Detailed information for compound 303993

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 327.851 | Formula: C19H22ClN3
  • H donors: 1 H acceptors: 1 LogP: 4.9 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: CN(CCCNc1c2cc(C)ccc2nc2c1ccc(c2)Cl)C
  • InChi: 1S/C19H22ClN3/c1-13-5-8-17-16(11-13)19(21-9-4-10-23(2)3)15-7-6-14(20)12-18(15)22-17/h5-8,11-12H,4,9-10H2,1-3H3,(H,21,22)
  • InChiKey: SBOPCMBWLYLGJB-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.002 0.0088 0.0178
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.002 0.0088 0.0178
Echinococcus granulosus histone acetyltransferase KAT2B 0.0039 0.0354 0.0339
Loa Loa (eye worm) hypothetical protein 0.0108 0.1302 0.3226
Echinococcus multilocularis acetyl coenzyme A carboxylase 1 0.0053 0.0544 0.0528
Loa Loa (eye worm) hypothetical protein 0.0092 0.1089 0.2691
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.002 0.0088 0.0178
Brugia malayi Nuclear hormone receptor family member nhr-25 0.002 0.0088 0.0178
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.002 0.0088 0.0178
Echinococcus granulosus death domain containing protein 0.0075 0.0855 0.0843
Loa Loa (eye worm) hypothetical protein 0.0108 0.1302 0.3226
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0108 0.1302 0.3226
Loa Loa (eye worm) hypothetical protein 0.0304 0.4 1
Schistosoma mansoni peripheral-type benzodiazepine receptor 0.0304 0.4 1
Loa Loa (eye worm) neuronal acetylcholine receptor protein 0.0092 0.1089 0.2691
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.02 0.2572 0.2573
Loa Loa (eye worm) hypothetical protein 0.02 0.2572 0.6415
Echinococcus multilocularis thyroid hormone receptor alpha 0.002 0.0088 0.0071
Loa Loa (eye worm) hypothetical protein 0.02 0.2572 0.6415
Loa Loa (eye worm) carboxyl transferase domain-containing protein 0.0051 0.0518 0.1259
Onchocerca volvulus 0.0108 0.1302 0.3104
Echinococcus granulosus nuclear receptor 2DBD gamma 0.002 0.0088 0.0071
Mycobacterium tuberculosis Probable pyruvate carboxylase Pca (pyruvic carboxylase) 0.002 0.0095 0.5
Brugia malayi Nuclear hormone receptor family member nhr-40 0.002 0.0088 0.0178
Brugia malayi gamma-aminobutyric-acid receptor beta subunit precursor 0.02 0.2572 0.6415
Brugia malayi acetylcholine receptor alpha subunit precursor, putative 0.02 0.2572 0.6415
Brugia malayi Nuclear hormone receptor family member nhr-3 0.002 0.0088 0.0178
Brugia malayi nuclear hormone receptor 0.002 0.0088 0.0178
Echinococcus multilocularis nicotinic acetylcholine receptor alpha subunit 0.02 0.2572 0.256
Wolbachia endosymbiont of Brugia malayi Acetyl/propionyl-CoA carboxylase, alpha subunit 0.002 0.0095 0.5
Brugia malayi glutamate-gated chloride channel alpha3A subunit, putative 0.0108 0.1302 0.3226
Onchocerca volvulus 0.0092 0.1089 0.2559
Schistosoma mansoni hypothetical protein 0.0162 0.2054 0.5114
Echinococcus multilocularis jun protein 0.02 0.2569 0.2557
Brugia malayi acetylcholine receptor protein, alpha-like chain, putative 0.02 0.2572 0.6415
Loa Loa (eye worm) hypothetical protein 0.02 0.2572 0.6415
Echinococcus multilocularis nicotinic acetylcholine receptor subunit type 0.0092 0.1089 0.1074
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.02 0.2572 0.6415
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription factor 0.02 0.2569 0.2557
