Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Cavia porcellus | Cysteinyl leukotriene receptor 1 | Starlite/ChEMBL | References |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
clogP | = 6.97 | Calculated partition coefficient (clogP) | ChEMBL. | 8176706 |
delta clogP (ADMET) | = 1.12 | Delta clogP-logP values | ChEMBL. | 8176706 |
ED50 (functional) | = 1.39 uM kg-1 | Effective dose against LTD4-induced bronchoconstriction in guinea pig after intravenous administration | ChEMBL. | 8381184 |
ED50 (functional) | = 1.39 uM kg-1 | Inhibition of percent protection from LTD4-induced dyspnea in a conscious guinea pig administered intravenously | ChEMBL. | 8176706 |
ED50 (functional) | = 1.39 uM kg-1 | Inhibition of percent protection from LTD4-induced dyspnea in a conscious guinea pig administered intravenously | ChEMBL. | 8176706 |
ED50 (functional) | = 19.96 uM kg-1 | Effective dose for the inhibition of percent protection from LTD4-induced dyspnea in a conscious guinea pig administered through oral route | ChEMBL. | 8176706 |
ED50 (functional) | = 19.96 uM kg-1 | Effective dose for the inhibition of percent protection from LTD4-induced dyspnea in a conscious guinea pig administered through oral route | ChEMBL. | 8176706 |
ED50 (functional) | = 20 uM kg-1 | Effective dose against LTD4-induced bronchoconstriction in guinea pig after peroral administration | ChEMBL. | 8381184 |
Ki (binding) | = -8.3 | Binding affinity to the leukotriene receptor (LTD4) from guinea pig lung parenchymal membranes assayed using [3H]-LTD4 as radioligand | ChEMBL. | 8381184 |
Ki (binding) | = 5.2 nM | Inhibition constant for displacement of [3H]-LTD4 on guinea pig lung parenchymal membranes | ChEMBL. | 8176706 |
Ki (binding) | = 5.2 nM | Inhibition constant for displacement of [3H]-LTD4 on guinea pig lung parenchymal membranes | ChEMBL. | 8176706 |
Log Ki (binding) | = 8.3 | Binding affinity to the leukotriene receptor (LTD4) from guinea pig lung parenchymal membranes assayed using [3H]-LTD4 as radioligand | ChEMBL. | 8381184 |
logP (ADMET) | = 5.85 | Partition coefficient (logP) | ChEMBL. | 8176706 |
pKB (binding) | = 8.7 | Binding affinity against leukotriene receptor (LTE4) from guinea pig tracheal spirals | ChEMBL. | 8381184 |
pKB (binding) | = 8.7 | Binding affinity against leukotriene receptor (LTE4) from guinea pig tracheal spirals | ChEMBL. | 8381184 |
pKB (binding) | = 8.7 | Binding constant in guinea pig tracheal spirals with LTE4 | ChEMBL. | 8176706 |
Ratio (functional) | = 14 | ED50 ratio of LTD4 peroral administration / LTD4 intravenous administration | ChEMBL. | 8381184 |
Ratio (functional) | = 14 | ED50(p.o.)/ED50(i.v.) ratio of the compound | ChEMBL. | 8176706 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
2 literature references were collected for this gene.