TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 271.271 | Formula: C14H13N3O3
H donors: 0 H acceptors: 3 LogP: -0.27 Rotable bonds: 2
Rule of 5 violations (Lipinski): 1
SMILES: C=CCN1CCc2c(C1=O)[n+]([O-])c1c([n+]2[O-])cccc1
InChi: 1S/C14H13N3O3/c1-2-8-15-9-7-12-13(14(15)18)17(20)11-6-4-3-5-10(11)16(12)19/h2-6H,1,7-9H2
InChiKey: BZAPJYQYONWWMB-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus granulosus	7TM GPCR rhodopsin	0.0074	0.028	0.036
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0126	0.0672	1
Loa Loa (eye worm)	hypothetical protein	0.0171	0.101	0.101
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.0074	0.028	0.0495
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0054	0.0122	0.0122
Brugia malayi	A-kinase anchor protein 10, precursor	0.004	0.0021	0.0021
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.0079	0.0318	0.0318
Echinococcus multilocularis	somatostatin receptor	0.0074	0.028	0.0495
Loa Loa (eye worm)	hypothetical protein	0.0074	0.028	0.028
Loa Loa (eye worm)	hypothetical protein	0.004	0.0021	0.0021
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.0074	0.028	0.028
Echinococcus multilocularis	neuropeptide s receptor	0.0074	0.028	0.0495
Echinococcus granulosus	tm gpcr rhodopsin	0.0074	0.028	0.036
Echinococcus multilocularis	neuropeptide receptor A26	0.0074	0.028	0.0495
Echinococcus multilocularis	ecdysone induced protein 78C	0.0079	0.0318	0.0562
Echinococcus granulosus	follistatin	0.0057	0.015	0.0193
Loa Loa (eye worm)	AGC/GRK/BARK protein kinase	0.0041	0.0029	0.0029
Echinococcus granulosus	geminin	0.0356	0.2415	0.3102
Echinococcus multilocularis	regulator of G protein signaling	0.004	0.0021	0.0038
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0074	0.028	0.0495
Brugia malayi	regulator of G-protein signaling egl-10	0.004	0.0021	0.0021
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.0074	0.028	0.0977
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0074	0.028	0.0977
Brugia malayi	hypothetical protein	0.0171	0.101	0.101
Giardia lamblia	Kinase, CMGC MAPK	0.0107	0.0528	0.5
Echinococcus granulosus	alpha 1A adrenergic receptor	0.0074	0.028	0.036
Schistosoma mansoni	regulator of G protein signaling	0.004	0.0021	0.0074
Loa Loa (eye worm)	hypothetical protein	0.0074	0.028	0.028
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.0079	0.0318	0.0408
Schistosoma mansoni	biogenic amine receptor	0.0074	0.028	0.0977
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0126	0.0672	1
Schistosoma mansoni	axis inhibition protein axin	0.004	0.0021	0.0074
Brugia malayi	hypothetical protein	0.0074	0.028	0.028
Echinococcus granulosus	biogenic amine 5HT receptor	0.0074	0.028	0.036
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.0074	0.028	0.028
Loa Loa (eye worm)	hypothetical protein	0.0171	0.101	0.101
Onchocerca volvulus		0.0171	0.101	0.101
Schistosoma mansoni	myosin xvIII	0.0074	0.028	0.0977
Loa Loa (eye worm)	steroid hormone receptor	0.0079	0.0318	0.0318
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0042	0.0034	0.0119
Echinococcus granulosus	mitogen activated protein kinase 3	0.0107	0.0528	0.0679
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0074	0.028	0.0977
Brugia malayi	hypothetical protein	0.0074	0.028	0.028
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.0074	0.028	0.0977
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0122	0.0122
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0079	0.0318	0.0318
Loa Loa (eye worm)	RGS-3 protein	0.004	0.0021	0.0021
Echinococcus multilocularis	dro:myosuppressin receptor	0.0074	0.028	0.0495
Echinococcus multilocularis	expressed protein	0.0783	0.5653	1
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0034	0.0034
Brugia malayi	follicle stimulating hormone receptor	0.0558	0.3945	0.3945
Brugia malayi	Kazal-type serine protease inhibitor domain containing protein	0.0057	0.015	0.015
Schistosoma mansoni	regulator of G protein signaling	0.004	0.0021	0.0074
Echinococcus granulosus	organic anion transporting polypeptide 30B	0.0171	0.101	0.1298
Schistosoma mansoni	lozenge	0.0056	0.0139	0.0484
Loa Loa (eye worm)	hypothetical protein	0.0057	0.015	0.015
Brugia malayi	ORL1-like opioid receptor	0.0074	0.028	0.028
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.0079	0.0318	0.0318
Echinococcus granulosus	biogenic amine 5HT receptor	0.0074	0.028	0.036
Echinococcus multilocularis	aldehyde dehydrogenase, mitochondrial	0.0126	0.0672	0.1189