Schistosoma mansoni nAChR subunit 0.02 0.2572 0.6415
Brugia malayi Uncoordinated protein 44 0.0075 0.0855 0.2103
Echinococcus multilocularis glycine receptor subunit beta 0.02 0.2572 0.256
Brugia malayi Protein kinase domain containing protein 0.0075 0.0855 0.2103
Echinococcus granulosus acetylcholine receptor subunit beta 1 0.02 0.2572 0.2573
Brugia malayi Carboxyl transferase domain containing protein 0.0051 0.0518 0.1259
Brugia malayi nicotinic acetylcholine receptor beta-1 chain precursor 0.02 0.2572 0.6415
Onchocerca volvulus 0.0108 0.1302 0.3104
Loa Loa (eye worm) hypothetical protein 0.0092 0.1089 0.2691
Schistosoma mansoni methylcrotonyl-CoA carboxylase 0.002 0.0095 0.0196
Echinococcus multilocularis nicotinic acetylcholine receptor subunit alpha 8 0.02 0.2572 0.256
Schistosoma mansoni nuclear hormone receptor 0.002 0.0088 0.0178
Echinococcus granulosus nicotinic acetylcholine receptor subunit alpha 8 0.02 0.2572 0.2573
Loa Loa (eye worm) nicotinic acetylcholine receptor non-alpha subunit 0.02 0.2572 0.6415
Loa Loa (eye worm) hypothetical protein 0.002 0.0088 0.0178
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.02 0.2572 0.6415
Schistosoma mansoni coup transcription factor 0.002 0.0088 0.0178
Brugia malayi ecdysteroid receptor 0.0185 0.2366 0.5897
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0108 0.1302 0.3226
Schistosoma mansoni nAChR subunit 0.02 0.2572 0.6415
Brugia malayi Death domain containing protein 0.0075 0.0855 0.2103
Echinococcus granulosus neuronal acetylcholine receptor subunit alpha 4 0.02 0.2572 0.2573
Loa Loa (eye worm) hypothetical protein 0.002 0.0088 0.0178
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.002 0.0088 0.0178
Loa Loa (eye worm) ligand-Gated ion Channel family member 0.02 0.2572 0.6415
Brugia malayi acetylcholine receptor, alpha-type subunit unc-38 precursor 0.02 0.2572 0.6415
Brugia malayi acetyltransferase, GNAT family protein 0.0132 0.1638 0.4071
Echinococcus granulosus Basic leucine zipper bZIP transcription factor 0.02 0.2569 0.257
Schistosoma mansoni retinoid-x-receptor (RXR) 0.002 0.0088 0.0178
Schistosoma mansoni hypothetical protein 0.0155 0.1946 0.4843
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0039 0.0354 0.5769
Brugia malayi RNA binding protein 0.0058 0.0614 0.1499
Schistosoma mansoni nAChR subunit 0.02 0.2572 0.6415
Chlamydia trachomatis biotin carboxylase 0.0018 0.0069 0.5
Echinococcus granulosus histone acetyltransferase KAT2B 0.0129 0.1587 0.1581
Loa Loa (eye worm) hypothetical protein 0.002 0.0088 0.0178
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.002 0.0088 0.0071
Echinococcus granulosus glycine receptor subunit alpha 1 0.02 0.2572 0.2573
Loa Loa (eye worm) hypothetical protein 0.0108 0.1302 0.3226
Loa Loa (eye worm) acetyltransferase 0.0132 0.1638 0.4071
Giardia lamblia Histone acetyltransferase GCN5 0.0036 0.0309 0.5
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.02 0.2572 0.6415
Echinococcus granulosus glycine receptor subunit alpha 1 0.02 0.2572 0.2573
Echinococcus granulosus glycine receptor subunit beta 0.02 0.2572 0.2573
Brugia malayi steroid hormone receptor 0.002 0.0088 0.0178
Loa Loa (eye worm) TAR-binding protein 0.0058 0.0614 0.1499
Loa Loa (eye worm) hypothetical protein 0.02 0.2572 0.6415
Echinococcus granulosus nicotinic acetylcholine receptor beta 1 subunit 0.02 0.2572 0.2573
