistosoma mansoni | aminoadipate-semialdehyde dehydrogenase | 0.0097 | 0.0063 | 0.1621 |
Trichomonas vaginalis | maltase-glucoamylase, putative | 0.0042 | 0.0008 | 0.0069 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0042 | 0.0008 | 0.0021 |
Brugia malayi | peptidase family M13 containing protein | 0.0045 | 0.001 | 0.0246 |
Echinococcus granulosus | disintegrin and metalloproteinase | 0.0042 | 0.0008 | 0.0117 |
Onchocerca volvulus | Matrix metalloproteinase homolog | 0.0412 | 0.0379 | 1 |
Echinococcus multilocularis | adam 17 protease | 0.0421 | 0.0388 | 0.4235 |
Wolbachia endosymbiont of Brugia malayi | peptide deformylase | 0.9982 | 1 | 1 |
Brugia malayi | Hemopexin family protein | 0.0263 | 0.023 | 0.5521 |
Echinococcus multilocularis | thioredoxin glutathione reductase | 0.01 | 0.0066 | 0.0718 |
Trypanosoma cruzi | polypeptide deformylase-like protein, putative | 0.3809 | 0.3794 | 1 |
Schistosoma mansoni | endothelin-converting enzyme-like 1 (damage-induced neuronal endopeptidase) | 0.0045 | 0.001 | 0.0264 |
Loa Loa (eye worm) | hypothetical protein | 0.0186 | 0.0152 | 0.1736 |
Schistosoma mansoni | family M13 non-peptidase homologue (M13 family) | 0.0092 | 0.0058 | 0.1501 |
Echinococcus granulosus | neuropeptide receptor A26 | 0.0542 | 0.051 | 0.7916 |
Leishmania major | pyruvate kinase | 0.0039 | 0.0005 | 0.0012 |
Loa Loa (eye worm) | matrixin family protein | 0.0412 | 0.0379 | 0.4412 |
Mycobacterium tuberculosis | Inositol-1-monophosphatase SuhB | 0.0039 | 0.0004 | 0.0004 |
Echinococcus granulosus | ATP dependent Clp protease proteolytic subunit | 0.0091 | 0.0057 | 0.0887 |
Mycobacterium leprae | PROBABLE POLYPEPTIDE DEFORMYLASE DEF (PDF) (FORMYLMETHIONINE DEFORMYLASE) | 0.9982 | 1 | 1 |
Echinococcus multilocularis | neuropeptide s receptor | 0.0542 | 0.051 | 0.5561 |
Echinococcus granulosus | thioredoxin glutathione reductase | 0.01 | 0.0066 | 0.1022 |
Trichomonas vaginalis | myo inositol monophosphatase, putative | 0.0043 | 0.0009 | 0.0077 |
Schistosoma mansoni | family M13 unassigned peptidase (M13 family) | 0.0092 | 0.0058 | 0.1501 |
Mycobacterium tuberculosis | NADPH-dependent mycothiol reductase Mtr | 0.0099 | 0.0065 | 0.0065 |
Brugia malayi | Matrixin family protein | 0.0186 | 0.0152 | 0.3649 |
Trypanosoma cruzi | Peptide deformylase 2, putative | 0.3809 | 0.3794 | 1 |
Loa Loa (eye worm) | matrix metalloproteinase | 0.0186 | 0.0152 | 0.1736 |
Plasmodium vivax | pyruvate kinase, putative | 0.0039 | 0.0005 | 0.0005 |
Chlamydia trachomatis | pyruvate kinase | 0.0039 | 0.0005 | 0.0005 |
Schistosoma mansoni | ADAM17 peptidase (M12 family) | 0.0421 | 0.0388 | 1 |
Loa Loa (eye worm) | glycosyl hydrolase family 31 protein | 0.0042 | 0.0008 | 0.0039 |
Schistosoma mansoni | matrix metallopeptidase-7 (M10 family) | 0.0186 | 0.0152 | 0.3916 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0042 | 0.0008 | 0.0021 |
Loa Loa (eye worm) | hypothetical protein | 0.0226 | 0.0193 | 0.2215 |
Loa Loa (eye worm) | hypothetical protein | 0.0091 | 0.0057 | 0.0613 |
Loa Loa (eye worm) | reprolysin | 0.0042 | 0.0008 | 0.0036 |
Mycobacterium tuberculosis | Possible exported protein | 0.1491 | 0.1464 | 0.1464 |
Schistosoma mansoni | lipoxygenase | 0.0096 | 0.0062 | 0.16 |
Schistosoma mansoni | subfamily M12B unassigned peptidase (M12 family) | 0.0042 | 0.0008 | 0.0195 |
Mycobacterium tuberculosis | Putative ferredoxin reductase | 0.0227 | 0.0193 | 0.0193 |
Loa Loa (eye worm) | hypothetical protein | 0.0186 | 0.0152 | 0.1736 |
Echinococcus granulosus | neutral alpha glucosidase AB | 0.0042 | 0.0008 | 0.0121 |
Echinococcus granulosus | arachidonate 5 lipoxygenase | 0.0138 | 0.0104 | 0.1611 |
Trichomonas vaginalis | sucrase-isomaltase, putative | 0.0042 | 0.0008 | 0.0069 |
Echinococcus multilocularis | atpase aaa+ type core atpase aaa type core | 0.0946 | 0.0917 | 1 |
Entamoeba histolytica | myo-inositol monophosphatase, putative | 0.0043 | 0.0009 | 0.0008 |
Schistosoma mansoni | endothelin-converting enzyme-related | 0.0045 | 0.001 | 0.0264 |
Trypanosoma cruzi | Peptide deformylase 2, putative | 0.3809 | 0.3794 | 1 |
Plasmodium vivax | glutathione reductase, putative | 0.0099 | 0.0065 | 0.0065 |
Brugia malayi | hypothetical protein | 0.0073 | 0.0039 | 0.0934 |
Trypanosoma cruzi | trypanothione reductase, putative | 0.0099 | 0.0065 | 0.0172 |
Trypanosoma cruzi | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0043 | 0.0009 | 0.0023 |
Mycobacterium leprae | probable zinc metalloprotease | 0.0183 | 0.015 | 0.0145 |