Echinococcus granulosus	nuclear receptor subfamily 1 group D	0.0042	0.0034	0.0044
Onchocerca volvulus		0.0074	0.028	0.028
Schistosoma mansoni	serine/threonine protein kinase	0.0107	0.0528	0.1844
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0079	0.0318	0.0318
Toxoplasma gondii	aldehyde dehydrogenase	0.0126	0.0672	0.6067
Onchocerca volvulus	Dopamine\/Ecdysteroid receptor homolog	0.0074	0.028	0.028
Onchocerca volvulus		0.0039	0.001	0.001
Schistosoma mansoni	growth hormone secretagogue receptor	0.0074	0.028	0.0977
Brugia malayi	hypothetical protein	0.0068	0.023	0.023
Echinococcus granulosus	tm gpcr rhodopsin	0.0074	0.028	0.036
Brugia malayi	Cytochrome P450 family protein	0.0039	0.0009	0.0009
Echinococcus granulosus	tm gpcr rhodopsin	0.0074	0.028	0.036
Onchocerca volvulus		0.0074	0.028	0.028
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.0074	0.028	0.0495
Echinococcus granulosus	hypothetical protein	0.0074	0.028	0.036
Schistosoma mansoni	single-minded	0.0052	0.0112	0.0392
Echinococcus granulosus	neuropeptide receptor	0.0074	0.028	0.036
Echinococcus multilocularis	neuropeptides capa receptor	0.0074	0.028	0.0495
Echinococcus multilocularis	jun protein	0.0086	0.037	0.0655
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0054	0.0122	0.0122
Echinococcus granulosus	expressed protein	0.0783	0.5653	0.7263
Schistosoma mansoni	regulator of G protein signaling	0.004	0.0021	0.0074
Echinococcus granulosus	single minded 2	0.0039	0.001	0.0012
Loa Loa (eye worm)	hypothetical protein	0.004	0.0021	0.0021
Echinococcus multilocularis	geminin	0.0356	0.2415	0.4272
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.0079	0.0318	0.0318
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0074	0.028	0.0977
Onchocerca volvulus		0.0074	0.028	0.028
Loa Loa (eye worm)	hypothetical protein	0.0074	0.028	0.028
Loa Loa (eye worm)	hypothetical protein	0.0074	0.028	0.028
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0074	0.028	0.0495
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0074	0.028	0.0495
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0079	0.0318	0.0562
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0074	0.028	0.0977
Brugia malayi	G protein-coupled receptor F59B2.13	0.0074	0.028	0.028
Loa Loa (eye worm)	hypothetical protein	0.0079	0.0318	0.0318
Onchocerca volvulus		0.0074	0.028	0.028
Loa Loa (eye worm)	hypothetical protein	0.0084	0.0352	0.0352
Loa Loa (eye worm)	hypothetical protein	0.0079	0.0318	0.0318
Loa Loa (eye worm)	hypothetical protein	0.0074	0.028	0.028
Brugia malayi	Serotonin receptor	0.0074	0.028	0.028
Schistosoma mansoni	nuclear hormone receptor superfamily protein-related	0.0415	0.2866	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0074	0.028	0.0495
Trypanosoma brucei	protein kinase, putative	0.0107	0.0528	0.5
Brugia malayi	Tachykinin-like peptides receptor 99D	0.0074	0.028	0.028
Schistosoma mansoni	opsin-like receptor	0.0074	0.028	0.0977
Trichomonas vaginalis	CMGC family protein kinase	0.0107	0.0528	1
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.0079	0.0318	0.0318
Echinococcus granulosus	Solute carrier organic anion transporter family	0.0171	0.101	0.1298
Loa Loa (eye worm)	hypothetical protein	0.0079	0.0318	0.0318
Loa Loa (eye worm)	hypothetical protein	0.0171	0.101	0.101
Loa Loa (eye worm)	hypothetical protein	0.0074	0.028	0.028
Echinococcus granulosus	g protein coupled receptor	0.0074	0.028	0.036
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.0074	0.028	0.028
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0079	0.0318	0.0562
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0074	0.028	0.0977
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.0079	0.0318	0.0408
Loa Loa (eye worm)	hypothetical protein	0.0074	0.028	0.028
Loa Loa (eye worm)	hypothetical protein	0.0074	0.028	0.028
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0054	0.0122	0.0122
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.0079	0.0318	0.0562
Loa Loa (eye worm)	hypothetical protein	0.0079	0.0318	0.0318
Onchocerca volvulus	Bile acid receptor homolog	0.023	0.1461	0.1461
Brugia malayi	hypothetical protein	0.0444	0.3082	0.3082
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.0079	0.0318	0.0318
Schistosoma mansoni	steroid hormone receptor ad4bp	0.0079	0.0318	0.1108
Echinococcus multilocularis	nuclear receptor subfamily 1 group D	0.0042	0.0034	0.006
Loa Loa (eye worm)	hypothetical protein	0.0074	0.028	0.028