Loa Loa (eye worm) hypothetical protein 0.02 0.2572 0.6415
Toxoplasma gondii acetyl-coA carboxylase ACC2 0.0053 0.0544 1
Echinococcus granulosus nicotinic acetylcholine receptor alpha subunit 0.02 0.2572 0.2573
Echinococcus granulosus translocator protein 0.0304 0.4 0.401
Loa Loa (eye worm) hypothetical protein 0.02 0.2572 0.6415
Leishmania major acetyl-CoA carboxylase, putative 0.0053 0.0544 1
Echinococcus multilocularis ecdysone induced protein 78C 0.002 0.0088 0.0071
Echinococcus granulosus nAChR subunit 0.0108 0.1302 0.1294
Schistosoma mansoni ankyrin 23/unc44 0.0075 0.0855 0.2103
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0039 0.0354 1
Schistosoma mansoni hypothetical protein 0.0155 0.1946 0.4843
Brugia malayi Nuclear hormone receptor family member nhr-19 0.002 0.0088 0.0178
Trypanosoma cruzi acetyl-CoA carboxylase 0.0033 0.0267 1
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.002 0.0088 0.0178
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.002 0.0088 0.0178
Echinococcus granulosus nuclear receptor 2DBD gamma 0.002 0.0088 0.0071
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.02 0.2572 0.6415
Schistosoma mansoni nAChR subunit (ShAR1-beta2-like) 0.02 0.2572 0.6415
Echinococcus granulosus gamma aminobutyric acid receptor subunit 0.0092 0.1089 0.1079
Echinococcus granulosus nAChR subunit 0.02 0.2572 0.2573
Brugia malayi Nuclear hormone receptor family member nhr-41 0.002 0.0088 0.0178
Schistosoma mansoni pyruvate carboxylase 0.002 0.0095 0.0196
Onchocerca volvulus 0.0304 0.4 1
Echinococcus multilocularis glycine receptor subunit alpha 1 0.02 0.2572 0.256
Loa Loa (eye worm) hypothetical protein 0.02 0.2572 0.6415
Onchocerca volvulus 0.02 0.2572 0.635
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.002 0.0088 0.0178
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.02 0.2572 0.6415
Brugia malayi RNA recognition motif domain containing protein 0.0058 0.0614 0.1499
Loa Loa (eye worm) acetylcholine receptor protein 0.0092 0.1089 0.2691
Loa Loa (eye worm) hypothetical protein 0.02 0.2572 0.6415
Echinococcus multilocularis propionyl coenzyme A carboxylase alpha chain 0.002 0.0095 0.0078
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0058 0.0614 0.1499
Trypanosoma brucei acetyl-CoA carboxylase 0.0053 0.0544 1
Loa Loa (eye worm) hypothetical protein 0.02 0.2572 0.6415
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.02 0.2572 0.6415
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.02 0.2572 0.6415
Brugia malayi Immunoglobulin I-set domain containing protein 0.0075 0.0855 0.2103
Echinococcus granulosus tar DNA binding protein 0.0058 0.0614 0.0601
Onchocerca volvulus 0.02 0.2572 0.635
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.002 0.0088 0.0178
Schistosoma mansoni nAChR subunit 0.02 0.2572 0.6415
Schistosoma mansoni neurotransmitter gated ion channel 0.0092 0.1089 0.2691
Trichomonas vaginalis bromodomain-containing protein, putative 0.0039 0.0354 0.5
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.02 0.2572 0.6415
Echinococcus granulosus glycine receptor subunit alpha 1 0.02 0.2572 0.2573
Schistosoma mansoni hypothetical protein 0.0075 0.0855 0.2103
Schistosoma mansoni tar DNA-binding protein 0.0058 0.0614 0.1499
Brugia malayi hypothetical protein 0.0123 0.1507 0.3741