Brugia malayi | Peptidase family M13 containing protein | 0.0183 | 0.015 | 0.3588 |
Mycobacterium ulcerans | zinc metalloprotease | 0.0183 | 0.015 | 0.015 |
Schistosoma mansoni | hypothetical protein | 0.0263 | 0.023 | 0.5924 |
Brugia malayi | Thioredoxin reductase | 0.0099 | 0.0065 | 0.1566 |
Mycobacterium leprae | PROBABLE NADH DEHYDROGENASE NDH | 0.0227 | 0.0193 | 0.0189 |
Schistosoma mansoni | subfamily M12B unassigned peptidase (M12 family) | 0.0042 | 0.0008 | 0.0195 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.0252 | 0.0219 | 0.0219 |
Brugia malayi | Glycosyl hydrolases family 31 protein | 0.019 | 0.0157 | 0.3757 |
Chlamydia trachomatis | ATP-dependent Clp protease proteolytic subunit | 0.0091 | 0.0057 | 0.0057 |
Mycobacterium tuberculosis | Probable dehydrogenase | 0.0227 | 0.0193 | 0.0193 |
Loa Loa (eye worm) | thioredoxin reductase | 0.0099 | 0.0065 | 0.0715 |
Schistosoma mansoni | hypothetical protein | 0.0048 | 0.0013 | 0.0346 |
Plasmodium falciparum | pyruvate kinase | 0.0039 | 0.0005 | 0.0005 |
Echinococcus granulosus | adam | 0.0073 | 0.0039 | 0.0604 |
Mycobacterium tuberculosis | Probable pyruvate kinase PykA | 0.0039 | 0.0005 | 0.0005 |
Trypanosoma brucei | glucosidase, putative | 0.0042 | 0.0008 | 0.0021 |
Brugia malayi | Matrixin family protein | 0.0186 | 0.0152 | 0.3649 |
Brugia malayi | Matrixin family protein | 0.0449 | 0.0417 | 1 |
Echinococcus multilocularis | disintegrin and metalloproteinase | 0.0042 | 0.0008 | 0.0082 |
Echinococcus multilocularis | arachidonate 5 lipoxygenase | 0.0138 | 0.0104 | 0.1132 |
Toxoplasma gondii | ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein | 0.0091 | 0.0057 | 0.0057 |
Loa Loa (eye worm) | zinc metallopeptidase 4 | 0.0045 | 0.001 | 0.0067 |
Onchocerca volvulus | Matrilysin homolog | 0.0412 | 0.0379 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0884 | 0.0854 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
ED50 (functional) | > 500 uM | Protection of ATH8 cells against the cytopathic effect of HIV. | ChEMBL. | 3497272 |
ID50 (functional) | > 500 uM | Required dose to reduce viability of normal uninfected ATH8 cells. | ChEMBL. | 3497272 |
Protection (functional) | = 10 % | Protection was determined by evaluation of cluster morphology and reclustering properties in mock infected MT-4 cells at 125 uM concentration; Range is 10-40 | ChEMBL. | 3497272 |
Protection (functional) | < 10 % | Protection was determined by evaluation of cluster morphology and reclustering properties in mock infected MT-4 cells at 5 uM concentration. | ChEMBL. | 3497272 |
Protection (functional) | < 10 % | Protection was determined by evaluation of cluster morphology and reclustering properties in mock infected MT-4 cells at 0.2 uM concentration | ChEMBL. | 3497272 |
Protection (functional) | = 10 % | Protection was determined by evaluation of cluster morphology and reclustering properties in mock infected MT-4 cells at 125 uM concentration; Range is 10-40 | ChEMBL. | 3497272 |
Protection (functional) | < 10 % | Protection was determined by evaluation of cluster morphology and reclustering properties in mock infected MT-4 cells at 5 uM concentration. | ChEMBL. | 3497272 |
Protection (functional) | < 10 % | Protection was determined by evaluation of cluster morphology and reclustering properties in mock infected MT-4 cells at 0.2 uM concentration | ChEMBL. | 3497272 |
Toxicity (ADMET) | < 10 % | Toxicity was determined by evaluation of cluster morphology and reclustering properties in mock infected MT-4 cells at 125 uM concentration | ChEMBL. | 3497272 |
Toxicity (ADMET) | < 10 % | Toxicity was determined by evaluation of cluster morphology and reclustering properties in mock infected MT-4 cells at 5 uM concentration | ChEMBL. | 3497272 |
Toxicity (ADMET) | < 10 % | Toxicity was determined by evaluation of cluster morphology and reclustering properties in mock infected MT-4 cells at 0.2 uM concentration | ChEMBL. | 3497272 |
Toxicity (ADMET) | < 10 % | Toxicity was determined by evaluation of cluster morphology and reclustering properties in mock infected MT-4 cells at 125 uM concentration | ChEMBL. | 3497272 |
Toxicity (ADMET) | < 10 % | Toxicity was determined by evaluation of cluster morphology and reclustering properties in mock infected MT-4 cells at 5 uM concentration | ChEMBL. | 3497272 |
Toxicity (ADMET) | < 10 % | Toxicity was determined by evaluation of cluster morphology and reclustering properties in mock infected MT-4 cells at 0.2 uM concentration | ChEMBL. | 3497272 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.