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription factor	0.0086	0.037	0.0655
Onchocerca volvulus	Neuropeptide F receptor homolog	0.0074	0.028	0.028
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.0074	0.028	0.0977
Echinococcus multilocularis	regulator of G protein signaling 3	0.004	0.0021	0.0038
Echinococcus multilocularis	organic anion transporting polypeptide 30B	0.0171	0.101	0.1787
Schistosoma mansoni	neuropeptide receptor	0.0074	0.028	0.0977
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.0074	0.028	0.0495
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.0074	0.028	0.0495
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.0079	0.0318	0.0318
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.0074	0.028	0.028
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.0079	0.0318	0.0318
Echinococcus granulosus	allatostatin A receptor	0.0074	0.028	0.036
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.0079	0.0318	0.1108
Trypanosoma cruzi	MFS transporter, putative	0.0171	0.101	1
Schistosoma mansoni	serine/threonine protein kinase	0.0041	0.0029	0.01
Echinococcus granulosus	neuropeptides capa receptor	0.0074	0.028	0.036
Loa Loa (eye worm)	hypothetical protein	0.0074	0.028	0.028
Echinococcus multilocularis	neuropeptide receptor	0.0074	0.028	0.0495
Onchocerca volvulus		0.0074	0.028	0.028
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.0079	0.0318	0.0318
Brugia malayi	MAP kinase sur-1	0.0107	0.0528	0.0528
Brugia malayi	sodium-independent organic anion transporter family protein	0.0171	0.101	0.101
Loa Loa (eye worm)	hypothetical protein	0.0074	0.028	0.028
Echinococcus multilocularis	G-protein coupled receptor, putative	0.0074	0.028	0.0495
Echinococcus granulosus	mitogen activated protein kinase	0.0107	0.0528	0.0679
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.0074	0.028	0.0977
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.0074	0.028	0.028
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.0074	0.028	0.028
Brugia malayi	nuclear hormone receptor	0.0079	0.0318	0.0318
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0034	0.0034
Loa Loa (eye worm)	hypothetical protein	0.0074	0.028	0.028
Echinococcus multilocularis	A kinase anchor protein 10, mitochondrial	0.004	0.0021	0.0038
Loa Loa (eye worm)	hypothetical protein	0.0074	0.028	0.028
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0074	0.028	0.0977
Loa Loa (eye worm)	hypothetical protein	0.0074	0.028	0.028
Loa Loa (eye worm)	hypothetical protein	0.0074	0.028	0.028
Loa Loa (eye worm)	hypothetical protein	0.0444	0.3082	0.3082
Brugia malayi	PXA domain containing protein	0.004	0.0021	0.0021
Schistosoma mansoni	amine GPCR	0.0074	0.028	0.0977
Onchocerca volvulus		0.0171	0.101	0.101
Loa Loa (eye worm)	hypothetical protein	0.0074	0.028	0.028
Loa Loa (eye worm)	hypothetical protein	0.0057	0.015	0.015
Brugia malayi	bZIP transcription factor family protein	0.0086	0.037	0.037
Echinococcus granulosus	Regulator of G protein signaling 20	0.004	0.0021	0.0027
Loa Loa (eye worm)	hypothetical protein	0.1356	1	1
Schistosoma mansoni	histamine h1 receptor	0.0074	0.028	0.0977
Toxoplasma gondii	transporter, major facilitator family protein	0.0171	0.101	1
Schistosoma mansoni	hypothetical protein	0.0074	0.028	0.0977
Schistosoma mansoni	z-protein (S1r protein)	0.004	0.0021	0.0074
Echinococcus multilocularis	Solute carrier organic anion transporter family	0.0171	0.101	0.1787
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.0079	0.0318	0.0408
Schistosoma mansoni	biogenic amine receptor	0.0074	0.028	0.0977
Loa Loa (eye worm)	hypothetical protein	0.0074	0.028	0.028
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0074	0.028	0.0977
Echinococcus granulosus	neuropeptide Y receptor	0.0074	0.028	0.036
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0074	0.028	0.0495
Echinococcus granulosus	rhodopsin orphan GPCR	0.0074	0.028	0.036
Schistosoma mansoni	nuclear hormone receptor	0.0079	0.0318	0.1108
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0079	0.0318	0.1108
Schistosoma mansoni	thyroid hormone receptor	0.0079	0.0318	0.1108
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0079	0.0318	0.0408
Brugia malayi	Steroid receptor seven-up type 2	0.0079	0.0318	0.0318
Schistosoma mansoni	regulator of G protein signaling	0.004	0.0021	0.0074
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0074	0.028	0.0495
Loa Loa (eye worm)	hypothetical protein	0.004	0.0021	0.0021
