TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 395.448 | Formula: C23H25NO5
H donors: 2 H acceptors: 3 LogP: 1.99 Rotable bonds: 2
Rule of 5 violations (Lipinski): 1
SMILES: O=C1C=CC2(O1)CCC1([C@]34C2Oc2c4c(CC1N(CC3)CC1CC1)ccc2O)O
InChi: 1S/C23H25NO5/c25-15-4-3-14-11-16-23(27)8-7-21(6-5-17(26)29-21)20-22(23,18(14)19(15)28-20)9-10-24(16)12-13-1-2-13/h3-6,13,16,20,25,27H,1-2,7-12H2/t16?,20?,21?,22-,23?/m0/s1
InChiKey: ZRIPUBOFPUUGEX-ILURHBKOSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Brugia malayi	TspO/MBR family protein	0.0521	0.2195	0.8402
Brugia malayi	RNase H family protein	0.0617	0.2612	1
Schistosoma mansoni	patched 1	0.0093	0.0331	0.0323
Onchocerca volvulus		0.0052	0.0151	0.0414
Trypanosoma brucei	SLACS retrotransposable element (part), putative	0.0052	0.0154	0.0146
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0036	0.0084	0.032
Echinococcus granulosus	expressed conserved protein	0.0204	0.0813	0.309
Trichomonas vaginalis	reverse transcriptases, putative	0.0052	0.0154	0.0559
Brugia malayi	Calcitonin receptor-like protein seb-1	0.01	0.0364	0.1392
Brugia malayi	beta-lactamase	0.0036	0.0084	0.032
Entamoeba histolytica	acyl-coA synthetase, putative	0.0027	0.0045	0.0425
Trypanosoma brucei	Endonuclease-reverse transcriptase/Reverse transcriptase (RNA-dependent DNA polymerase), putative	0.0052	0.0154	0.0146
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0036	0.0084	0.0075
Brugia malayi	hypothetical protein	0.0052	0.0154	0.0589
Brugia malayi	hypothetical protein	0.0052	0.0154	0.0589
Brugia malayi	ERG2 and Sigma1 receptor like protein	0.0217	0.0873	0.3342
Onchocerca volvulus	Telomerase reverse transcriptase homolog	0.0052	0.0154	0.0424
Echinococcus multilocularis	RNA directed DNA polymerase	0.0052	0.0154	0.0189
Echinococcus granulosus	RNA directed DNA polymerase reverse transcriptase	0.0052	0.0154	0.0559
Brugia malayi	hypothetical protein	0.0052	0.0154	0.0589
Loa Loa (eye worm)	hypothetical protein	0.002	0.0015	0.003
Mycobacterium tuberculosis	Probable hydrolase	0.0036	0.0084	0.0812
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0027	0.0045	0.0396
Plasmodium falciparum	ataxin-2 like protein, putative	0.0026	0.0041	1
Echinococcus granulosus	Niemann Pick C1 protein	0.031	0.1276	0.4867
Schistosoma mansoni	hypothetical protein	0.009	0.0317	0.0308
Brugia malayi	beta-lactamase family protein	0.0036	0.0084	0.032
Mycobacterium ulcerans	esterase/lipase LipP	0.0036	0.0084	0.0344
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0036	0.0084	0.0344
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0053	0.0156	0.0597
Echinococcus multilocularis	telomerase reverse transcriptase subunit	0.0052	0.0154	0.0189
Mycobacterium ulcerans	acyl-CoA synthetase	0.0027	0.0045	0.0168
Loa Loa (eye worm)	hypothetical protein	0.002	0.0015	0.003
Brugia malayi	Pao retrotransposon peptidase family protein	0.0052	0.0154	0.0589
Loa Loa (eye worm)	hypothetical protein	0.002	0.0015	0.003
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0045	0.0168
Brugia malayi	RNA binding protein	0.0064	0.0204	0.0779
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0045	0.0168
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0027	0.0045	0.0425
Echinococcus multilocularis	RNA directed DNA polymerase (reverse transcriptase)	0.0052	0.0154	0.0189
Trypanosoma cruzi	hypothetical protein, conserved	0.0052	0.0154	0.0559
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0079	0.0271	0.0341