Loa Loa (eye worm) GABA receptor subunit 0.0108 0.1302 0.3226
Loa Loa (eye worm) hypothetical protein 0.0092 0.1089 0.2691
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0108 0.1302 0.3226
Echinococcus granulosus Ankyrin 0.0076 0.0859 0.0847
Schistosoma mansoni steroid hormone receptor ad4bp 0.002 0.0088 0.0178
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.002 0.0088 0.0071
Mycobacterium tuberculosis Probable acetyl-/propionyl-coenzyme A carboxylase alpha chain (alpha subunit) AccA2: biotin carboxylase + biotin carboxyl carrie 0.002 0.0095 0.5
Schistosoma mansoni tar DNA-binding protein 0.0058 0.0614 0.1499
Brugia malayi Nuclear hormone receptor-like 1 0.002 0.0088 0.0178
Loa Loa (eye worm) hypothetical protein 0.0108 0.1302 0.3226
Onchocerca volvulus Bile acid receptor homolog 0.0185 0.2366 0.5823
Echinococcus multilocularis glycine receptor subunit alpha 1 0.02 0.2572 0.256
Brugia malayi hypothetical protein 0.0092 0.1089 0.2691
Loa Loa (eye worm) hypothetical protein 0.002 0.0088 0.0178
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0132 0.1638 0.1624
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.002 0.0088 0.0178
Echinococcus granulosus nicotinic acetylcholine receptor a11 subunit 0.02 0.2572 0.2573
Loa Loa (eye worm) hypothetical protein 0.0108 0.1302 0.3226
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.02 0.2572 0.6415
Brugia malayi bZIP transcription factor family protein 0.02 0.2569 0.6408
Trypanosoma brucei 3-methylcrotonyl-CoA carboxylase alpha subunit, putative 0.002 0.0095 0.1741
Onchocerca volvulus Putative nachr subunit 0.02 0.2572 0.635
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0092 0.1089 0.2691
Echinococcus granulosus netrin receptor unc 5 0.0075 0.0855 0.0843
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.02 0.2572 0.6415
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.002 0.0088 0.0071
Schistosoma mansoni retinoblastoma-binding protein 4 (rbbp4) 0.0076 0.0859 0.2113
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.002 0.0088 0.0178
Echinococcus multilocularis ankyrin repeat and death domain containing protein 0.0075 0.0855 0.0839
Mycobacterium ulcerans tryptophan-rich sensory protein 0.0304 0.4 1
Echinococcus multilocularis gamma aminobutyric acid receptor subunit 0.0092 0.1089 0.1074
Loa Loa (eye worm) RNA binding protein 0.0058 0.0614 0.1499
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.002 0.0088 0.0071
Loa Loa (eye worm) hypothetical protein 0.0092 0.1089 0.2691
Schistosoma mansoni acetylcholine receptor subunit beta 0.0092 0.1089 0.2691
Echinococcus granulosus FTZ F1 alpha 0.002 0.0088 0.0071
Loa Loa (eye worm) LGC-31 protein 0.02 0.2572 0.6415
Schistosoma mansoni neurotransmitter gated ion channel 0.0092 0.1089 0.2691
Entamoeba histolytica hypothetical protein 0.0108 0.1302 1
Loa Loa (eye worm) hypothetical protein 0.0304 0.4 1
Schistosoma mansoni neurotransmitter gated ion channel 0.0108 0.1302 0.3226
Brugia malayi Nuclear hormone receptor family member nhr-19 0.002 0.0088 0.0178
Loa Loa (eye worm) hypothetical protein 0.0092 0.1089 0.2691
Onchocerca volvulus 0.0092 0.1089 0.2559
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.002 0.0088 0.0071
Schistosoma mansoni nicotinic acetylcholine receptor alpha 0.0108 0.1302 0.3226