Brugia malayi	neuropeptide F receptor	0.0074	0.028	0.028
Brugia malayi	sodium-independent organic anion transporter family protein	0.0171	0.101	0.101
Loa Loa (eye worm)	hypothetical protein	0.0171	0.101	0.101
Brugia malayi	Kazal-type serine protease inhibitor domain containing protein	0.0057	0.015	0.015
Echinococcus granulosus	neuropeptide FF receptor 2	0.0074	0.028	0.036
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0074	0.028	0.036
Echinococcus granulosus	neuropeptide Y receptor	0.0074	0.028	0.036
Echinococcus multilocularis	mitogen activated protein kinase 3	0.0107	0.0528	0.0935
Brugia malayi	bHLH-PAS transcription factor	0.0039	0.001	0.001
Echinococcus multilocularis	neuropeptide FF receptor 2	0.0074	0.028	0.0495
Schistosoma mansoni	neuropeptide receptor	0.0074	0.028	0.0977
Echinococcus multilocularis	neuropeptide receptor	0.0074	0.028	0.0495
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.0074	0.028	0.036
Echinococcus granulosus	peptide allatostatin:somatostatin	0.0074	0.028	0.036
Brugia malayi	putative neuropeptide receptor NPR1	0.0074	0.028	0.028
Brugia malayi	G protein-coupled receptor	0.0074	0.028	0.028
Echinococcus granulosus	rhodopsin orphan GPCR	0.0074	0.028	0.036
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0074	0.028	0.0977
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.0074	0.028	0.0977
Echinococcus granulosus	FTZ F1 alpha	0.0079	0.0318	0.0408
Brugia malayi	ecdysteroid receptor	0.023	0.1461	0.1461
Echinococcus granulosus	axis inhibition protein axin	0.004	0.0021	0.0027
Loa Loa (eye worm)	hypothetical protein	0.0074	0.028	0.028
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0034	0.0034
Schistosoma mansoni	hypothetical protein	0.0356	0.2415	0.8426
Loa Loa (eye worm)	cytochrome P450 family protein	0.0039	0.0009	0.0009
Loa Loa (eye worm)	hypothetical protein	0.0171	0.101	0.101
Loa Loa (eye worm)	hypothetical protein	0.0074	0.028	0.028
Onchocerca volvulus	Protein ultraspiracle homolog	0.0079	0.0318	0.0318
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.0079	0.0318	0.0408
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.0074	0.028	0.028
Schistosoma mansoni	amine GPCR	0.0074	0.028	0.0977
Echinococcus granulosus	rhodopsin orphan GPCR	0.0074	0.028	0.036
Brugia malayi	Serotonin receptor	0.0074	0.028	0.028
Loa Loa (eye worm)	hypothetical protein	0.0074	0.028	0.028
Schistosoma mansoni	biogenic amine receptor	0.0074	0.028	0.0977
Echinococcus multilocularis	regulator of G protein signaling 3	0.004	0.0021	0.0038
Brugia malayi	secreted modular calcium-binding protein 1	0.0057	0.015	0.015
Trypanosoma brucei	mitogen activated protein kinase 4, putative	0.0107	0.0528	0.5
Onchocerca volvulus	Putative organic anion transporter	0.1356	1	1
Echinococcus granulosus	serotonin receptor	0.0074	0.028	0.036
Brugia malayi	hypoxia-induced factor 1	0.0162	0.0942	0.0942
Brugia malayi	Kazal-type serine protease inhibitor domain containing protein	0.0057	0.015	0.015
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0074	0.028	0.0977
Schistosoma mansoni	agrin	0.0057	0.015	0.0525
Schistosoma mansoni	hypothetical protein	0.0356	0.2415	0.8426
Echinococcus multilocularis	fmrfamide receptor	0.0074	0.028	0.0495
Brugia malayi	Dopamine receptor protein 1	0.0074	0.028	0.028
Loa Loa (eye worm)	hypothetical protein	0.0074	0.028	0.028
Echinococcus multilocularis	g protein coupled receptor	0.0074	0.028	0.0495
Echinococcus granulosus	aldehyde dehydrogenase mitochondrial	0.0126	0.0672	0.0863
Onchocerca volvulus		0.0074	0.028	0.028
Loa Loa (eye worm)	hypothetical protein	0.0074	0.028	0.028
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0079	0.0318	0.0318
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0034	0.0034
Schistosoma mansoni	hypothetical protein	0.0074	0.028	0.0977
Onchocerca volvulus		0.0171	0.101	0.101
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0074	0.028	0.036
Schistosoma mansoni	serine/threonine protein kinase	0.0041	0.0029	0.01
Loa Loa (eye worm)	hypothetical protein	0.0074	0.028	0.028
Loa Loa (eye worm)	hypothetical protein	0.0074	0.028	0.028
Echinococcus multilocularis	g protein coupled receptor	0.0074	0.028	0.0495
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.0074	0.028	0.036
Trichomonas vaginalis	CMGC family protein kinase	0.0107	0.0528	1
Brugia malayi	hypothetical protein	0.0042	0.0034	0.0034
Echinococcus multilocularis	FTZ F1 alpha	0.0079	0.0318	0.0562
Echinococcus granulosus	Basic leucine zipper bZIP transcription factor	0.0086	0.037	0.0475