Brugia malayi	Pao retrotransposon peptidase family protein	0.0052	0.0154	0.0589
Mycobacterium ulcerans	tryptophan-rich sensory protein	0.0521	0.2195	1
Loa Loa (eye worm)	hypothetical protein	0.0114	0.0422	0.1893
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0032	0.0064	0.0214
Loa Loa (eye worm)	hypothetical protein	0.0217	0.087	0.3942
Plasmodium vivax	hypothetical protein, conserved	0.0036	0.0084	1
Schistosoma mansoni	tar DNA-binding protein	0.0064	0.0204	0.0195
Echinococcus multilocularis	RNA directed DNA polymerase (reverse transcriptase)	0.0052	0.0154	0.0189
Mycobacterium tuberculosis	Probable lipase LipE	0.0036	0.0084	0.0812
Giardia lamblia	Reverse transcriptase/endonuclease, putative	0.0052	0.0154	0.0559
Echinococcus multilocularis	Niemann Pick C1 protein	0.031	0.1276	0.1646
Entamoeba histolytica	hypothetical protein	0.0079	0.0271	0.3047
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0064	0.0255
Trypanosoma cruzi	hypothetical protein, conserved	0.0036	0.0084	0.0289
Leishmania major	hypothetical protein, conserved	0.0026	0.0041	0.0124
Leishmania major	4-coumarate:coa ligase-like protein	0.0027	0.0045	0.0141
Onchocerca volvulus		0.0521	0.2195	0.8374
Echinococcus granulosus	ribonuclease H1	0.0617	0.2612	1
Trypanosoma cruzi	PAB1-binding protein , putative	0.0026	0.0041	0.0124
Loa Loa (eye worm)	hypothetical protein	0.002	0.0015	0.003
Trypanosoma brucei	SLACS reverse transcriptase, putative	0.0052	0.0154	0.0146
Trypanosoma cruzi	C-8 sterol isomerase, putative	0.0217	0.0873	0.3321
Loa Loa (eye worm)	hypothetical protein	0.0217	0.0873	0.3955
Brugia malayi	Pao retrotransposon peptidase family protein	0.0052	0.0154	0.0589
Schistosoma mansoni	tar DNA-binding protein	0.0064	0.0204	0.0195
Echinococcus multilocularis	tar DNA binding protein	0.0064	0.0204	0.0253
Brugia malayi	Zinc knuckle family protein	0.0052	0.0154	0.0589
Schistosoma mansoni	tar DNA-binding protein	0.0064	0.0204	0.0195
Entamoeba histolytica	hypothetical protein	0.0079	0.0271	0.3047
Leishmania major	hypothetical protein, conserved	0.0036	0.0084	0.0289
Brugia malayi	Pao retrotransposon peptidase family protein	0.0052	0.0154	0.0589
Mycobacterium tuberculosis	Probable lipase LipD	0.0036	0.0084	0.0812
Brugia malayi	Pao retrotransposon peptidase family protein	0.0052	0.0154	0.0589
Brugia malayi	Zinc knuckle family protein	0.0052	0.0154	0.0589
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0053	0.0156	0.0675
Onchocerca volvulus		0.0036	0.0084	0.015
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0084	0.0344
Echinococcus granulosus	sterol regulatory element binding protein	0.0093	0.0331	0.1239
Loa Loa (eye worm)	hypothetical protein	0.0521	0.2195	1
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.0231	0.0934	1
Mycobacterium ulcerans	beta-lactamase	0.0036	0.0084	0.0344
Mycobacterium tuberculosis	Possible maturase	0.0052	0.0154	0.1571
Trypanosoma brucei	unspecified product	0.0669	0.284	0.2834
Leishmania major	4-coumarate:coa ligase-like protein	0.0027	0.0045	0.0141
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0053	0.0156	0.0192
Leishmania major	C-8 sterol isomerase-like protein	0.0217	0.0873	0.3321
Echinococcus multilocularis	GPCR, family 2	0.0032	0.0064	0.0073
Schistosoma mansoni	cellular tumor antigen P53	0.0052	0.0151	0.0143
Trypanosoma brucei	ingi protein (ORF1)	0.0669	0.284	0.2834
Echinococcus multilocularis	RNA directed DNA polymerase (reverse transcriptase)	0.0052	0.0154	0.0189