Echinococcus multilocularis nAChR subunit 0.0108 0.1302 0.1287
Echinococcus multilocularis nicotinic acetylcholine receptor beta 1 subunit 0.02 0.2572 0.256
Brugia malayi excitatory GABA receptor EXP-1A 0.02 0.2572 0.6415
Loa Loa (eye worm) nicotinic acetylcholine receptor alpha subunit 0.02 0.2572 0.6415
Loa Loa (eye worm) hypothetical protein 0.02 0.2572 0.6415
Schistosoma mansoni thyroid hormone receptor 0.002 0.0088 0.0178
Loa Loa (eye worm) hypothetical protein 0.0304 0.4 1
Schistosoma mansoni nAChR subunit (ShAR1-alpha-like) 0.02 0.2572 0.6415
Loa Loa (eye worm) hypothetical protein 0.0092 0.1089 0.2691
Echinococcus granulosus jun protein 0.02 0.2569 0.257
Brugia malayi hypothetical protein 0.0092 0.1089 0.2691
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0039 0.0354 0.5
Echinococcus granulosus retinoic acid receptor rxr beta a 0.002 0.0088 0.0071
Loa Loa (eye worm) hypothetical protein 0.0092 0.1089 0.2691
Onchocerca volvulus 0.0304 0.4 1
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.02 0.2572 0.6415
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.002 0.0088 0.0071
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0092 0.1089 0.2691
Brugia malayi hypothetical protein 0.0092 0.1089 0.2691
Onchocerca volvulus 0.0304 0.4 1
Loa Loa (eye worm) hypothetical protein 0.0092 0.1089 0.2691
Brugia malayi nuclear receptor NHR-88 0.002 0.0088 0.0178
Onchocerca volvulus Netrin receptor homolog 0.0075 0.0855 0.196
Brugia malayi Acetylcholine receptor protein, alpha-like chain 1 precursor 0.0092 0.1089 0.2691
Schistosoma mansoni Tr4/Tr2 (homologue) 0.002 0.0088 0.0178
Loa Loa (eye worm) ACC-1 protein 0.02 0.2572 0.6415
Schistosoma mansoni acetylcholine receptor-related 0.0092 0.1089 0.2691
Loa Loa (eye worm) hypothetical protein 0.02 0.2572 0.6415
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0039 0.0354 0.5769
Schistosoma mansoni netrin receptor unc5 0.0075 0.0855 0.2103
Echinococcus multilocularis nAChR subunit 0.02 0.2572 0.256
Loa Loa (eye worm) hypothetical protein 0.02 0.2572 0.6415
Schistosoma mansoni nAChR subunit 0.0092 0.1089 0.2691
Trypanosoma brucei 3-methylcrotonyl-CoA carboxylase alpha subunit, putative 0.002 0.0095 0.1741
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0092 0.1089 0.2691
Echinococcus multilocularis glycine receptor subunit alpha 1 0.02 0.2572 0.256
Echinococcus multilocularis netrin receptor unc 5 0.0075 0.0855 0.0839
Echinococcus granulosus geminin 0.0155 0.1946 0.1942
Schistosoma mansoni nAChR subunit 0.02 0.2572 0.6415
Loa Loa (eye worm) hypothetical protein 0.0092 0.1089 0.2691
Brugia malayi hypothetical protein 0.0092 0.1089 0.2691
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0108 0.1302 0.3226
Brugia malayi Nuclear hormone receptor family member nhr-14 0.002 0.0088 0.0178
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.002 0.0088 0.0178
Echinococcus multilocularis nicotinic acetylcholine receptor a11 subunit 0.02 0.2572 0.256
Schistosoma mansoni tar DNA-binding protein 0.0058 0.0614 0.1499
Schistosoma mansoni nAChR subunit (ShAR1-beta-like) 0.02 0.2572 0.6415
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.02 0.2572 0.6415
Onchocerca volvulus 0.02 0.2572 0.635
Loa Loa (eye worm) acetylcholine receptor alpha subunit 0.02 0.2572 0.6415
Brugia malayi nicotinic acetylcholine receptor alpha subunit, putative 0.02 0.2572 0.6415