Onchocerca volvulus		0.0074	0.028	0.028
Echinococcus multilocularis	regulator of G protein signaling 7	0.004	0.0021	0.0038
Echinococcus multilocularis	orexin receptor type 2	0.0074	0.028	0.0495
Brugia malayi	sodium-independent organic anion transporter family protein	0.0171	0.101	0.101
Echinococcus multilocularis	sex peptide receptor	0.0074	0.028	0.0495
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0074	0.028	0.0495
Loa Loa (eye worm)	nuclear hormone receptor-like 1	0.0042	0.0034	0.0034
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0079	0.0318	0.0562
Brugia malayi	Nuclear hormone receptor-like 1	0.0042	0.0034	0.0034
Loa Loa (eye worm)	CMGC/MAPK/ERK1 protein kinase	0.0107	0.0528	0.0528
Loa Loa (eye worm)	hypothetical protein	0.023	0.1461	0.1461
Loa Loa (eye worm)	hypothetical protein	0.0074	0.028	0.028
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.0079	0.0318	0.0562
Echinococcus multilocularis	beta adrenergic receptor kinase	0.0041	0.0029	0.0051
Echinococcus multilocularis	fmrfamide receptor	0.0074	0.028	0.0495
Loa Loa (eye worm)	hypothetical protein	0.0079	0.0318	0.0318
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0074	0.028	0.0495
Echinococcus multilocularis	transfer RNA-Lys	0.0039	0.001	0.0017
Echinococcus granulosus	orexin receptor type 2	0.0074	0.028	0.036
Schistosoma mansoni	amine GPCR	0.0074	0.028	0.0977
Loa Loa (eye worm)	hypothetical protein	0.0074	0.028	0.028
Schistosoma mansoni	amine GPCR	0.0074	0.028	0.0977
Loa Loa (eye worm)	G-protein coupled receptor	0.0074	0.028	0.028
Onchocerca volvulus		0.0074	0.028	0.028
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0074	0.028	0.0977
Schistosoma mansoni	opsin-like receptor	0.0074	0.028	0.0977
Schistosoma mansoni	organic anion transporter	0.0171	0.101	0.3525
Onchocerca volvulus		0.0444	0.3082	0.3082
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.0079	0.0318	0.0318
Brugia malayi	hypothetical protein	0.0074	0.028	0.028
Brugia malayi	neuropeptide F receptor	0.0074	0.028	0.028
Schistosoma mansoni	aryl hydrocarbon receptor	0.0052	0.0112	0.0392
Echinococcus granulosus	sex peptide receptor	0.0074	0.028	0.036
Brugia malayi	Regulator of G protein signaling domain containing protein	0.004	0.0021	0.0021
Loa Loa (eye worm)	runx1	0.0056	0.0139	0.0139
Echinococcus multilocularis	neuropeptide Y receptor	0.0074	0.028	0.0495
Echinococcus granulosus	dro:myosuppressin receptor	0.0074	0.028	0.036
Brugia malayi	Dopamine receptor	0.0074	0.028	0.028
Schistosoma mansoni	adenoreceptor	0.0074	0.028	0.0977
Onchocerca volvulus		0.0074	0.028	0.028
Schistosoma mansoni	neuropeptide F-like receptor	0.0074	0.028	0.0977
Schistosoma mansoni	ecdysone-induced protein 78c (dr-78)	0.0042	0.0034	0.0119
Schistosoma mansoni	neuropeptide F-like receptor	0.0074	0.028	0.0977
Echinococcus granulosus	neuropeptide receptor A26	0.0074	0.028	0.036
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.0074	0.028	0.036
Brugia malayi	G-protein coupled receptor	0.0074	0.028	0.028
Schistosoma mansoni	hypothetical protein	0.0074	0.028	0.0977
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0079	0.0318	0.0408
Echinococcus multilocularis	agrin	0.0057	0.015	0.0266
Brugia malayi	hypothetical protein	0.0074	0.028	0.028
Loa Loa (eye worm)	hypothetical protein	0.0057	0.015	0.015
Onchocerca volvulus	Steroid hormone receptor family member cnr14 homolog	0.0079	0.0318	0.0318
Echinococcus multilocularis	follistatin	0.0057	0.015	0.0266
Onchocerca volvulus		0.0074	0.028	0.028
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.0079	0.0318	0.1108
Onchocerca volvulus	Putative organic anion transporter	0.0171	0.101	0.101
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.0074	0.028	0.0977
Brugia malayi	hypothetical protein	0.0042	0.0034	0.0034
Loa Loa (eye worm)	hypothetical protein	0.0074	0.028	0.028
Loa Loa (eye worm)	hypothetical protein	0.0074	0.028	0.028
Onchocerca volvulus		0.0074	0.028	0.028
Loa Loa (eye worm)	hypothetical protein	0.0074	0.028	0.028
Entamoeba histolytica	hypothetical protein	0.004	0.0021	0.5
Loa Loa (eye worm)	sodium-independent organic anion transporter	0.0171	0.101	0.101
Echinococcus granulosus	agrin	0.0057	0.015	0.0193
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.0074	0.028	0.0495
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.0079	0.0318	0.0318
Echinococcus granulosus	rhodopsin orphan GPCR	0.0074	0.028	0.036
Brugia malayi	hypothetical protein	0.0074	0.028	0.028