Trichomonas vaginalis	conserved hypothetical protein	0.0093	0.0331	0.1239
Trichomonas vaginalis	D-aminoacylase, putative	0.0036	0.0084	0.0289
Brugia malayi	TAR-binding protein	0.0064	0.0204	0.0779
Schistosoma mansoni	niemann-pick C1 (NPC1)	0.022	0.0885	0.0877
Mycobacterium ulcerans	acyl-CoA synthetase	0.0027	0.0045	0.0168
Brugia malayi	AMP-binding enzyme family protein	0.0027	0.0045	0.0173
Onchocerca volvulus		0.0521	0.2195	0.8374
Toxoplasma gondii	LsmAD domain-containing protein	0.0026	0.0041	0.0124
Brugia malayi	Pao retrotransposon peptidase family protein	0.0052	0.0154	0.0589
Schistosoma mansoni	hypothetical protein	0.0052	0.0154	0.0146
Trichomonas vaginalis	penicillin-binding protein, putative	0.0036	0.0084	0.0289
Mycobacterium leprae	Probable lipase LipE	0.0036	0.0084	1
Echinococcus granulosus	RNA directed DNA polymerase	0.0052	0.0154	0.0559
Echinococcus multilocularis	RNA directed DNA polymerase (reverse transcriptase)	0.0052	0.0154	0.0189
Giardia lamblia	Reverse transcriptase/endonuclease, putative	0.0052	0.0154	0.0559
Schistosoma mansoni	scy1(yeast) protein kinase-like	0.0052	0.0154	0.0146
Brugia malayi	reverse transcriptase	0.0052	0.0154	0.0589
Loa Loa (eye worm)	hypothetical protein	0.0052	0.0151	0.0653
Echinococcus multilocularis	RNA directed DNA polymerase (reverse transcriptase)	0.0052	0.0154	0.0189
Trypanosoma cruzi	hypothetical protein, conserved	0.0036	0.0084	0.0289
Trichomonas vaginalis	reverse transcriptase [C. elegans], putative	0.0052	0.0154	0.0559
Plasmodium falciparum	acyl-CoA synthetase	0.002	0.0015	0.2003
Chlamydia trachomatis	acylglycerophosphoethanolamine acyltransferase	0.002	0.0015	0.5
Brugia malayi	RNase H family protein	0.0617	0.2612	1
Brugia malayi	AMP-binding enzyme family protein	0.0027	0.0045	0.0173
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0084	0.0344
Brugia malayi	Pao retrotransposon peptidase family protein	0.0052	0.0154	0.0589
Mycobacterium ulcerans	long-chain-fatty-acid-CoA ligase	0.0027	0.0045	0.0168
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0084	0.0344
Echinococcus multilocularis	Niemann Pick C1 protein	0.0217	0.087	0.112
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0019	0.001	0.0017
Brugia malayi	RNA recognition motif domain containing protein	0.0064	0.0204	0.0779
Schistosoma mansoni	serine/threonine protein kinase	0.0052	0.0154	0.0146
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0045	0.0168
Echinococcus granulosus	Protein patched homolog 1	0.0093	0.0331	0.1239
Trypanosoma brucei	RNA helicase, putative	0.2312	1	1
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0079	0.0271	0.1008
Trypanosoma brucei	PAB1-binding protein , putative	0.0026	0.0041	0.0032
Mycobacterium ulcerans	fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE	0.0036	0.0084	0.0344
Onchocerca volvulus		0.0521	0.2195	0.8374
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0027	0.0045	0.0425
Plasmodium falciparum	ataxin-2 like protein, putative	0.0026	0.0041	1
Schistosoma mansoni	hypothetical protein	0.0079	0.0271	0.0263
Mycobacterium tuberculosis	Probable esterase/lipase LipP	0.0036	0.0084	0.0812
Echinococcus multilocularis	protein dispatched 1	0.0106	0.0388	0.0494
Brugia malayi	beta-lactamase family protein	0.0036	0.0084	0.032
Schistosoma mansoni	protein kinase	0.0052	0.0154	0.0146
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0032	0.0064	0.0214
Loa Loa (eye worm)	hypothetical protein	0.0521	0.2195	1
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0036	0.0084	0.0075