Echinococcus granulosus ankyrin repeat and death domain containing protein 0.0075 0.0855 0.0843
Brugia malayi Steroid receptor seven-up type 2 0.002 0.0088 0.0178
Loa Loa (eye worm) hypothetical protein 0.0092 0.1089 0.2691
Loa Loa (eye worm) hypothetical protein 0.02 0.2572 0.6415
Brugia malayi glutamate-gated chloride channel alpha3A subunit, putative 0.0092 0.1089 0.2691
Schistosoma mansoni nAChR subunit 0.02 0.2572 0.6415
Echinococcus multilocularis translocator protein 0.0304 0.4 0.399
Brugia malayi hypothetical protein 0.0092 0.1089 0.2691
Schistosoma mansoni RAR-like nuclear receptor 0.002 0.0088 0.0178
Loa Loa (eye worm) hypothetical protein 0.0092 0.1089 0.2691
Loa Loa (eye worm) hypothetical protein 0.0108 0.1302 0.3226
Plasmodium falciparum biotin carboxylase subunit of acetyl CoA carboxylase, putative 0.0038 0.0343 1
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.002 0.0088 0.0071
Loa Loa (eye worm) hypothetical protein 0.02 0.2572 0.6415
Loa Loa (eye worm) hypothetical protein 0.002 0.0088 0.0178
Brugia malayi Nuclear hormone receptor family member nhr-31 0.002 0.0088 0.0178
Onchocerca volvulus 0.02 0.2572 0.635
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.002 0.0088 0.0071
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.002 0.0088 0.0178
Loa Loa (eye worm) hypothetical protein 0.0092 0.1089 0.2691
Loa Loa (eye worm) hypothetical protein 0.002 0.0088 0.0178
Schistosoma mansoni nAChR subunit 0.0092 0.1089 0.2691
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.02 0.2572 0.256
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.002 0.0088 0.0071
Loa Loa (eye worm) hypothetical protein 0.0185 0.2366 0.5897
Loa Loa (eye worm) hypothetical protein 0.02 0.2572 0.6415
Schistosoma mansoni methylcrotonyl-CoA carboxylase 0.002 0.0095 0.0196
Brugia malayi Nuclear hormone receptor family member nhr-25 0.002 0.0088 0.0178
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0075 0.0855 0.2103
Brugia malayi Nuclear hormone receptor family member nhr-1 0.002 0.0088 0.0178
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0132 0.1638 0.4071
Schistosoma mansoni jun-related protein 0.0162 0.2054 0.5114
Loa Loa (eye worm) hypothetical protein 0.02 0.2572 0.6415
Brugia malayi TspO/MBR family protein 0.0304 0.4 1
Loa Loa (eye worm) steroid hormone receptor 0.002 0.0088 0.0178
Loa Loa (eye worm) hypothetical protein 0.0076 0.0859 0.2113
Echinococcus multilocularis nuclear factor of activated T cells 5 0.0736 0.995 0.995
Echinococcus granulosus ecdysone induced protein 78C 0.002 0.0088 0.0071
Echinococcus granulosus acetyl coenzyme A carboxylase 1 0.0053 0.0544 0.053
Loa Loa (eye worm) ACC-1 protein 0.02 0.2572 0.6415
Brugia malayi Neuronal acetylcholine receptor protein, alpha-2 chain precursor 0.0092 0.1089 0.2691
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.002 0.0088 0.0071
Loa Loa (eye worm) hypothetical protein 0.0075 0.0855 0.2103
Echinococcus multilocularis tar DNA binding protein 0.0058 0.0614 0.0598
Loa Loa (eye worm) excitatory GABA receptor EXP-1A 0.02 0.2572 0.6415
Loa Loa (eye worm) hypothetical protein 0.0092 0.1089 0.2691
Schistosoma mansoni nAChR subunit 0.02 0.2572 0.6415
Echinococcus multilocularis acetylcholine receptor subunit beta 1 0.02 0.2572 0.256