Loa Loa (eye worm)	hypothetical protein	0.0074	0.028	0.028
Brugia malayi	larval opioid receptor	0.0074	0.028	0.028
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.0074	0.028	0.028
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0074	0.028	0.0495
Echinococcus multilocularis	G protein coupled receptor 139	0.0074	0.028	0.0495
Loa Loa (eye worm)	kazal-type serine protease inhibitor domain-containing protein	0.0057	0.015	0.015
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.0074	0.028	0.028
Schistosoma mansoni	neuropeptide receptor	0.0074	0.028	0.0977
Loa Loa (eye worm)	hypothetical protein	0.004	0.0021	0.0021
Schistosoma mansoni	amine GPCR	0.0074	0.028	0.0977
Echinococcus granulosus	rhodopsin orphan GPCR	0.0074	0.028	0.036
Echinococcus multilocularis	expressed protein	0.0057	0.015	0.0266
Loa Loa (eye worm)	G-protein coupled receptor	0.0074	0.028	0.028
Echinococcus granulosus	g protein coupled receptor	0.0074	0.028	0.036
Brugia malayi	PXA domain containing protein	0.004	0.0021	0.0021
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0074	0.028	0.0977
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.0074	0.028	0.0495
Brugia malayi	Nuclear hormone receptor-like 1	0.0042	0.0034	0.0034
Brugia malayi	Kazal-type serine protease inhibitor domain containing protein	0.0057	0.015	0.015
Onchocerca volvulus		0.0074	0.028	0.028
Schistosoma mansoni	serine/threonine protein kinase	0.0041	0.0029	0.01
Brugia malayi	putative neuropeptide receptor	0.0074	0.028	0.028
Loa Loa (eye worm)	hypothetical protein	0.0074	0.028	0.028
Onchocerca volvulus		0.0074	0.028	0.028
Loa Loa (eye worm)	neuropeptide F receptor	0.0074	0.028	0.028
Brugia malayi	SPARC precursor	0.0057	0.015	0.015
Schistosoma mansoni	aldehyde dehydrogenase	0.0126	0.0672	0.2345
Loa Loa (eye worm)	hypothetical protein	0.0171	0.101	0.101
Echinococcus granulosus	g-protein coupled receptor	0.0074	0.028	0.036
Brugia malayi	Nuclear hormone receptor-like 1	0.0079	0.0318	0.0318
Echinococcus granulosus	G protein coupled receptor 139	0.0074	0.028	0.036
Entamoeba histolytica	hypothetical protein	0.004	0.0021	0.5
Echinococcus granulosus	jun protein	0.0086	0.037	0.0475
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.0079	0.0318	0.0408
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.0074	0.028	0.0495
Onchocerca volvulus		0.0171	0.101	0.101
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.0079	0.0318	0.1108
Brugia malayi	photoreceptor-specific nuclear receptor	0.0079	0.0318	0.0318
Schistosoma mansoni	alpha-1 adrenergic receptor	0.0074	0.028	0.0977
Schistosoma mansoni	neuropeptide receptor	0.0074	0.028	0.0977
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0074	0.028	0.0495
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.0074	0.028	0.0977
Loa Loa (eye worm)	hypothetical protein	0.0079	0.0318	0.0318
Schistosoma mansoni	regulator of G protein signaling 3 rgs3	0.004	0.0021	0.0074
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.0074	0.028	0.036
Echinococcus granulosus	neuropeptide s receptor	0.0074	0.028	0.036
Leishmania major	aldehyde dehydrogenase, mitochondrial precursor	0.0126	0.0672	1
Brugia malayi	Probable G protein-coupled receptor kinase F19C6.1, putative	0.0041	0.0029	0.0029
Brugia malayi	sulfakinin receptor protein	0.0074	0.028	0.028
Loa Loa (eye worm)	hypothetical protein	0.0074	0.028	0.028
Loa Loa (eye worm)	melatonin receptor type 1A	0.0074	0.028	0.028
Brugia malayi	nuclear receptor RXR	0.0042	0.0034	0.0034
Loa Loa (eye worm)	hypothetical protein	0.004	0.0021	0.0021
Onchocerca volvulus		0.0074	0.028	0.028
Schistosoma mansoni	retinoic acid receptor RXR	0.0079	0.0318	0.1108
Echinococcus granulosus	neuropeptides capa receptor	0.0074	0.028	0.036
Echinococcus granulosus	7tm_1 domain containing protein	0.0074	0.028	0.036
Brugia malayi	hypothetical protein	0.0074	0.028	0.028
Onchocerca volvulus		0.0074	0.028	0.028
Onchocerca volvulus		0.0074	0.028	0.028
Onchocerca volvulus		0.0057	0.015	0.015
Echinococcus granulosus	g protein coupled receptor	0.0074	0.028	0.036
Echinococcus granulosus	tachykinin peptides receptor 99D	0.0074	0.028	0.036
Loa Loa (eye worm)	hypothetical protein	0.0175	0.1045	0.1045
Brugia malayi	Regulator of G protein signaling domain containing protein	0.004	0.0021	0.0021
Echinococcus granulosus	beta-adrenergic receptor kinase	0.0041	0.0029	0.0037
Loa Loa (eye worm)	hypothetical protein	0.0074	0.028	0.028
Brugia malayi	regulator of G-protein signaling rgs-7	0.004	0.0021	0.0021