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0032	0.0064	0.0073
Schistosoma mansoni	hypothetical protein	0.0032	0.0064	0.0056
Loa Loa (eye worm)	hypothetical protein	0.0093	0.0331	0.1476
Echinococcus granulosus	KRAB A domain containing protein	0.0052	0.0154	0.0559
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0036	0.0084	0.0098
Brugia malayi	exodeoxyribonuclease III family protein	0.0019	0.0008	0.0033
Entamoeba histolytica	hypothetical protein	0.0079	0.0271	0.3047
Treponema pallidum	ribonuclease H (rnhA)	0.0617	0.2612	1
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0032	0.0064	0.0073
Schistosoma mansoni	hypothetical protein	0.0032	0.0064	0.0056
Echinococcus granulosus	GPCR family 2	0.0032	0.0064	0.0214
Trichomonas vaginalis	reverse transcriptases, putative	0.0052	0.0154	0.0559
Giardia lamblia	Reverse transcriptase/endonuclease, putative	0.0052	0.0154	0.0559
Toxoplasma gondii	ribonuclease HI protein	0.0617	0.2612	1
Mycobacterium tuberculosis	Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase)	0.002	0.0015	0.007
Onchocerca volvulus		0.0052	0.0154	0.0424
Trypanosoma brucei	hypothetical protein, conserved	0.0036	0.0084	0.0075
Echinococcus granulosus	tumor protein p63	0.0354	0.1467	0.5601
Brugia malayi	CHE-14 protein	0.0093	0.0331	0.1268
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0019	0.001	0.0017
Brugia malayi	hypothetical protein	0.0052	0.0154	0.0589
Loa Loa (eye worm)	hypothetical protein	0.0069	0.0225	0.0991
Schistosoma mansoni	hypothetical protein	0.009	0.0317	0.0308
Wolbachia endosymbiont of Brugia malayi	ribonuclease HI	0.0617	0.2612	1
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0032	0.0064	0.0255
Loa Loa (eye worm)	hypothetical protein	0.002	0.0015	0.003
Trichomonas vaginalis	esterase, putative	0.0036	0.0084	0.0289
Trypanosoma brucei	retrotransposon hot spot protein 4 (RHS4), interrupted	0.0669	0.284	0.2834
Brugia malayi	hypothetical protein	0.021	0.0842	0.3223
Trypanosoma brucei	ribonuclease H1	0.0617	0.2612	0.2606
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0053	0.0156	0.0148
Echinococcus multilocularis	RNA directed DNA polymerase (reverse transcriptase)	0.0052	0.0154	0.0189
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0053	0.0156	0.0148
Brugia malayi	reverse transcriptase	0.0052	0.0154	0.0589
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0064	0.0204	0.0892
Trypanosoma cruzi	ribonuclease H1, putative	0.0617	0.2612	1
Onchocerca volvulus		0.0052	0.0154	0.0424
Mycobacterium tuberculosis	Probable conserved lipoprotein	0.0036	0.0084	0.0812
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0084	0.0344
Brugia malayi	Pao retrotransposon peptidase family protein	0.0052	0.0154	0.0589
Mycobacterium ulcerans	lipase LipD	0.0036	0.0084	0.0344
Loa Loa (eye worm)	TAR-binding protein	0.0064	0.0204	0.0892
Mycobacterium ulcerans	hypothetical protein	0.0036	0.0084	0.0344
Trichomonas vaginalis	D-aminoacylase, putative	0.0036	0.0084	0.0289
Giardia lamblia	Reverse transcriptase/endonuclease, putative	0.0052	0.0154	0.0559
Loa Loa (eye worm)	beta-lactamase	0.0036	0.0084	0.0344
Trichomonas vaginalis	D-aminoacylase, putative	0.0036	0.0084	0.0289
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.01	0.0364	0.1392
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0084	0.0344
Echinococcus multilocularis	RNA directed DNA polymerase (reverse transcriptase)	0.0052	0.0154	0.0189
Mycobacterium ulcerans	fatty-acid-CoA ligase	0.0027	0.0045	0.0168
