Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | carnitine O palmitoyltransferase 2 | 0.0176 | 0.1368 | 0.1279 |
Trichomonas vaginalis | set domain proteins, putative | 0.023 | 0.1832 | 0.5 |
Schistosoma mansoni | choline o-acyltransferase | 0.0176 | 0.1368 | 0.1279 |
Trypanosoma cruzi | choline/carnitine O-acyltransferase, putative | 0.0176 | 0.1368 | 1 |
Echinococcus granulosus | carnitine O palmitoyltransferase 1 liver | 0.0176 | 0.1368 | 0.1287 |
Loa Loa (eye worm) | hypothetical protein | 0.0029 | 0.0102 | 0.0022 |
Brugia malayi | hypothetical protein | 0.0026 | 0.0081 | 0.0081 |
Trypanosoma brucei | carnitine O-palmitoyltransferase II, putative | 0.0176 | 0.1368 | 1 |
Trypanosoma cruzi | choline/carnitine O-acyltransferase, putative | 0.0176 | 0.1368 | 1 |
Brugia malayi | Choline/Carnitine o-acyltransferase family protein | 0.0176 | 0.1368 | 0.1368 |
Entamoeba histolytica | hypothetical protein | 0.0038 | 0.0178 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0157 | 0.1203 | 0.1131 |
Onchocerca volvulus | 0.0317 | 0.2583 | 1 | |
Onchocerca volvulus | 0.0176 | 0.1368 | 0.5102 | |
Echinococcus granulosus | geminin | 0.0178 | 0.1384 | 0.1303 |
Leishmania major | carnitine/choline acetyltransferase, putative | 0.0176 | 0.1368 | 1 |
Brugia malayi | Choline/Carnitine o-acyltransferase family protein | 0.0176 | 0.1368 | 0.1368 |
Schistosoma mansoni | hypothetical protein | 0.0178 | 0.1384 | 0.1295 |
Brugia malayi | hypothetical protein | 0.0317 | 0.2583 | 0.2583 |
Leishmania major | carnitine palmitoyltransferase-like protein | 0.0176 | 0.1368 | 1 |
Trypanosoma cruzi | carnitine/choline acetyltransferase, putative | 0.0176 | 0.1368 | 1 |
Echinococcus multilocularis | geminin | 0.0178 | 0.1384 | 0.1295 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0125 | 0.0932 | 0.0858 |
Loa Loa (eye worm) | hypothetical protein | 0.1178 | 1 | 1 |
Schistosoma mansoni | choline o-acyltransferase | 0.1178 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0317 | 0.2583 | 0.2523 |
Echinococcus multilocularis | muscleblind protein 1 | 0.0157 | 0.1203 | 0.1112 |
Echinococcus granulosus | histone lysine methyltransferase setb | 0.0029 | 0.0102 | 0.0009 |
Brugia malayi | Choline/Carnitine o-acyltransferase family protein | 0.0176 | 0.1368 | 0.1368 |
Entamoeba histolytica | hypothetical protein | 0.0038 | 0.0178 | 0.5 |
Brugia malayi | Muscleblind-like protein | 0.0157 | 0.1203 | 0.1203 |
Toxoplasma gondii | histone lysine methyltransferase SET/SUV39 | 0.0029 | 0.0102 | 1 |
Trypanosoma brucei | carnitine O-acetyltransferase, putative | 0.0176 | 0.1368 | 1 |
Onchocerca volvulus | 0.0176 | 0.1368 | 0.5102 | |
Trypanosoma cruzi | choline/carnitine O-acetyltransferase, putative | 0.0176 | 0.1368 | 1 |
Echinococcus granulosus | choline O acetyltransferase | 0.1178 | 1 | 1 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0176 | 0.1368 | 1 |
Loa Loa (eye worm) | choline O-acetyltransferase | 0.1178 | 1 | 1 |
Trypanosoma cruzi | carnitine O-acetyltransferase, putative | 0.0176 | 0.1368 | 1 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0176 | 0.1368 | 1 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0038 | 0.0178 | 0.0086 |
Brugia malayi | Pre-SET motif family protein | 0.0029 | 0.0102 | 0.0102 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0176 | 0.1368 | 1 |