Echinococcus multilocularis	g protein coupled receptor	0.0074	0.028	0.0495
Echinococcus granulosus	axis inhibition protein axin	0.004	0.0021	0.0027
Schistosoma mansoni	regulator of G protein signaling 17 19 20 (rgs17 19 20)	0.004	0.0021	0.0074
Onchocerca volvulus		0.0068	0.023	0.023
Loa Loa (eye worm)	hypothetical protein	0.0074	0.028	0.028
Schistosoma mansoni	regulator of G protein signaling 17 19 20 (rgs17 19 20)	0.004	0.0021	0.0074
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.0079	0.0318	0.0318
Trichomonas vaginalis	CMGC family protein kinase	0.0107	0.0528	1
Brugia malayi	PAS domain containing protein	0.0052	0.0112	0.0112
Loa Loa (eye worm)	hypothetical protein	0.0074	0.028	0.028
Brugia malayi	hypothetical protein	0.0175	0.1045	0.1045
Loa Loa (eye worm)	hypothetical protein	0.0074	0.028	0.028
Entamoeba histolytica	hypothetical protein	0.004	0.0021	0.5
Echinococcus granulosus	fmrfamide receptor	0.0074	0.028	0.036
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.0079	0.0318	0.0562
Brugia malayi	hypothetical protein	0.0074	0.028	0.028
Loa Loa (eye worm)	neuropeptide F receptor	0.0074	0.028	0.028
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.0074	0.028	0.0495
Echinococcus multilocularis	serotonin receptor	0.0074	0.028	0.0495
Brugia malayi	Melatonin receptor type 1A	0.0074	0.028	0.028
Loa Loa (eye worm)	PXA domain-containing protein	0.004	0.0021	0.0021
Loa Loa (eye worm)	G protein signaling regulator EGL-10	0.004	0.0021	0.0021
Schistosoma mansoni	neuropeptide f receptor 76f	0.0074	0.028	0.0977
Schistosoma mansoni	coup transcription factor	0.0079	0.0318	0.1108
Echinococcus multilocularis	serotonin receptor	0.0074	0.028	0.0495
Brugia malayi	RE15519p	0.0074	0.028	0.028
Loa Loa (eye worm)	TYRA-2 protein	0.0074	0.028	0.028
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0034	0.0034
Brugia malayi	Dopamine receptor protein 2	0.0074	0.028	0.028
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.0079	0.0318	0.0318
Onchocerca volvulus		0.0171	0.101	0.101
Echinococcus multilocularis	Regulator of G protein signaling 20	0.004	0.0021	0.0038
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0079	0.0318	0.0318
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0074	0.028	0.0977
Onchocerca volvulus		0.0079	0.0318	0.0318
Loa Loa (eye worm)	hypothetical protein	0.0074	0.028	0.028
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0074	0.028	0.0977
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0079	0.0318	0.0318
Loa Loa (eye worm)	hypothetical protein	0.0074	0.028	0.028
Loa Loa (eye worm)	hypothetical protein	0.0074	0.028	0.028
Onchocerca volvulus	Putative organic anion transporter	0.0171	0.101	0.101
Loa Loa (eye worm)	hypothetical protein	0.0074	0.028	0.028
Echinococcus granulosus	rhodopsin orphan GPCR	0.0074	0.028	0.036
Echinococcus multilocularis	axis inhibition protein axin	0.004	0.0021	0.0038
Echinococcus multilocularis	g-protein coupled receptor	0.0074	0.028	0.0495
Brugia malayi	steroid hormone receptor	0.0079	0.0318	0.0318
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.0079	0.0318	0.1108
Echinococcus granulosus	rhodopsin orphan GPCR	0.0074	0.028	0.036
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.0079	0.0318	0.0562
Echinococcus multilocularis	regulator of G protein signaling 7	0.004	0.0021	0.0038
Echinococcus multilocularis	neuropeptide Y receptor	0.0074	0.028	0.0495
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0074	0.028	0.0495
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0079	0.0318	0.0318
Schistosoma mansoni	regulator of G protein signaling	0.004	0.0021	0.0074
Echinococcus granulosus	regulator of G protein signaling 3	0.004	0.0021	0.0027
Echinococcus multilocularis	mitogen activated protein kinase	0.0107	0.0528	0.0935
Brugia malayi	G-protein coupled receptor	0.0074	0.028	0.028
Loa Loa (eye worm)	agrin synaptic family protein	0.0057	0.015	0.015
Loa Loa (eye worm)	hypothetical protein	0.0444	0.3082	0.3082
Echinococcus granulosus	somatostatin receptor	0.0074	0.028	0.036
Echinococcus granulosus	regulator of G protein signaling 3	0.004	0.0021	0.0027
Echinococcus multilocularis	neuropeptides capa receptor	0.0074	0.028	0.0495
Loa Loa (eye worm)	hypothetical protein	0.0079	0.0318	0.0318
Brugia malayi	hypothetical protein	0.0074	0.028	0.028
Schistosoma mansoni	axis inhibition protein axin	0.004	0.0021	0.0074
Schistosoma mansoni	jun-related protein	0.007	0.0248	0.0864