Brugia malayi	Pao retrotransposon peptidase family protein	0.0052	0.0154	0.0589
Mycobacterium ulcerans	long-chain-fatty-acid--CoA ligase	0.0027	0.0045	0.0168
Onchocerca volvulus	Ribonuclease H1 homolog	0.0617	0.2612	1
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0041	0.0148
Echinococcus granulosus	translocator protein	0.0521	0.2195	0.8397
Echinococcus multilocularis	sterol regulatory element binding protein	0.0093	0.0331	0.0419
Schistosoma mansoni	tar DNA-binding protein	0.0064	0.0204	0.0195
Echinococcus multilocularis	ribonuclease H1	0.0617	0.2612	0.3383
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0053	0.0156	0.0192
Trichomonas vaginalis	penicillin-binding protein, putative	0.0036	0.0084	0.0289
Schistosoma mansoni	phosphoglucomutase	0.0617	0.2612	0.2606
Mycobacterium tuberculosis	Probable esterase LipL	0.0036	0.0084	0.0812
Plasmodium vivax	ataxin-2 like protein, putative	0.0026	0.0041	0.429
Echinococcus granulosus	RNA directed DNA polymerase reverse transcriptase	0.0052	0.0154	0.0559
Brugia malayi	Pao retrotransposon peptidase family protein	0.0052	0.0154	0.0589
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0019	0.001	0.0017
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0053	0.0156	0.0567
Schistosoma mansoni	tar DNA-binding protein	0.0064	0.0204	0.0195
Brugia malayi	latrophilin 2 splice variant baaae	0.0069	0.0225	0.0862
Echinococcus multilocularis	atpase aaa+ type core atpase aaa type core	0.1785	0.7706	1
Schistosoma mansoni	hypothetical protein	0.009	0.0317	0.0308
Schistosoma mansoni	hypothetical protein	0.009	0.0317	0.0308
Loa Loa (eye worm)	abnormal chemotaxis protein 14	0.0093	0.0331	0.1476
Leishmania major	4-coumarate:coa ligase-like protein	0.0027	0.0045	0.0141
Leishmania major	ribonuclease H1, putative	0.0617	0.2612	1
Echinococcus granulosus	RNA directed DNA polymerase reverse transcriptase	0.0052	0.0154	0.0559
Mycobacterium tuberculosis	Conserved protein	0.0036	0.0084	0.0812
Giardia lamblia	Ribonuclease H	0.0617	0.2612	1
Trichomonas vaginalis	NeSL-1_NeSL reverse transcriptases, putative	0.0052	0.0154	0.0559
Giardia lamblia	Reverse transcriptase/endonuclease	0.0052	0.0154	0.0559
Loa Loa (eye worm)	RNA binding protein	0.0064	0.0204	0.0892
Mycobacterium ulcerans	hypothetical protein	0.0027	0.0045	0.0168
Brugia malayi	Pao retrotransposon peptidase family protein	0.0052	0.0154	0.0589
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0053	0.0156	0.0567
Echinococcus multilocularis	tumor protein p63	0.0354	0.1467	0.1895
Brugia malayi	AMP-binding enzyme family protein	0.0027	0.0045	0.0173
Entamoeba histolytica	hypothetical protein	0.0079	0.0271	0.3047
Schistosoma mansoni	hypothetical protein	0.0052	0.0154	0.0146
Schistosoma mansoni	phosphoglucomutase	0.0617	0.2612	0.2606
Brugia malayi	Latrophilin receptor protein 2	0.0032	0.0064	0.0246
Echinococcus multilocularis	translocator protein	0.0521	0.2195	0.284
Trichomonas vaginalis	ribonuclease H1, putative	0.0617	0.2612	1
Echinococcus multilocularis	expressed conserved protein	0.0204	0.0813	0.1045
Schistosoma mansoni	transcription factor LCR-F1	0.0079	0.0271	0.0263
Mycobacterium ulcerans	acyl-CoA synthetase	0.0027	0.0045	0.0168
Echinococcus granulosus	beta LACTamase domain containing family member	0.0036	0.0084	0.0289
Plasmodium vivax	acyl-CoA synthetase, putative	0.002	0.0015	0.0859
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0084	0.0344
Echinococcus granulosus	RNA directed DNA polymerase reverse transcriptase	0.0052	0.0154	0.0559