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.02 0.2572 0.6415
Onchocerca volvulus 0.0092 0.1089 0.2559
Echinococcus multilocularis FTZ F1 alpha 0.002 0.0088 0.0071
Brugia malayi TAR-binding protein 0.0058 0.0614 0.1499
Loa Loa (eye worm) hypothetical protein 0.0304 0.4 1
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0092 0.1089 0.2691
Schistosoma mansoni tar DNA-binding protein 0.0058 0.0614 0.1499
Schistosoma mansoni tar DNA-binding protein 0.0058 0.0614 0.1499
Onchocerca volvulus 0.0304 0.4 1
Schistosoma mansoni retinoic acid receptor RXR 0.002 0.0088 0.0178
Echinococcus multilocularis glycine receptor subunit beta 0.02 0.2572 0.256
Echinococcus multilocularis neuronal acetylcholine receptor subunit alpha 4 0.02 0.2572 0.256
Loa Loa (eye worm) hypothetical protein 0.02 0.2572 0.6415
Loa Loa (eye worm) hypothetical protein 0.0092 0.1089 0.2691
Mycobacterium leprae Probable bifunctional protein acetyl-/propionyl-coenzyme A carboxylase, alpha chain AccA3 (BccP) 0.002 0.0095 0.5
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.02 0.2572 0.6415
Brugia malayi Cation transporter family protein 0.02 0.2572 0.6415
Loa Loa (eye worm) hypothetical protein 0.0108 0.1302 0.3226
Loa Loa (eye worm) hypothetical protein 0.0092 0.1089 0.2691
Toxoplasma gondii acetyl-CoA carboxylase ACC1 0.0053 0.0544 1
Loa Loa (eye worm) hypothetical protein 0.02 0.2572 0.6415
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0092 0.1089 0.1079
Schistosoma mansoni thyroid hormone receptor 0.002 0.0088 0.0178
Loa Loa (eye worm) hypothetical protein 0.02 0.2572 0.6415
Echinococcus granulosus propionyl coenzyme A carboxylase alpha chain 0.002 0.0095 0.0078
Onchocerca volvulus 0.02 0.2572 0.635
Schistosoma mansoni acetyl-CoA carboxylase 0.0053 0.0544 0.1322
Brugia malayi hypothetical protein 0.0157 0.1979 0.4925
Loa Loa (eye worm) hypothetical protein 0.0108 0.1302 0.3226
Loa Loa (eye worm) hypothetical protein 0.0108 0.1302 0.3226
Onchocerca volvulus 0.0157 0.1979 0.4833
Echinococcus granulosus nuclear factor of activated T cells 5 0.0736 0.995 1
Echinococcus multilocularis Ankyrin 0.0076 0.0859 0.0843
Loa Loa (eye worm) hypothetical protein 0.0194 0.2494 0.6219
Onchocerca volvulus 0.02 0.2572 0.635
Brugia malayi Cation transporter family protein 0.02 0.2572 0.6415
Brugia malayi Nuclear hormone receptor family member nhr-49 0.002 0.0088 0.0178
Brugia malayi photoreceptor-specific nuclear receptor 0.002 0.0088 0.0178
Echinococcus multilocularis geminin 0.0155 0.1946 0.1933
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.002 0.0088 0.0178
Echinococcus granulosus glycine receptor subunit beta 0.02 0.2572 0.2573
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0092 0.1089 0.1074
Echinococcus granulosus nicotinic acetylcholine receptor subunit type 0.02 0.2572 0.2573
Brugia malayi Cation transporter family protein 0.02 0.2572 0.6415

Activities

Activity type Activity value Assay description Source Reference
K app (binding) = 0.000029 Binding constant of the compound were determined from viscometric titrations with calf thymus DNA ChEMBL. 4009616

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

No external resources registered for this compound

Bibliographic References

1 literature reference was collected for this gene.

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