Loa Loa (eye worm)	AGC/GRK/GRK protein kinase	0.0041	0.0029	0.0029
Echinococcus granulosus	regulator of G protein signaling 7	0.004	0.0021	0.0027
Schistosoma mansoni	RAR-like nuclear receptor	0.0079	0.0318	0.1108
Schistosoma mansoni	follistatin	0.0057	0.015	0.0525
Brugia malayi	hypothetical protein	0.004	0.0021	0.0021
Brugia malayi	hypothetical protein	0.004	0.0021	0.0021
Loa Loa (eye worm)	hypothetical protein	0.004	0.0021	0.0021
Brugia malayi	hypothetical protein	0.0074	0.028	0.028
Brugia malayi	GnHR receptor homolog	0.0074	0.028	0.028
Echinococcus multilocularis	allatostatin A receptor	0.0074	0.028	0.0495
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.0079	0.0318	0.1108
Schistosoma mansoni	hypothetical protein	0.007	0.0248	0.0864
Loa Loa (eye worm)	hypoxia-induced factor 1	0.0162	0.0942	0.0942
Brugia malayi	hypothetical protein	0.0171	0.101	0.101
Schistosoma mansoni	hypothetical protein	0.0074	0.028	0.0977
Loa Loa (eye worm)	hypothetical protein	0.0074	0.028	0.028
Schistosoma mansoni	opsin-like receptor	0.0074	0.028	0.0977
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.0074	0.028	0.0495
Schistosoma mansoni	organic anion transporter	0.0171	0.101	0.3525
Echinococcus granulosus	Solute carrier family 22 5	0.1064	0.7784	1
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0074	0.028	0.0495
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0074	0.028	0.0977
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0126	0.0672	1
Echinococcus granulosus	ecdysone induced protein 78C	0.0079	0.0318	0.0408
Loa Loa (eye worm)	hypothetical protein	0.0074	0.028	0.028
Mycobacterium tuberculosis	Probable aldehyde dehydrogenase	0.0126	0.0672	0.5
Schistosoma mansoni	aldehyde dehydrogenase	0.0126	0.0672	0.2345
Echinococcus granulosus	neuropeptide receptor	0.0074	0.028	0.036
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.0079	0.0318	0.0318
Echinococcus granulosus	A kinase anchor protein 10 mitochondrial	0.004	0.0021	0.0027
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0074	0.028	0.0977
Schistosoma mansoni	thyroid hormone receptor	0.0079	0.0318	0.1108
Brugia malayi	nuclear receptor NHR-88	0.0079	0.0318	0.0318
Echinococcus multilocularis	Protein lozenge	0.0056	0.0139	0.0245
Toxoplasma gondii	CMGC kinase, MAPK family (ERK) MAPK-1	0.0107	0.0528	0.4395
Onchocerca volvulus		0.0074	0.028	0.028
Echinococcus granulosus	regulator of G protein signaling 7	0.004	0.0021	0.0027
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.0074	0.028	0.0977
Echinococcus multilocularis	axis inhibition protein axin	0.004	0.0021	0.0038
Trichomonas vaginalis	CMGC family protein kinase	0.0107	0.0528	1
Loa Loa (eye worm)	hypothetical protein	0.0074	0.028	0.028
Loa Loa (eye worm)	hypothetical protein	0.0074	0.028	0.028
Brugia malayi	hypothetical protein	0.0074	0.028	0.028
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0558	0.3945	0.3945
Brugia malayi	AKH receptor	0.0074	0.028	0.028
Loa Loa (eye worm)	hypothetical protein	0.0057	0.015	0.015
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.0079	0.0318	0.0318
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0074	0.028	0.0495
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0074	0.028	0.0977
Loa Loa (eye worm)	hypothetical protein	0.0074	0.028	0.028

Activities

Activity type	Activity value	Assay description	Source	Reference
MIC (functional)	= 0.78 ug ml-1	Tested in vitro for the minimum inhibitory concentration(MIC) against Strep. pyogenes	ChEMBL.	7108904
MIC (functional)	= 1.56 ug ml-1	Tested in vitro for the minimum inhibitory concentration(MIC) against S. choleraesuis	ChEMBL.	7108904
MIC (functional)	= 3.12 ug ml-1	Tested in vitro for the minimum inhibitory concentration(MIC) against E. coli	ChEMBL.	7108904
MIC (functional)	= 3.12 ug ml-1	Tested in vitro for the minimum inhibitory concentration(MIC) against E. coli	ChEMBL.	7108904
MIC (functional)	= 6.25 ug ml-1	Tested in vitro for the minimum inhibitory concentration(MIC) against P. multocida	ChEMBL.	7108904
Protection (functional)	= 0 %	Tested in vivo for the antibacterial activity against Salmonella choleraesuis after oral administration of 25 mg/kg in mice	ChEMBL.	7108904
Protection (functional)	= 30 %	Tested in vivo for the antibacterial activity against Salmonella choleraesuis after sc administration of 25 mg/kg in mice	ChEMBL.	7108904

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL168993

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 290888