Plasmodium vivax | SET domain protein, putative | 0.0029 | 0.0102 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0157 | 0.1203 | 0.1131 |
Onchocerca volvulus | 0.0176 | 0.1368 | 0.5102 | |
Brugia malayi | Pre-SET motif family protein | 0.0202 | 0.1591 | 0.1591 |
Brugia malayi | MH2 domain containing protein | 0.0125 | 0.0932 | 0.0932 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0176 | 0.1368 | 1 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0026 | 0.0081 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0038 | 0.0178 | 0.5 |
Trypanosoma cruzi | carnitine O-palmitoyltransferase II, putative | 0.0176 | 0.1368 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0176 | 0.1368 | 0.1298 |
Schistosoma mansoni | hypothetical protein | 0.0178 | 0.1384 | 0.1295 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0038 | 0.0178 | 0.0076 |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | 0.0202 | 0.1591 | 0.1523 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0176 | 0.1368 | 1 |
Echinococcus multilocularis | muscleblind protein | 0.0157 | 0.1203 | 0.1112 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0125 | 0.0932 | 0.0858 |
Schistosoma mansoni | hypothetical protein | 0.0038 | 0.0178 | 0.0076 |
Echinococcus multilocularis | choline O acetyltransferase | 0.1178 | 1 | 1 |
Brugia malayi | Choline O-acetyltransferase | 0.1178 | 1 | 1 |
Trypanosoma cruzi | choline/carnitine O-acyltransferase, putative | 0.0176 | 0.1368 | 1 |
Echinococcus granulosus | muscleblind protein | 0.0157 | 0.1203 | 0.112 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0176 | 0.1368 | 1 |
Onchocerca volvulus | 0.0176 | 0.1368 | 0.5102 | |
Echinococcus multilocularis | carnitine O palmitoyltransferase 1, liver | 0.0176 | 0.1368 | 0.1279 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0026 | 0.0081 | 0.5 |
Loa Loa (eye worm) | carnitine O-palmitoyltransferase I isoform | 0.0176 | 0.1368 | 0.1298 |
Leishmania major | choline/Carnitine o-acyltransferase-like protein | 0.0176 | 0.1368 | 1 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0038 | 0.0178 | 0.0076 |
Trypanosoma cruzi | carnitine/choline acetyltransferase, putative | 0.0176 | 0.1368 | 1 |
Brugia malayi | hypothetical protein | 0.0038 | 0.0178 | 0.0178 |
Echinococcus granulosus | carnitine O palmitoyltransferase 2 | 0.0176 | 0.1368 | 0.1287 |
Trypanosoma brucei | carnitine O-palmitoyltransferase II, putative | 0.0176 | 0.1368 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0038 | 0.0178 | 0.5 |
Onchocerca volvulus | 0.023 | 0.1832 | 0.697 | |
Trypanosoma brucei | carnitine O-palmitoyltransferase, putative | 0.0176 | 0.1368 | 1 |
Loa Loa (eye worm) | choline/Carnitine O-acyltransferase | 0.0176 | 0.1368 | 0.1298 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (ADMET) | = 3.6 | Inhibitory potency to aminopyrine N-demethylase activity (P450) in hepatic microsomes from phenobarbitone-induced rats. | ChEMBL. | 7120277 |
logP (ADMET) | = 2.36 | Partition coefficient (logP) | ChEMBL. | 7120277 |
pI50 (ADMET) | = 3.6 | Inhibitory potency to aminopyrine N-demethylase activity (P450) in hepatic microsomes from phenobarbitone-induced rats. | ChEMBL. | 7120277 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.