Loa Loa (eye worm)	hypothetical protein	0.0521	0.2195	1
Trypanosoma brucei	ingi protein (ORF1)	0.0669	0.284	0.2834
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0019	0.001	0.0017
Schistosoma mansoni	hypothetical protein	0.0032	0.0064	0.0056
Onchocerca volvulus		0.0036	0.0084	0.015
Brugia malayi	hypothetical protein	0.0079	0.0271	0.1038
Brugia malayi	Pao retrotransposon peptidase family protein	0.0052	0.0154	0.0589
Mycobacterium ulcerans	fatty-acid-CoA ligase	0.002	0.0015	0.003
Brugia malayi	RNase H family protein	0.0617	0.2612	1
Echinococcus granulosus	tar DNA binding protein	0.0064	0.0204	0.0749
Trypanosoma brucei	C-8 sterol isomerase, putative	0.0217	0.0873	0.0865
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.01	0.0364	0.1624
Schistosoma mansoni	phosphoglucomutase	0.0617	0.2612	0.2606
Brugia malayi	Pao retrotransposon peptidase family protein	0.0052	0.0154	0.0589
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0053	0.0156	0.0148
Mycobacterium tuberculosis	Conserved protein	0.0036	0.0084	0.0812
Trypanosoma cruzi	ribonuclease H1, putative	0.0617	0.2612	1
Loa Loa (eye worm)	hypothetical protein	0.0521	0.2195	1
Schistosoma mansoni	hypothetical protein	0.0032	0.0064	0.0056
Trypanosoma brucei	hypothetical protein, conserved	0.0669	0.284	0.2834
Onchocerca volvulus		0.0036	0.0084	0.015
Brugia malayi	reverse transcriptase	0.0052	0.0154	0.0589
Mycobacterium tuberculosis	Conserved protein	0.0036	0.0084	0.0812
Trypanosoma cruzi	PAB1-binding protein , putative	0.0026	0.0041	0.0124
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0032	0.0064	0.0246
Echinococcus multilocularis	protein patched	0.0093	0.0331	0.0419
Mycobacterium leprae	conserved hypothetical protein	0.0036	0.0084	1
Entamoeba histolytica	Niemann-Pick C1 protein, putative	0.0217	0.087	1
Echinococcus multilocularis	RNA directed DNA polymerase (reverse transcriptase)	0.0052	0.0154	0.0189
Toxoplasma gondii	ABC1 family protein	0.0036	0.0084	0.0289
Brugia malayi	Pao retrotransposon peptidase family protein	0.0052	0.0154	0.0589
Brugia malayi	Niemann-Pick C1 protein precursor	0.0217	0.087	0.3332
Loa Loa (eye worm)	hypothetical protein	0.01	0.0364	0.1624
Onchocerca volvulus		0.0521	0.2195	0.8374
Mycobacterium ulcerans	long-chain fatty-acid CoA ligase	0.0027	0.0045	0.0168
Brugia malayi	hypothetical protein	0.0026	0.0041	0.0156
Echinococcus multilocularis	RNA directed DNA polymerase (reverse transcriptase)	0.0052	0.0154	0.0189
Mycobacterium tuberculosis	Possible conserved lipoprotein LpqK	0.0036	0.0084	0.0812
Echinococcus granulosus	Niemann Pick C1 protein	0.0217	0.087	0.331
Schistosoma mansoni	peripheral-type benzodiazepine receptor	0.0521	0.2195	0.2188
Mycobacterium tuberculosis	Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase)	0.0027	0.0045	0.0396
Schistosoma mansoni	hypothetical protein	0.0069	0.0225	0.0217

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 10 nM	In vitro opioid receptor binding competition against 1 nM [3H]- Naltrexone in the absence of NaCl.	ChEMBL.	2409280
IC50 (binding)	= 10 nM	In vitro opioid receptor binding competition against 1 nM [3H]- Naltrexone in the presence of 100 mM NaCl.	ChEMBL.	2409280
Ratio (binding)	= 1	Ratio of IC50 value in presence of NaCl to that of NaCl absence against opioid receptor.	ChEMBL.	2409280

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: 389493

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 306499